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Dihydromyricetin CAS 27200-12-0

Molecular Formula: C15H12O8

Formula Weight: 320.25

ZSpharmac: Dihydromyricetin Supplier

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Product Name: Dihydromyricetin
CAS No: 27200-12-0
Purity: 99%

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Basic Info

Product Name:Dihydromyricetin
Other Names:Dihydromyricetin DMY
CAS:27200-12-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Beige Powder
EINECS No.:200-001-8
Storage:-20°C
Provide:Dihydromyricetin MSDS;
Dihydromyricetin COA

What is Dihydromyricetin?

Dihydromyricetin (DMY) is a wild woody creeping plant (creeping plant tea) essence of the classification Vitis vinifera, additionally known as dihydromyricetin, dihydromyricetin, as well as also staphylococcin.
Rattan tea is likewise described as “berry tea”, Shentang berry, Maoyan enzyme tea, longevity rattan, and so forth. The people have the routine of alcohol intake berry tea thinking about that old times, which can be traced back to the moment when Shennong tasted a hundred natural herbs in ancient times. It has a history of greater than 6,000 years. The earliest “Publication of Songs Collection” is called Gucha Gouteng. The taste is first bitter and after that remarkable, with a strong aftertaste. Dihydromyricetin is the significance of Vitis creeping plant tea, which is the key active element flavonoids in vine tea. This sort of material has lots of unique impacts such as scavenging complimentary radicals, anti-oxidation, anti-thrombosis, anti-tumor, along with anti-inflammatory; Dihydromyricetin is an unique kind of flavonoids, which can alleviate alcohol poisoning, prevent alcoholic liver, fatty liver, hinder liver cell wear and tear, lower the occurrence of liver cancer cells, stand up to hypertension, prevent platelet aggregation artificial insemination and apoplexy in vivo. It has special influences in developing as well as additionally lowering blood lipid as well as likewise blood sugar degrees, improving turf task as well as additionally safeguarding the liver.

Dihydromyricetin Property

storage temp. -20°C
solubility DMSO: ≥5mg/mL (warmed)
form powder
Boiling point 780.7±60.0 °C(Predicted)
density 1.808±0.06 g/cm3(Predicted)
Melting point 239-241 °C
pKa7.38±0.60(Predicted)
color white to beige

 

The Role of Dihydromyricetin

Dimyricetin is just one of the primary active ingredients of rattan tea, which has a range of organic features, such as scavenging free radicals, anti-oxidation, anti-hypertension, anti-thrombosis, anti-tumor, anti-inflammatory as well as several various other special results. As a special flavonoid substance, dihydromyricetin not just has the basic attributes of flavonoids, but likewise has the features of alleviating alcoholism, stopping alcoholic liver, fatty liver, inhibiting liver cell degeneration, as well as minimizing the incidence of liver cancer cells. Shields the liver and also safeguards the liver, and is a good product for easing hangover and sobering up.
Anti-bacterial influence: Medical experiments reveal that dihydromyricetin works versus Bacillus subtilis, Staphylococcus aureus, Salmonella, Escherichia coli, Bacillus aerogenes, Saccharomyces cerevisiae, Rhodotorula viscosus, Penicillium, Aspergillus niger, Aspergillus flavus, Mao Both mold and mildew as well as rhizopus have anti-bacterial impact, especially on Gram-positive and also Gram-negative cocci or bacilli.
Regulative impacts on blood sugar level and blood lipids: Pharmacological experiments by intragastric monitoring of mice expose that dihydromyricetin can substantially impede the surge of blood sugar level in mice induced by alloxan, epinephrine, streptozotocin, and more, as well as at the same time surge product insulin levels, The seepage of lymphocytes in pancreatic cells was dramatically lowered, the inflammatory action was substantially lessened, and the variety of islets was substantially boosted. Dihydromyricetin can lessen lotion triacylglycerol (TG) product in streptozotocin-induced hyperglycemia rats, however has no substantial impact on product total up to cholesterol (TC) as well as high-density lipoprotein cholesterol (HDL2C) internet content.
Hepatoprotective result: Dihydromyricetin has a substantial safety influence on the carbon tetrachloride poisoning injury of rat hepatocytes cultured in vitro, as well as additionally the computer mouse liver injury generated by D2 galactosamine as well as additionally lipopolysaccharide. Dihydromyricetin can safeguard the liver, speed up the quick decay of acetaldehyde, a metabolite of ethanol, and likewise transform it right into a non-toxic substance, decreasing its damage to liver cells. In addition to that, dihydromyricetin can enhance the boost of product lactate dehydrogenase job activated by liver cell problems, prevent the development of collagen fibers in hepatic M cells, as a result shielding the liver in addition to considerably lowering the damages of ethanol to the liver. The typical state of the liver is rapidly brought back. Microherb test validates that dihydromyricetin can secure the liver, quicken the rapid fragmentation of acetaldehyde, a metabolite of ethanol, as well as likewise transform it right into a safe compound, lowering the damages to liver cells. Dihydromyricetin acts promptly as well as additionally has a durable effect. It is an excellent thing for protecting the liver and relieving hangover.
Antioxidant impact: Dihydromyricetin with a purity of 98% can dramatically inhibit the formation of malondialdehyde (MDA) in rat myocardial, liver and also mind cells homogenate, as well as prevent the development of MDA with the increase of the focus of dihydromyricetin The effect boosts, as well as the scavenging price of dihydromyricetin with a material of 99% to diphenyltrinitrophenylhydrazine (DPPH) totally free radicals in the test system. Dihydromyricetin can dramatically prevent the development of MDA in oils, as well as the antioxidant effect enhances with the increase of the pureness of dihydromyricetin (60% to 90%); it has a solid antioxidant impact on pet oils as well as vegetable oils.
Anti-tumor result: Anti-tumor pharmacodynamic studies in recent times have found that of its active components, the small molecular substance of staphylophyllin, has a relatively solid anti-cancer effect. Artificial insemination and also in vitro anti-tumor researches have located that the substance can improve the healing impact of lumps as well as boost the vital symptoms of patients by hindering the growth of lump blood vessels, regulating and boosting mobile immune feature, etc. It reveals evident anti-tumor impact.

Extraction Method of Dihydromyricetin

A method for extracting dihydromyricetin from rattan tea, specifically comprising the steps of:

(1) Soak the dried leaves of vine tea in a solvent;

(2) filter, the wet vine tealeaves are carried out microwave radiation treatment;

(3) The filtrate is merged with the rattan tea leaves irradiated by microwaves, heated and extracted in a water bath;

(4) Filtrate while hot, and the filtrate is crystallized and separated.

The solvent described in above-mentioned step (1) is water or ethanol; The solid-liquid ratio of above-mentioned vine tea dry leaf and solvent is 1: 12~20g/ml, and optimum solid-liquid ratio is 1: 20g/ml, and optimal solvent is water.

The microwave treatment time described in the above step (2) is 1 to 3 minutes; the optimum microwave treatment time is 3 minutes, and the optimum microwave power is high-grade, i.e. 900W.

The water bath heating time described in the above step (3) is 30 to 120 minutes, and the water bath temperature is 60 to 90° C.; the optimum water bath heating time is 120 minutes.

The Market Prospect of Dihydromyricetin

Snake-toothed snake grape, also known as vine tea, is a standard folk medicine and has been widely utilized to treat skin diseases, boils, osteomyelitis, intense lymphadenitis as well as various other transmittable illness. Dihydromyricetin is extensively made use of in Chinese patent medicine prep work such as tablet computers, pills, and granules for the therapy of breathing tract infections and alcoholism. Antitumor pharmacodynamic research studies recently have actually located that of its energetic components, the little molecular substance of staphylophyllin, has a strong anticancer effect. The research on dihydromyricetin has acquired creation license consent in the application field of preparation of anti-leukemia and also nasopharyngeal cancer medications. It has been prepared to get in the scientific test stage as a brand-new medication. The development of the new typical Chinese medication, staphylophyllin shot, is expected to provide a new therapeutic medication for most of people with leukemia as well as nasopharyngeal cancer. Microherb has finished the removal and also filtration modern technology of vine tea remove (complete flavonoids of Serpent dentata grape) and also dihydromyricetin, as well as completed associated toxicology experiments and also efficacy research studies, and developed dihydromyricetin as an effective additive component Organic food such as instantaneous tea, complete flavonoids lozenges of snake tooth snake, and also dihydromyricetin anti-alcohol as well as liver-protecting capsules.

About Products:
If you need Dihydromyricetin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Dihydromyricetin, ZSpharmac will provide Dihydromyricetin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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