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Dihydromyricetin CAS 27200-12-0

Molecular Formula: C15H12O8

Formula Weight: 320.25

ZSpharmac: Dihydromyricetin Supplement

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Product Name: Dihydromyricetin
CAS No: 27200-12-0
Purity: 99%

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Basic Info

Product Name:Dihydromyricetin
Other Names:Dihydromyricetin DMY
CAS:27200-12-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Beige Powder
EINECS No.:200-001-8
Storage:-20°C
Provide:Dihydromyricetin MSDS;
Dihydromyricetin COA

What is Dihydromyricetin?

Dihydromyricetin is also known as dihydromyricetin, snake grapevine and so on. Dihydromyricetin is a polyphenolic hydroxy dihydroflavonol compound, which exists in plants such as Vitiaceae, Myricaceae, Garcinia, Euphorbiaceae, Olive, and Leguminosae, among which Vitiaceae Tooth snake grape, that is, vine tea is the most abundant in content, as high as 37.4% to 38.5%.

In addition to the general properties of flavonoids such as hepatoprotective, antioxidant, and antibacterial, dihydromyricetin also has the effect of inhibiting tumor activity including liver cancer, breast cancer, and ovarian cancer. Dysglycemia has ameliorating effects, especially recent studies have found that it also has good neuroprotective activity against Alzheimer’s disease, Parkinson’s disease, alcohol addiction and depression.

Dihydromyricetin Properties:

storage temp. -20°C
solubility DMSO: ≥5mg/mL (warmed)
Melting point 239-241 °C
pKa7.38±0.60(Predicted)
Boiling point 780.7±60.0 °C(Predicted)
density 1.808±0.06 g/cm3(Predicted)
form powder
color white to beige

 

Dihydromyricetin Uses

Dimyricetin is among the major energetic parts of creeping plant tea, with a selection of organic features, such as cost-free extreme scavenging, anti-oxidation, anti-hypertension, anti-thrombosis, anti-tumor, anti-inflammatory as well as other strange impacts. As an unique type of flavonoids, dihydromyricetin not just has the general buildings of flavonoids, yet additionally has the functions of eliminating alcohol addiction, stopping alcoholic liver, fatty liver, inhibiting the deterioration of liver cells, and also minimizing the occurrence of liver cancer cells. A good item to protect the liver as well as protect the liver, hangover and hangover.

1. Antibacterial result: Medicinal experiments have actually shown that dihydromyricetin has anti-bacterial impacts on Bacillus subtilis, Staphylococcus aureus, Salmonella, Escherichia coli, Aerogenes, Saccharomyces cerevisiae, Rhododendron, Penicillium, Aspergillus niger, Aspergillus flavus, Mucor and also Rhizopus all have anti-bacterial impacts, particularly on Gram-positive, Gram-negative cocci or bacilli.

2. Controling effect on blood sugar level as well as blood lipids: Pharmacological experiments of mouse gavage reveal that dihydromyricetin can dramatically inhibit the rise of blood sugar level in mice caused by alloxan, epinephrine, streptozotocin, etc, and also at the same time increase serum insulin At the same time, the lymphocyte infiltration in pancreatic tissue was considerably lowered, the inflammatory feedback was considerably alleviated, as well as the variety of pancreatic islets was significantly enhanced. Dihydromyricetin can minimize serum triacylglycerol (TG) web content in streptozotocin-induced hyperglycemia rats, yet has no considerable result on lotion amount to cholesterol (TC) and also high-density lipoprotein cholesterol (HDL2C) material.

3. Hepatoprotective impact: Dihydromyricetin has significant protective impact on rat hepatocytes from carbon tetrachloride poisoning injury, D2 galactosamine and lipopolysaccharide-induced liver injury in mice. Dihydromyricetin can secure the liver, accelerate the rapid decay of acetaldehyde, a metabolite of ethanol, and transform it right into a non-toxic substance, minimizing its damages to liver cells. In addition, dihydromyricetin can improve the rise of serum lactate dehydrogenase task triggered by liver cell injury, hinder the development of collagen fibers in hepatic M cells, so regarding safeguard the liver as well as shield the liver, and significantly decrease the damage of ethanol to the liver. The typical state of the liver can be promptly recovered. Microherb examination proves that dihydromyricetin can protect the liver, speed up the rapid decomposition of acetaldehyde, a metabolite of ethanol, right into non-toxic compounds, as well as reduce damages to liver cells. Dihydromyricetin functions quickly as well as has a long-lasting effect.

4. Antioxidant effect: Dihydromyricetin with a purity of 98% can considerably prevent the formation of malondialdehyde (MDA) in rat myocardial, liver and also brain cells homogenates, as well as hinder MDA with the boost of dihydromyricetin concentration. The effect of generation enhanced, and the scavenging price of diphenyltrinitrophenylhydrazine (DPPH) cost-free radicals in the examination system with a content of 99% dihydromyricetin. Dihydromyricetin can dramatically inhibit the development of MDA in oil, and also the antioxidant impact is improved with the rise of dihydromyricetin purity (60%-90%); it has solid antioxidant result on animal and also vegetable oils.

5. Anti-tumor effect: Recently, the anti-tumor pharmacodynamics research study found that a person of its energetic components, the tiny particle compound of rhodopsin, has a fairly solid anti-cancer impact. Artificial insemination and also in vivo anti-tumor research studies have actually located that the substance can improve lump treatment effects and improve individuals’ vital signs by inhibiting tumor blood vessel growth, managing and boosting cellular immune function, etc revealed substantial tumor suppressor impact.

6.hangover and liver protection

There is still a lack of treatment for alcohol abuse and dependence, and currently, the FDA has only approved three oral medications and one injectable drug. Dihydromyricetin can increase the expression of GABAARs a4 subunits in hippocampus and neurons, play a role in resisting alcoholism and alcohol dependence, and is expected to be a candidate drug for the treatment of alcohol use disorder (AUD). Giving dihydromyricetin can prolong the tolerance time of drunken mice, and can significantly shorten the sobering time, which proves that dihydromyricetin has a good anti-drunk and hangover effect.

In addition, dihydromyricetin can also effectively protect liver damage, and can inhibit lactate dehydrogenase (LDH), ALT, aspartate aminotransferase (AST), lactate dehydrogenase (LDH), ALT, aspartate aminotransferase (AST), The increase of α-vitamin E and GSG/GSSH has better liver protection. Dihydromyricetin has protective effects on P. acnes and lipopolysaccharide-induced liver injury in mice, and inhibits the secretion of LTB4 and LTC4 in peritoneal neutrophils in a dose-dependent manner. The ethanol-induced mouse liver injury model also demonstrated that dihydromyricetin can effectively increase the level of hepatic reduced glutathione (GSH) and reduce the level of hepatic MDA. In addition, dihydromyricetin can also reduce the amount of triacylglycerol (TG), reduce steatosis of liver cells, and has a significant protective effect on ethanol-induced liver injury. ethanol-induced membrane lipid peroxidation.

The Extraction Method of Dihydromyricetin

A method for extracting dihydromyricetin from rattan tea, specifically comprising the steps:

(1) soak the dried leaves of rattan tea in a solvent;

(2) filter, carry out microwave radiation treatment with wet rattan tea leaves;

(3) the filtrate is combined with the vine tea leaves through microwave radiation, and the extraction is carried out by heating in a water bath;

(4) Filter while hot, and the filtrate is crystallized and separated.

The solvent described in the above-mentioned step (1) is water or ethanol; the solid-to-liquid ratio of the above-mentioned vine tea dried leaves and the solvent is 1: 12~20g/ml, the optimum material-to-liquid ratio is 1: 20g/ml, and the best solvent is water.

The microwave treatment time in the above step (2) is 1 to 3 minutes; the optimum microwave treatment time is 3 minutes, and the optimum microwave power is high-grade, namely 900W.

The water bath heating time in the above step (3) is 30 to 120 minutes, and the water bath temperature is 60 to 90°C; the optimum water bath heating time is 120 minutes.

Application and Prospect of Dihydromyricetin

At present, rattan tea is mainly used as a health care product. In the future, dihydromyricetin will be used in combination with some clinical drugs, including adriamycin, streptozotocin, cisplatin and other anti-tumor drugs to improve anti-tumor efficacy and reduce adverse reactions. and drug resistance; combined use with antiarrhythmic, angina pectoris and hypertension drugs to improve efficacy; combined with sedative-hypnotic drugs to improve efficacy and other applications.

In summary, the antibacterial, anti-inflammatory, anti-tumor, cardiovascular system function regulation and neuroprotective effects of dihydromyricetin have been continuously confirmed. my country’s rattan tea is rich in resources and has a wide range of sources, and has high development and utilization value. In the future, with the attention and support for the development of rattan tea, the value of dihydromyricetin in various fields will gradually appear, and its application value will become higher and higher.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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