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DMAPA CAS 109-55-7

Molecular Formula: C5H14N2

Formula Weight: 102.18

ZSpharmac: DMAPA Supplier

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Product Name: DMAPA
CAS No: 109-55-7
Purity: 99%

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Basic Info

Product Name:DMAPA
Other Names:3-Dimethylaminopropylamine
CAS:109-55-7
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Liquid
EINECS No.:203-680-9
Storage:Store Below +30°C.
Provide:DMAPA MSDS;
DMAPA COA

What is DMAPA?

Diamines are an essential course of chemical compounds that are widely utilized as resources, intermediates or items. As an example, diamines are essential architectural devices in the synthesis of polyamides and various other polycondensation responses. N,N-Dimethyl-1,3-diaminopropane (DMAPA) is a crucial intermediate made use of in the industrial prep work of lubricants. In addition.

DMAPA Property

Melting point -60 °C
Boiling point 133 °C(lit.)
density 0.812 g/mL at 25 °C(lit.)
vapor density 3.6 (vs air)
vapor pressure 5 mm Hg ( 20 °C)
refractive index n20/D 1.435(lit.)
Fp 90 °F
storage temp. Store below +30°C.
form Liquid
pka10.13±0.10(Predicted)
color Clear
PH12.7 (100g/l, H2O, 20℃)
explosive limit2.3-12.35%(V)
Water Solubility SOLUBLE

 

DMAPA Uses

  1. DMAPA is commonly utilized in the manufacture of aesthetic raw materials, such as palmitoamide dimethyl propylamine, cocamidopropyl betaine, mink amidopropylamine, and so on.
  2. DMAPA is made use of as an intermediate in natural synthesis to prepare dyes, ion exchange materials, epoxy material healing agents, oils and also cyanide-free zinc plating ingredients, fiber and leather treatment agents and fungicides. The molecules of this item contain both key as well as tertiary amino teams. It is utilized as a treating representative for epoxy material as well as has both functions of healing agent as well as accelerator. Mostly used in laminated products, spreadings as well as adhesives, and so on, the general dose is 2-6 components.
  3. DMAPA is used in natural synthesis. Epoxy resin treating

Application of DMAPA

Application one.
CN201511019713.3 reveals an artemisinin by-product and its synthesis technique as well as application. The artemisinin derivative is N-( 3-N’, N’- dimethylamino-propyl) -10- azadeoxyartemisinin, which makes use of artemisinin as a resources, successively integrated with DMAPA It can be responded with p-toluenesulfonic acid. By examining the spreading inhibitory activity of the by-product on different human growth cell lines as well as human typical cell lines, the applicant found that it has inhibitory impacts on human bladder cancer cells cell T-24, human ovarian cancer cell SK-OV-3, human gastric cancer cell line MGC80- 3 The 3 cell lines all showed considerable proliferation repressive activity, have good potential medicinal value, and also are anticipated to be used in the prep work of numerous antitumor drugs.

Application two.
CN201510025397.4 discloses a 1,8-naphthalimide derivative and also its synthesis method as well as application. The derivative is N-(3,4-methylenedioxyphenethyl)-4-(3-N, N-dimethylamino)propylamino-1,8-naphthalimide, which The substance is gotten by reacting 4-bromo-1,8 naphthalene dicarboxylic anhydride with 3,4-methylenedioxyphenethylamine and also DMAPA together. The synthetic method is basic and also very easy to control. The applicant explored its spreading inhibitory activity on 9 type of human growth cell lines as well as two normal cell lines, and also the results revealed that its anti-tumor task artificial insemination is amazing, has excellent prospective medicinal value, as well as is anticipated to be utilized in the growth of numerous anti-tumor medicines. preparation.

Application three.
CN201911150842.4 discloses a method for preparing an amphiphilic polymer modified ultrafiltration membrane, which comes from the area of membrane layer separation technology. The certain scheme is as complies with: 1. Terephthaloyl chloride, 3,3′-dimethyl Base-4,4′-diaminodiphenylmethane and DMAPA are liquified in a blended solution of dimethylformamide and also triethylamine, and copolymerized at low temperature to prepare a polyamide polymer. Second, the polyamide polymer is mixed with 1, 3-propane sultone reaction to obtain amphiphilic zwitterionic polyamide, third, blend amphiphilic zwitterionic polyamide and also polysulfone to get casting remedy, and also make use of non-solvent stimulated stage inversion method to prepare ultrafiltration membrane layer. In the spreading option of organic solvent, the hydrophobic polyamide section in the amphiphilic polymer is similar in polarity to polysulfone, which raises its compatibility. In the water phase, the hydrophilic section of the amphiphilic polymer is enhanced on the surface of the membrane layer, which plays an antifouling effect.

Preparation of DMAPA

Report one
Step 1. Obtain a mixture of acrylonitrile and dimethylamine at a molar ratio of 1:1-3, and vaporize the mixture at 100-120°C to obtain a primary vaporized mixture;

Step 2, make the primary vaporized mixture undergo amination reaction under the action of a portion of activated carrier, the reaction temperature is 100-120°C, the reaction pressure is 0.3-0.5MPa, and the volume space velocity of acrylonitrile is 0.1-0.25h-1, obtain a catalytic mixture;

Step 3, making the primary catalytic mixture vaporize at a high temperature under the condition of 150-180° C. to obtain the secondary vaporization mixture;

Step 4, let the secondary vaporized mixture undergo hydrogenation reaction under the action of another activated carrier, the reaction temperature is 150-180°C, the reaction pressure is 0.3-0.5MPa; the volume space velocity is 0.1-0.25h-1, and the secondary Catalyst;

Step 5. Lower the temperature of the secondary catalyst to 40° C., and collect the liquid phase, which is specifically DMAPA.

Report two
A method for preparing DMAPA, said method comprising the steps of:

a) Add acrylonitrile into the synthesis kettle, control the temperature at 120°C, add dimethylamine under the conditions of stirring and cooling water circulation, and remove dimethylamine through vacuum distillation at a pressure of 0.03MPa to obtain N,N-di Methylaminoacrylonitrile; the molar ratio of acrylonitrile to dimethylamine is 1:1;

b) Add the N,N-dimethylaminoacrylonitrile prepared in step a) into the autoclave, add a hydrogenation catalyst, feed liquid ammonia into the autoclave, raise the temperature to 80°C, keep the pressure at 2.5 MPa, and feed hydrogen , stirring while maintaining the temperature at 80°C, reacting, initial distillation after sedimentation, rectification to obtain DMAPA, and then storage tank packaging; the mol ratio of hydrogenation catalyst to N,N-dimethylpropionitrile is 10:1; The fraction with a temperature higher than 134°C is sent to rectification. The reaction liquid in the autoclave is taken for testing, and the content of N,N-dimethyl-1,3-diaminopropane is 99.4%, the residual content of propionitrile is 0.01%, and the content of light components impurities 0.15%, heavy component impurity content 0.61%, including secondary amine 0.37%.

Synthesis of DMAPA

The synthesis process is performed in batch setting in two bubble columns 100 operating in parallel, each having a volume of 9.1 m3 and also outfitted with a reflux condenser 160 (warmth exchange area = 75 m2), vaporizing at 5-1 bar Cool and also amazing with secondary air conditioning water at below 100 ° C through a dual wall. The cooling tool in the condenser 160 is brine (Tin = -5 ° C; Tout = 0 ° C), and the additional air conditioning water has an inflow temperature of 34 ° C and also an outflow temperature level of 43 ° C. Include DMA (2914kg) using inlet 110, include water (124kg) through inlet 120, (wherein 2727kg is fresh DMA, 107kg is fresh water, et cetera is from intermediate container 170), they are added together first, and afterwards by means of the nozzle from Inlet 130 pumped ACN (3108 kg) over 2.5 hrs. At the inlet, the warmth of response causes fluid DMA to evaporate, which assists in mixing of the response mixture in the bubble column. The evaporated DMA is compressed in a reflux condenser using outlet 140. Throughout the reaction, the stress was reduced from 5 bar to 1 bar through a temperature-controlled stress regulator, enabling the DMA to vaporize at a consistent temperature or less than the maximum temperature of 100 ° C. Besides the ACN has actually been included, the feed pump 180 is switched to circulation to complete the conversion. After an added 1 hour of reaction, the components of the reactor were warmed using the dual wall surface with 4 bar steam (151 ° C.) as well as at the same time the majority of the DMA and a part of water and DMAPN were evaporated (overall 308 kg, of which 204 kg was DMA as well as 16 kg was water, 88kg is DMAPN), compressed as well as temporarily kept in container 170 up until utilized in the next batch. When the bottom temperature rises to 130 ° C, the dissipation procedure is completed. The reactor result (5942 kg), still containing concerning 1.1% DMA as well as 1.8% water, was cooled and also released by means of electrical outlet 150 into tank 190.

About Products:
If you need DMAPA as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of DMAPA, our company, ZSpharmac will provide DMAPA raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get DMAPA Quotation