Epigallocatechin Gallate Solubility can inhibit the digestion and absorption of nutrients to achieve weight loss by down-regulating the activity of digestive enzymes. In vivo and in vitro studies have confirmed that catechin can down-regulate the activities of digestive enzymes such as pancreatic α-amylase, glucosidase and glucose transporter. Studies have shown that galloylated catechins such as EGCG can inhibit the absorption of glucose by enterocytes due to the competitive inhibition with Na+glucose cotransporters. EGCG inhibits α-amylase activity through hydrophobic association and hydrogen bond formation with pancreatic α-amylase. Lipids are emulsified, hydrolyzed, and absorbed in the small intestine. Lipid transporters on the apical surface of the small intestine facilitate the transfer of fatty acids and cholesterol into enterocytes. The absorbed lipids are packaged in chylomicrons and secreted into the lymphatic system. Many studies have proved that tea polyphenols can interfere with the lipid emulsification process and inhibit the activity of pancreatic lipase and phospholipase. For example, studies have shown that the intervention of Epigallocatechin Gallate Solubility increased the lipid content in the feces of HFD mice, which indicated that the absorption of lipids was inhibited, and they demonstrated in vitro studies that EGCG dose-dependently inhibited pancreatic lipase in a non-competitive manner activity. Food-derived EGCG can regulate energy metabolism by changing the composition of gut microbiota and affecting the growth of certain species of gut microbiota. By supplementing the high-fat diet of HFD-induced C57BL/6J mice with 4% green tea powder, it was found that green tea intake could effectively reduce the body weight of the mice and reduce the accumulation of triglyceride and cholesterol in the liver, which was correlated with The amount of Akkermansia in the microbiome of the small intestine and/or the amount of total microorganisms in the small intestine correlates. The study found that green tea consumption increased the proportion of bifidobacteria in the human gut microbiota, and the number of bifidobacteria was positively correlated with improved glucose tolerance and enhanced insulin sensitivity. Studies have shown that adding 0.6% EGCG (w/w) to the diet of rats, after feeding for 4 weeks, the starch and protein content in rat feces increased significantly compared with the control group, which indicated that food-derived EGCG intervention has an effect on The absorption of starch and protein, and the relative weight of VAT in rats were reduced. By studying the intestinal microbial composition of rats, it was found that EGCG intervention reduced the number of Clostridium microorganisms and increased the number of Bacteroides.