Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Close this search box.

Ectoine CAS 96702-03-3

Molecular Formula: C6H10N2O2

Formula Weight: 142.16

ZSpharmac: Ectoine Cosmetic Raw Material Suppliers

Product Name: Ectoine
CAS No: 96702-03-3
Purity: 99%

Navigation Bar

Basic Info

Product Name:Ectoine
Other Names:Ectoin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:431-910-1
Provide:Ectoine MSDS;
Ectoine COA

What is Ectoine?

The chemical formula of Ectoine is 2-methyl-1,4,5,6,-ectoine-4-carboxylic acid, also called ectoine. It is a new type of water-soluble amphoteric acid found in 1985. Ionic amino acid by-products. In 1985, Galinski first identified and separated ectoine from halophilic microorganisms by nuclear magnetic vibration and mass spectrometry. Under high salt focus, Ectoine features as an osmotic tension making up solute and gathers in large amounts in some halophilic germs to stand up to adjustments in the high osmotic pressure of the outside ambience.

Ecdoine is in addition called tetrahydromethylpyrimidinecarboxylic acid. Ectoin safeguards halophilic microorganisms from injury. It has 2 significant features: 1) Hydrating: It is an important compound to maintain osmotic tension balance. Its distinctive molecular structure has a solid water particle complexing ability, which can make the cells The entirely complimentary water is structured and is an exceptional natural cream. 2) Mending: Ectoin can hold up against the damages of ultraviolet rays to the skin and repair service cell DNA damages triggered by ultraviolet rays.

Ectoine Property

Melting point ~280°
alpha D20 +140° (c = 1.0 in methanol)
Boiling point 381.5±35.0 °C(Predicted)
density 1.37
storage temp. 2-8°C
solubility methanol: 20 mg/mL, clear, colorless
form Solid
color White to Off-White
Water Solubility Water : 250 mg/mL (1758.58 mM)


Ectoine Uses

Ectoin is an all-natural and efficient cosmetic energised ingredient. Due to the truth that it has a range of cell protection functions, it can be made use of in a selection of cosmetics with numerous functions. Ectoine has moisturizing, antioxidant, photoaging security, sun defense and other functions.
Excellent moisturizing structures
Pretreating the skin with Ectoine can decrease skin damages set off by dehydration; one bit of Ectoine can complex 4 or 5 water fragments and framework the entirely complimentary water in cells. Compared to glycerin, ectoine is much more moisturizing to the skin.
Appropriate data show that Ectoine can consistently improve the skin’s moisturizing and water-holding capability throughout the application period. The skin’s water-holding ability will not reduce quickly after discontinuation of use. After a week of discontinuation, the skin’s water-holding capability is still greater than that of the control group.
Antioxidant impact
Professional tests have actually exposed that ectoin can stop the weakening of the antioxidant capacity of cells with age and has a certain anti-oxidant capability.
Speculative data exposes that the combined use 0.1 mMEctoine, 0.5 mM drug and 1.5 mM mannitol can decrease the single-strand breakage of human glial cell DNA under 400-800nm source of light, reduce the strength of ROS oxidation feedback, as a result lessening light oxidation of the skin. damages.
Body immune system defense
Langerhans cells in the skins play an important responsibility in the skin’s body immune system, yet they are extremely conscious UV tension. Ectoine can avoid the selection of Langerhans cells from being lessened by ultraviolet radiation, allowing the skin’s immune system to keep normal efficiency.
Protection versus photoaging and sunlight defense
Skin aging is not only the result of the flow of time, however among the necessary outdoors aspects is ultraviolet rays, especially UVA (320-400nm).
In the entire ultraviolet band, UVA has the lengthiest wavelength and the lowest power. However, unlike UVB, the adjustment in UVA internet content in sunshine is actually little influenced by latitude, time period, environment and period. Subsequently, the UVA direct exposure gotten everyday and annual Dosages are almost cared for and continue to develop in huge amounts throughout our lives.

Preparation Method of Ectoine

At present, Ectoine is mostly removed from halophilic microorganisms. The industrial innovation of using halophilic microorganisms to generate ectoine has actually been established. This modern technology makes use of high-concentration glycerol as the carbon resource and utilizes a Produced by a procedure called “bacterial milking”.
The “bacterial milking” procedure is that halophilic bacterial strains grow and replicate in high-concentration (such as 100g/L) salt culture liquid. Ectoine functions as a osmotic stress settlement solute and gathers in huge quantities in some halophilic microorganisms to withstand the exterior setting. Modifications in high osmotic pressure; when the cell focus reaches the highest degree, the salt focus unexpectedly drops from a high focus (such as 100g/L) to a reduced focus (such as 20g/L). When stimulated by hypotonicity, the microorganisms can promptly Ectoine accumulated in cells is released to the outside world to prevent cell growth or damage because of a reduction in environmental osmotic stress. Finally, Ectoine can be additional detoxified with filtering, condensation and various other innovations to acquire Ectoine.
Literature shows that utilizing the above method, approximately 2g Ectoine can be gotten per litre of society liquid daily.

Biological Activity of Ectoin

Ectoine is a natural cell protectant, an amino acid derivative produced by bacteria residing in extremely harsh environmental problems. Ectoine is used as an osmoregulation compatibility solute to boost hydration on the skin surface and support the lipid layer, and is generally utilized in skin treatment. Ectoine has an excellent safety account and can be utilized to examine hay fever.

About Products:
If you need the cosmetic raw material Ectoin, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company, as an experienced Ectoin manufacturer and supplier, ZSpharmac will provide Ectoin raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Ectoine Quotation