Zhishang Chemical

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Zhishang Chemical

DL-Methionine Powder CAS 59-51-8

Molecular Formula: C5H11NO2S

Formula Weight: 149.21

ZSpharmac: DL-Methionine Powder Supplement

Product Name: DL-Methionine Powder
CAS No: 59-51-8
Purity: 99%

Basic Info

Product Name:DL-Methionine Powder
Other Names:DL-Methionine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:White Crystals or Crystalline Powder
EINECS No.:200-432-1
Storage:Ventilated Dry Place 2-8°C
Provide:DL-Methionine Powder MSDS;
DL-Methionine Powder COA

What is DL-Methionine Powder?

DL-Methionine Powder (Methionine, additionally referred to as methionine), is a vital amino acid in all metazoans. In addition to cysteine, DL-Methionine Powder is one of both sulfur-containing protoamino acids

DL-Methionine Powder Properties:

Melting point 284 °C (dec.)(lit.)
alpha -1~+1°(D/20℃)(c=8,HCl)
Boiling point 306.9±37.0 °C(Predicted)
density 1.34
refractive index 1.5216 (estimate)
storage temp. 2-8°C
solubility 1 M HCl: 0.5 M at 20 °C, clear, colorless
pka2.13(at 25℃)
form Crystals or Crystalline Powder
color White
optical activity[α]/D, c = 5 in 5 M HCl (inactive)
Water Solubility 2.9 g/100 mL (20 ºC)


DL-Methionine Powder Uses

  1. DL-Methionine Powder is suitable for the avoidance as well as therapy of liver disease and poisoning such as arsenic or benzene. It can likewise be used to treat dysentery as well as lack of nutrition caused by insufficient healthy protein after persistent infectious diseases.
  2. DL-Methionine Powder is a feed dietary supplement. Lack of methionine in livestock as well as chicken will cause stunted growth, fat burning, compromised liver as well as kidney functions, muscle atrophy, and also fur damage. Including 1kg of methionine to the feed amounts the dietary value of 50kg of fish dish. The general enhancement amount in the feed is 0,05%-0.2%.
  3. DL-Methionine Powder is a dietary supplement. Added to the above foods to enhance amino acid balance. Requirements vary with cystine intake. Adult guys need 1.1 g/d.The taste of sea urchin is associated with methionine, the wonderful preference of sea urchin is connected to glycine and alanine, the bitter preference is associated with valine, and the umami taste is associated with glutamic acid. As a result, these amino acids can be formulated into flavor representatives. It is still made use of for amino acid mixture and comprehensive amino acid preparation. According to my nation’s GB2760-86 laws, it can be made use of as flavor.
  4. The material of industrial DL-Methionine Powder is greater than 98.5%, which is among the amino acids necessary for the development of animals and also chicken. It is the “skeleton” amino acid of biosynthetic healthy protein. It has a strong regulatory effect on the metabolic process of pets as well as is extensively made use of in medicine, food and feed. as well as cosmetics. It can be made use of to create liver-protecting preparations by using its anti-fatty liver result. As a result of its unique odor, it is only used for fish cake items. In the feed industry, methionine is made use of in the biggest quantity. Feed ingredients, amongst the ranges of amino acid dietary feed ingredients, DL-Methionine Powder accounts for 60%, lysine represent 30%, as well as other amino acids account for around 10%.
    DL-Methionine Powder for biochemical research; for mammalian and insect cell culture applications where mixed isomers are indicated.
  5. DL-Methionine Powder for biochemical research; for mammalian and insect cell culture applications where mixed isomers are indicated.

DL-Methionine Powder Preparation Method

1. The synthesis technique using acrolein as basic material is generally embraced. Acrolein and methyl mercaptan are condensed in the existence of formic acid and copper acetate to create 3-methylthiopropanal. After that combine with sodium cyanide as well as ammonium bicarbonate option. The reaction was carried out at 90 ° C to obtain methylthioethyl hydantoin. Without separation as well as purification, it can be heated to 180 ° C with 28% salt hydroxide remedy, as well as hydrolyzed to create salt DL-Methionine Powder. The completed DL-Methionine Powder is acquired by neutralization with hydrochloric acid.

2, D-configuration and L-configuration methionine have the same physiological function, and DL-form is mostly used, so it is advantageous to manufacture by synthetic method. Generally obtained by the reaction of acrolein and methyl mercaptan.

3. The extraction method can be used to prepare DL-Methionine Powder, but there are the following methods in industry:

1. The Rhone-Planck Process

2. Degussa DL-Methionine Powder process raw material consumption quota: acrolein 480kg/t, methyl mercaptan 400kg/t, sodium cyanide 420kg/t.

DL-Methionine Powder Waste Liquid Treatment Method

A waste liquid treatment method for producing DL-Methionine Powder, comprising the following steps:

S1, the saponification solution is separated by cation exchange resin to obtain sodium sulfate mother liquor, flocculant and coagulant aid are added to the sodium sulfate mother liquor, alkali is added to adjust the pH value of the solution, and the solution is fully mixed and filtered to obtain a filtrate;

S2, in the filtrate, add acid solution for acidification, the acidified solution is concentrated and then hot filtered to carry out solid-liquid separation to obtain sodium sulfate solid and sodium sulfate filtrate;

S3, the sodium sulfate solid is washed with desalted water to obtain a sodium sulfate product, when the methionine content in the sodium sulfate filtrate is less than or equal to 1%, return to step S1, and mix with the sodium sulfate mother liquor, when the sodium sulfate filtrate The methionine content is more than or equal to 1% , enter the methionine extraction process;

S4, mixing electrodialysis concentrated water and reverse osmosis concentrated water, adjusting pH and concentrating, cooling and crystallization, and separating to obtain methionine and methionine filtrate;

S5, after the sodium sulfate filtrate in S2 and the methionine filtrate in S4 are combined, separated into methionine solution and sodium sulfate solution by chromatography, return in S1 after the sodium sulfate solution is concentrated and removed impurities, merge with sodium sulfate mother liquor, and execute S1- S4;

S6, after mixing the methionine in S4, the methionine solution in S5 and the saponification solution in S1, stripping deamination and promoting the decomposition of methionine intermediate into methionine;

S7, the distilled water of S2, S4 and S5 is combined to obtain desalted water after adsorption by anion exchange resin.

Is It OK to Overdose on DL-Methionine Powder During Pregnancy?

It is not possible for the following reasons:
Research has shown the role that DL-Methionine Powder overload may play during pregnancy, and it is suggested that targeting this amino acid’s actions could lead to the creation of new antipsychotics. The study also provides insights into the neurodevelopmental mechanisms of methionine’s effects, which lead to changes in the expression of several genes critical to brain development, particularly those associated with schizophrenia.

Amal Alachkar and colleagues built on methods from the 1960s and 1970s in which schizophrenia patients who were injected with methionine had worsening symptoms. The researchers hypothesized that giving pregnant rats three daily injections of methionine might develop schizophrenia in the pups. It found that pups injected with mothers showed deficits on nine different tests, including three symptoms of schizophrenia: positive symptoms of hyperactivity and stereotyping, negative symptoms of interpersonal deficits, and cognitive impairment with memory loss.

The researchers treated the rats with antipsychotic drugs, haloperidol for positive symptoms and clozapine for negative symptoms and cognitive impairment, with similar efficacy to humans.

Alachka, a professor of pharmacology, said the study is the first to propose a mouse model in which methionine affects neurodevelopment, leading to schizophrenia-like behaviors, a model that provides more specific details on the biology of schizophrenia.
Methionine is one of the building blocks of protein, it is not synthesized by our body and needs to be ingested externally. The study pointed out that methionine plays an important role in fetal development, and excessive intake during pregnancy may have long-term effects on offspring.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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