Ectoine CAS 96702-03-3

Molecular Formula: C6H10N2O2

Formula Weight: 142.16

ZSpharmac: Ectoine Supplement

Product Name: Ectoine

CAS No: 96702-03-3

Purity: 99%

Basic Info

Product Name:	Ectoine
Other Names:	ECTOINE
CAS:	96702-03-3
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White to Off-White Solid
EINECS No.:	431-910-1
Storage:	2-8°C
Provide:	Ectoine MSDS； Ectoine COA

What is Ectoine?

Ectoine is also called tetrahydromethylpyrimidine carboxylic acid. The ectoine shields halophilic germs from damage, and it has primary functions: Hydrating: It is an essential compound to keep the balance of osmotic pressure. Its unique molecular framework has solid water = sub-complexing ability, which can make the cost-free water in cells structured, as well as is an excellent all-natural moisturizing representative.

Ectoine Properties:

Melting point	~280°
alpha	D20 +140° (c = 1.0 in methanol)
Boiling point	381.5±35.0 °C(Predicted)
density	1.37
storage temp.	2-8°C
solubility	methanol: 20 mg/mL, clear, colorless
pka	3.14±0.20(Predicted)
form	Solid
color	White to Off-White

Ectoine Efficacy And Role

Ectoine is a natural and effective cosmetic energetic ingredient. Due to its wide variety of cell protection features, it can be utilized in many aesthetic items with different functions. Ectoine has the features of hydrating, anti-oxidation, protection versus photoaging, and sun defense. great moisturizing

Pretreating the skin with Ectoine can decrease skin damages caused by dehydration; one particle of Ectoine can complex 4 or five water molecules to structure the complimentary water in cells. Contrasted to glycerin, ectoine is a lot more moisturizing to the skin. Relevant data show that throughout the application duration of Ectoine, the skin’s water-holding ability can remain to improve, as well as the skin’s water-holding capability will certainly not go down promptly after discontinuation. The skin’s water-holding ability is still higher than that of the control team after one week of discontinuation.

Antioxidant effect
Clinical tests have actually shown that ectoine can stop the weakening of the antioxidant capability of cells with the boost old, and has a certain antioxidant ability.

body immune system defense
Langerhans cells in the skins play a key function in the skin’s body immune system, yet are really sensitive to UV anxiety.

Protection against photoaging and also sun defense
In the whole ultraviolet band, UVA has the lengthiest wavelength and also the most affordable energy, yet unlike UVB, the modification of UVA web content in sunlight is little impacted by latitude, time period, climate and season, so the daily and annual UVA direct exposure The doses are practically repaired and also develop in big amounts over our life times.

Preparation Method of Ectoine

Presently, Ectoine is mostly removed from halophilic bacteria strains, as well as the commercial modern technology of using halophilic germs to produce tetrahydropyrimidine has been established. It is created by a procedure called “microbial milking”. The “microbial milking” procedure is the development and reproduction of halophilic bacteria stress in a high concentration (such as 100g/L) of salt society solution. Ectoine is used as osmotic pressure to compensate for the buildup of solutes in some halophilic bacteria to withstand the exterior atmosphere. Adjustments in high osmotic stress; when the cell focus gets to the highest possible, the salt focus suddenly goes down from a high concentration (such as 100g/L) to a low concentration (such as 20g/L), as well as when stimulated by hypotonicity, bacteria can instantaneously Ectoine built up in cells is released to the outdoors to prevent cell swelling or fragmentation triggered by the decrease of ecological osmotic pressure. Ultimately, Ectoine can be more detoxified by filtering, crystallization and various other modern technologies. The literary works reveals that with those method, about 2 g of Ectoine can be obtained per litre of society tool daily.

The Rise and Fall of Icdoin

Ectoine and its by-product, 5-hydroxytetrahydropyrimidine, work solutes and also chemical chaperones that are extensively manufactured by bacteria as well as some archaea as well as work as cytoprotective representatives under extreme problems of osmotic stress and anxiety as well as high or reduced development temperature levels. The function-preserving buildings of ectoine have actually caused countless biotechnological as well as biomedical applications as well as have actually facilitated the development of industrial-scale manufacturing procedures. The synthesis of ectoine needs a huge quantity of power as well as biosynthetic resources. As a result, bacteria have actually established means to make use of ecto- pyrimidine as a nutrient when ecto- pyrimidine is no longer needed as a stress protectant. Below, we summarize our present understanding concerning the phylogenetic circulation of ectopyrimidine-producing and also consuming bacteria. We highlight the architectural enzymology of the tetrahydropyrimidine biosynthesis and intake paths, an understanding that has actually just recently been accomplished. The isomeric types of the crucial metabolite N-acetyldiaminobutyric acid (ADABA) have distinctive synthesis and degradation pathways. γ-ADABA functions as the preferred substratum for tetrahydropyrimidine synthase, while the α-ADABA isomer is generated by ectoine hydrolase as a catabolic intermediate. It acts as an interior inducer for the hereditary control of ectopyrimidine assimilation genes via the GabR/MocR-type regulator EnuR. Our evaluation highlights the relevance of architectural enzymology for inspiring mechanistic understanding of biological-scale metabolic networks. It works as an inner inducer for the hereditary control of ectopyrimidine assimilation genetics by means of the GabR/MocR-type regulator EnuR. Our review highlights the importance of architectural enzymology for encouraging mechanistic understanding of biological-scale metabolic networks. The isomeric kinds of the vital metabolite N-acetyldiaminobutyric acid (ADABA) have unique synthesis and degradation paths. γ-ADABA serves as the favored substratum for tetrahydropyrimidine synthase, while the α-ADABA isomer is generated by ectoine hydrolase as a catabolic intermediate. It functions as an internal inducer for the hereditary control of ectopyrimidine assimilation genes via the GabR/MocR-type regulator EnuR. Our evaluation highlights the value of architectural enzymology for inspiring mechanistic understanding of biological-scale metabolic networks. It works as an internal inducer for the hereditary control of ectoine catabolic genetics through the GabR/MocR-type regulator EnuR. Our review highlights the relevance of structural enzymology for encouraging mechanistic understanding of biological-scale metabolic networks. Our evaluation highlights the relevance of architectural enzymology for inspiring mechanistic understanding of biological-scale metabolic networks.

Ectoine for Ocular Surface Irritation And Inflammation

The ocular surface is exposed to different non-specific stress factors, resulting in inflammation and also swelling of the epithelial cells, creating pain to the client. Ectoine is a bacterially derived polar electrolyte efficient in shielding proteins as well as biofilms from damage brought on by extreme ecological conditions such as warmth, UV light, high osmotic pressure or desiccation. Evidence from preclinical and also clinical researches shows its performance in the treatment of a number of epithelium-related inflammatory diseases including the eye surface area. In this testimonial, we assessed 16 current medical trials checking out the use of ectopic eye decrease in clients with allergic conjunctivitis or other nonspecific ocular swelling triggered by eye surgery. The outcomes of these research studies were reviewed together with other published service tetrahydropyrimidines. Finally, people with ocular surface area irritability as well as nonspecific inflammation have actually been effectively treated with eye declines containing tetrahydropyrimidine. In these clients, substantial enhancement in ocular signs of sensitive rhinoconjunctivitis, postoperative second completely dry eye, or postoperative eye re-epithelialization was observed. Using tetrahydropyrimidine as an add-on to antihistamines, allergic reaction patients experience increased alleviation within a few days, and its use as an add-on to anti-biotics allows for faster wound closure. Ectoine is a natural compound with outstanding tolerability and also security profile, making it a helpful option for patients with inflammatory inflammation of the eye surface,

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.