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DL-Serine CAS 302-84-1

Molecular Formula: C3H7NO3

Formula Weight: 105.09

ZSpharmac: DL-Serine Supplier

Product Name: DL-Serine
CAS No: 302-84-1
Purity: 99%

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Basic Info

Product Name:DL-Serine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:206-130-6
Storage:Store Below +30°C.
Provide:DL-Serine MSDS;
DL-Serine COA

What is DL-Serine?

DL-serine, the English name is DL-Serine, it is a white crystalline strong under regular temperature level and also stress. DL-serine is an amino acid by-product, additionally referred to as β-hydroxyalanine. Its chemical formula is C3H7NO3. It is named for its earliest origin from silk. Serine is a neutral aliphatic hydroxyl-containing amino acid. It plays a vital duty in the metabolic rate of fat as well as fats and muscle It contributes in the development of afferent neuron, in the manufacturing and also handling of cell membranes, as well as in the synthesis of muscle cells and also the sheath that borders afferent neuron. This chemical is mainly used in substance amino acid preparations to supplement amino acids. At the same time, the substance is likewise an important natural chemical, and also N-methyl-D-aspartic acid (NMDA) receptor is its essential endogenous ligand, both of which play a vital function in the main system. The production methods of DL-serine normally consist of fermentation approach, protein hydrolysis removal approach, chemical synthesis approach, organic enzyme technique and so forth.

DL-Serine Property

Melting point 240 °C (dec.) (lit.)
Boiling point 197.09°C (rough estimate)
density 1.53
refractive index 1.4368 (estimate)
storage temp. Store below +30°C.
solubility H2O: soluble
form Crystalline Powder
pka2.19(at 25℃)
color White
Water Solubility 50.23 g/L (25 ºC)


Application of DL-Serine

DL-serine is widely used in medication, food, cosmetics and also various other sectors as a basic amino acid for protein make-up. The existing global market need for DL-serine is 10,000 t/year. DL-serine is a non-essential amino acid, which is a crucial precursor associated with the synthesis of intracellular organic compounds such as purine, pyrimidine, and also phospholipids. In addition, the compound is also a raw material for compound amino acid infusion, and can also be used as a raw material for light chemical industry. Because DL-serine has special wettability and moisture retention, it is widely used in high-end cosmetics at home and abroad. D-serine in this chemical is one of the most important D-type amino acids in mammals, accounting for about 1/3 of the total free serine in the body. In addition, DL-serine has carboxyl, amino, and hydroxyl groups at the same time, and can also be used as an intermediate in organic synthesis and medicinal chemistry, and is mostly used in the modification and preparation of functional molecules and bioactive molecules.

DL-Serine Preparation Method

DL-Serine can be acquired in the complying with means:
1. Removal approach. The healthy protein consisting of more serine is hydrolyzed, and afterwards extracted and also refined with ion exchange resin.
2. Usage glycolaldehyde, hydrocyanic acid and also ammonia as raw materials to synthesize aminonitrile, and after that hydrolyze it to obtain it.
3. Fermentation approach. Making use of sugar as carbon source as well as glycine as forerunner, it can be generated by fermentation with Corynebacterium glycinophilus or Sarcina microalbicans. Or utilize methanol as a carbon resource and also use Pseudomonas 3ab or Pseudomonas MS31 to create it via fermentation.
4. Making use of acrylonitrile as basic material, after chlorination, α, β-dichloropropionitrile is produced, and after that ammonified to generate α-chloro-β-aminopropionitrile, and afterwards aziridine-2-carboxylate is created in alkaline service Salt acid, DL-serine can be prepared by strongly acidic cation exchange resin.
5. Using chloroacetaldehyde as raw material, lower it with salt bisulfite and also react with antacids to generate α-amino-β-sodium chloroethanesulfonate, which is additional cyanided with salt cyanide to get α-amino-β- Chloropropionitrile is finally obtained by the acrylonitrile technique.
6, α-isocyanacetamide responds with formaldehyde to create quinazoline intermediate, which can be gotten by direct hydrolysis.
7. Electrolytic decrease method. First oxidize ethyl propionate to the matching oxime, after that utilize lithium chloride as the sustaining electrolyte, as well as both poles are lead and platinum, specifically, and carry out electrolytic reduction to get it.
8. Using ethanolamine as basic material, it is oxidized with hydrogen peroxide under the action of stimulant salt tungstate, then cyanated with salt cyanide to create aminonitrile, and lastly hydrolyzed in hydrochloric acid to get DL-Serine.

Amino Acid Composition of Mulberry Leaf Protein and Silkworm Body Protein

The amino acid structure of mulberry fallen leave protein and additionally silkworm body protein is various, mainly because of the truth that the material sections of 6 kinds of alanine, methionine, glycine, tyrosine, phenylalanine as well as proline in silkworm body healthy and balanced protein are above those in mulberry leaf protein, especially methionine as a necessary amino acid, silkworm body healthy protein is 2.7 times greater than mulberry fallen leave protein, in addition to need to be built up from a huge quantity of food consumed. Various other non-essential amino acids can be generated in silkworms besides from mulberry leaves.The cocoon silk healthy and balanced protein generated in the silkworm body is different from the silkworm body healthy and balanced as well as balanced healthy protein. The product section of non-essential amino acids such as glycine, alanine, serine in addition to tyrosine is significantly larger. The overall of these 4 amino acids gets to 79.68%, while the silkworm body healthy protein just represented 43.26%, particularly the biggest boost in serine. It can be seen that the manufacturing of cocoon silk healthy along with well balanced protein is not stemmed from silkworm body healthy and balanced protein, nevertheless is straight synthesized in silk gland cells using at no cost amino acids in blood as items.
Alanine in addition to glycine, which are considerably raised in silkworms, can be produced by transferring the amino team from an extra amino acid (glutamic acid or aspartic acid) to pyruvate or glyoxylate, especially, with the engagement of transaminase. Alanine can be produced under the succeeding task of glutamic aminotransferase, oxaloacetate decarboxylase as well as also glutamic aminotransferase. It can in addition be produced by ornithine aminotransferase (Xu Tingsen et al., 1980).Silk gland tissue can use ketomalonate as an amino receptor to take on transamination to develop aminomalonate, and after that produce glycine under the catalysis of aminomalonate decarboxylase (Zou Baixiang et al., 1979). Glycine can be changed right into serine, glucose can likewise produce serine with 3-phosphohydroxypyruvate, as well as serine can generate alanine with pyruvate. Tyrosine can be created from phenylalanine, and also cystine can be generated from methionine but not reversely, so phenylalanine as well as likewise methionine are both crucial amino acids. When the feed is plentiful in tyrosine along with cystine, the need of phenylalanine in addition to methionine can be minimized.

About Products:
If you need DL-Serine, the cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced DL-Serine manufacturer and supplier, ZSpharmac will provide DL-Serine raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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