Zhishang Chemical

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Zhishang Chemical


Molecular Formula: C16H12O6

Formula Weight: 300.26

ZSpharmac: DIOSMETIN Supplement

Product Name: DIOSMETIN
CAS No: 520-34-3
Purity: 99%

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Basic Info

Product Name:DIOSMETIN
Other Names:Geranin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Yellow to Yellow Neat
EINECS No.:208-291-8
Storage:Sealed in Dry,2-8°C


DIOSMETIN is isolated from plants, mainly by alcohol extraction, extraction, chromatography, chromatography, crystallization and other processes; it can also be obtained from hesperidin semi-synthesized. A study has introduced a method of extracting and isolating geranilin from peppermint. The method uses supercritical extraction technology to extract, separates with macroporous adsorption resin and countercurrent chromatography technology, and finally recrystallizes to obtain geranyl lignin products. Another study introduced a method for the isolation of DIOSMETIN from the rind of Gualou. The method utilizes a polyamide column combined with semi-preparative high performance liquid chromatography to separate and purify geranin. There is also a method using hesperidin as a raw material, which is hydrolyzed by an acidic ethanol solution to obtain hesperetin, and the latter is refined by adding iodine dehydrogenation in a pyridine solution to obtain DIOSMETIN, which is an intermediate product for the preparation of luteolin from hesperidin. . The raw materials used in these methods are not readily available, hindering the large-scale production of geranialignin.

DIOSMETIN Properties:

Melting point 256-258°C
Boiling point 576.7±50.0 °C(Predicted)
density 1.512±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO: soluble1mg/mL, clear, light yellow to yellow
form neat
color light yellow to yellow


The Role and Use of DIOSMETIN

1. It has been researched that DIOSMETIN has a boosting result.
2. DIOSMETIN has a substantial sensitization result on the chemiluminescence of potassium ferricyanide-luminol system. The test results program that after adding potassium ferricyanide service to alkaline luminol solution for 0.8 S, the luminescence intensity boosts. 0.5 times, and then gradually reduced after 3.85 S; in the combined option of alkaline luminol and potassium ferricyanide, adding geranyl, the luminous strength of Chemicalbook more than increased after 0.55 S, and the luminescence value of the last altered. over the previous. This completely reveals that geranialin has a strong animating result on the chemiluminescence of alkaline luminol oxidized by potassium ferricyanide service.
3. DIOSMETIN can be made use of to produce useful foods, cosmetics as well as future medications with anti-oxidative, anti-infective, anti-shock as well as various other results. An all-natural flavonoid that prevents human CYP1A enzyme activity. Geranin has anti-mutagenic and also anti-allergic homes.

Pharmacological Action and Application of DIOSMETIN

As one of the natural flavonoids, DIOSMETIN has a strong antioxidant effect. Zou Shujun et al proved that geranialignin has a certain scavenging effect on DPPH·, O2. And with the increase of the concentration, the clearance rate showed an upward trend, that is, a dose-effect relationship was presented. By comparing the change of absorbance value of 95% ethanol solution containing 1,1-diphenyl-2-trinitrophenylhydrazine radical (DPPH·) at 517 nm wavelength before and after adding geranialignin, it was found that after adding geranialignin, the The decrease in the absorbance value of the solution indicates that the single electron pairing of geranialignin and DPPH·, the DPPH· concentration in the solution decreases, which proves that geranialignin has the ability to scavenge DPPH· free radicals, and has stronger antioxidant activity, and its activity is stronger than that of VitC.

Globally, a growing number of methicillin-resistant Staphylococcus aureus (MRSA) have limited therapeutic options, and natural compounds have been shown to have antibacterial effects against MRSA. Geranin had no direct antibacterial activity against MRSA strains, however, DIOSMETIN significantly inhibited the activity of MRSA pyruvate kinase in a dose-dependent manner, which may lead to ATP deficiency, affecting the bacterial jet pump, making geranin against MRSA. Bacteriostatic effect.

In the human breast epithelial cancer cell line MCF-7 cells, DIOSMETIN treatment resulted in a dose- and time-dependent increase in the activity of cytochrome P450 1A1 (CYP1A1) in the cells. Geranin increased the transcription of CYP1A1 gene by increasing the content of CYP1A1 mRNA. Geranin increases CYP1A1 gene transcription and activity, inhibits CYP1A1 enzymatic activity, and thus inhibits the activation of carcinogens.

DIOSMETIN can inhibit the proliferation of MCF-7 cells and promote cell apoptosis by activating the JNK apoptosis pathway in vitro. Geranin inhibits the proliferation of breast cancer MDA-MB468 and normal breast MCF-10a cells, and the compound was found to be selective for cancer cells, mildly toxic to normal breast cells, and inhibit MDA-MB468 cells in G1 phase. stagnation. DIOSMETIN, extracted from traditional Chinese medicine, has been found to have anticancer activity.

In a mouse model of Alzheimer’s disease (AD) with tau hyperphosphorylation and cognitive impairment, oral administration of geranin reduces levels of brain amyloid beta (Aβ) oligomers and increases inhibitory glycogen synthase Kinase 3 (GSK-3β) phosphorylation while selectively reducing γ-secretase activity, Aβ degeneration, tau hyperphosphorylation, and pro-inflammatory effects in microglia in vitro. Therefore, geranilin is considered to have a therapeutic effect on AD.

DIOSMETIN can protect doxorubicin (ADR)-induced retinal cell damage, effectively reduce ADR-mediated inhibition of proliferation of SD rat and human retinal pigment epithelial cells (ARPE-19), and reduce apoptosis. Geranin inhibited ADR-induced oxidative stress, DNA damage and mitochondrial damage in ARPE-19, decreased ROS level, increased intracellular GDH level, and significantly reversed ADR-induced Bcl-2 protein expression in ARPE-19 cells. Therefore, geranialin protects vision by reducing DNA damage and reducing apoptosis caused by oxidative stress in ARPE-19 cells through antioxidant effects.

In citrus fruits, DIOSMETIN has anti-inflammatory and antioxidant properties. In a bombesin-induced acute pancreatitis (AP) mouse model, pretreatment with geranin significantly reduced serum amylase and lipase levels, histological damage, tumor necrosis factor-α (TNF-α) secretion, Interleukin (IL) 1β, IL-6, myeloperoxidase (MPO) activity, trypsinogen-activated peptide (TAP) levels, induce the expression of nitric oxide synthase (iNOS), and activate the NF-κB signaling pathway. Therefore, geranialin may become a new therapeutic drug in future clinical trials for the treatment of AP. In vitro, geranialin scavenges free radicals. Therefore, by inhibiting NF-κB signaling through antioxidant effects, reducing inflammatory mediators and cytokines, and inhibiting hepatocyte apoptosis, geranialin has a protective effect on endotoxin-induced acute liver failure in mice.

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common clinical syndrome of diffuse pneumonia with high mortality and limited treatment options. DIOSMETIN has long been recognized as an active ingredient in Chinese herbal medicine due to its antioxidant and anti-inflammatory effects. In human bronchial epithelial cells (HBE), transforming growth factor-β1 (TGF-β1) increased EMT and ROS production, and geranialin significantly inhibited TGF-β1-induced increased cell migration and neural cadherins calcium, cadherin, Alterations in muscle actin expression. In addition, geranin inhibited TGF-β1-in

duced intracellular ROS generation, PI3K/Akt and MAPK pathways, down-regulated NOX4, and up-regulated SOD and catalase expression. It was demonstrated that geranialin attenuated TGF-β1-induced EMT by inhibiting ROS generation and inactivating PI3K/Akt and MAPK pathways, thereby reducing the process of airway remodeling and fibrosis.

Geranin can alleviate the pathological changes of lung tissue and relieve respiratory diseases such as EMT, bronchial asthma, and lung injury through anti-inflammatory and antioxidant effects and triggering different signaling pathways.

DIOSMETIN pretreatment reduced the inflammatory response and tubular cell apoptosis in acute kidney injury, and significantly increased the expression of antioxidant proteins. The renoprotective effect of geranialin involves inhibition of Nf-κB expression and mitochondrial apoptosis pathway and activation of Nrf2/HO-1 pathway. Therefore, geranialin can improve renal injury after renal ischemia/reperfusion.

Preparation of DIOSMETIN

Method: a semi-synthetic process of geranialignin, comprising: adding water and concentrated sulfuric acid to diosmin for hydrolysis, suction filtration, and washing the filter cake to obtain crude geranialignin; adding Ethanol with a concentration of 50-60% is heated to reflux, filtered, the filtrate is concentrated under reduced pressure, and crystallized by cooling to obtain the first pure geranialignin product; add ethanol with a concentration of 90-95% to the first pure product of geranialignin, and heat under reflux , filtered, the filtrate was concentrated under reduced pressure, cooled and crystallized to obtain geranialignin.

The process uses water as a solvent to prepare geranialignin in one step, the synthesis process is simple, the raw materials are readily available, the reaction conditions are stable, the operation is simple, the production cost is low, the product yield can reach 60-65%, and the purity can reach 98-99%. It can be used for large-scale production of geranialignin. The synthetic reaction formula is:

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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