Like the traditional imidazole antibacterial product ketoconazole, ELUBIOL is a new broad-spectrum antifungal item of imidazole, which can prevent the biosynthesis of fungal ergosterol and change the make-up of various other lipid compounds in the cell membrane layer. It has antagonistic impacts on Candida, Cryptococcus neoformans, Histoplasma capsulatus, Blastomyces dermatitidis as well as Coccidioides, yet compared to ketoconazole, the latter can not be made use of in personal treatment items, while ELUBIOL water-soluble It is far better than ketoconazole, appropriate for usage in the field of personal treatment products, and has been consisted of in the scope of use of individual treatment items in Europe, with an extremely broad market prospect.
ELUBIOL Property
Boiling point
734.8±60.0 °C(Predicted)
density
1.37
storage temp.
under inert gas (nitrogen or Argon) at 2-8°C
solubility
DMSO: 15 mg/mL (26.72 mM);;
pka
6.88±0.12(Predicted)
Preparation of ELUBIOL
The synthesis of ELUBIOL, in US Pat. 4-yl] Methanol p-toluenesulfonate (Ⅲ, active ester type) as raw material, obtained by condensation with 4-(4-hydroxyphenyl)-1-piperazine carboxylate ethyl ester (IV), the details are as follows:
In US4335125, ELUBIOL is recrystallized with 2-methyl-2-pentanone, and the obtained neoconazole has a melting point of 112.2°C. In the world patent WO93/18743, the synthesis of neoconazole is based on ketoconazole as the starting material. After hydrolysis and acylation, purification and crystal transformation to obtain type I neoconazole, the details are as follows:
Its purification is to crystallize with 2-methyl-2-pentanone, the reaction and crystallization yield is 84.9%, and then transform to type I with acetone, the yield of transformation is 82.1%, and the total yield of type I is 69.7%. Type I ELUBIOL has a melting point of 127.6°C.
In WO93/18743, the type I and type II properties of ELUBIOL are also mentioned. The DSC maximum peak of type I with high melting point is at 127.6°C, while the maximum DSC peak of type II with low melting point is at 110.9°C. The type is more stable, and it is preferentially used in cosmetics for the human body. In the above two patents, 2-methyl-2-pentanone is used for recrystallization, which is not only expensive and uneconomical, but also ketone chemicals remain in the product, which is harmful to human health. In the Chinese patent publication CN101665490A, it is mentioned that ethyl acetate is used for recrystallization, and the recrystallization yield is 69.8% to 84.5%. Ethyl acetate is used for recrystallization of organic matter, but the yield is not high, and the melting point of the product is not mentioned.
CN201210075893.7 provides a new method for purifying ELUBIOL. The steps of the technical solution are as follows:
Step (1). Dissolving the ELUBIOL crude product at a temperature of 5085° C. with a mixed solution of water and lower alkanol, the ratio of water and lower alkanol in the mixed solution is 3/71/19;
The low alkane alcohol in described step (1) comprises methyl alcohol, ethanol, propanol, Virahol; The weight ratio of the mixed solution of described water and lower alkane alcohol and ELUBIOL crude product is 10/12/ 1;
Step (2). In the mixed solution in which the ELUBIOL crude product is dissolved, add activated carbon for decolorization, filter to remove carbon, and cool to -515°C to crystallize; then filter and dry again, and the content of the obtained neoconazole essence is above 99.0%, HPLC The purity is above 99.5%, and the melting point is between 127.6 and 130°C.
About Products: If you need ELUBIOL, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price. As an experienced ELUBIOL manufacturer and supplier, ZSpharmac will provide ELUBIOL raw materials to customers all over the world for a long time. Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.
Company Profile and Corporate Culture
Company Profile：
ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .
The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .
The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.
Corporate Culture：
OUR MISSION Help China Chemicals to benefit the happiness of human life OUR VISSION Become the most trusted chemical supplier in the world OUR BUSINESS PHILOSOPHY Striver – oriented, enrich employees, customer first, deep service, seek development OUR VALUES Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight
About Us
The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.
“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.
Company Info
Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.
Service
Pre-Sales Service
* Prompt reply and 24 hours online, professional team to provide best price and high quality product.
* Sample testing support.
* Every batch of products will be tested to ensureits quality.
*The packing also can be according the customers` requirment.
*Any inquiries will be replied within 24 hours.
*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.
After-Sales Service
*The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
*Product has any problem can return.
FAQ
Do you accept sample order?
We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Is there a discount?
Different quantity has different discount.
Shipping
1. ≤50kg, Express delivery recommended, usually called as DDU service;
2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;
4. For high value products, please select air shipping and express delivery for safe.
