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Disodium EDTA CAS 139-33-3

Molecular Formula: C10H14N2Na2O8

Formula Weight: 336.21

ZSpharmac: Disodium EDTA Supplier

Product Name: Disodium EDTA
CAS No: 139-33-3
Purity: 99%

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Basic Info

Product Name:Disodium EDTA
Other Names:Ethylenediaminetetraacetic Acid Disodium Salt
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:205-358-3
Provide:Disodium EDTA MSDS;
Disodium EDTA COA

What is Disodium EDTA?

The molecular weight of disodium EDTA is 372.25. Additionally known as disodium ethylenediaminetetraacetate, frequently referred to as disodium ethylenediate, abbreviated as disodium EDTA, code M-23. White or somewhat yellow crystalline powder. Soluble in water, insoluble in ethanol and also ether. It starts to lose crystal water at 100 ° C and comes to be anhydrous salt at 120 ° C. It can react with calcium ions in difficult water to develop soluble salts. It can also eliminate the damaging result of copper ions and also iron ions on Caiyi designer throughout storage space, and prevent the formation of haze. It is a vital complexing agent as well as water softener. Made use of in photographic programmer, shade designer, pre-bath, stabilization, taking care of as well as various other remedies. The container is sealed and also stored in an awesome, dry as well as ventilated area. Presently, the devices for massive production of disodium EDTA at home and also abroad is a basic enamel activator, and also the procedure of its mature process is roughly as complies with: particularly, taking EDTA and also salt hydroxide or Na2CO3 for neutralization reaction, and then focusing, cooling down, condensation, purification, dehydration, drying, packaging as well as other processes to acquire finished products, however because each catalyst is added at once during the response procedure, the response solubility is not well regulated, as well as side reactions are prone to happen, the return is low, and the pureness is likewise low. Affected, the appearance is substandard. For that reason, the existing modern technology and tools for this production of disodium EDTA require to be improved.

Disodium EDTA Property

Melting point 248 °C (dec.)(lit.)
Boiling point >100 °C
density 1.01 g/mL at 25 °C
storage temp. 2-8°C
solubility H2O: clear, colorless
form solution
color ≤5 (0.5 M)(APHA)
Water Solubility Miscible with water.


Application of disodium EDTA

Disodium EDTA is a powerful chelating agent, preservative and antioxidant. Because of its high stability constant, it can form stable complexes with most of the metal ions other than alkali metals, eliminate metal ions or by their It can inhibit the water turbidity of boiled food, prevent the oxidation and discoloration of the food, so as to play the role of anti-oxidation, color protection and anti-corrosion, and make the product quality stable. Oxidant, antiseptic and preservative, widely used in the preservation and color protection of fruits, vegetable products, dairy products, beverages, meat products, preserved fruits, sauces, as well as the antioxidant of oils and flavors. Its main uses can be summarized as:
1) Used as man-made fiber stabilizer.

2) For fabric bleach.

3) It is used as a developer in the photographic industry.

4) As a preservative in the food industry, a vegetable preservative, such as the preparation of a food antioxidant additive containing disodium EDTA and glucono-delta-lactone as a stabilizer, which is composed of the following components: anti-oxidative sodium metabisulfite , ascorbic acid, sodium D-isoascorbate, sodium ascorbate or ascorbyl palmitate, disodium EDTA or sodium phytate, tea polyphenols, bamboo leaf antioxidant or rosemary extract, sodium citrate, glucose Acid-delta-lactone, silicon dioxide or microcrystalline cellulose, the percentage of each component is: sodium metabisulfite: 5-40%, ascorbic acid: 5-60%, glucono-delta-lactone: 2-30%, D-Sodium Erythorbate: 1-20%, Disodium EDTA: 1-15%, Sodium Citrate: 2-20%, Silicon Dioxide: 0.5-5% The sum of the weights of the above components is 100 %. By inhibiting the activity of polyphenol oxidase in food, delaying the degradation of vitamins, preventing oxidation, etc., the present invention slows down the browning of processed vegetables, fruits, candied fruit and other products, effectively prolongs the shelf life of the products, and is more efficient than conventional preservatives. Effectively extend the preservation time more than double.

5) Leather industry.

6) Mine is used as mineral processing agent.

7) The chemical industry is used as a reducing agent to produce Haibo raw materials.

8) Introducing sulfo group in organic synthesis, synthesizing dyes and pigments.

9) In addition, it is also used in paper industry, electroplating industry, foundry industry, pharmaceutical industry, some sodium sulfite products are used as water reducing agent and environmental protection sewage treatment, etc. For example, a method for preparing graphene with a three-dimensional macro-porous structure includes the following steps: a) preparing an aqueous solution of disodium EDTA; b) preparing graphene oxide powder; c) using the graphene oxide prepared in step b) The powder is added to the disodium EDTA aqueous solution prepared in step a), and ultrasonically dispersed to obtain a graphene oxide-disodium EDTA solution; d) the graphene oxide obtained in step c) is obtained -After the disodium EDTA solution is sealed, in-situ self-assembly is performed at 90-100 °C to obtain a three-dimensional graphene hydrogel. The advantages of the present invention are: 1) low requirements for equipment operation, green energy saving and easy mass production; 2) low preparation cost, simplifying the preparation operation of three-dimensional graphene; 3) the size and shape of three-dimensional graphene can be determined by the feeding of graphene oxide The concentration is adjusted by mixing with the volume and shape of the container.

Preparation of disodium EDTA

A preparation method of pharmaceutical grade disodium EDTA, the steps of the preparation method of pharmaceutical grade disodium EDTA are as follows:

S1: Material and liquid preparation: Obtain monochloroacetic acid and place it in a round-bottomed flask, add sodium carbonate, until the liquid in the round-bottomed flask begins to bubble, add ethylenediamine, let stand for a while, and add 35-45% 50 parts of sodium hydroxide, add distilled water to the round bottom flask until the liquid volume is 300ml;

S2: preliminary reaction: the round-bottomed flask in step S1 and the solution in the round-bottomed flask are installed with a cooling and reflux device, the solution in the round-bottomed flask is subjected to graded insulation treatment, and the round-bottomed flask is removed after the insulation is completed;

S3: Obtain the crude product of EDTA: remove the round-bottomed flask in step S2 and cool it for 35-45 minutes, add concentrated hydrochloric acid to the round-bottomed flask to adjust the pH to 1.2, and a white precipitate appears in the solution, obtain the white precipitate , the white precipitate is the crude product of EDTA;

S4: Crude product purification: obtain the white precipitate in step S3, place the white precipitate in a clean beaker, add a deionized aqueous solution to the beaker, stir evenly, let stand for 5 minutes, filter with a sieve, and retain the solid filtrate;

S5: Preparation of disodium EDTA: obtain the solid filtrate in step S4, place the solid filtrate in a clean beaker, add sodium hydroxide solution, let stand for 20 minutes, and add sodium carbonate to adjust the pH value to 4-5;

S6: distillation and crystallization: the reaction solution in the beaker in the step is cooled for 1 hour, and the cooled solution is placed in a distillation tower for distillation to prepare disodium EDTA crystals;

S7: remove crystal water: place the disodium EDTA crystal obtained in step S6 in a decrystallization apparatus, remove crystal water, and obtain disodium EDTA solid powder;

S8: Quality inspection: test and save the disodium EDTA powder obtained in step S7.

The Specific Embodiment of Disodium EDTA

In a 250ml three-flask with a thermometer, a condenser and a stirrer, mix 15.1 g of ethylenediamine with a mass percent of 99.4% as well as 173.3 g of salt hydroxide with a mass percent of 30%. Within 5 hours, 163 g of hydroxyacetonitrile with a mass percentage web content of 35% was added dropwise, and also after the going down was completed, the temperature was elevated to 110 ° C. to react for 30 minutes, and also 130 g of water and also 0.2 g of hydrogen peroxide were added. 75g EDTA was contributed to adjust the pH of the response service to 5-6. Turned on carbon was included in the response solution for decolorization, 42g of EDTA was included in the decolorized response service to adjust the pH to 3.5 to 4.5, and the reaction service was focused, crystallized, divided and dried out to get 147.5 g of a white crystalline item of EDTA disodium salt with a content of 99.3%, the return is 60.5% (computed as salt hydroxide). The mom liquor after separating the disodium salt of EDTA can be acidified with sulfuric acid to obtain EDTA, which is used to readjust the pH value.

About Products:
If you need Disodium EDTA, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Disodium EDTA manufacturer and supplier, ZSpharmac will provide Disodium EDTA raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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