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DL-Thioctic Acid CAS 1077-28-7

Molecular Formula: C8H14O2S2

Formula Weight: 206.33

ZSpharmac: DL-Thioctic Acid Supplier

Product Name: DL-Thioctic Acid
CAS No: 1077-28-7
Purity: 99%

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Basic Info

Product Name:DL-Thioctic Acid
Other Names:α-Lipoic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Crystals or Crystalline Powder
EINECS No.:214-071-2
Provide:DL-Thioctic Acid MSDS;
DL-Thioctic Acid COA

What is DL-Thioctic Acid?

DL-Thioctic Acid is an unique anti-free radical material, regularly referred to as a wide anti-oxidant. It is a vitamin-like compound generated in the body. Unlike other anti-oxidants with distinct impacts produced in the body, DL-lipoic acid is neither strictly fat-soluble neither water-soluble, which allows it to promote the task of other anti-oxidants in the body as well as additionally is furthermore a thoroughly offered substitute for antioxidants. Preference. For example, if the content of vitamin C along with vitamin E saved in the body is very reduced, DL-Thioctic Acid can be momentarily supplemented. Due to the fact that DL-lipoic acid can cross the blood-brain obstacle, it can assist turn around the unfavorable results of stroke.
DL-Thioctic Acid furthermore helps keep typical blood sugar degrees and likewise prevent extreme problems of diabetes mellitus. As we age, the body can not create sufficient DL-lipoic acid to keep health and wellness. If you are over forty. After that do not lose out on the opportunity to supplement DL-lipoic acid. DL-Lipoic Acid is readily available as tablet computer systems or as an antioxidant formula containing DL-Thioctic Acid. It is encouraged to take 1-2 tablet computer systems of 50mg DL-lipoic acid daily.

DL-Thioctic Acid Property

Melting point 28 °C (lit.)
Boiling point 217 °C/150 mmHg (lit.)
density 1.097 g/mL at 25 °C (lit.)
vapor density 3.6 (vs air)
vapor pressure <0.98 atm ( 100 °C)
refractive index n20/D 1.477(lit.)
Fp 280 °F
storage temp. 2-8°C
solubility H2O: 1 M at 20 °C, clear, colorless
form Viscous Liquid or Low Melting Solid
color APHA: ≤15
Specific Gravity1.09
OdorMild ammoniacal; faint, fishy; characteristic.
PH11.0-12.0 (25℃, 1M in H2O)
pka8.88(at 25℃)
explosive limit2.1-10.6%(V)
Water Solubility MISCIBLE


DL-Thioctic Acid Uses

  1. DL-Thioctic Acid is a high-efficiency antioxidant that plays an important function in the avoidance and therapy of numerous diseases.
  2. DL-Thioctic Acid In the field of medication, α-lipoic acid is commonly used in the avoidance and auxiliary therapy of diabetic issues as well as its relevant complications. It can enhance glucose metabolic rate, minimize oxidative stress and anxiety, soothe symptoms of diabetic neuropathy, protect against diabetic cataract, as well as prevent diabetic cardio damages.
  3. DL-Thioctic Acid is a vitamin medicine that can promote fat metabolic process. It is utilized for the therapy as well as healthcare of acute and persistent liver disease, cirrhosis, hepatic coma, fatty liver, diabetes mellitus as well as various other conditions.
  4. DL-Thioctic Acid is an antioxidant and works as a coenzyme such as pyruvate dehydrogenase (pyruvatedehydrogenase) and also glycine decarboxylase (glycinedecarboxylase), exogenous lipoic acid is decreased by 2 or more enzymes in the cell. This reduced type hinders the cellular procedure of scavenging complimentary radicals. Rise glutathione (glutathione) synthesis, control transcription element task. Lowered phagocytosis of macrophage myelin.

DL-Thioctic Acid--"Universal Antioxidant"

Scavenge free radicals and active oxygen
DL-Thioctic Acid can scavenge hydroxyl radicals (OH), hydrogen peroxide (H2O2), singlet oxygen (1O2), nitric oxide radicals (NO ), peroxynitroso (OONO) and hypochlorite acid (HClO). Although α-LA cannot scavenge peroxide radicals (ROO·) and superoxide radicals (O—2 ·), the reduced state of α-LA, DHLA, can scavenge free radicals other than singlet oxygen. Therefore, α-LA LA and DHLA can scavenge all the above-mentioned free radicals during the mutual conversion and metabolic regeneration process in the organism.

Interactions with other antioxidants
DHLA is a strong reducing agent that can regenerate many oxidized antioxidants such as ascorbic acid, vitamin E, glutathione (GSH), coenzyme Q, thioredoxin, etc. The redox of DL-Thioctic Acid and DHLA activates the metabolic cycle of other antioxidants in the organism, forming a unique biological antioxidant regeneration cycle network, maintaining the normal level of antioxidants in the body, and jointly exerting the biological antioxidant effect.

DL-Thioctic Acid also significantly increases intracellular GSH levels. GSH is a water-soluble endogenous antioxidant involved in many important physiological processes. GSH deficiency leads to the production of reactive oxygen species and mitochondrial dysfunction, ultimately leading to neuronal apoptosis. The important biochemical feature of Parkinson’s disease (PD) is the significant reduction of GSH level, so α-LA has a positive effect on the prevention and treatment of PD. The synthesis of GSH in organisms is affected by the availability of cysteine. α-LA can be quickly absorbed by cells and reduced to DHLA, which can be dispersed into various tissues. DHLA reduces cystine to cysteine. Cellular uptake of cysteine is ten times faster than cystine, thereby accelerating GSH biosynthesis. DHLA can increase the concentration of GSH by 30% to 70%.

In the field of medicine, DL-Thioctic Acid is widely used in the prevention and auxiliary treatment of diabetes and its related complications.

Diabetes and chronic complications of diabetes
Enhance sugar metabolism
In 1970, Haugaard et al found that DL-Thioctic Acid can enhance the metabolism of glucose. Studies in recent years have once again confirmed that α-LA can enhance the absorption of glucose by skeletal muscle and red blood cells of non-insulin-dependent diabetic animals and lower blood sugar.

Reduce oxidative stress
Due to the decrease of the body’s antioxidant capacity in diabetics, lipid peroxidation products (such as thiobarbituric acid active substances, lipid peroxides, oxidatively damaged DNA bases, etc.) increase, and the protective antioxidant vitamin E. The levels of vitamin C and reduced GSH decreased. Oxidative stress is an important factor causing diabetic complications. Hyperglycemia stimulates the polyol pathway, leading to the formation of advanced glycation end products (AGE), which induces the production of reactive oxygen species, thereby enhancing oxidative stress. α-LA can reduce oxidative stress by scavenging reactive oxygen species free radicals.

Relieve symptoms of diabetic neuropathy
α-LA can scavenge free radicals, regenerate antioxidant substances, weaken oxidative stress, speed up nerve conduction rate, correct neuropeptide defects, and restore neuropeptide Y, nerve growth factor and substance P, thereby effectively alleviating or eliminating the frequent occurrence of diabetes Symptoms of neuropathy.

Prevent Diabetic Cataracts
α-LA can inhibit the polyol pathway, reduce the accumulation of sorbitol, maintain the level of NADPH in cells, inhibit the formation of AGE, increase the GSH content in the lens, and thus protect the lens. In vitro experiments have shown that α-LA has specific protection against glucose-induced lens opacity.

Prevention of cardiovascular damage in diabetes
Studies have shown that DL-Thioctic Acid and DHLA have a strong inhibitory effect on the activation of NF-κB caused by NF-α, H2O2, TNF-α and AGE. α-LA can down-regulate the expression of cell adhesion molecules ICAM-1 and VCAM-1, reduce the expression of endothelial cytokines and endothelin, and relieve endothelial dysfunction. α-LA can correct hyperglycemia-induced abnormality of endothelium-derived hyperpolarization factor and nitric oxide, reduce the effect of diabetes on the expression and activity of cardiac nitric oxide synthase (NOS), and regulate NO-mediated endothelial Cell-dependent vasodilation, maintaining the normal relaxation function of blood vessels.

DL-Thioctic Acid is a high-efficiency antioxidant that plays an important role in the prevention and treatment of many diseases.

In the field of health food, antioxidant food health products are mainly used to scavenge free radicals in the body and prevent lipid peroxidation, so as to achieve the purpose of preventing and assisting the treatment of certain diseases.

The antioxidant properties of DL-Thioctic Acid and its clinical application research have matured, and more and more research will focus on its application in the field of health food in the future. The safety of α-LA has been proven in Europe for decades, so the safety of the biggest problem in food application is guaranteed.

DL-Thioctic Acid Preparation

First weigh 100g of plastic chloride and also placed it into a 500mL three-necked flask outfitted with a stirrer, dropping funnel and also thermostat. At area temperature level, include 25mL of sulfuric acid option with a mass concentration of 65%, and then put the three-necked flask in an ultrasonic oscillator., at an ultrasonic frequency of 25KHz and an ultrasonic power of 100W for oscillating response for 35min. After the oscillating reaction mores than, raise the temperature of the three-necked flask to 85 ° C at a rate of 3 ° C/min, as well as gradually include 50mL of 80%trichloro For methane service, the dropwise addition is completed within 15 minutes. During the dropwise enhancement, the mixing state is constantly maintained. After the dropwise addition is finished, the temperature level is secured as well as increased to 50 ° C, as well as the stress is increased to 0.2 MPa. After 1 hr of polymerization response, 1,2,5,7 -tetrachlorooctane; then pour the produced 1,2,5,7-tetrachlorooctane into the container, and include 1,2,5,7-tetrachlorooctane top quality 1 times sodium hydroxide therein, Mix at 40 ° C at a rate of 500r/min for 5min. After the stirring is finished, allow it stand for 40min, filter, remove the deposit and also leave the liquid to obtain 2,4,6-triene octanol; next, the 2,4, Placed 6-triene octanol in the response kettle, seal the response pot, and feed H2S into the bottom of the reaction pot at a price of 2L/min under the problem of the temperature level of the reaction kettle at 110 ° C and also the stress of 0.5 MPa, as well as stop the feeding after 25min., willingly cooled to room temperature to create 4,6-diene-α-lipoic acid; then feed hydrogen chloride at the bottom of the reactor containing 4,6-diene-α-lipoic acid at a rate of 3 L/min, While feeding, raise the temperature of the activator to 160 ° C at a price of 8 ° C/min, and the stress of the reactor to 0.6 MPa, stop feeding after 20min, and utilize a follower to cool it to space temperature quickly to obtain DL-Thioctic Acid; The obtained DL-Thioctic Acid was put in a dealt with activator, as well as 50% calcium oxide was added to the mass of α-lipoctyl alcohol. The chosen temperature variety was controlled to be 45 ° C, the stress variety was 1MPa, and also the response was mixed for 15 mins. The maximum temperature level array is 48 ° C, as well as the pressure range is 1.2 MPa. Remain to stir and also respond for 10 minutes, after that add α-lipoctyl alcohol 30% magnesium oxide to it, blend well, let stand for 45 minutes, and after that put it in an ice bath to cool to Acquire crystals at 3 ° C, filter to get filtrate; finally add hydrochloric acid option with a mass concentration of 35% to the acquired filtrate, change the pH to 1, put it in a stove, and completely dry it at 105 ° C till consistent weight, Then placed the dried item into a pulverizer as well as pulverize with a 100-mesh filter to acquire DL-Thioctic Acid.

About Products:
If you need DL-Thioctic Acid as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced DL-Thioctic Acid manufacturer and supplier, ZSpharmac will provide DL-Thioctic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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