Zhishang Chemical

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Zhishang Chemical

Diethanolamine Sigma CAS 111-42-2

Molecular Formula: C4H11NO2

Formula Weight: 105.14

ZSpharmac: Diethanolamine Sigma Supplement

Product Name: Diethanolamine Sigma
CAS No: 111-42-2
Purity: 99%

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Basic Info

Product Name:Diethanolamine Sigma
Other Names:Diethanolamine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystal or Colorless Liquid
EINECS No.:203-868-0
Provide:Diethanolamine Sigma MSDS;
Diethanolamine Sigma COA

What is Diethanolamine Sigma?

Ethanolamine EA is the most essential item among amino alcohols, including monoethanolamine MEA, Diethanolamine SigmaDEA as well as triethanolamine TEA. Ethanolamine is an important organic intermediate, extensively utilized in surfactants, artificial detergents, petroleum additives, artificial resins as well as rubber plasticizers, accelerators, vulcanizing agents and lathering representatives, along with gas filtration, liquid antifreeze, Printing as well as dyeing, medication, pesticide, building and construction, army and also various other areas. Many downstream items of ethanolamine are essential great chemical intermediates, and also they are additionally one of the most sought-after chemical items in our nation. Consequently, the application and also growth of ethanolamine has been enhanced to meet the requirements of domestic great chemicals on the one hand, as well as advertise the quick growth of the ethanolamine market on the other hand.

Diethanolamine Sigma, additionally referred to as bishydroxyethylamine, 2,2′-iminobisethanol, is a white crystal or anemic liquid with solid hygroscopicity. It is easily soluble in water, methanol, ethanol, acetone and also benzene, as well as its solubility in benzene (g/100g) at 25 ° C is 4.2 as well as 0.8 in ether. Its usages are: gas detoxifying agent, which can soak up acid gases in the gas, such as carbon dioxide, hydrogen sulfide, sulfur dioxide, and so on. The “Benfield” option used in the artificial ammonia market is generally made up of this item; it is additionally utilized as an emulsifier., lubricating substances, shampoos, thickeners, etc; natural synthesis intermediates for the production of detergent resources, preservatives and day-to-day chemicals (such as surfactants); synthesis of morpholine.

Diethanolamine Sigma Property

Melting point 28 °C (lit.)
Boiling point 217 °C/150 mmHg (lit.)
density 1.097 g/mL at 25 °C (lit.)
vapor density 3.6 (vs air)
vapor pressure <0.98 atm ( 100 °C)
refractive index n20/D 1.477(lit.)
Fp 280 °F
storage temp. 2-8°C
solubility H2O: 1 M at 20 °C, clear, colorless
form Viscous Liquid or Low Melting Solid
color APHA: ≤15
Specific Gravity1.09
OdorMild ammoniacal; faint, fishy; characteristic.
PH11.0-12.0 (25℃, 1M in H2O)
pka8.88(at 25℃)
explosive limit2.1-10.6%(V)
Water Solubility MISCIBLE


Diethanolamine Sigma Uses

  1. Utilized as thickener, foam improver in shampoos as well as light cleaning agents, as conditioner in man-made fiber along with leather manufacturing. Diethanolamine Sigma reacts with 70% sulfuric acid to dry out and cyclize to create morpholine (ie, 1,4-oxazacyclohexane). Both morpholine along with diethanolamine are intermediates in organic synthesis. For instance, they can be used to produce some optical bleaching reps in the material market. The fat salts of morpholine can be made use of as chemicals. Morpholine can also be utilized to generate the central inhibitor Fulco. dealt with or as a solvent. Diethanolamine is used in logical chemistry as a reagent as well as a set fluid for gas chromatography to uniquely maintain and divide alcohols, diols, amines, pyridines, quinolines, piperazines, thiols, thioethers as well as water.
  2. Diethanolamine Sigma is an essential rust prevention that can be made use of in main home heating central heating boiler water therapy, coolant for car engines, drilling and also lowering oils, as well as other kinds of fueling oil oils. It is additionally used as an absorbent for cleansing acid gas in gas. Made use of as an emulsifier in numerous cosmetics and likewise pharmaceuticals. It is used as a lubricating substance in the fabric market, as a wetting agent, a softener along with different other natural artificial raw materials.
  3. Benefited from as acid absorbent, plasticizer, conditioner, emulsifier, and so on in adhesives. It is likewise used as a soaking up for acid gases (such as hydrogen sulfide, carbon dioxide, and also extra) in oil gas, gas as well as various other gases. It is the raw thing for the synthesis of medicines, pesticides, shade intermediates along with surfactants. It is made use of as an emulsifier for oils and also waxes, as well as a conditioner for natural leather along with artificial fibers under acidic problems. Made use of as a thickener along with foam improver in shampoos in addition to light cleansing representatives. Furthermore utilized as detergent, lubricating substance, brightener and engine piston ash remover.
  4. Made use of as a complexing representative for silver, cadmium, lead, along with zinc plating.
  5. Used as logical reagents, acid gas absorbents, conditioners and lubricating substances, and also in all-natural synthesis.

"Diethanolamine Sigma", a Prohibited and Restricted Substance in Cosmetics

In the cosmetics industry, diethanolamine and other alcohol amine products are used as pH balancers, which can be used in beauty and skin care products and washing products. In addition, diethanolamine may also be brought into cosmetics with raw materials such as surfactant coconut oil diethanolamine. However, because Diethanolamine Sigma may cause dermatitis and eczema in direct contact with the skin, and react with nitrates to generate potential carcinogens—nitrosamines, which endanger the health of users, the European Pharmacopoeia and my country’s chemical industry standards all use ethanolamines such as ethanolamine. Class substances are listed as quality control standards.

The 2015 edition of “Cosmetics Safety and Technical Specifications” clearly stipulates that diethanolamine is a prohibited component, and the mass fraction of secondary alkylamines (typically represented by diethanolamine) in cosmetics shall not exceed 0.5%, and other restrictions and requirements stipulate that it cannot be combined with sub-alkanes. used together with a nitration system.

my country’s entry-exit inspection industry standard SN/T 2017-2008 “Determination of Monoethanolamine, Diethanolamine and Triethanolamine in Import and Export Cosmetics” uses gas chromatography-mass spectrometry to detect the content of ethanolamines in cosmetics. The lower limit of determination is 0.05% (mass fraction).

  • About Us:
    Our company, as an experienced Diethanolamine manufacturer and supplier, ZSpharmac will supply Diethanolamine raw materials to customers all over the world for a long time.
  • Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.
  • If you have demand for Diethanolamine and related products, please contact our service staff directly, we will provide you with high-quality products at the best price.

Diethanolamine Sigma Induces Differential DNA Synthesis in Hepatocytes

Chronic direct exposure to diethanolamine increases the incidence as well as multiplicity of liver developments in computer mice. Diethanolamine is acknowledged to stop mobile choline uptake. Thinking about that choline shortage produces lumps in rats, diethanolamine deficiency using choline may include in lump development in rats. The potential for diethanolamine to operate in human beings via this setting of activity doubts. This research study had a look at the results of diethanolamine (0-500 μg/ mL) and choline exhaustion on DNA synthesis as well as alterations in the expression of genes associated with cell growth courses in main societies of computer mouse, rat, as well as additionally human hepatocytes. In mouse in addition to rat hepatocytes, DNA synthesis was raised (3- to 4-fold more than controls) adhering to therapy with 10 μg/ ml diethanolamine and also greater focus. In contrast, diethanolamine quit working to increase DNA synthesis in human hepatocytes. Culture of hepatocytes in media including lowered choline (1/10 to 1/100 of normal media; 0.898 to 0.0898 mg/l vs 8.98 mg/l) raised DNA synthesis (in computer system mouse as well as rat hepatocytes). 1.6-fold and also 1.8-fold of control), especially); nonetheless, choline deficiency did not induce DNA synthesis in human hepatocytes. Computer mouse and also rat hepatocytes bred in tool supplemented with a 2- to 50-fold additional of choline lowered diethanolamine-induced DNA synthesis to take care of degrees or listed below. Genes expression evaluation of computer mouse along with rat hepatocytes after diethanolamine treatment disclosed improved expression of genetics linked to cell development as well as additionally decreased expression of genes connected with apoptotic paths. These results receive the concept that choline fatigue is central to the setting of activity of diethanolamine-induced liver growths in rodents. In addition, thinking about that diethanolamine treatment or choline fatigue fell short to create DNA synthesis in human hepatocytes, these outcomes suggest that people may not be at risk for the cancer causing outcomes of diethanolamine.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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