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Dipotassium Glycyrrhizinate CAS 68797-35-3

Molecular Formula: C42H63KO16

Formula Weight: 863.05

ZSpharmac: Dipotassium Glycyrrhizinate Supplier

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Product Name: Dipotassium Glycyrrhizinate
CAS No: 68797-35-3
Purity: 99%

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Basic Info

Product Name:Dipotassium Glycyrrhizinate
Other Names:DPG
CAS:68797-35-3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:272-296-1
Storage:Under Inert Atmosphere
Provide:Dipotassium Glycyrrhizinate MSDS;
Dipotassium Glycyrrhizinate COA

What is Dipotassium Glycyrrhizinate?

Dipotassium Glycyrrhizate (DPG) is an active ingredient extracted from the root of the leguminous plant Glycyrrhizauralensis Fisch. In general, licorice is mainly divided into three categories: licorice, licorice inflating fruit, licorice glabra (also known as licorice).

Dipotassium Glycyrrhizinate Property

Melting point >215oC (dec.)
density 1.277 at 20℃
vapor pressure 0Pa at 20℃
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form Solid
color White to Off-White

 

The Role of Dipotassium Glycyrrhizinate

Dipotassium glycyrrhizinate can reduce the production of pro-inflammatory factors (IL-4, IL-13), so it can be used as a potential ingredient to improve atopic dermatitis.

Dipotassium glycyrrhizinate can inhibit the inflammatory factor (PGE2) produced after UVB irradiation, and has the effect of controlling erythema and inflammation. In addition, the study mentioned that dipotassium glycyrrhizinate can relieve skin sensitivity stimulated by lactic acid.

Dipotassium glycyrrhizinate 2% can promote skin wound healing through re-epithelialization.

Studies have shown that a serum containing dipotassium glycyrrhizinate can help relieve symptoms of mild to moderate rosacea.

Mechanism of Action of Dipotassium Glycyrrhizinate

1. Regulate immunity

Dipotassium glycyrrhizinate has mineral corticosteroid (Mineralocorticoid)-like effect—sodium retention and potassium excretion and glucocorticoid (Glucocorticoid)-like effect—sugar metabolism, but long-term use has no side effects.

Direct action: It is generally believed that the chemical structure of glycyrrhetinic acid in dipotassium glycyrrhizinate is similar to that of adrenocortical hormone (Cortin). It acts on the hormone receptor (Receptor) on the cell membrane to affect ion channels, activate or inhibit enzymes Activity, regulation of substance metabolism, regulation of excitability of cholinergic nerves. As a result, the permeability of the capillary wall and cell membrane is reduced, the inflammatory exudation is reduced, and the formation and release of histamine (Histamine) and other toxic substances are inhibited, thus playing a good anti-inflammatory effect.

Indirect effect: Glycyrrhetinic acid in dipotassium glycyrrhizinate inhibits the destruction of adrenal cortex hormones in the body, thus increasing its content in the blood, thereby enhancing the body’s resistance to inflammation.

2. Anti-allergic effect

Glycyrrhizic acid and its potassium salt have a good anti-allergic effect, and have a good effect on inhibiting the production of histamine and skin redness and itching, especially for certain anaphylactic shock. The basic unit between the stimuli that cause itching and the impulses that occur at the free nerve endings is the physiologically active mediator. Among them, histamine is the material basis of itching, and any factor that stimulates mast cells can cause mast cells to degranulate and release histamine, thereby causing itching. Therefore, antihistamines and drugs that stabilize mast cells and reduce the release of histamine can be used clinically to treat common itching. Pruritus is a common complication of skin sensitivity, and its main allergens and pathways of action are similar to allergic reactions. Experiments have shown , Dipotassium glycyrrhizinate inhibits the occurrence of type I hypersensitivity reactions and can largely reduce the incidence of itching.

3. Regulating immune function

Whitening and Anti-Inflammatory Effects of Dipotassium Glycyrrhizinate

Dipotassium glycyrrhizinate is not only ideal for hair along with skin treatment, nonetheless additionally for dental health treatment.

Skin care: bleaching – prevent melanin production, brighten up complexion. Anti-inflammatory– Ideal for the treatment of skin inflammation such as injuries, dermatitis, burns, and so on, and likewise look after delicate, prone and short-tempered skin.

Dental Treatment: For the treatment of gingival swelling, dental wellness along with tooth safety and security.

Scalp Therapy: Alleviates scratchy scalp.

lightening
Dipotassium glycyrrhizinate can impede the manufacturing of melanin. In the speculative study, the back skin of test subject was chosen. Under UVB irradiation, the skin brightness coefficient (L worth) of the skin pretreated with 0.5% dipotassium glycyrrhizinate was greater than that of the control team. Considerably, the speculative outcomes reveal that dipotassium glycyrrhizinate can dramatically avoid melanin manufacturing, as well as likewise can be taken advantage of to stop skin pigmentation and also melanin production after sunlight straight exposure, in addition to is a potential skin lightening agent.

Anti-inflammatory as well as also anti-allergic
Dipotassium glycyrrhizinate acts on hormone receptors on the cell membrane layer, influences ion networks, activates or hinders enzyme activity, manages material metabolic rate along with excitability of cholinergic nerves, thus reducing the leaks in the structure of capillary wall surface surfaces and likewise cell membrane layer layers, to complete the feature of decreasing inflammatory exudation, as well as also hinder the development as well as additionally launch of histamine as well as numerous other dangerous substances, therefore playing an excellent anti-inflammatory outcome.

When dipotassium glycyrrhizinate acts upon RAW264.7 cells advertised by LPS, it can hinder the secretion of inflammatory moderator NO as well as inflammatory cytokine IL-6 by cells to varying degrees.

Consequently, dipotassium glycyrrhizinate is utilized in cosmetics to help in lowering skin redness as well as likewise inflammation, which prevail in various diseases such as rosacea as well as additionally psoriasis. Another professional test exposed that dipotassium glycyrrhizinate can successfully treat atopic dermatitis.

About Products:
If you need Dipotassium Glycyrrhizinate as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Dipotassium Glycyrrhizinate, ZSpharmac will provide Dipotassium Glycyrrhizinate raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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