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Zhishang Chemical

Dim Chrysin CAS 480-40-0

Molecular Formula: C15H10O4

Formula Weight: 254.24

ZSpharmac: Dim Chrysin Supplement

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Product Name: Dim Chrysin
CAS No: 480-40-0
Purity: 99%

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Basic Info

Product Name:Dim Chrysin
Other Names:Chrysin
CAS:480-40-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Crystalline Powder
EINECS No.:207-549-7
Storage:Keep in Dark Place,Sealed in Dry,Room Temperature
Provide:Dim Chrysin MSDS;
Dim Chrysin COA

What is Dim Chrysin?

Dim Chrysin exists in the seeds as well as stem bark of Oroxylumindicum (L.) Vent.], the heartwood of Pinus yearn (Pinusmon-ticola Dougl.), and also the heart of P. aristata Engelm. wood and various other plants.
Modern pharmacological researches have shown that Dim Chrysin has a wide variety of medicinal tasks, such as anti-tumor impact; anti-allergic impact; anti-inflammatory result; anti-viral effect; anti-pathogenic microorganism impact and also hypoglycemic result. Medicines with Dim Chrysin as the main energetic component have been utilized in lots of countries and regions. Different by-products acquired by structural alteration with Dim Chrysin as the very first substance likewise revealed similar or much better pharmacological activity.

Dim Chrysin Properties:

Melting point 284-286 °C(lit.)
Boiling point 357.45°C (rough estimate)
density 1.2693 (rough estimate)
refractive index 1.4872 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Crystalline Powder
pka6.50±0.40(Predicted)
color Yellow

 

The Efficacy And Role of Dim Chrysin

1. Antibacterial and also anti-inflammatory
Dim Chrysin is a natural medical component. It is an energetic flavonoid compound drawn out from the conventional Chinese medication timber butterfly by utilizing high-tech innovation. It has noticeable repressive and removal results on a selection of sensitive and pathogenic germs in the human body., After the body takes in Dim Chrysin, the antibacterial as well as anti-inflammatory capacity of the body can be substantially improved.

2. Cancer cells prevention as well as treatment
Dim Chrysin is a medical component with strong anti-cancer and anti-cancer capability. It can hinder the task of health hazards in the human body, avoid them from harming human cells, and also stop the reproduction of cancer cells in the body, which can create cancer in human beings. The rate has actually dropped dramatically, and it can stop the spread of human cancer.

3. Anti-radiation
Dim Chrysin, a medicinal component, can not just improve the body’s anti-cancer capability, however likewise protect against the spread of cancer cells, and also it also has extremely anti-radiation ability. It will certainly cause damages to the body’s body immune system, as well as there will be obvious side effects. After taking anticancer medicines including Dim Chrysin, the damage of radiotherapy as well as radiation treatment to the body can be lessened.

4. Prevention of embolism
Dim Chrysin additionally has extremely anticoagulant capability, and can increase the task of platelets in human blood, and also can promote blood flow. People taking these medications including chrysin can shield the cardiovascular system as well as protect against apoplexy. Dim Chrysin can additionally tidy up free radicals in the body and stop the aging of human blood vessels, which is likewise a crucial factor for its capability to prevent cardiovascular disease.

Dim Chrysin Preparation

(1) Synthesis of 2′-hydroxy-4′,6′-dimethoxychalcone
Weigh 4.2g of 1,3,5-trimethoxybenzene (0.025mol) and 3.7g of cinnamic acid (0.025mol) into a dry round-bottomed flask, then add 15.0mL of boron trifluoride ether, and condense at 80°C with a drying tube backflow. After 3 hours of reaction, the heating was stopped to room temperature, and red needle-like crystals were precipitated, and the crystals were filtered out. The crystals were added to 100 mL of ethanol aqueous solution and heated under reflux for 2.5 hours to obtain an orange clear liquid, which was decolorized and filtered by adding activated carbon. After cooling, the yellow solid was washed out, filtered, and the washed filter cake was dried to obtain 5.35 g of 2′-hydroxy-4′,6′-dimethoxychalcone, with a yield of 75.4%.

Structural parameters 1H NMR (400 MHz, DMSO-d6), δ: 3.83 (s, 3H, OCH3-4′), 3.91 (s, 3H, OCH3-6′), 6.14 (d, J = 1.6 Hz, 1H, H-3′), 6.17 (d, J = 1.6 Hz, 1H, H-5′), 7.45–7.49 (m, 3H, H-3,4,5), 7.65(d, 1H, J =16 Hz , H-α), 7.72–7.74 (m, 2H, H-2,6), 7.78 (d, J =16 Hz, 1H, H-β), 13.41 (s,1H, OH-2′).

(2) Synthesis of Dim Chrysin
Weigh 5.7g (0.02 mol) of 2′-hydroxy-4′,6′-dimethoxychalcone synthesis, add 30 mL of DMSO to dissolve completely, add 0.13 g of elemental iodine at room temperature, and warm up to 80 °C for reaction 4h hours. After cooling to room temperature, the reaction solution was poured into 200 mL of 2% NaHSO3 solution, and the solid was filtered out after full stirring. After drying, it was recrystallized with absolute ethanol to obtain 4.79 g of Dim Chrysin as pale yellow powdery crystals, with a yield of 84.9%.

Structural parameters 1H NMR (400 MHz, DMSO-d6), δ: 3.83(s, 3H, OCH3-7), 3.90(s, 3H, OCH3-5), 6.50(d, 1H, J=2.4 Hz, H- 8), 6.76(s, 1H, H-3), 6.85(d, 1H, J=2.4 Hz, H-6), 7.56(m, 3H, H-4′,5′,6′), 8.03( m, 2H, H-2′, 3′).

Pharmacological Effects of Dim Chrysin

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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