Zhishang Chemical

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Zhishang Chemical

Epidermal Growth Factor CAS 62253-63-8

Molecular Formula: C270H401N73O83S7

Formula Weight: 6221.96724

ZSpharmac: Epidermal Growth Factor Supplement

Product Name: Epidermal Growth Factor
CAS No: 62253-63-8
Purity: 99%

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Basic Info

Product Name:Epidermal Growth Factor
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:810-845-4
Provide:Epidermal Growth Factor MSDS;
Epidermal Growth Factor COA

What is Epidermal Growth Factor?

The Epidermal Growth Factor (Epidermal Growth Factor), commonly known as EGF, was awarded the Nobel Prize in Medicine and Physiology in 1986 for its discovery and research contributors. EGF is a protein of 53 amino acids, and its molecular weight is also much larger than that of peptides used in skin care. It was first used in the medical field, mainly to help repair and regenerate damaged epidermis, such as treating burns, scalds, etc.

Simply put, Epidermal Growth Factor is a type of functional small molecule protein that exists in human skin, which is mainly derived from human monocytes/macrophages and mast cells. It can stimulate the proliferation and differentiation of epidermal cells, so as to replace the aging and dead cells with new cells, and achieve the effect of repairing and proliferating skin surface cells. (It sounds awesome, but there are wood!) Just like any good thing in the human body, the content is the highest in childhood, but as the age increases, the EGF produced by the human body gradually decreases.

Methylglyoxal Miel Properties:

storage temp. -20°C
form powder
color white


Epidermal Growth Factor Efficacy

  1. Epidermal Growth Factor, as a medical external preparation, is still very popular. It is mainly used for the treatment of skin burns and scald wounds (superficial II degree to deep II degree burns and scald wounds), residual wounds, donor site wounds and chronic ulcer wounds, or for the treatment of wounds. Post-operative repairs such as microneedling and laser. These wounded skins are used under the guidance of a doctor’s diagnosis and there is no problem. At the same time, Epidermal Growth Factor is also used in some gastrointestinal diseases, corneal transplantation and so on.
  2. Epidermal Growth Factor can stimulate the metabolism of epidermal cells, the division and proliferation of various types of tissue cells, enhance cell movement, division and growth and the synthesis of interstitial proteins, promote the growth of skin cells, and promote the healing of various types of wounds.
  3. Although Epidermal Growth Factor can repair wounds, it does not mean that skin problems can be treated with it! If you have a skin disease and the skin barrier function is not sufficient, such as psoriasis and chronic eczema, Epidermal Growth Factor may promote excessive skin thickening, thereby aggravating the disease. Be sure to follow the doctor’s advice!

Why Epidermal Growth Factor is Banned

Epidermal Growth Factor is managed by prescription drugs in hospitals, and in January 2019, the State Drug Administration had made it clear that Epidermal Growth Factor should not be used as a cosmetic raw material. In the 2015 edition of the “Catalogue of the Names of Cosmetic Raw Materials Used” in China, EGF is no longer present.

So the question is, since it does have applications in medicine, it means that this ingredient is not useless, so why is EGF banned?

1. Anything less than 500 Daltons can penetrate the skin, while anything greater than 500 cannot. Therefore, common allergens are often less than 500 Daltons. EGF is a “53 peptide” composed of 53 amino acids with a molecular weight of up to 6000 Daltons. It has almost no absorption for normal skin and cannot penetrate the stratum corneum of the skin, and the stratum corneum cells are dead and have no ability to reproduce and differentiate. Cells, Epidermal Growth Factor used in skin care products can only play a very good moisturizing effect, but nothing else.

2. Abusing Epidermal Growth Factor may lead to uncontrollable skin growth and the formation of “tumor”-like nodular hyperplasia. Reports of epidermal growth factor being overused by injections and causing excessive growth of skin tissue are often seen. And some patients with skin diseases, their own skin cells are unhealthy and problematic. At this time, it is very risky and difficult to control if you encounter Epidermal Growth Factor again. Some scholars believe that external use of Epidermal Growth Factor is suspected of promoting the growth of skin cancer cells.

The Difference Between Oligopeptide-1 And Epidermal Growth Factor

Oligopeptide: The molecular weight sector is typically listed below 1000 Daltons, likewise known as tiny peptides, oligopeptides, oligopeptides or small molecular energetic peptides, usually made up of 4-10 amino acids, and the unwanted is called polypeptide, amino acid More than 50 polypeptides are called healthy proteins.

Amino acids are the constituents of proteins. Normally, we believe that after ingesting proteins, totally free amino acids and oligopeptides can be produced by the activity of peptide protease as well as chymotrypsin, and after that can be soaked up by the human body.

The oligopeptide does not require to experience this step and can be directly soaked up without food digestion.

Oligopeptide-1: Epidermal Growth Factor is a sort of oligopeptide containing glycine, histidine as well as lysine. According to the 2015 version of the “Brochure of Names of Aesthetic Raw Materials Used by the State Fda”, Epidermal Development Variable can be added to cosmetics as a basic material.

Skin Growth Aspect: Additionally referred to as Epidermal Development Variable (EGF), it is a “53 peptide” composed of 53 amino acids with a molecular weight of 6200 Dalton units.

Although Skin Development Element as well as oligopeptide-1 differ by only one word, their parts are really different. As mentioned over, oligopeptide-1 is composed of three amino acids, while Epidermal Development Variable is composed of 53 amino acids.

Oligopeptide-1 ≠ Human Oligopeptide-1
On January 10, 2019, the State Drug Administration clearly mentioned that oligopeptide-1 as well as Epidermal Growth Element (Skin Growth Aspect, EGF) are not the same material.

Oligopeptide-1 is included in my country’s “Brochure of Names of Aesthetic Raw Materials Made Use Of” (2015 edition), and also is typically made use of as a skin conditioning representative. Nonetheless, human oligopeptide-1 is not included in this brochure, and also is generally used much more in the clinical area. Currently, EGF is primarily used as a medical outside preparation for the therapy of skin burns and also scald injuries (superficial II level to deep II level burns and also scald wounds), residual wounds, contributor website injuries and also persistent ulcer injuries, or for the treatment of microneedle, laser wait on postoperative fixing. These wounded skins are utilized under the guidance of a physician’s diagnosis and there is no problem.

It is not recommended for normal skin, since the skin is hard to take in. We understand that molecules smaller sized than 500-800 Daltons can be easily taken in by the skin. The molecular weight of this EGF is 6200, so the skin can not absorb it.

Due to its huge molecular weight, Epidermal Development Variable is hard to be absorbed under typical skin obstacle conditions. When the skin obstacle feature wants, various other potential safety issues might arise. Due to efficiency and also safety and security factors to consider, Epidermal Development Element should not be utilized as a cosmetic basic material.

Consequently, unlike oligopeptide-1, Epidermal Growth Variable can not be made use of as a cosmetic basic material. It is prohibited to include human oligopeptide-1 or Epidermal Growth Factor to the formula or claim to consist of human oligopeptide-1 or Skin Development Element.

Oligopeptide-1 can be included in cosmetics and also used as a skin conditioner. Conditioning agents can be considered components in cosmetics that act on the skin, that is, aesthetic actives. Various from thickeners as well as emulsifiers. The lightening, moisturizing, anti-aging, and also acne-removing effects of cosmetics are primarily attained through the included skin conditioning agents to make the most of the effect. As mentioned earlier, oligopeptide-1 is composed of 3 amino acids. Oligopeptides with a small molecular weight can have higher skin leaks in the structure than polypeptides as well as are much more quickly soaked up by human skin. At the same time, due to the fact that the molecular weight is small to a particular extent, the organic activity will be qualitative. leap. The smaller sized the molecular weight of the peptide, the shorter the “amino acid chain”, as well as the less complicated it is to be taken in and also utilized by the human body. As a result, including oligopeptide-1 to cosmetics can play a role in working with and also promoting penetration, and also with various other active ingredients, the impact of the product is 1 +1 > 2.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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