Zhishang Chemical

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Zhishang Chemical

Dodecamethylcyclohexasiloxane CAS 540-97-6

Molecular Formula: C12H36O6Si6

Formula Weight: 444.92

ZSpharmac: Dodecamethylcyclohexasiloxane Supplement

Product Name: Dodecamethylcyclohexasiloxane
CAS No: 540-97-6
Purity: 99%

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Basic Info

Product Name:Dodecamethylcyclohexasiloxane
Other Names:Dodecamethylcyclohexasiloxane Wiki
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colourless Liquid
EINECS No.:208-762-8
Provide:Dodecamethylcyclohexasiloxane MSDS;
Dodecamethylcyclohexasiloxane COA

Application of Dodecamethylcyclohexasiloxane in Cosmetics

Hair Conditioning *Skin Conditioning *Skin Conditioning – Emollient Solvent.

Dodecamethylcyclohexasiloxane Property

Melting point -3°C
Boiling point 245 °C
density 0,959 g/cm3
vapor pressure 4.7Pa at 25℃
refractive index 1.4015
Fp >76°C
storage temp. 2-8°C
solubility Chloroform (Sparingly), Ethyl Acetate (Slightly)
form liquid
color Colourless
Specific Gravity0.9672
Water Solubility 5.1μg/L at 23℃


Dodecamethylcyclohexasiloxane Absorption, Distribution and Excretion

The transdermal absorption of pure D6 radiolabeled with (14 )C following in vitro application to human skin was analyzed. Test substances were performed in Teflon under semi-closed problems utilizing a flow-through diffusion cell system. Human epidermis was prepared from abdominal skin (6 benefactors). The skin with the top dermis is separated from the remainder of the skin by a skin cut, and also the skin examples are repetitively placed. Skin samples from 3 donors passed obstacle honesty screening. Physical receptor liquid is pumped under the skin example. Pure Dodecamethylcyclohexasiloxane was carried out to skin samples from each of the 6 donors at a target dosage of 6 mg/sq cm during a 24-hour exposure duration. At the end of the assay, most of the applied dose was situated on the skin surface area (46.407% of used dosage) or evaporated from the management site as well as collected in charcoal catches (40.057% of applied dose). Few (14 )C-D6 pass through the skin and also enter the receptor fluid. The portion of applied pure (14 )C-D6 recuperated from all examples assessed was 89.542% +/- 4.154%, consisting of 3.075% of applied pure Dodecamethylcyclohexasiloxane (SE of the mean = 0.852% of the applied dosage located in the skin). The outcomes of one more experiment revealed that the fraction of Dodecamethylcyclohexasiloxane observed in the skin did not pass through the skin yet continued to evaporate after 24 hours of skin cleaning. Consequently, it was wrapped up that under the problems of this assay, D6 was not absorbed percutaneously.

Dodecamethylcyclohexasiloxane Antidote and Emergency Treatment

Immediate First Aid: Guarantee adequate decontamination. If the person is not taking a breath, start mouth-to-mouth resuscitation, preferably with a qualified demand shutoff resuscitator, bag valve mask device, or pocket mask. Perform CPR if needed. Right away flush contaminated eyes with gently running water. Do not cause throwing up. If vomiting takes place, place the individual in an onward or left lateral setting (head down preferably) to maintain the air passage open as well as stop goal. Maintain the patient quiet as well as preserve normothermia. seek clinical therapy …

Basic therapy: Develop a clear airway (oropharyngeal or nasopharyngeal airway, if needed). Aspirate if necessary. Watch for indications of respiratory system deficiency as well as assist with ventilation if required. Inhale oxygen at a price of 10 to 15 L/min with a non-rebreather mask. Monitor for lung edema and deal with if needed … Screen for shock and also deal with if essential … Predict seizures and treat if essential … For eye contamination, use water quickly Flush eyes. Continually flush each eye with 0.9% typical saline (NS) throughout transportation … do not use emetics. When consumed, wash mouth and also take up to 200 mL of water at a rate of 5 mL/kg If individual can ingest, has a strong trick response, as well as is not drooling, make use of for dilution … Decontamination Dry sterilized dressings cover skin burns…

Advanced therapy: Think about orotracheal or nasotracheal intubation to control the air passage in individuals who are unconscious, have severe pulmonary edema, or have extreme respiratory system distress. Positive pressure ventilation strategies with a bag-valve mask tool may be valuable. Take into consideration drug treatment for pulmonary edema … Take into consideration beta agonists such as albuterol for extreme bronchospasm … Display heart rhythm and treat arrhythmias if required … Launch IV D5W/ SRP: “Maintain Open”, Minimum Circulation Rate/. If indications of hypovolemia appear, make use of 0.9% typical saline (NS) or lactated Ringer’s solution. For hypotension with indications of hypovolemia, use care with liquids. Look for signs of liquid overload … Treat seizures with diazepam or lorazepam … Use proparacaine hydrochloride as an auxiliary eye rinse …

About Products:
If you need Dodecamethylcyclohexasiloxane, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Dodecamethylcyclohexasiloxane manufacturer and supplier, ZSpharmac will provide Dodecamethylcyclohexasiloxane raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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