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Epigallocatechin Gallate Solubility CAS 989-51-5

Molecular Formula: C22H18O11

Formula Weight: 458.37

ZSpharmac: Epigallocatechin Gallate Solubility Supplier

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Product Name: Epigallocatechin Gallate Solubility
CAS No: 989-51-5
Purity: 99%

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Basic Info

Product Name:Epigallocatechin Gallate Solubility
Other Names:(-)-Epigallocatechin Gallate
CAS:989-51-5
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Light Brown Neat
EINECS No.:479-560-7
Storage:2-8°C
Provide:Epigallocatechin Gallate Solubility MSDS;
Epigallocatechin Gallate Solubility COA

What is Epigallocatechin Gallate Solubility?

Epigallocatechin Gallate Solubility is one of the most effective active component in catechins, making up about 8% to 13% of the gross weight of environment-friendly tea, as well as is likewise the part with the highest content in catechins. (-)-Epigallocatechin gallate is an ester developed by α-diphenoxybenzopyran and also gallic acid. It has the basic residential property of phenolic anti-oxidant. There are 6 ortho phenolic hydroxyl teams in its molecular structure, so it has numerous properties superior to other catechins.

Epigallocatechin Gallate Solubility Property

Melting point 222-224°C
alpha D -185 ±2°(ethanol)
refractive index -175.5 ° (C=1, EtOH)
storage temp. 2-8°C
solubility H2O: ≥5mg/mL, clear
form neat
Boiling point 909.1±65.0 °C(Predicted)
density 1.90±0.1 g/cm3(Predicted)
pKa7.75±0.25(Predicted)
color White to Light Brown
Water Solubility Soluble in ethanol, dimethyl formamide, water.

 

Epigallocatechin Gallate Solubility Uses

Epigallocatechin Gallate Solubility (EGCG) is a component extracted from Chinese environment-friendly tea. It is the primary active as well as water-soluble component of environmentally friendly tea. It is the get rid of the highest possible material of catechins, making up 9%-13% of the gross weight of environment-friendly tea, because With an unique stereochemical framework, EGCG has extremely strong antioxidant task. The antioxidant activity is at the very least 100 times that of vitamin C along with 25 times that of vitamin E.It can shield cells and also DNA from damage. This damages is believed to be associated with cancer cells, Heart problem as well as various other significant diseases belong, and also these results of EGCG are attributed to their capacity to scavenge oxygen totally free radicals (antioxidant).

Epigallocatechin Gallate Solubility plays an essential duty in the battle against cancer cells as well as cardiovascular diseases. Additionally, it is likewise made use of as a turnaround representative of growth multidrug resistance, which can boost the level of sensitivity of cancer cells to chemotherapy and minimize the toxicity to the heart.

Epigallocatechin Gallate Solubility is the main component of environment-friendly tea polyphenols, as well as likewise the major part of green tea catechins. The catechins consist of EGCG, EGC, ECG, EC, GCG, and so on, amongst which the antioxidant task is EC. Lots of studies have actually shown that EGCG It has anti-free extreme DNA damages, anti-radiation and also ultraviolet rays, stops oil peroxidation, decreases the web content of low-density cholesterol, ultra-low-density cholesterol as well as triglyceride in lotion, interferes with the signal transmission required for cancer cell survival, and also prevents carcinogenicity in diet Materials, together with various other enzymes and anti-oxidants in the intestines, liver, as well as lungs, obstruct the task of particular carcinogens, scavenge cost-free radicals, resist the effects of air pollution, sunlight direct exposure, and cigarette smoking, and also prevent skin aging and also wrinkling.

Epigallocatechin Gallate Solubility Biological Activity

Green tea and its extracts have strong weight-loss and fat-reducing effects. As early as 1999, it was found that green tea extract intervention can significantly improve the energy consumption and fat oxidation levels of young men. Some experiments based on cell level and animal models have also revealed the role of green tea and catechins in weight loss and fat loss. For example, studies have shown that Epigallocatechin Gallate Solubility can reduce the viability of 3T3-L1 preadipocytes and inhibit the differentiation ability of preadipocytes by inducing the production of ROS and activating the AMPK pathway, thereby reducing adipogenesis and controlling the expansion of adipose tissue. By intervening food-derived EGCG in male DIO mice, it was shown that EGCG can increase the level of fat oxidation, and EGCG reduced the visceral fat weight of rats in a dose-dependent manner. Studies have shown that in rats fed a high-fat diet supplemented with food-derived EGCG (3.2g/kgfood), after 16 weeks of feeding, the rats lost weight, decreased epididymal fat coefficient, and significantly decreased FFAs and fasting insulin levels. Based on previous research, the weight loss and fat loss mechanism of Epigallocatechin Gallate Solubility can be divided into direct mechanism and indirect mechanism. The direct mechanism is the effect of EGCG on the digestive organs, such as inhibiting the digestion and absorption of nutrients by inhibiting the activity of digestive enzymes and changing the intestinal flora. The indirect mechanism is that EGCG regulates the expression of obesity-related genes and proteins in AT, muscle tissue, and liver tissue.

Preparation of Epigallocatechin Gallate Solubility

1) Extraction and separation of tea polyphenols

Dry 10g of tea leaves in an oven and grind them into powder. After plugging the outlet of the funnel with absorbent cotton, put the tea leaves into a constant-pressure dropping funnel, and fill it with absolute ethanol. Use a circulating condensing device and heat with a water bath at a temperature of about 87°C. When the condensate drops out, start timing, and after 2 hours, replace the distillation device to concentrate the extract. Add activated carbon powder to the extract to decolorize, filter with suction and collect the filtrate, adjust the pH of the filtrate with 10% citric acid solution, then add a certain proportion of ethyl acetate and water for extraction, take the upper oily ester layer and Use a rotary evaporator to recover ethyl acetate and dry it to obtain crude tea polyphenols.

2) Pretreatment of polyamide

The polyamide was stirred in ethanol and soaked for 24 hours. After filtration, the filter cake was washed 3 times with 20 mL of ethanol each time (the ethanol can be recovered and reused). Pour the treated polyamide into the chromatographic column to allow the polyamide to settle naturally, release the excess ethanol solution in the column, make the liquid level slightly higher than the surface of the polyamide particles, close the piston, and then use 5% NaOH solution to , 10% acetic acid solution, and finally rinsed with distilled water until the pH of the effluent was 7.

3) Separation and collection of (-)-epigallocatechin gallate

Add appropriate amount of distilled water to dissolve the obtained tea polyphenol crude product and put it on a polyamide column. First use 100mL distilled water for elution, control the flow rate to 4mL/min, when the liquid level in the chromatography column is slightly higher than the height of the polyamide column, use a certain concentration of ethanol-water solution for elution, the flow rate is 3.0mL/min, to Complete elution. Fractions containing (-)-epigallocatechin gallate were combined, ethanol was recovered, evaporated and dried at a temperature of 40° C., and solid powder of (-)-epigallocatechin gallate was recovered.

About Products:
If you need Epigallocatechin Gallate Solubility, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Epigallocatechin Gallate Solubility manufacturer and supplier, ZSpharmac will provide Epigallocatechin Gallate Solubility raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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