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Edulcorante Sucralose CAS 56038-13-2

Molecular Formula: C12H19Cl3O8

Formula Weight: 397.63

ZSpharmac: Edulcorante Sucralose Supplier

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Product Name: Edulcorante Sucralose
CAS No: 56038-13-2
Purity: 99%

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Basic Info

Product Name:Edulcorante Sucralose
Other Names:Sucralose
CAS:56038-13-2
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:259-952-2
Storage:2-8°C
Provide:Edulcorante Sucralose MSDS;
Edulcorante Sucralose COA

What is Edulcorante Sucralose?

Sucralose is a white powder item that is quickly soluble in water, ethanol as well as methanol. It is presently the only functional sugar that takes advantage of sucrose as a raw material. Its sweetness is 600 times that of sucrose, as well as additionally its sweet taste is pure. The wonderful taste is extremely similar to sucrose, with no bitter aftertaste; no calories, no cavities, good stability, especially in aqueous service. After an extended period of toxicological examinations, it has actually been revealed that it is very safe, and also it is presently the very best beneficial sugar. It has actually been authorized for use by more than 30 countries consisting of the U.S.A., Canada, Australia, Russia, along with China. Presently, Edulcorante Sucralose has been commonly used in drinks.

Edulcorante Sucralose Property

Melting point 115-1018°C
Boiling point 104-107 C
alpha D +68.2° (c = 1.1 in ethanol)
density 1.375 g/cm
vapor pressure 0Pa at 25℃
storage temp. 2-8°C
solubility Do you have solubility information on this product that you would like to share
form Powder
pka12.52±0.70(Predicted)
color White
PH6-8 (100g/l, H2O, 20°C)
optical activity[α]/D 86.0±2.0°, c = 1 in H2O
Water Solubility Soluble in Water.

 

Edulcorante Sucralose Uses

  1. Edulcorante Sucralose is a non-nutritive sweetener, commonly utilized in beverage, food, medication, cosmetics and various other markets, because sucralose is a new kind of non-nutritive sugar, it is an excellent food for patients with excessive weight, cardiovascular disease and diabetes Additive, for that reason, its application in health food and medication remains to increase. In recent times, some clinical investigates have utilized it as a tracer particle to identify the permeability of the colon, and most of the approaches used are gas chromatographic analysis. Sensitivity and specificity require further study. This item is one of the most perfect extreme sweetener today and can be consumed by kids, teenagers, youth, middle-aged, elderly as well as people with different conditions without any dietary uncertainties.
  2. Edulcorante Sucralose has in fact been thoroughly used in drinks, table sugar, gelato, baked goods, eating gum, coffee, dairy products, treats, fruit juices, jelly foods, desserts, enjoyable sauces, syrups, soy sauces, medications, cosmetics as well as additionally other markets. The United States, Canada as well as various other countries have changed sucrose and various other sugar in a variety of foods. Sucralose does not harm teeth, doesn’t create disease like sucrose, fructose, as well as maltose, and isn’t low-cost as well as costly like various other nutritive sweeteners. Sucralose can be taken in by obese, cardio as well as diabetic person people.

Safety of Edulcorante Sucralose

How risk-free is Edulcorante Sucralose?
As a matter of fact, as a food additive, sugar will undergo a strict security analysis before being authorized for usage. For the security evaluation of sucralose, in the past two decades, there have been greater than 100 studies entailing various health risks of sucralose, including toxicity, carcinogenicity, reproductive health and wellness, kidney health and wellness, mind health and also Blood wellness, youngster wellness and nourishment, and more. These research studies suggest that sucralose is risk-free for usage as a food active ingredient in the general population, consisting of youngsters as well as pregnant or breastfeeding ladies.

Edulcorante Sucralose is risk-free to consume
Everyone is most worried regarding whether they can eat it. Actually, whether you can consume it or otherwise depends on just how much you consume.

After several environmental as well as security research studies, JECFA established in 1990 that the allowable daily intake (ADI) of sucralose was 15 mg per kilogram. The safety limit developed by the USA is less than that of JECFA, which is 5 mg per kilogram of body weight daily. For a 60 kg adult, the daily restriction is 0.3 grams. Considering that the sweet taste of Edulcorante Sucralose is 600 times that of sucrose, which is equivalent to the sweetness created by 180 grams of sucrose, typical intake will certainly not “surpass the requirement”, which implies that its security is very good, and also there is no demand to worry way too much about regular diet.

Let’s speak about the research study stated in the CSPI report. This research is actually an animal experiment. The experimenters used sucralose at doses of 500 mg per kg, 2000 mg per kg, 8000 mg per kg and 16000 mg per kg for three teams of mice, as well as observed the response after eating. It turned out that the computer mice had an enhanced threat of developing blood-forming lumps (leukemia). Comparing the information meticulously, you will locate that the dosage made use of in the experiment is 100-3200 times the safety line set by the United States FDA. This dosage is also huge, as well as it is impossible for ordinary people to accomplish this quantity with a normal diet. Furthermore, this is an animal experiment and can not totally represent the human condition. So, don’t be daunted by this research whatsoever.

Edulcorante Sucralose Production Method

The artificial training course of Edulcorante Sucralose can be approximately divided into 3 teams: monoester technique, chemical-enzymatic technique as well as group transfer approach
Chemical-enzymatic technique.
6-group security approach This approach was created by Tate-Lyle Business. First off, the pressure of Bacillus is utilized to ferment glucose at 30 ° C to create glucose-6-acetic acid, the best emphasis of glucose-6-acetic acid can get to 15g/L, in addition to the return can reach 85% of the scholastic return. Then, the glucose-6-acetic acid is cleansed by the mix of methanol removal and also silica gel column chromatography separation, and the filtration return is 80% to 85%.
Under the activity of the β-fructosyltransferase generated by Bacillus subtilis, the mixed response of glucose-6-acetic acid and also sucrose generates sucrose-6-acetic acid, the focus of sucrose-6-acetic acid can get to 120g/L, and also the return of this action is 58%. Sucrose-6-acetic acid with a purity of 70% can be divided by chromatography. Response of sucrose-6-acetic acid with Vilsmeier reagent made from phosphorus pentachloride as well as DMF yields 4,1′,6′,- trichloro-4,1′,6′- tideoxygalactosucrose pentaacetic acid, this activity return is 39%. Edulcorante Sucralose is obtained after removing the acetic acid team of sucralose pentaacetic acid, and the yield of deacetic acid is 90%. In this strategy, the fermentation cost of glucose-6-acetic acid is rather high, the purification of sucrose-6-acetic acid is difficult, as well as the complete return concerns 20%. The artificial course is as follow:
The synthesis method using raffinose as raw material was in addition established by Tate-Lyle Company. In plants such as beet along with cottonseed, raffinose is currently not offered in huge amounts. It can be synthesized from a saturated solution of galactose as well as likewise sucrose at 30 ° C under the activity of galactosidase, and also the item focus can reach 7.5 g/L.
Chlorination of raffinose with thionyl chloride in the existence of triphenylphosphine to produce 4,1′,6′,6″- tetrachloro-4,1′,6′,6″- tetradeoxygalactose cotton Youngster sugar heptaacetic acid. 4,1′,6′,6″- tetrachloro-4,1′,6′,6″- tetradeoxygalactose raffinose (TCR) is acquired after deacetic acid of the last, determined as raffinose, the return of creating TCR was 32.6%. Under the action of α-galactosidase at 30 ° C, TCR hydrolyzes for 24-hour to produce sucralose, as well as likewise the hydrolysis return is 80% to 90%. The total return is 26% ~ 29%.

Monoester method
The Act was recommended by KhanRA along with MuytiKS in 1982. Utilizing the feedback principle of alkyd esterification, attempt to protect a particular hydroxyl group in the sucrose fragment, as well as get as high a monoester internet content as possible by controlling the troubles. After that dividing, chlorination, deesterification along with filtration are completed to get the thing. This technique is tough to control the setup as well as level of esterification, as well as the return is just 5% to 7%.

Base transfer strategy
Utilizing sucrose as sources, it is obtained by tritylation (safeguarding 3 vital hydroxyl teams), acetylation (protecting 5 second hydroxyl groups), detrityl group, acetyl team movement, chlorination, deacetylation as well as other steps. Sucralose.
Tritylation and also Acetylation Liquify 50 g of sucrose and 60 g of N-methylmorpholine in 100 mL of dimethylformamide at 50 ° C. Fifty percent an hour later, an overall of 141.8 g of trityl chloride (purity 97%) was included 3 times, and likewise home heating was continued for 3.5 h. After that include 42.7 g of sodium bicarbonate as well as preserve the temperature at 50 ° C for 1h. The solution was vacuum-dried, after that liquified in 96.6 mL of acetic anhydride, and after that 15.6 g of potassium acetate was consisted of, heated up to 115 ° C and likewise preserved a constant temperature level for 3h. After cooling, 400 mL of ethanol was included in obtain 183.2 g of crystalline material, which contained 124.6 g of 6,1,6′-trioxy-trityl-pentaacetyl sucrose (TRISPA), with a yield of 68.6%.
Trityl elimination 200g TRISPA was liquified in 800mL toluene, cooled down to 0 ° C, and likewise 1.7 g hydrogen chloride gas was passed through, as well as also a precipitate developed after 4.5 h. Cleanse it in nitrogen for 1 human resources to eliminate reoccuring hydrogen chloride gas, filter it and clean it with 65mL of toluene to come to be granular, redissolve it in 120mL of 1% triethylamine toluene solution, filter the mix once more, and likewise clean it with 65mL of toluene. After drying, 81 g of 2,3,3′,4,4′-pentaoxo-acetyl sucrose (4-PAS) was acquired, with a return of 80%.
Acetyl movement Liquify 50g of 4-PAS in 100mL of water, heat to 60 ° C, filter while hot, along with fantastic to location temperature level. Consisted of 2.5 mL of pyridine and also stirred at area temperature degree for 2.5 h. The choice was acidified with 2.5 mL of focused hydrochloric acid as well as also extracted with dichloromethane (2 x 125 mL). Emphasis the essence to 50 mL, include heptane (3 × 50 mL) and also mix to speed up crystals. After 20 mins, filter, clean the crystals with 30 mL of heptane, as well as likewise completely dry under vacuum cleaner for 16 hours to obtain 34 g of 2,3,3′,4′,6-pentaacetylsucrose (6-PAS), with a return of 58%.
Chlorination Stir 50g of 6-PAS as well as 50.3 g of triphenylphosphine oxide (TPPO) right into 150mL of toluene choice to make a slurry, consist of 32.8 mL of thionyl chloride at area temperature level, reflux the treatment for 2.5 h as well as great to 40 ° C. After that add 200mL of water to more amazing to 0 ° C, blend the mix highly for 1h, filter it, and also clean it with 75mL of toluene: water (1:2) to acquire unrefined 4,1′,6′-trichloro-4,1′, 6′-trideoxy-acetyl-sucrose-galactose (TOSPA). It was dissolved in 200 mL of warm methanol, stirred at 20 ° C for 1 h, recrystallized as well as filtered once more to obtain 40 g of pure TOSPA, with a return of 75%.
Deacetylation Dissolve 50g TOSPA and additionally 0.5 g sodium methoxide in 125mL methanol as well as additionally stir under vacuum cleaner for 1.5 h. After including Amberlite IRC50 (H+) material, mix once more to counteract the solution, filter, and also decolorize the filtrate with 2 g of activated carbon and additionally 2 g of diatomaceous planet, and then concentrate. After including 100 mL of ethyl acetate, Edulcorante Sucralose formed and precipitated. After cleaning and drying, the product reviewed 26 g along with had a purity of 92%.

About Products:
If you need Edulcorante Sucralose, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Edulcorante Sucralose manufacturer and supplier, ZSpharmac will provide Edulcorante Sucralose raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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