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Doxymycin CAS 564-25-0

Molecular Formula: C22H24N2O8

Formula Weight: 444.43

ZSpharmac: Doxymycin Supplier

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Product Name: Doxymycin
CAS No: 564-25-0
Purity: 99%

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Basic Info

Product Name:Doxymycin
Other Names:Doxycycline
CAS:564-25-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Yellow or Yellow Crystalline Powder
EINECS No.:209-271-1
Storage:2-8°C
Provide:Doxymycin MSDS;
Doxymycin COA

What is Doxymycin?

Doxymycin is a long-acting broad-spectrum semi-synthetic tetracycline antibiotic processed by oxytetracycline. It has a broad-spectrum anti-bacterial impact and also strong anti-bacterial result. Crettsia, Mycoplasma pneumoniae, Mycoplasma trachomatis and amoeba etc. Especially conscious usual microorganisms in the respiratory system tract of patients with chronic bronchitis. At the same time, it has specific antitussive, expectorant and antiasthmatic impacts. Additionally, the medication is also widely used in veterinary medication to deal with infections triggered by various bacteria.

Doxymycin Property

Melting point 206-209°C (dec.)
Boiling point 554.44°C (rough estimate)
density 1.3809 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO : 125 mg/mL (281.26 mM; Need ultrasonic)
pkapKa 3.5 (Uncertain);7.7 (Uncertain);9.5 (Uncertain)
Water Solubility 0.63g/L(25 ºC)

 

Doxymycin Use And Principle of Action

Doxymycin, also known as doxycycline hydrochloride as well as deoxyoxytetracycline, is a semi-synthetic tetracycline antibiotic with high effectiveness, broad array as well as low toxicity. Its anti-bacterial spectrum is similar to that of oxytetracycline, yet its result is 2 to 10 times much more effective. In the pig market, it is presently usually made use of for the evasion as well as therapy of Eperythrozoon. In addition, it can additionally be made use of to deal with colibacillosis, salmonellosis, mycoplasma problem along with psittacosis.
It is a tetracycline broad-spectrum anti-bacterial in addition to anti-mycoplasma medication. Its liquid alternative is acidic and also well took in when taken by mouth. It is easily soluble in water, as well as is promptly influenced by steel ions in water to develop a difficult, creating a red remedy as well as also lowering the efficacy of the drug.Therefore, in the choice of the medication, it is really vital to pick a product with preparation innovation and great security.
In animal and vet clinics, Doxymycin is mainly made use of to deal with respiratory system infections triggered by delicate germs as well as mycoplasma. Amongst many pathogenic microbes, doxycycline is especially efficient against throat and also bronchitis triggered by Gram-negative microorganisms as well as mycoplasma.
The primary reason that Doxymycin has far better effect on animals as well as fowl throat and also bronchitis is that it has a broad antibacterial range as well as solid anti-bacterial result. In addition to its great impact on Gram-positive germs and also Gram-negative germs, it can also prevent respiratory mycoplasma, rickettsia and other virus that are immune or insensitive to various other medicines.
Additionally, Doxymycin is soaked up swiftly after dental administration, and also can apply its optimal result in regarding 3 hours, and preserves its result in the body for a very long time. The 3rd is that doxycycline has certain antitussive, expectorant and also antiasthmatic effects. These impacts have been validated by pet experiments, as well as they are all attributes that anti-biotics do not have.

Preparation of Doxymycin

Put 100g of methanol, 10g of oxytetracycline base and 0.1g of methanolic ammonia in the reaction flask in turn, stir at 20~30°C for 30min, then start cooling to -10~-15°C, add 5g of dry and crushed NBS at one time, stir for 15min, TLC monitored the complete reaction of the raw materials, and a large amount of solids precipitated out in the reaction bottle, which was filtered through a filter rejection machine, and the filter cake was washed with cold methanol to obtain oxytetracycline 11α-bromo-6,12-hemiketal, with a yield of 95%. Dry at low temperature until the dry content is about 90%. After fractional distillation of the mother liquor, the resulting methanol is used mechanically.

Add 500mL of anhydrous treated benzene into a reaction kettle with a dehydration device, blow nitrogen into the reaction kettle, slowly add 11α-bromo-6,12-hemiketal oxytetracycline 100g under stirring, and then add HZSM-5 20g, first stirred at room temperature for 2 hours, then slowly raised the temperature to reflux reaction and discharged the water generated by the reaction in time, after TLC monitored the complete reaction of the raw materials, slowly lowered the temperature to 50°C, filtered the reaction solution while it was hot, and filtered out Solid hydroxyl dehydrating agent, distill the filtrate to remove the reaction solvent benzene, dilute the raffinate with double the amount of ethanol, slowly add ammonia ethanol solution (7%), neutralize the reaction solution to pH 1~2, cool to 0 ℃, shake filter, wash with cold ethanol 50mL, add 50g p-toluenesulfonic acid to the filtrate, and add a small amount of seed crystals to precipitate crystals, cool to 0°C shake filter, wash with cold ethanol to obtain 11α-bromo-6-methine Oxytetracycline p-toluenesulfonic acid 105g, yield 100% (by weight). After the mother liquor is neutralized to neutral with alkali, the benzene and ethanol obtained by distillation can be used mechanically.

Add 400mL of DMF and 200mL of water into the reaction bottle, then add 100g of 11α-bromo-6-methine oxytetracycline p-toluenesulfonic acid and 12g of palladium carbon (5wt%), and finally add the chiral catalyst tetraisopropyl oxide Titanium 4g and S-biphenol 5g, stir for 10min, add p-toluenesulfonate, stir evenly, suck into the hydrogenation tank, close the valve, use a vacuum pump to 40mm Hg, maintain for 15min, and inject hydrogen at 30~35℃, keep The internal pressure is 1.5~2 kg/cm2, and the hydrogen gas is passed through for 2 hours under stirring until the hydrogen absorption is slow, and the sample is taken for TLC. When the internal pressure is zero, feed nitrogen to drive away the remaining hydrogen, add nitrogen to 50°C, pass nitrogen, filter through a filter press, and fully press filter with DMF solution (heated to 50°C) with a content of 10wt%~50wt% Washing, then washing the palladium carbon with an appropriate amount of distilled water, combining the filtrate and the washing liquid into the reaction kettle, so that the DMF content in the solution is 40wt%~42wt%, cooling to 5 ° C, centrifugal filtration, the filter cake is washed once with a small amount of cold ethanol, After drying, α-6-debromooxytetracycline p-toluenesulfonate (Doxymycin p-toluenesulfonate) was obtained with a yield of 45% (by weight).

Indications for Doxymycin

1. Bacterial diseases are primarily used in the breathing tract, such as pleuropneumonia, porcine lung illness as well as various other diseases, doxycycline + florfenicol + antipyretic medications are effective;
2. Actinomycetes, that is, pustules that can grow in different put on the pig body. Along with Streptococcus pyogenes, there is one more scenario brought on by actinomycetes. Normally, the effect of doxycycline is much better;
3. Typical, “body” illness; mycoplasma is likewise bronchial asthma illness, Doxymycin+ Florfenicol (Mycoplasma) works well;
4. For chlamydia, the initial kind is abortion of plants and also the pearly afterbirth should be thought about, and also the treatment result is better with Doxymycin; for the 2nd type of conjunctivitis, it is much better to use tetracycline eye goes down for red eyes;
5. Spirochetes (swine dysentery, etc) as well as rickettsia are less made use of, so I won’t claim much more;
6. Bugs are blood protozoa, that is, we often state that the red body and also various other illness, Doxymycin management effect is better;
7. Oxytetracycline is usually used in the avoidance and therapy of plants, the damages is much less and the effect is extra moderate; Doxymycin is primarily utilized in drawing piglets that commonly show up after seven days, yellow with white, white with gray in the feces; During the canine days, fat pigs frequently have a fever rebound, consistently.

About Products:
If you need Doxymycin, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Doxymycin manufacturer and supplier, our company,ZSpharmac will provide Doxymycin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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