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DIOSMETIN CAS 520-34-3

Molecular Formula: C16H12O6

Formula Weight: 300.26

ZSpharmac: DIOSMETIN Supplier

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Product Name: DIOSMETIN
CAS No: 520-34-3
Purity: 99%

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Basic Info

Product Name:DIOSMETIN
Other Names:5,7,3′-Trihydroxy-4′-Methoxyflavone
CAS:520-34-3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Yellow to Yellow Neat
EINECS No.:208-291-8
Storage:Sealed in Dry,2-8°C
Provide:DIOSMETIN MSDS;
DIOSMETIN COA

What is DIOSMETIN?

Dioxynignin is a monomer extracted from lemons. In spearmint, crawler incense, and several other all-natural plants additionally have diosmin.

DIOSMETIN Property

Melting point 256-258°C
Boiling point 576.7±50.0 °C(Predicted)
density 1.512±0.06 g/cm3(Predicted)
vapor pressure 0Pa at 20℃
storage temp. Sealed in dry,2-8°C
solubility DMSO: soluble1mg/mL, clear, light yellow to yellow
pka6.50±0.40(Predicted)
form neat
color light yellow to yellow
Water Solubility 19μg/L at 20℃

 

Pharmacological Action and Application of Diosmin

Anti-oxidize effect
As one of the natural flavonoids, diosmin has a strong antioxidant effect. Zou Shujun and others proved that diosmin has a certain scavenging effect on DPPH· and O2. And with the increase of the concentration, the clearance rate showed an upward trend, that is, there was a dose-effect relationship. Comparing the change of absorbance value at 517 nm wavelength of 95% ethanol solution containing 1,1-diphenyl-2-trinitrophenylhydrazine radical (DPPH·) before and after adding diosmin, it was found that after adding diosmin, The absorbance value of the solution decreases, indicating that the single-electron pairing of diosmin and DPPH· reduces the concentration of DPPH· in the solution, which proves that diosminin has the ability to scavenge DPPH·free radicals, and has strong antioxidant activity, and its activity is stronger than that of VitC .

Antibacterial effect
Globally, the increasing number of methicillin-resistant Staphylococcus aureus (MRSA) has limited treatment options, and natural compounds have been shown to be antimicrobial against MRSA. Geranolin has no direct antibacterial activity against MRSA strains, however, geranolin significantly inhibits the activity of MRSA pyruvate kinase in a dose-dependent manner, which may lead to the lack of ATP, affecting the bacterial jet pump, and making geranolin inhibit the activity of MRSA pyruvate kinase. MRSA is bacteriostatic.

Antitumor effect
In the human breast epithelial carcinoma cell line MCF-7, diosmin treatment increased the activity of cytochrome P450 1A1 (CYP1A1) in a dose- and time-dependent manner. By increasing the level of CYP1A1 mRNA, diosmin increased the transcription of CYP1A1 gene. Diyerin increases CYP1A1 gene transcription and activity, inhibits CYP1A1 enzyme activity, thereby inhibiting the activation of carcinogens.

Dioxynignin can inhibit the proliferation of MCF-7 cells and promote cell apoptosis by activating the JNK cell apoptosis pathway in vitro. Dioxynignin inhibited the proliferation of breast cancer MDA-MB468 and normal breast MCF-10a cells. It was found that this compound is selective for cancer cells, slightly toxic to normal breast cells, and makes MDA-MB468 cells arrest in the G1 phase. lag. Diyerin, extracted from traditional Chinese medicine, has been found to have anticancer activity.

Nervous system disease
Oral administration of diosmin reduces levels of brain β-amyloid (Aβ) oligomers and increases inhibitory glycogen synthase in a mouse model of tau hyperphosphorylation and cognitive impairment in Alzheimer’s disease (AD) Kinase 3 (GSK-3β) phosphorylation while selectively reducing γ-secretase activity, Aβ denaturation, tau hyperphosphorylation, and pro-inflammatory effects in microglia in vitro. Therefore, diosmin is considered to have a therapeutic effect on AD.

Eye disease
Dioxynignin can protect retinal cell damage induced by doxorubicin (ADR), effectively reduce ADR-mediated inhibition of proliferation and apoptosis in SD rats and human retinal pigment epithelial cells (ARPE-19). Diyerin inhibited ADR-induced oxidative stress, DNA damage, and mitochondrial damage in ARPE-19, decreased ROS levels, increased intracellular GDH levels, and significantly reversed the expression of Bcl-2 protein in ARPE-19 cells induced by ADR. Therefore, diosmin can protect eyesight by reducing DNA damage and reducing apoptosis caused by oxidative stress in ARPE-19 cells through anti-oxidation.

Liver Disease
In citrus fruits, diosmin has anti-inflammatory and antioxidant properties. In a mouse model of bombesin-induced acute pancreatitis (AP), diosmin pretreatment significantly reduced serum amylase and lipase levels, histological damage, tumor necrosis factor (TNF-α) secretion, Interleukin (IL) 1β, IL-6, myeloperoxidase (MPO) activity, trypsinogen activating peptide (TAP) level, induced expression of nitric oxide synthase (iNOS), and activated NF-κB signaling pathway. Therefore, diosmin may become a new therapeutic drug in future clinical trials for the treatment of AP. In vitro, diosmin scavenge free radicals. Therefore, by inhibiting NF-κB signaling through antioxidative effects, reducing inflammatory mediators and cytokines, and inhibiting hepatocyte apoptosis, diosmin has protective effects against endotoxin-induced acute liver failure in mice.

Lung disease
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common clinical syndrome of diffuse pneumonia with high mortality and limited treatment options. Due to its antioxidant and anti-inflammatory effects, diosmin has long been considered as an active ingredient in Chinese herbal medicine. In human bronchial epithelial cells (HBE), transforming growth factor-β1 (TGF-β1) enhanced EMT and ROS production, and diosmin significantly inhibited TGF-β1-induced increased cell migration and N-cadherin calcium, cadherin, Alterations in muscle actin expression. In addition, diosmin inhibited TGF-β1-induced intracellular ROS generation, PI3K/Akt and MAPK pathways, down-regulated NOX4, and up-regulated the expressions of SOD and catalase. It was demonstrated that diosmin attenuated TGF-β1-induced EMT by inhibiting ROS generation and inactivating PI3K/Akt and MAPK pathways to reduce the process of airway remodeling and fibrosis.

Through anti-inflammation, anti-oxidation and triggering different signaling pathways, diosmin can reduce lung histopathological changes and alleviate respiratory diseases such as EMT, bronchial asthma and lung injury.

Synthetic Process of Diosmin

A semi-synthetic process for diosmin, comprising:

(1) adding water and concentrated sulfuric acid to diosmin for hydrolysis, suction filtration, and washing the filter cake with water to obtain crude diosmin;

(2) Add ethanol with a concentration of 50-60% to the crude diosmin, heat to reflux, filter, concentrate the filtrate under reduced pressure, crystallize at lower temperature, and obtain primary diosmin;

(3) Add ethanol with a concentration of 90-95% to the primary pure diosmin, heat to reflux, filter, concentrate the filtrate under reduced pressure, crystallize at lower temperature, and obtain diosmin.

The process uses water as a solvent to prepare geranolin in one step. The synthesis process is simple, the raw materials are easy to obtain, the reaction conditions are stable, the operation is simple, the production cost is low, the product yield can reach 60-65%, and the purity can reach 98-99%. It can be used for large-scale production of diosmin.

Preparation of Diosmin

Method: A semi-synthetic process of diosmin, including: adding water and concentrated sulfuric acid to diosmin for hydrolysis, suction filtration, washing the filter cake with water to obtain crude diosmin; adding Ethanol with a concentration of 50-60% is heated to reflux, filtered, the filtrate is concentrated under reduced pressure, and cooled to crystallize to obtain a pure product of diosmin; add ethanol with a concentration of 90-95% to the pure product of diosmin, and heat to reflux , filtered, and the filtrate was concentrated under reduced pressure, cooled and crystallized to obtain diosmin.

The process uses water as a solvent to prepare geranolin in one step. The synthesis process is simple, the raw materials are easy to obtain, the reaction conditions are stable, the operation is simple, the production cost is low, the product yield can reach 60-65%, and the purity can reach 98-99%. It can be used for large-scale production of diosmin. The synthetic reaction formula is:

About Products:
If you need Diosmin, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Diosmin manufacturer and supplier, ZSpharmac will provide Diosmin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get DIOSMETIN Quotation