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Dimethyl Isosorbide CAS 5306-85-4

Molecular Formula: C8H14O4

Formula Weight: 174.2

ZSpharmac: Dimethyl Isosorbide Raw Material Supplier

Product Name: Dimethyl Isosorbide
CAS No: 5306-85-4
Purity: 99%

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Basic Info

Product Name:Dimethyl Isosorbide
Other Names:Isosorbide Dimethyl Ether
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear ColorlessLiquid
EINECS No.:226-159-8
Storage:Room Temperature
Provide:Dimethyl Isosorbide MSDS;
Dimethyl Isosorbide COA

What is Dimethyl Isosorbide?

Isosorbide dimethyl ether looks like a colorless oily liquid, is really secure under neutral conditions, is hygroscopic, and is miscible with several organic solvents, so it is typically utilized as a solvent. DMI can advertise the penetration of active ingredients into the skin layer of the skin and provide full play to the efficiency of the active components. Primarily utilized in drugs and cosmetics.

Dimethyl Isosorbide Property

Melting point -70°C
Boiling point 93-95 °C0.1 mm Hg(lit.)
density 1.15 g/mL at 25 °C(lit.)
vapor pressure 12.54Pa at 20℃
refractive index n20/D 1.461(lit.)
Fp 227 °F
storage temp. Sealed in dry,Room Temperature
form Liquid
color Clear colorless to light yellow
PH7.0-8.0 (100g/l, H2O, 20℃)
optical activity[α]21/D +96.1°, c = 2 in chloroform
Water Solubility Soluble in water.


Dimethyl Isosorbide Uses

  1. Dimethyl Isosorbide is an useful study chemical.
  2. Dimethyl Isosorbide is utilized in cosmetics: it can dramatically boost the impacts of sun defense, anti-wrinkle, freckle removal, acne removal, skin care and hydrating, weight-loss, breast enhancement cream, hair development representative, hair dye and other items. It is a perfect solvent, penetrant and carrier in the cosmetics market.
  3. Dimethyl Isosorbide is made use of in the pharmaceutical area: ointments and tinctures for exterior use. The efficiency of the product is substantially boosted.
  4. Dimethyl Isosorbide is made use of in pesticides: it can enhance the infiltration of chemicals inside and outside the body of parasites, improve the efficacy, and lower the resistance of insects; lower the frequency and dosage of chemicals, minimize environmental pollution, and particularly lower the straight damage of chemicals to human beings.

Preparation Method of Dimethyl Isosorbide

Dimethyl Isosorbide is produced from isosorbide with methylation. The methylating reagents utilized include dimethyl sulfate (US License US4659846 and US4322359), dimethyl carbonate (US License US4700871), methyl chloride (USA License US4435586 and Globe Permit WO2007096511).

When dimethyl sulfate is utilized to make dimethyl isosorbide, the return can get to greater than 70%, and the best reported in the compositions is 83.5%. As everybody acknowledge, dimethyl sulfate is a very dangerous chemical, a health hazard, and damaging to the health of operators. When dimethyl isosorbide is produced from dimethyl carbonate, the greatest conversion price of isosorbide is merely 89%, and the weight portion of dimethyl isosorbide to monomethyl ether in the product is 59:41. Consequently, dimethyl carbonate is not an ideal resources for the synthesis of dimethyl isosorbide.

When producing isosorbide dimethyl ether, the solvents utilized consist of tert-butyl alcohol, acetone, dimethyl sulfoxide, etc. These solvents have downsides such as lessened steaming points, fundamental volatilization, issue in solvent recuperation, environmental pollution, and high usage expenses. Fuertes, Patrick enhanced the solvent in TO2007096511, making use of the methylated thing Dimethyl Isosorbide as the solvent, and the yield was improved to 95%. However, utilizing dimethyl isosorbide as a solvent has reasonably high production expenses.

An improved and improved procedure for creating Dimethyl Isosorbide can not just reduced manufacturing prices however additionally reduction environmental pollution. It is defined by:

Proceed as adhere to:
( 1) Consist of solvent, isosorbide, base and phase transfer driver to the response vessel;
( 2) Mix, elevate temperature level, and dry under lowered stress;
( 3) Come on methyl chloride and complete the etherification reaction under a specific anxiety and temperature level;
( 4) Include acid to decrease the impacts of;
( 5) Purification and desalination;
( 6) Filtration under lessened tension to obtain the item isosorbide dimethyl ether and recover the solvent; the antacids utilized in the reaction is picked from salt hydroxide, potassium hydroxide or salt methoxide; the stage transfer energizer is a phase transfer of quaternary ammonium salts Driver, or quaternary phosphonium salt stage transfer energizer; The solvent is an alkyl-terminated lowered molecular weight polyether, and the constructing formula of the alkyl-terminated minimized molecular weight polyether is:


In the formula, R1 and R2 correspond or numerous straight or branched alkyl teams; the alkyl group utilized includes 1 to 15 carbon atoms; R3 and R4 are hydrogen atoms or methyl groups; m+n is an integer from 4 to 15.

Contact Us

About Products:
If you need the cosmetic raw material Dimethyl Isosorbide, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Dimethyl Isosorbide, ZSpharmac will provide Dimethyl Isosorbide raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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