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Dodecamethylcyclohexasiloxane CAS 540-97-6

Molecular Formula: C12H36O6Si6

Formula Weight: 444.92

ZSpharmac:  Dodecamethylcyclohexasiloxane Supplier

Product Name: Dodecamethylcyclohexasiloxane
CAS No: 540-97-6
Purity: 99%

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Basic Info

Product Name:Dodecamethylcyclohexasiloxane
Other Names:Cyclohexasiloxane
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colourless Liquid
EINECS No.:208-762-8
Provide:Dodecamethylcyclohexasiloxane MSDS;
Dodecamethylcyclohexasiloxane COA

What is Dodecamethylcyclohexasiloxane?

Dodecamethylcyclohexasiloxane, English name Dodecamethylcyclohexasiloxane, is a colorless liquid at normal temperature and pressure. Since the molecule of dodecamethylcyclohexasiloxane contains hydrophilic oxygen atoms and hydrophobic methyl groups, it is almost insoluble in water and has better solubility in non-polar organic solvents. Due to the large radius of the silicon atom, the orientation of the silicon atom and the methyl group is not very regular, resulting in a non-completely symmetrical molecular shape, which also has a certain impact on the physical and chemical properties of dodecamethylcyclohexasiloxane. Influence.

Dodecamethylcyclohexasiloxane Property

Melting point -3°C
Boiling point 245 °C
density 0,959 g/cm3
vapor pressure 4.7Pa at 25℃
refractive index 1.4015
Fp >76°C
storage temp. 2-8°C
solubility Chloroform (Sparingly), Ethyl Acetate (Slightly)
form liquid
color Colourless
Specific Gravity0.9672
Odorat 100.00?%. odorless
Water Solubility 5.1μg/L at 23℃


Application of Dodecamethylcyclohexasiloxane

There are multiple oxygen atoms in the molecular structure of dodecamethylcyclohexasiloxane, which has properties similar to crown ethers, and can complex with metal ions such as magnesium ions.


In a dry reaction flask, dodecamethylcyclohexasiloxane (0.56 mmol) was dissolved in 5 mL of trifluorotoluene, then 0.156 g (0.32 mmol) of magnesium iodide was added to the mixture and heated the suspension. The suspension was then heated to 70°C with vigorous stirring and the reaction was stirred at this temperature for 10 minutes. After the reaction was complete, the reaction mixture was freed of solvent under reduced pressure, then the remaining solid was dissolved in 10 mL of DCM, and the solution was stirred at ambient temperature for another 15 minutes. The solution was filtered, and the resulting filtrate was again desolvated under reduced pressure to obtain a solid powder, which was then washed with 4 mL of n-pentane. The powder was dissolved in 5 mL of DCM, and 15 mL of n-pentane was added thereto to separate the mixture. The solution was left standing at 24°C for several days, and then crystallized with DCM/benzene/n-pentane solution (1:1:8) at ambient temperature to obtain the target product molecule.

Stability of Dodecamethylcyclohexasiloxane

Dodecamethylcyclohexasiloxane is a relatively stable organosilicon compound that can exist stably at room temperature. However, under the conditions of high temperature, strong acid or strong alkali, dodecamethylcyclohexasiloxane may decompose or hydrolyze. This stability is related to the stability of the silicon-oxygen bond in the molecule. The silicon-oxygen bond is a relatively strong chemical bond, so the compound is relatively stable at room temperature.

Ecological Information on Dodecamethylcyclohexasiloxane

The manufacturing and use dodecamethylcyclohexasiloxane as an intermediate in the manufacture of siloxane polymers, an ingredient in cosmetic and personal care items, and a texturizing representative in specific food as well as other industrial Waste is released right into ecological streams. It is used as an unpredictable excipient in cosmetics such as skin treatment, deodorants/antiperspirants, hair care items, and also color cosmetics, leading to route release into the environment through dissipation. Consumer as well as specialist use individual care products containing dodecamethylcyclohexasiloxane results in 100% loss of the material to the setting; a lot of the loss (90%) is lost to the air and the rest to wastewater. If launched to air, the vapor pressure at 25 ° C is 0.0169 mm Hg, indicating that dodecamethylcyclohexasiloxane will only exist in the atmosphere as a vapor. Fumed dodecamethylcyclohexasiloxane weakens in the atmosphere by reaction with photochemically generated hydroxyl radicals; the half-life of this reaction in air is estimated to be 9 days. Dodecamethylcyclohexasiloxane does not soak up at wavelengths > 290 nm, so straight photolysis by sunlight is not anticipated. Volatile methylsiloxanes are generally released or dispersed into the environment and can be carried over cross countries around the globe, but are less likely to deposit on surface media in remote locations. The international home time of unstable methylsiloxanes is relatively brief, with the majority of the global mass disappearing within 3 months of completion of launch. If dodecamethylcyclohexasiloxane is launched right into dirt, no movement is expected based on an approximated Koc of 870,000. Volatilization from moist dirt surfaces is expected to be a considerable fate procedure based on Henry’s law constant of 25.0 atm-cu m/mole. Nonetheless, sorption by dirt is expected to attenuate volatilization. Dodecamethylcyclohexasiloxane is a volatile methylsiloxane that is expected to vaporize from dry dirt surfaces. Dissipation of dodecamethylcyclohexasiloxane was gauged in dirt researches as well as its evaporation price was discovered to vary with dampness content, soil kind, and also family member humidity. Under certain wet conditions, volatilization of the dirt may be the major loss process. Utilizing the 28-day biodegradability test, the biodegradation price was 4.47%, indicating that biodegradation is not a vital ecological fate process. Nevertheless, this substance can be abiotically deteriorated in dirt by a device believed to include catalytic hydrolysis. The reported abiotic half-lives ranged from 1.8 to 202 days for both dirts. If launched to the approximated Koc, dodecamethylcyclohexasiloxane is anticipated to adsorb to suspended solids and also debris in water. Volatilization from the water surface area is anticipated to be an important fate procedure based upon the Henry’s law constant for this substance. The estimated volatilization half-lives were 6.2 hours and also 8.4 days for the model river as well as version lake, respectively. Nevertheless, volatilization from the water surface area is expected to deteriorate the column as a result of adsorption of put on hold solids as well as debris in the water. The approximated volatilization half-life of the model cell is > 1 year if adsorption is taken into consideration. Gauged BCF values of 1,160 and 1,660 indicate really high bioconcentrations in aquatic microorganisms. Dodecamethylcyclohexasiloxane is conveniently hydrolyzed in acidic and also fundamental water with reported half-lives of 42 hrs (pH 4), 401 days (pH 7) as well as 125 hrs (pH 9) at 25 ° C. Nonetheless, strong adsorption to sediments may limit the price of hydrolysis under all-natural conditions. waters. Work-related exposure to dodecamethylcyclohexasiloxane may happen with inhalation and dermal exposure in work environments where dodecamethylcyclohexasiloxane is produced or made use of. Surveillance information show that the basic population might be subjected to dodecamethylcyclohexasiloxane with breathing of ambient air, inhalation of air near cosmetic or individual care items including dodecamethylcyclohexasiloxane, ingestion of fish, and also skin exposure Customer products consisting of dodecamethylcyclohexasiloxane.

About Products:
If you need Dodecamethylcyclohexasiloxane, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Dodecamethylcyclohexasiloxane, ZSpharmac will provide Dodecamethylcyclohexasiloxane raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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