Zhishang Chemical

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Zhishang Chemical

Dipotassium Glycyrrhizinate CAS 68797-35-3

Molecular Formula: C42H63KO16

Formula Weight: 863.05

ZSpharmac: Dipotassium Glycyrrhizinate Supplement

Product Name: Dipotassium Glycyrrhizinate
CAS No: 68797-35-3
Purity: 99%

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Basic Info

Product Name:Dipotassium Glycyrrhizinate
Other Names:Dipotassium Glycyrrhizinate Standard
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:272-296-1
Storage:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Provide:Dipotassium Glycyrrhizinate MSDS;
Dipotassium Glycyrrhizinate COA

What is Dipotassium Glycyrrhizinate?

Licorice is a seasonal natural herb, belonging to the leguminous member of the family, which is a medical along with edible source. The from a physical point ofview energetic elements in licorice are primarily triterpenoids, flavonoids as well as glycyrrhizin materials. Among them, dipotassium glycyrrhizate is a potassium salt of glycyrrhizate drawn out from licorice. It is a natural sweetener with anti-inflammatory, anti-viral, liver protection as well as cleansing as well as likewise immune feature enhancement outcomes. Compared to sucrose, the pleasant preference intensity is 80-100 times that of sucrose. As a sugar, dipotassium glycyrrhizate has the advantages of high wonderful preference, cost-effective as well as high security. According to the artificial additive criterion, dipotassium glycyrrhizinate can be utilized as a sugar in flour items.

Dipotassium glycyrrhizate is a by-product of glycyrrhizic acid, which has anti-inflammatory, anti-allergic, anti-ulcer, as well as promo of epithelial cell cells regeneration. 0.5% dipotassium glycyrrhizate choice as well as 0 . The anti-inflammatory impact of 1% dexamethasone was comparable, but there were no significant negative effects. Dipotassium glycyrrhizate is a white powder with the high qualities of high sweet taste, terrific water solubility, reduced heat energy, low lathering, low hemolysis, security and non-toxicity. At the same time, dipotassium glycyrrhizate has anti-inflammatory, anti-ulcer, antioxidant, antibacterial, injury healing, as well as additionally reliable scavenging effects on superoxide ions and also hydroxyl absolutely free radicals. For that reason, in the cosmetics market, it can be utilized in skin lotion, shower gel, imperfection cream, face mask, and so on; in the pharmaceutical field, it can be used in eye declines, lotion for stomatitis; in the day-to-day chemical sector, it can be made use of in tooth paste, mouth wash, reducing lotion Wait.

Dipotassium glycyrrhizate has the features of boosting resistance, protecting against swelling, anti-cancer, anti-virus, anti-stress, causing the activity of glucocorticoid in the body, as well as turning on the self-repairing capability of cells. It is commonly thought that it associates with its chemical structure. Glycyrrhetinic acid itself It has a comparable framework to steroid hormonal agents, so it plays the feature of hormones in the body; and its framework is various from steroid hormonal representatives, so there are no significant negative responses as well as side effects of hormones. This verdict has in fact been verified by numerous research study organizations.

Dipotassium Glycyrrhizinate Property

Melting point >215oC (dec.)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form Solid
color White to Off-White


Dipotassium Glycyrrhizinate Uses

  1. Dipotassium glycyrrhizate is primarily made use of in medication, food, beverage as well as health care products markets. Dipotassium glycyrrhizinate can be made use of to enhance the dissolution rate of amphotericin B (AMB) and also the bioavailability of the medication in suppositories.
  2. Application scope of dipotassium glycyrrhizate: In the field of medicine, dipotassium glycyrrhizate can be utilized in eye drops as well as ointments; in the cosmetics industry, it can be made use of in sunscreen, freckle lotion, skin care cream, cream, and so on; in the day-to-day chemical market, it can be made use of in tooth paste; In the food market, it can be used as potassium supplement, sugar, preservative, and flavoring representative for sporting activities beverages.

The Mechanism of Action of Dipotassium Glycyrrhizinate

1. Regulation of immune function

Dipotassium glycyrrhizinate has mineralocorticoid-like effects—sodium retention and potassium excretion and glucocorticoid (Glucocorticoid)-like effects—glucose metabolism, but long-term use has no side effects.

Direct effect: It is generally believed that the chemical structure of glycyrrhetinic acid in dipotassium glycyrrhizinate is similar to that of adrenocortical hormone (Cortin), which affects ion channels and activates or inhibits enzymes by acting on hormone receptors (Receptors) on the cell membrane. Activity, regulate substance metabolism, regulate the excitability of cholinergic nerves. As a result, the permeability of capillary walls and cell membranes is reduced, the inflammatory exudation is reduced, and the formation and release of histamine and other toxic substances are inhibited, thus playing a good anti-inflammatory effect.

Indirect effect: that is, the glycyrrhetic acid in dipotassium glycyrrhizate inhibits the destruction of adrenal cortex hormones in the body, so that its content in the blood increases accordingly, thereby enhancing the body’s resistance to inflammation.

2. Anti-allergic effect

Glycyrrhizic acid and its potassium salts have good anti-allergic effects, inhibit histamine production and skin redness and itching, and especially have obvious protective effects on certain anaphylactic shocks. The basic unit between the stimuli that cause itching and the impulses that occur in free nerve endings is the mediator with physiological activity. Among them, histamine is the material basis of pruritus, and any factor that stimulates mast cells can degranulate mast cells to release histamine, thereby triggering itching. Therefore, the clinical use of antihistamines and stabilizing mast cells to reduce histamine release can treat common itching. Itching is a common complication of skin sensitivity. Its main allergens and action routes are similar to allergic reactions. , Dipotassium glycyrrhizate inhibits the occurrence of type I hypersensitivity reaction, which can greatly reduce the incidence of itching.

3. Regulate immune function

Application of Dipotassium Glycyrrhizinate in Toothpaste

Dipotassium Glycyrrhizinate and Glycyrrhizinate products are currently used as anti-allergic ingredients in cosmetics and anti-inflammatory and anti-allergic drugs, and practice has proved that the effect is very significant. Similarly, many people with oral and gum allergies are in great need of a toothpaste that is effective against allergies and has no adverse reactions and dependencies. In oral medicine, zinc licorice capsules are used in combination with vitamin B 2 to treat canker sores and are considered miraculous. Oral diseases have a high incidence and are increasingly concerned by people. And we also believe that prevention is more important than treatment for oral diseases, so a toothpaste that can be anti-inflammatory, anti-allergic, prevent and relieve various oral diseases will be welcomed by many people.

In addition, Dipotassium Glycyrrhizinate can be used as a safe and efficient natural sweetener to replace sodium saccharin in toothpaste, and its sweetness is 300 times that of sucrose. Currently on the market oral care products include Helus periodontal ointment under Lion King, Germany Grant-Gelclair (oral ulcer drug), Angileptol oral care solution under Sigma-Tau Pharmaceuticals, Neo-Stomygen toothpaste under Gruppo Stomygen, and Aventis in Italy. Fluocaril anti-allergic toothpaste, GSK’s periodentyl anti-allergic toothpaste, Japan Youhaotooth oral care toothpaste, domestic well-known Yunnan Baiyao’s anti-allergic toothpaste, etc. Recommended dosage of Dipotassium Glycyrrhizinate in toothpaste 0. 1% to 0.5%.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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