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Diosgenin CAS 512-04-9

Molecular Formula: C27H42O3

Formula Weight: 414.63

ZSpharmac: Diosgenin Cosmetic Raw Material Suppliers

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Product Name: Diosgenin
CAS No: 512-04-9
Purity: 99%

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Basic Info

Product Name:Diosgenin
Other Names:DIOCTYLMALONATE
CAS:512-04-9
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Pale Yellow Solid
EINECS No.:208-134-3
Storage:2-8°C
Provide:Diosgenin MSDS;
Diosgenin COA

What is Diosgenin?

Diosgenin (Diosgenin) is stemmed from the rhizomes of monocotyledonous herbaceous twining vines of the Dioscoreaceae family, such as yam, turmeric, yellowtail, pangolin, etc, as well as is utilized in the production of hydrocortisone, prednisone, norethindrone, fluocinolone, as well as dexamethasone. It is an essential standard resources for numerous steroidal medications such as metasone.

Diosgenin Property

Melting point 205-208°C
Boiling point 473.46°C (rough estimate)
alpha D25 -129° (c = 1.4 in CHCl3)
density 1.0483 (rough estimate)
refractive index 1.4700 (estimate)
storage temp. 2-8°C
solubility chloroform: 20 mg/mL, clear, slightly yellow
pka15.02±0.70(Predicted)
form Solid
color White to Pale Yellow
Water Solubility Soluble in chloroform (50 mg/ml), ethanol (83 mg/ml at 25°C), water (<1 mg/ml at 25°C), DMSO (<1 mg/ml at 25°C), and methanol.

 

Efficacy and Function of Diosgenin

The yam is a decorative creeping plant belonging to Asia. Yams are utilized in Chinese natural medicine and traditionally used to treat ailments associated with the stomach, spleen, lungs and also kidneys. The diosgenin in its root is a phytoestrogen, an all-natural phytoestrogen. Diosgenin is a course of steroidal saponins dispersed in plants of the category Solanum and Dioscorea. Modern researches have actually shown that it has anti-inflammatory, anti-oxidant, anti-diabetic and also anti-tumor activities.

” Diamonds” was first recorded in the “Shan Hai Jing” in the Spring and Autumn Period, “Shen Nong’s Materia Medica” in the Han Dynasty, “Tu Jing Materia Medica” and also “Looking For Yasmin Seedlings” in the Song Empire, “Compendium of Materia Medica” in the Ming Empire, and “Plant Labels and also Details of Plants” in the Qing Empire. All are recorded. In the 1930s, Japanese scholars isolated diosgenin and introduced a hydroxyl team at the 11-position of the steroid nucleus by microbial techniques, making diosgenin a crucial basic material for the synthesis of steroid hormonal agent drugs, which actually opened a new phase in the research study of diosgenin, known as one of both significant breakthroughs in the pharmaceutical market in the 20th century. China as well as Mexico are the nations with the most abundant yam resources on the planet, and the manufacturing of diosgenin accounts for 67% of the globe’s complete manufacturing. With the change of Mexico’s farming structure, China has ended up being the globe’s largest producer of diosgenin.

Anticancer
A large number of experiments have actually progressively demonstrated the inhibitory impact and system of diosgenin on cancer cells. The scientists found that diosgenin had noticeable repressive effect on liver cancer SMMC-7721, human cervical cancer cells Hela, stomach adenocarcinoma MGc80-3 cells and also development. Dioscin was cytotoxic to the growth cell line K562 in vitro. Dioscin can considerably hinder the development of human leukemia cytokine HL60, generate cell differentiation as well as apoptosis, and have comparable impacts on other lump cell lines. The researchers studied the results of diosgenin on the spreading, cell cycle, apoptosis, and cyclooxygenase expression as well as activity of the human osteosarcoma 1547 cell line. The outcomes revealed that diosgenin could hinder the growth of 1547 cells, quit the cellular division cycle in G1 stage, and also induce cell apoptosis. The Chengdu Institute of Biology of the Chinese Academy of Sciences efficiently developed the first brand-new medicines for the treatment of coronary heart disease as well as cerebrovascular disease in China – Guanxinning as well as Diao Xinxuekang by using water-soluble diosgenin.

Arthritis
Test-tube research studies show that diosgenin, extracted from wild yam origins, helps protect against the development of osteo arthritis and also rheumatoid joint inflammation.

Moreover, in a 30-day computer mouse research study, oral management of wild yam remove at 91 mg per extra pound of body weight (200 mg/kg) daily significantly reduced markers of inflammation– a greater dose of 182 mg per pound (400 mg/kg) kg) soothes nerve pain.

Antidiabetic
The compound also positively influences insulin resistance-associated endothelial dysfunction in an IKKβ/ IRS-1-dependent way, thus serving in the prevention or treatment of cardiovascular diseases connected with insulin resistance as well as diabetic issues. It was later revealed that chronic management of diosgenin to diabetic rats has a hypoglycemic impact as well as can recover vascular sensitivity via endothelium-dependent and also independent systems, at the very least partially by combating lipid peroxidation, apoptosis, and swelling.

One more study showed that the task of glucokinase lowered and also the tasks of glucose-6-phosphatase and fructose-1,6-bisphosphatase increased in the liver after diosgenin was carried out to diabetic person rats. Furthermore, among other favorable modifications in numerous criteria connected to diabetes, diosgenin supplementation reduced blood sugar degrees in diabetic rats compared to the typical chow-fed rat group. This outcome associates with previous records that diosgenin has hypoglycemic residential or commercial properties.

Application of Diosgenin

1. Mix medicines having autophagy preventions as well as diosgenin and also utilizes thereof

CN201410521576.2 reveals a new combination medicine for treating tumors, especially associates with a mix medicine having an autophagy inhibitor and also diosgenin as well as its usage, and also specifically associates with the mix drug being administered in combination or used sequentially in the prep work of treatments Make use of in chronic myeloid leukemia, severe leukemia, lymphoma, liver cancer cells or adjuvant therapy of imatinib-resistant growth medications. The combination medicine contains one or more risk-free dosages of autophagy preventions as well as diosgenin It is characterized by having no apparent cytotoxicity or supporting murder impact on growths yet can enhance autophagy by hindering it. The killing result of diosgenin on tumor cells boosts its alleviative result. This mix medication can significantly hinder the expansion of lump cells and induce growth cell apoptosis via diosgenin, along with cause autophagy in tumor cells. Autophagy contributes in shielding growth cells when diosgenin kills lump cells. The restraint of cell autophagy can substantially improve the murder impact of diosgenin on growth cells.

2. A plant salt having diosgenin.

CN201610242016.2 supplies a plant salt including diosgenin and a preparation method thereof. The plant salt of today creation has the obvious function of lowering blood fat, the feature of obviously decreasing the high blood pressure of hypertensive individuals, and the feature of laxative as well as laxative. The technological option taken on by the present innovation is as follows: a plant salt including diosgenin. The plant salt includes the adhering to parts: Suaeda salsa extract, Sophora japonica pollen, pineapple powder, perilla powder, Rhodiola rosea essence, Raspberry remove, diosgenin.

Compared to prior art, the advantageous result of the here and now creation is:
1. Consuming the plant salt of the here and now creation has apparent blood-lipid-lowering function. After testing, it can considerably minimize the TC, TG, as well as LDL-C levels in computer mouse product as well as boost the HDL-C degree in mouse lotion;

2. Consuming the plant salt of today creation can dramatically minimize the high blood pressure of individuals with hypertension, with a reliable rate of 93 to 99% as well as a significant rate of 80 to 87%;.

3. Consuming the plant salt of the present invention can substantially improve the irregular bowel movements signs of clients, and also the efficient price of enhancing irregularity is 84-92%;.

4. There is no adverse sign of physical discomfort after consuming the plant salt of today creation.

Diosgenin Preparation

Before 2003, the pre-fermentation-acid hydrolysis procedure was widely made use of in my country to create diosgenin. Compared to the traditional acid direct hydrolysis process, the yield of diosgenin was boosted, however the amount of acid utilized was generally equivalent to the conventional process. Consequently, Pollution is basically the like typical procedures. In the course of the study, it was discovered that the production process of diosgenin utilized a great deal of acid, and the source of the high COD and also body worths in the wastewater was that while the diosgenin in Dioscorea scutellaria was hydrolyzed into diosgenin, the Starch and cellulose are hydrolyzed into sugars (monosaccharides, disaccharides, trisaccharides as well as polysaccharides). In order to decrease the quantity of acid, Li Xiang et al. evaluated the circulation as well as residential properties of starch, cellulose, lignin, dioscin, etc. The splitting up of saponins decreases the quantity of acid to a certain extent, lowers the COD value, figure value, chroma, etc. of wastewater, as well as recoups starch and also cellulose in Dioscorea scutellaria. In 2003, with the assistance of the nationwide environmental protection task, Shaanxi Provincial Environmental management Bureau utilized this technology for the commercial manufacturing of dioscin, as well as developed a separation-based clean manufacturing version business of diosgenin in Shangluo area– Shanyang Jinchuan Fengxing Chemical Co., Ltd. Accountable company, from the point of view of procedure, the consumption of acid, coal, and also gasoline in this innovation are 10% -15%, 25% -50%, and also 30% -35% of the typical process, respectively, and also the drainage discharge is 90% of the typical procedure, the COD worth and also body value of the wastewater are 10% of those of the traditional procedure, as well as 20% to 25% of the starch in the dioscorea can be recouped. Nonetheless, due to the long procedure course, large devices investment as well as high price, as well as because the recycled starch contains sediment, the application of recycled starch is restricted. In order to decrease the production expense of diosgenin, LinliQiu et al. presented ultrasonic technology into the research of dioscin extraction on the basis of typical ethanol removal innovation, which greatly saved the removal time of dioscin, enhanced the extraction performance of diosgenin, and also raised The return of diosgenin. Nonetheless, because of the huge loss of ethanol during the extraction procedure and bad security, the promotion and application of this technology have been limited. Liu Shuxing et al. made use of surfactants in the research of dioscin removal, as well as discovered that the enhancement of surfactants dramatically decreased the quantity portion of ethanol when the yield of diosgenin stayed unmodified. The production procedure of diosgenin, which makes use of surfactant salt lauryl sulfate as removal agent as well as flocculation technology as the core, successfully decreases the amount of acid utilized in the production procedure of diosgenin, reduces pollution and also decreases expenses. Nonetheless, there is usually a phenomenon that diosgenin crystals are encapsulated by dodecyl alcohol (oil), that makes it challenging to different diosgenin, and the obtained diosgenin products are commonly of reduced pureness.

CN201410145370.4 gives a technique for dividing high-purity diosgenin, which is straightforward to operate as well as eco-friendly, and also can effectively solve the problem of difficult splitting up and also filtration of diosgenin.

The here and now innovation is recognized with the complying with technical services:
An approach for separating high-purity diosgenin, including two actions of rough splitting up and also fine treatment. The specific operating actions of the rough separation are:

1) Submerse the smashed Dioscorea scutellariae in salt lauryl sulfate remedy, essence for 2-4 hours, ultrasonically extract, and then centrifuge to get the dioscin remove and filter residue;

2) Remain to ultrasonically remove the filter deposit with sodium lauryl sulfate service, after that centrifuge, and incorporate the essence gotten by centrifugation with the dioscin remove obtained in step 1) to acquire the complete dioscin essence;

3) According to the quantity ratio of total dioscin extract: flocculant An aqueous remedy = 100: (4-10), include 0.8% to 1.2% flocculant An aqueous solution to the overall dioscin remove by mass fraction up until micelles are formed Finally, quit stirring, and after standing still for 5-20 minutes, filter to get filter residue 1 and filtrate 1, then include a liquid service of flocculant B with a mass portion of 2% -6% to filtrate 1, and also stand at 40-50 ° C for 1-2 After 3 hours, centrifuge to get filtrate 2 as well as filter deposit 2. Combine filter deposit 1 as well as filter residue 2 to obtain unrefined diosgenin;

Wherein, the flocculant A consists of 95% -100% chitosan and also 0% -5% xanthan gum in mass portion; the flocculant B includes 55-60% Rod bentonite, 40-45% bentonite making clear agent;

4) According to the ratio of adding 2.5-3mL of sulfuric acid per g of unrefined dioscin, include the crude diosgenin to sulfuric acid with a concentration of 1.3-1.8 mol/L, hydrolyze it at 105-108 ° C for 4-6 hours, as well as dissolve the hydrolyzate After cooling as well as reducing the effects of, filter, wash the filter deposit with water until the effluent is neutral, and after that completely dry, then remove the dried out filter residue by reflux, amazing and also take shape to obtain crude diosgenin;

The particular steps of the great treatment are:
( 1) Dropping water at a temperature level of 60-90 ° C into the crude product of diosgenin, mixing well, after that centrifuging, disposing of the upper layer of water and oil to acquire diosgenin;

( 2) After duplicating the operation of step (1) for 2 to 4 times on the purified diosgenin, the diosgenin with moisture is dried to obtain high-purity diosgenin.

About Products:
If you need the cosmetic raw material Diosgenin, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Diosgenin manufacturer and supplier, ZSpharmac will provide Diosgenin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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