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Emodin CAS 518-82-1

Molecular Formula: C15H10O5

Formula Weight: 270.24

ZSpharmac: Emodin Supplier

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Product Name: Emodin
CAS No: 518-82-1
Purity: 99%

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Basic Info

Product Name:Emodin
Other Names:Emodine
CAS:518-82-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Orange Powder
EINECS No.:208-258-8
Storage:2-8°C
Provide:Emodin MSDS;
Emodin COA

What is Emodin?

The scientific name of Emodin is “1,3,8-trihydroxy-6-methylanthraquinone”. Molecular formula C15H10O5. Molecular weight 270.24. In the form of free and glycosides, it exists in the rhizomes and roots of the Polygonaceae plants Rhubarb palmatum, Rhubarb, and Rhubarb Tangut. Orange crystal. The melting point is 256-257°C. Capable of vacuum sublimation (1,600 Pa). Soluble in ethanol, sodium hydroxide, sodium carbonate, ammonia solution, slightly soluble in ether, chloroform, carbon tetrachloride, benzene, almost insoluble in water. Its triacetate is a yellow crystal with a melting point of 197°C. Its 3-methyl ether (also known as emodin methyl ether) is dark red needle crystal with a melting point of 207°C. Can be extracted from plants or synthesized chemically. Aloe-emodin is one of the main components of aloe essential oil. It exists in aloe in a free state, or in rhubarb, senna and aloe as a glycoside.

Emodin is the dry rhizome and root of Polygonum cuspidatum. The rhizome of Rhubarb palmatum belongs to plant medicine. The physiological activity of emodin determines that it can be used not only in medical treatment, but also in health care and daily chemicals, in hair care and skin care products, and can also be incorporated into natural pigments, and can also be used as a laxative.

Emodin Property

Melting point 255 °C (dec.)(lit.)
Boiling point 373.35°C (rough estimate)
density 1.3280 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. 2-8°C
solubility DMSO: soluble
form powder
pka6.39±0.20(Predicted)
color orange
Water Solubility <0.1 g/100 mL at 19 ºC

 

The Role of Emodin

1. Anti-tumor effect: A large number of domestic and foreign research results show that emodin has obvious inhibitory effect on various human and animal tumors, such as breast cancer, cervical cancer, pancreatic cancer, liver cancer, oral squamous cell carcinoma, leukemia and so on.

2. Renal protection, anti-renal interstitial fibrosis and diuretic effect.

3. Liver protection.

4. Emodin has the functions of preventing and treating liver cancer, fatty liver, liver cell fibrosis, inhibiting hepatitis B virus, and protecting damaged liver cells.

5. Effects on the gastrointestinal tract: Emodin has the effects of purging, resisting ulcers and stress ulcers caused by Helicobacter pylori, and protecting the intestinal private membrane of rats. The mechanism may be that it inhibits tumor necrosis factor (TFN)- a generation and a large release of NO, the generation of oxygen free radicals is reduced and the aggregation and activation of neutrophils.

6. Anti-oxidation: Emodin has the effect of anti-oxidation and scavenging free radicals, and its prevention and treatment of atherosclerosis is related to anti-lipid peroxidation. Guo Yang et al. discussed the antioxidant effect of emodin on the periodontal tissue of rats with experimental periodontitis. The results show that emodin can significantly increase the activity of superoxide dismutase (SOD), reduce the content of malondialdehyde (MDA) in serum, and increase the activity of glutinous peroxidase. Restoring periodontal tissue health has obvious effect.

7. Beneficial to the cardiovascular system.

8. Therapeutic effect on acute pancreatitis: the combined application of emodin and Huangmipu can reduce pancreatitis and lung injury, reduce serum amylase, tissue necrosis factor and interleukin (IL) 6 levels, and its mechanism of action is to reduce Tissue expression of TLR4, and TLR4 plays an important role in acute pancreatic injury and inflammatory response.

9. Effects on the immune system: On the one hand, emodin can inhibit and treat excessive inflammatory reactions; on the other hand, it can promote the normal immune defense function of the body and play a two-way regulatory role.

10. Effects on bone metabolism: The effects of emodin on bone metabolism are as follows. First, emodin has an estrogen-like effect, which can quickly restore the sexual cycle of castrated female rats. Clinical trials have found that it has a follicle hormone-like effect, and it has an estrogen-like effect on patients with dysmenorrhea and endometritis when taken orally. Estrogen receptors have a high affinity and can stimulate the receptors to produce biological effects. Secondly, emodin has anti-superoxide anion free radical activity and anti-aging effect, and the effect of emodin on lipid metabolism and regulation of adipocyte differentiation may also be beneficial to the treatment of osteoporosis.

Chemical Composition of Emodin

More than 130 compounds have been isolated and identified from various rhubarb, including anthraquinone and its glycosides, anthrone, bisanthrone and its glycosides, stilbenes and their glycosides, gallate, and naphthalene derivatives , chromanone and its glycosides, phenylbutanones, tannins, etc. Among them, anthraquinones are important representative components. Free anthraquinones mainly include: Rhein, Emodin, Physcion, Aloe-emodin, Chrysophanol, etc. Anthraquinone glycosides mainly include: chrysophanol-1-glucoside, chrysophanol-8-glucoside, emodin-1-glucoside, emodin-8-glucoside, emodin-8-glucoside, rhubarb Phytomethyl ether-8-gentiobioside, aloe-emodin-8-glucoside, aloe-emodin-3-glucoside, rhein-8-glucoside, etc. Bianthrone glycosides include sennoside (Sennoside) A, B, C, D, E, F and so on. Stilbene and its glycosides include Rhaponticin, Rhapontigenin and De-oxyrhaponticin. A variety of tannins contained in rhubarb include both hydrolyzable tannins and condensed tannins [4]. The hydrolyzed tannins and related compounds include various galloyl glucose and 1-0 galloyl-6-0-cinnamoyl-β-D-glucose (1). Condensed tannins and related compounds include catechin, epicatechin and their polymers. In addition, rhubarb also contains a variety of phenylbutanone glycosides.

Emodin Inhibits Autophagy and Apoptosis of Gastrointestinal Mucosal Cells

Autophagy and apoptosis are important forms of degeneration and necrosis of gastrointestinal mucosal cells. It is generally believed that autophagy is a protective mechanism for the normal body, and the foreign antigens and inflammatory factors that are harmful to the body are removed through the spontaneous action of autophagy. , to ensure the balance of the internal environment of the body. It has been reported that autophagy can participate in regulating the mechanical barrier of the gastrointestinal mucosa, removing intracellular bacteria, and inhibiting inflammation. Therefore, autophagy can significantly promote the repair of the gastrointestinal mucosa. Zheng Ying et al. found that emodin can promote the division of rat small intestinal crypt epithelial cells IEC-6 cells and up-regulate the expression of autophagy-related genes Beclin-1 and LC3 in a hypoxic environment. Therefore, it is believed that emodin can promote autophagy Protective effect on gastrointestinal mucosal cells under hypoxic environment. At present, although there are few research reports on emodin promoting autophagy, existing studies have shown that emodin has anti-inflammatory, anti-aging, and free radical scavenging effects, and these effects are all involved in autophagy, so emodin protects gastric The mechanism of intestinal mucosa is definitely related to autophagy, which deserves further study.

For gastrointestinal mucosal injury, apoptosis is also one of the important mechanisms of its occurrence. Research by Zhao Hongxian and others found that diabetic rats with gastric mucosal injury would highly express the Caspase12 protein related to the apoptosis of gastric mucosal epithelial cells. In rats, ig emodin 8 g/L, 5 mL/kg, once/d, Caspase12 Down-regulation of protein expression significantly alleviated endoplasmic reticulum stress and reduced gastric mucosal damage. This study suggested that emodin can protect gastric mucosa by inhibiting the expression of Caspase12 protein, thereby inhibiting gastric mucosal apoptosis. However, some studies also believe that the mechanism of emodin’s inhibition of gastrointestinal mucosal cell apoptosis has nothing to do with the endoplasmic reticulum stress pathway. The theoretical basis and experimental basis have been established for the in-depth development of new emodin drugs based on the inhibition of gastrointestinal mucosal apoptosis. In addition, mitochondrial respiratory chain cytochrome c (cyt c) is also involved in the regulation of apoptosis. Wu Xueping’s research shows that cyt c is highly expressed in gastric mucosal epithelial cells injured in diabetic rats, so it is believed that gastric mucosal damage is related to cyt c mediated Gastric epithelial cell apoptosis is closely related. The study also administered emodin 8 g/L, 5 mL/kg, 1 time/d to model rats, and found that emodin can reduce the expression of cyt c protein in gastric mucosal cells, reduce gastric mucosal damage in rats, and relieve diabetic gastropathy. The mechanism may be that emodin can inhibit the release of cyt c from gastric mucosal epithelial cells, thereby inhibiting the activation of mitochondrial pathway and reducing the apoptosis of gastric mucosal epithelial cells. In addition, through experimental studies on rat models of severe pancreatitis, it has been found that emodin also has a protective effect on intestinal mucosal barrier damage caused by severe pancreatitis, and its mechanism is mainly through down-regulating the expression of Bax (pro-apoptotic factor) gene, thereby Inhibit the excessive apoptosis of intestinal mucosal cells, reduce the damage of intestinal mucosal barrier, and reduce the translocation of intestinal endotoxin, and finally achieve the effect of protecting the gastrointestinal mucosa.

In short, the important mechanism of emodin to protect the gastrointestinal mucosa is to promote autophagy and inhibit apoptosis, thereby alleviating the process of gastrointestinal mucosal damage and achieving the purpose of repairing the gastrointestinal mucosa.

About Products:
If you need Emodin, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Emodin manufacturer and supplier, ZSpharmac will provide Emodin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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