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Endothelin CAS 117399-94-7

Molecular Formula: C109H159N25O32S5

Formula Weight: 2491.9

ZSpharmac: Endothelin Supplier

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Product Name: Endothelin
CAS No: 117399-94-7
Purity: 99%

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Basic Info

Product Name:Endothelin
Other Names:ENDOTHELIN 1
CAS:117399-94-7
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:N/A
Storage:Under -20°C
Provide:Endothelin MSDS;
Endothelin COA

What is Endothelin?

Endothelin (ET-1) is an energetic peptide isolated from the supernatant of cultured porcine aortic endothelial cells, which has a strong vasoconstrictive result. Endothelin 1 has a loved one molecular mass of 2491.9, totally free amino and also carboxyl terminals, and also 2 disulfide bonds. Endothelin has actually been shown to be existing in many mammals, consisting of humans. Although vascular endothelial cells are the main resource of endothelin-1, cardiomyocytes, vascular smooth muscle mass cells, kidney tubular epithelial cells, as well as glial cells can all produce endothelin-1, suggesting that endothelin-1 can individually join the complex regulatory mechanisms of different organs.

Endothelin Property

Boiling point 2467.3±65.0 °C(Predicted)
density 1.273±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 1% acetic acid: >1 mg/mL
form powder
color white
Water Solubility Soluble in water.

 

Endothelin Uses

Synthetic peptides with human and porcine endothelin sequences. The biological source is a potent agonist of the human endothelin ETA and ETB endothelin receptors with the same sequence. Induces production of hypoxia-inducible factor 1α vascular endothelial growth factor.

Physiological Functions of Endothelin

The duty of endothelin in the process of tumor angiogenesis has actually brought in comprehensive focus. Endothelin-1 can straight and indirectly promote angiogenesis in growths with a paracrine fashion. Research studies have actually confirmed that endothelin 1 is very expressed in lung cancer cells tissues and takes part in inducing the spreading of lung cancer cells. Endothelin 1 is everywhere existing in lung cancer cells. The material of endothelin may be related to the level of growth distinction. Endothelin 1 can be used as a detection index of lung adenocarcinoma and squamous cell carcinoma. The reduced the degree of lump distinction, the greater the web content of endothelin 1, and also the greater the level of lump differentiation, the lower the web content of endothelin 1.

In chronic cardiac arrest, the focus of endothelin 1 enhances, which has straight toxicity to cardiomyocytes, solid favorable inotropic result, hypertrophic activity of cardiomyocytes as well as induction of ventricular arrhythmia, etc, and also participates in the wear and tear of persistent cardiac arrest development. Endothelin 1 acts by triggering 2 receptor subtypes, endothelin-1A and also endothelin-1B receptors, which pair to numerous GTP-binding proteins relying on the cell type and put in equivalent biological impacts. Endothelin 1 antagonist is expected to become a new target for the treatment of persistent cardiac arrest.

Zhu Nan et al. reviewed that the activation of endothelin resulting in peritoneal angiogenesis is a possible device of peritoneal injury. Methods: Human peritoneal mesothelial cells (HPMCs) (HMrSV5) were cultured, high sugar promoted HPMCs, as well as the adjustments of endothelin 1 were observed; exogenous endothelin 1 was added, and extracellular signal-regulated kinase 1/2 (ERK1/ 2) and E26 transcription factor-1 (Ets-1) phosphorylation; Ets-1 was prevented utilizing siRNA as well as blocking antibody, respectively, and the expansion of HPMC was measured by BrdU; finally, 5 random choices were assessed by utilizing ImageJ software program via tubule formation assay The complete capillary size of the area. Outcomes: High glucose can generate high expression of ET-1 in HMPC (2.5%, F=5.561, P=0.036; 4.25%, F=4.784, P=0.008); Generated by exogenous endothelin 1, ERK1/2 in HPMC The phosphorylation degree of MEK-1 was substantially up-regulated (F=66.347, P=0.026); the expression of transcription variable Ets-1 downstream of ERK1/2 was significantly increased (F=110.614, P=0.031); blocking MEK-1 substantially removed the impact of endothelin on Activation of ERK1/2 (F=56.361, P=0.006); after adding ETA and ETB receptor inhibitors, ETAR prevention can substantially reduce the expression of Ets-1 (F=131.191, P=0.039). Endothelin 1 can generate the spreading of HPMCs (F=4.671, P=0.046), which can be undermined by endothelin 1 antagonists (F=5.329, P<0.001; F=5.362, P<0.001); antibody and siRNA-mediated Ets-1 clog had comparable antiproliferative impacts (F=5.638, P<0.001; F=4.611, P=0.007). Therefore, endothelin-1 specifically advertises the expansion of HPMCs through the ERK1/2-Ets -1 signaling path. In addition, the conditioned tool of HPMsC treated with endothelin 1 could substantially promote the manufacturing of vascular endothelial development aspect (VEGF) in HPMCs (F=11.614, P<0.001) and endothelial cell angiogenesis. Verdict: Endothelin 1 promotes HPMCs expansion, VEGF production as well as endothelial cell angiogenesis with ERK1/2-Ets -1 signaling path.

About Products:
If you need Endothelin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced endothelin manufacturer and supplier, ZSpharmac will provide endothelin raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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