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Eicosapentaenoic Acid Sigma CAS 10417-94-4

Molecular Formula: C20H30O2

Formula Weight: 302.45

ZSpharmac: Amrinone Supplement

Product Name: Eicosapentaenoic Acid Sigma
CAS No: 10417-94-4
Purity: 99%

Basic Info

Product Name:Eicosapentaenoic Acid Sigma
Other Names:EPA
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:Colorless to Pale Yellow liquid
Provide:Eicosapentaenoic Acid Sigma MSDS;
Eicosapentaenoic Acid Sigma COA

What is Eicosapentaenoic Acid Sigma?

Eicosapentaenoic Acid Sigma is the English acronym of eicosapentaenoic acid, which is the major part of fish oil. Eicosapentaenoic Acid Sigma belongs to the omega-3 collection of polyunsaturated fatty acids, and also is a vital nutrient that can not be manufactured by the body itself yet is vital.If you simply eat vegetable oil for a long time without consuming the necessary Eicosapentaenoic Acid Sigma, it will lead to thrombosis, myocardial infarction and other cardiovascular and cerebrovascular diseases. Eicosapentaenoic Acid Sigma is an important intermediate in the biosynthesis of biologically active prostaglandins.

In addition, Eicosapentaenoic Acid Sigma is known to have the following pharmacological effects: 1) platelet aggregation inhibitory effect (thrombolytic effect); 2) blood neutral lipid lowering effect; 3) blood very low density lipoprotein [“VLDL”]-cholesterol and low density Lipoprotein [“LDL”]-cholesterol lowering effect and blood high-density lipoprotein [“HDL”]-cholesterol (anti-arteriosclerotic effect) raising effect; 4) blood viscosity lowering effect; 5) hypotensive effect; 6) anti-arteriosclerosis effect inflammatory effect; and 7) antitumor effect. Likewise, Eicosapentaenoic Acid Sigma provides a natural way to lower blood cholesterol and triglycerides.

Eicosapentaenoic Acid Sigma Properties:

Melting point −54-−53 °C(lit.)
Boiling point 439℃
density 0.943 g/mL at 25 °C(lit.)
refractive index n20/D 1.4977(lit.)
Fp 93 °C
storage temp. -20°C
solubility Soluble in methanol
form liquid
color Colorless to pale yellow


Eicosapentaenoic Acid Sigma Uses

  1. Eicosapentaenoic Acid Sigma has the functions of lowering blood lipid, lowering blood pressure and lowering blood sugar, which can prevent and improve arteriosclerosis and prevent high blood pressure. However, in the application of prevention and treatment of cardiovascular disease, side effects such as gastrointestinal discomfort, pulmonary embolism, skin reaction and agranulocytosis may occur.
  2. Eicosapentaenoic Acid Sigma as Important polyunsaturated fat of the aquatic food web that serves as a forerunner for the prostaglandin-3 as well as thromboxane-3 families.

Eicosapentaenoic Acid Sigma Properties

Eicosapentaenoic Acid Sigma is an omega-3 unsaturated fatty acid, an essential fatty acid for body nutrition. mp54°C. Instable, easy to oxidize and crack. Natural Eicosapentaenoic Acid Sigma mainly exists in plankton such as diatoms. The mechanisms of Eicosapentaenoic Acid Sigma+DHA-enriched fish oil for lowering blood lipids are: increasing the excretion of fecal sterols; changing the fatty acid composition of lipoproteins; inhibiting the synthesis of VLDL and LDL; and promoting the degradation and clearance of VLDL.

Eicosapentaenoic Acid Sigma Production Method

Method 1: Using cod liver or minced fish as raw material to process cod liver or minced fish to obtain refined fish oil. After the refined fish oil is pre-concentrated by urea inclusion, under the conditions that the extraction pressure is 11-15MPa, the extraction temperature is 35°C, the rectification pressure is 11-15MPa, and the rectification temperature is 40-85°C, EPA+DHA is purified to 90%, adopt a two-step separation method, EPA is purified to 67%, and DHA is purified to more than 90%. Fish oil fatty acid ethyl ester [supercritical CO2 extraction] → [separation] EPA
Method 2: Using herring leftovers as raw materials Using herring leftovers as raw materials, polyunsaturated fatty acids were prepared, wherein the total content of EPA and DHA was 64.8%.
Method 3: Using arachidonic acid as raw material Using arachidonic acid as raw material, desaturation is carried out to prepare EPA. Arachidonic acid [desaturated] → EPA
Method 4. Supercritical Multi-Fluid Precision Distillation Technology
Method 5. Extraction of fish oil by light alkaline hydrolysis Method 6. Extraction of fish oil by potassium method Results (n=3): fish oil extraction rate was 24.4%; acid value was 2.58; iodine value was 309; saponification value was 178.7; peroxide value was 0.070 %; EPA content is 15.05%.

Eicosapentaenoic Acid Sigma is an omega-3 unsaturated fatty acid, an essential fatty acid for body nutrition. mp54°C. Instable, easy to oxidize and crack. Natural Eicosapentaenoic Acid Sigma mainly exists in plankton such as diatoms. The mechanisms of Eicosapentaenoic Acid Sigma+DHA-enriched fish oil for lowering blood lipids are: increasing the excretion of fecal sterols; changing the fatty acid composition of lipoproteins; inhibiting the synthesis of VLDL and LDL; and promoting the degradation and clearance of VLDL.

Eicosapentaenoic Acid Sigma Extraction Method

CN201510549973.5 discloses a method for extracting Eicosapentaenoic Acid Sigma from fish processing by-products. The by-products of fish processing are high in fish oil, which contains Eicosapentaenoic Acid Sigma. In the invention, the by-products after fish processing are washed, the solid-liquid weight ratio is 1:1-1.2, and the concentration of 90-95% ethanol is added, and then ground into slurry, centrifuged, and the ethanol is recovered to obtain a recovered liquid ; Take the recovered liquid for supercritical fluid extraction, adjust the extraction pressure to 20-30Mpa, the extraction temperature to 35-55°C, and extract for 3-4 hours. When collecting, adjust the collection pressure to 25-38Mpa, the collection temperature to 40-60°C, and the flow rate of carbon dioxide to be Separation is carried out under the condition of 2-3 ml/g to obtain a complex extract containing Eicosapentaenoic Acid Sigma. Extract and separate the by-products existing in fish processing, turn waste into treasure, the extraction and separation process is pollution-free, no waste water is discharged, the extraction rate is high, the product properties are stable, the resources are effectively utilized, the product cost is reduced, and the product is increased. Competitiveness.

Other Applications of Eicosapentaenoic Acid Sigma

CN201010145085 reported the enhancement of Eicosapentaenoic Acid Sigma(EPA) to walnut oil. Select fish oil containing Eicosapentaenoic Acid Sigma (EPA) as resources, add ethyl acetate modifier, stir at -2 ° C, liquify in vacuum cleaner, drain oil, get rid of deposit, and also filter to acquire polished eicosanol Pentaenoic acid (EPA) service. Select 500kg of high-grade walnut oil, make use of the interlayer tank MJG-300 to manage its temperature at 24 ° C, and make use of a mixer to mix at 1,200 rpm for 15 minutes. The ready Eicosapentaenoic Acid Sigma (EPA) remedy is 6% by quantity. Gradually add the walnut oil to the walnut oil and also stir until the oil is clear without turbidity, that is, the walnut oil with Eicosapentaenoic Acid Sigma (EPA) included. The approach boosts the health care value of the walnut oil item, makes the healthcare effect of the product a lot more essential, can play an apparent cardiovascular and also cerebrovascular healthcare result after consumption, helps reduce the material of cholesterol as well as triglyceride, and also promotes the metabolic rate of saturated fatty acids in the body.

CN200580049052 reports a synergistically thermally steady, therapeutically active triglyceride as well as cholesterol controlled oil make-up consisting of the typical highly unsaturated Eicosapentaenoic Acid Sigma (EPA) as well as docosahexaenoic acid (DHA). Today invention prevents the restrictions of existing EPA/DHA unclean resources such as fish oil, algae, and so on, and also supplies a synergistically steady edible oil preparation making up at least 50% and less than 100% pure eicosapentaenoic acid as well as dimethicone Docosahexaenoic acid with no encapsulated/protected kind incorporated with oil components/ingredients for collaborating security. Today creation additionally offers a beneficial application/use of the shocking, unanticipated thermal security of the beneficial actives EPA as well as DHA. Today innovation therefore gives a selection of different media, consisting of thermally stable media for day-to-day EPA/DHA consumption, and offers guarantee of a secure, healthy and balanced lifestyle.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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