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Dipotassium Tetrachloroplatinate CAS 10025-99-7

Molecular Formula: Cl4KPt-

Formula Weight: 375.98

ZSpharmac: Dipotassium Tetrachloroplatinate Supplement

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Product Name: Dipotassium Tetrachloroplatinate
CAS No: 10025-99-7
Purity: 99%

Basic Info

Product Name:Dipotassium Tetrachloroplatinate
Other Names:Potassium Tetrachloroplatinate(II)
CAS:10025-99-7
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Red-Brown Crystals or Crystalline Powder
EINECS No.:233-050-9
Storage:Inert Atmosphere,Room Temperature
Provide:Dipotassium Tetrachloroplatinate MSDS;
Dipotassium Tetrachloroplatinate COA

What is Dipotassium Tetrachloroplatinate?

Dipotassium Tetrachloroplatinate is an important intermediate in the prep work of antitumor medications such as carboplatin, cisplatin and oxaliplatin, as well as has an excellent market possibility. Presently, concerning the preparation technique of potassium chloroplatinite, just couple of literatures report the preparation of its research laboratory. It is pointed out in the literary works that potassium chloroplatinate is made use of as a basic material, as well as potassium oxalate, hydrazine hydrate as well as sulfur dioxide are used as decreasing agents to synthesize potassium chloroplatinite. Due to the weak minimizing ability of potassium oxalate, the major steel material of the manufactured product is difficult to satisfy the demands; the lowering ability of hydrazine hydrate is strong, it requires to be thinned down by a particular several to satisfy the response needs, and its toxicity is also a problem that can not be overlooked; sulfur dioxide is utilized as a reducing representative to react Compared with the liquid response system, the gas-liquid two-phase is presented right into the system, which is harder to run and is not eco-friendly. The approach disclosed in license JP3131529 uses chloroplatinic acid as basic material and also hydrazine dihydrochloride as reducing agent. The drawback of this technique is that in the preparation of potassium chloroplatinate service, hydrochloric acid is made use of as solvent, and its concentration is purely limited. Additionally, the preparation procedure is prolonged and the manufacturing expense is high.

Dipotassium Tetrachloroplatinate Properties:

Melting point 250°C
density 3.38 g/mL at 25 °C(lit.)
storage temp. Inert atmosphere,Room Temperature
form Crystals or Crystalline Powder
color Red-brown
Specific Gravity3.38
Water Solubility 10 g/L (20 ºC)

Dipotassium Tetrachloroplatinate Uses

  1. Dipotassium Tetrachloroplatinate is a vital basic material for the prep work of other platinum compounds.
  2. Dipotassium Tetrachloroplatinate is used as an oxaliplatin intermediate.
  3. Dipotassium Tetrachloroplatinate is made use of in the prep work of precious metal stimulants and also precious metal coatings.
  4. Dipotassium Tetrachloroplatinate was made use of as a logical reagent.

Dipotassium Tetrachloroplatinate SUMMARY OF THE INVENTION

The purpose of the present invention is to aim at the deficiencies of the above-mentioned prior art, and propose a preparation method of Dipotassium Tetrachloroplatinate with short preparation process, low production cost and good operating environment. The object of the present invention is achieved through the following technical solutions. A preparation method of Dipotassium Tetrachloroplatinate , characterized in that the preparation process is to react a chloroplatinic acid solution prepared by using sponge molybdenum as a raw material with a potassium chloride solution to prepare Dipotassium Tetrachloroplatinate , and then use hydrazine hydrochloride as a reducing agent Reduction of potassium chloroplatinate to prepare potassium chloroplatinite as a pharmaceutical intermediate. A preparation method of Dipotassium Tetrachloroplatinate of the present invention is characterized in that the preparation process of the potassium chloroplatinate solution is to react sponge platinum with aqua regia, and after the reaction is stopped, concentrated hydrochloric acid is added dropwise to catch the nitrate until the system is no longer any longer. Take brown nitrogen oxides, add an appropriate amount of water to drive the acid, filter, and heat and concentrate the filtrate to 100~200g/L.
A kind of preparation method of Dipotassium Tetrachloroplatinate of the present invention is characterized in that the process of preparing Dipotassium Tetrachloroplatinate solution by reacting chloroplatinic acid solution and potassium chloride is to make the chloroplatinic acid solution with concentration of 100~200g/L, stirring It was added dropwise to the potassium chloride solution with a mass concentration of 15% to 30%, and 0.8 to 1.0 g of potassium chloride was added to each gram of platinum, and the solution appeared yellow precipitate. The Dipotassium Tetrachloroplatinate precipitate was filtered and the resulting precipitate was washed to neutrality with deionized water.
A preparation method of Dipotassium Tetrachloroplatinate according to the present invention is characterized in that using hydrazine hydrochloride as a reducing agent to reduce potassium chloroplatinate to prepare a pharmaceutical intermediate Dipotassium Tetrachloroplatinate , and the process is to prepare a suspension with potassium chloroplatinate (the mass concentration in platinum is 100%~150%), the mass concentration is that 20%~35% hydrazine hydrochloride solution is added dropwise to the suspension, every gram of platinum adds 0.3~0.5g hydrazine hydrochloride, carries out reduction reaction, drips After completion, the reaction was carried out at 60~80°C for 2-3h, cooled, and the mixture was filtered to obtain insoluble matter and scarlet filtrate; the insoluble matter was Dipotassium Tetrachloroplatinate and platinum black, which were recovered and processed; the filtrate was evaporated and concentrated, After the Dipotassium Tetrachloroplatinate crystals appear, vacuum drying at 50-60° C. to obtain a dark red Dipotassium Tetrachloroplatinate product. By adopting the method of the present invention, the prepared potassium chloroplatinite is analyzed and tested by XRD, and the platinum content is 46.9±0.2%, and the potassium content is 19.0±0.2°/. The total content of metal impurities is not more than 0.08%. The preparation process is short, the production cost is low and the operating environment is good.

The Preparation Method of Dipotassium Tetrachloroplatinate

A preparation method of Dipotassium Tetrachloroplatinate , the preparation process is as follows: using sponge platinum as raw material to prepare chloroplatinic acid solution and potassium chloride solution to prepare Dipotassium Tetrachloroplatinate , and then using hydrazine hydrochloride as reducing agent to reduce chloroplatinic acid Potassium for the preparation of pharmaceutical intermediates Dipotassium Tetrachloroplatinate . Include the following steps: a) Preparation of Dipotassium Tetrachloroplatinate : Weigh a certain amount of sponge platinum, put it into a beaker after washing, add an appropriate amount of aqua regia in batches, and heat appropriately. The reaction process is based on the principle of uniform bubbling. After the reaction was stopped, concentrated hydrochloric acid was added dropwise under heating and boiling to catch the nitrate until the system no longer took brown nitrogen oxides, and then an appropriate amount of water was added to catch the acid. After filtering, the filtrate was heated and concentrated to the desired concentration, and then cooled. Accurately weigh a certain amount of potassium chloride, dissolve it in water to make a 15%-30% solution, filter, and use the filtrate for later use. Take an appropriate amount of the above chloroplatinic acid solution and add it dropwise to the potassium chloride solution under stirring, and the solution will appear yellow precipitate. After the dropwise addition, continue to stir for about 1-2 hours to complete the reaction. After filtration, the obtained precipitate was washed with deionized water to neutrality, and the washing solution was concentrated and recovered. Vacuum dry at 70-90℃, and the product will be ready for later use after passing the test. b) Synthesis of potassium chloroplatinite: prepare 20%-35% hydrazine dihydrochloride solution. Take a certain amount of potassium chloroplatinate in step (a) and put it into a flask, add distilled water, heat to 60-80° C., and stir. Using a constant pressure funnel, the reducing agent hydrazine dihydrochloride solution was added dropwise to the potassium chloroplatinate suspension to carry out the reduction reaction. After the dropwise addition, the reaction was continued for 2-3 h, cooled, and the mixture was filtered to obtain insoluble matter and scarlet filtrate. c) drying of product and recovery of precious metals: in step (b), the insolubles are potassium chloroplatinate and platinum black, which are recovered. The filtrate is potassium chloroplatinite solution, and the filtrate is evaporated and concentrated until potassium chloroplatinite crystals appear, then vacuum-dried at 50-60 ° C for about 1 hour to obtain a dark red potassium chloroplatinite product. Samples were taken for total elemental analysis and XRD testing. In the method of the present invention, the concentration of described potassium chloride is 15%-30%, and optimum is 20%; Vacuum drying temperature is 70-90 DEG C, optimum is 80 DEG C. In the method of the present invention, the reducing agent is hydrazine dihydrochloride, the concentration is 20%-35%, the optimum reduction temperature is 60-80°C, and the optimum is 75°C. Weigh 100g of platinum sponge, put it into a beaker after washing, add an appropriate amount of aqua regia, heat appropriately, and the reaction process is based on the principle of uniform bubbling. After the reaction is stopped, the obtained solution is concentrated to have crystals to separate out, and concentrated hydrochloric acid is added dropwise to catch the nitrification until the system no longer takes brown nitrogen oxides, and then concentrated until there is crystallization to separate out, and an amount of deionized water is added to catch the acid. Filtration, and the filtrate was prepared into a 50g/L solution for later use. Weigh 80.0 g of potassium chloride to prepare a 20% solution, filter, and use the filtrate for later use. The above-mentioned chloroplatinic acid solution was taken and added dropwise to the potassium chloride solution under stirring, and the solution appeared yellow precipitate. After the dropwise addition, continued stirring for 1-2h to complete the reaction. Weigh 200g of potassium chloroplatinate into a 4L beaker, add 1500ml of distilled water, stir, heat to 75°C, dissolve 22g of hydrazine hydrochloride in distilled water to prepare a 25% hydrazine hydrochloride solution, and use a constant pressure funnel to remove the hydrazine hydrochloride solution. Add dropwise to potassium chloroplatinate. After the dropwise addition, continue stirring and heating for 2-3h. After cooling, the mixture was filtered, and the insolubles were collected in a concentrated manner. The filtrate was scarlet, evaporated and concentrated until crystals appeared, and then vacuum-dried at 50° C. for 1 h to obtain dark red potassium chloroplatinite crystals. The product is easily soluble in water, clear after dissolving, no inconsistencies visible to the naked eye, eld is 95.5%. The crystal was sampled for full element analysis and XRD detection, platinum content: 46.9%, potassium content: 18.5%, and no compounds other than potassium chloroplatinite were detected.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vission
Become the most trusted chemical supplier in the world
Our Business Philososphy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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