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Diazolidinyl Urea CAS 78491-02-8

Molecular Formula: C8H14N4O7

Formula Weight: 278.22

ZSpharmac: Diazolidinyl Urea Raw Material Supplier

Product Name: Diazolidinyl Urea
CAS No: 78491-02-8
Purity: 99%

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Basic Info

Product Name:Diazolidinyl Urea
Other Names:Diazolidinylurea
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:278-928-2
Provide:Diazolidinyl Urea MSDS;
Diazolidinyl Urea COA

What is Diazolidinyl Urea?

Diazolidinyl Urea, also known as diazolidinyl urea, its chemical name is diazolidinyl urea, its CAS registration number is 78491-02-8, it is a commonly used preservative, mainly used in cosmetics and personal care products. As an organic compound, Diazolidinyl Urea slowly releases formaldehyde when exposed to moisture, thereby playing a sterilizing and antiseptic role, effectively preventing the growth of bacteria and mold in the product, and extending the shelf life of the product.

Diazolidinyl Urea Property

Boiling point 421.04°C (rough estimate)
density 1.4734 (rough estimate)
vapor pressure 0Pa at 20℃
refractive index 1.6590 (estimate)
storage temp. 2-8°C
solubility Water (Slightly)
form Solid
color White to Off-White
Water Solubility 1000g/L at 20℃


Diazolidinyl Urea Uses

Cosmetics and personal care products:
Diazolidinyl Urea is widely used as a preservative in personal care products such as cosmetics, skin care products, shampoos, shower gels, deodorants, etc. It can effectively prevent microbial contamination of products during use and storage and extend the shelf life of products. It inhibits the growth of bacteria and fungi by slowly releasing formaldehyde.

Pharmaceutical Industry:
Diazolidinyl Urea may also be used as a preservative ingredient in certain pharmaceutical preparations, particularly in products such as topical ointments, solutions or eye drops where sterile conditions must be maintained.

Household cleaning products:
It can also be used in household cleaning products, such as hand soap, laundry detergent, etc., as an antiseptic additive to improve the antibacterial properties of the product.

Industrial applications:
In some industrial environments, Diazolidinyl Urea may also be used in industrial products that require anti-corrosion protection, such as certain industrial cleaning agents, lubricants, adhesives, etc., to ensure that products are protected from microbial damage during storage and use.

Diazolidinyl Urea Advantages and Features

Anti-corrosion performance:
Diazolidinyl Urea is an effective antimicrobial and preservative that inhibits the growth of bacteria and mold in cosmetics and personal care products, protects products from microbial contamination, and extends product shelf life.

Stability and compatibility:
This ingredient has good chemical stability under normal storage conditions and good compatibility with other cosmetic ingredients. It can be used in a variety of formulation systems without affecting the sensory and performance of the product.

Slow-release formaldehyde:
Diazolidinyl Urea can slowly release formaldehyde in a water-based environment. Formaldehyde is a powerful bactericide and can achieve anti-corrosion effects at lower concentrations, thereby reducing the effective concentration required for overall anti-corrosion.

Compared with some high-end or new preservatives, the production and procurement costs of Diazolidinyl Urea are relatively low, so it is highly cost-effective in industrial production.

Wide range of applications:
Can be used in many types of personal care products, such as skin care products, shampoo products, makeup, perfume, shaving cream, nail polish remover, etc., as well as certain types of pharmaceuticals and household cleaning products.


Fluorescence spectrophotometer dimension: Diazoalkylurea decays due to the damage of the N-hydroxymethyl bond in ammonium acetate-acetate barrier solution and launches formaldehyde. The last goes through Hantzsch reaction with acetylacetone in the presence of ammonia to develop dihydropyridine derivatives:

Dihydropyridine derivatives have characteristic absorption at 410nm and fluorescence at 510nm. The material of diazoalkylurea can be quantitatively figured out by identifying the fluorescence intensity of dihydropyridine derivatives. The degree of bosom of the N-hydroxymethyl bond of diazoalkylurea is associated with the response problems. Under the conditions of this experiment, 2 N-hydroxymethyl bonds in each molecule of diazoalkylurea are damaged to launch two particles of formaldehyde.

The dimension steps are: consider 12.9 mg Diazolidinyl Urea right into a 100 ml volumetric flask, weaken it to quantity with (1 + 9) methanol, and after that dilute it 100 times with methanol liquid option to obtain an examination solution with a theoretical content of 1.29 μg/ ml. Take 4 ml of the test option, include an equivalent quantity of Nash’s reagent, react at 60 ° C for 1 hour, and then gauge the fluorescence intensity under the exact same conditions. The loved one fluorescence strength measured was 26.5.

Doi T, Takeda A, Asada A, Kajimura K. Characterization of the decomposition of compounds derived from imidazolidinyl urea in cosmetics and patch test materials. Contact Dermatitis. 2012 Nov;67(5):284-92. doi: 10.1111/j.1600-0536.2012.02073.x. Epub 2012 May 7. PMID: 22564140.

As a company specializing in the production and supply of Diazolidinyl Urea raw materials, we are committed to providing customers with high-quality products and preferential prices. We have rich experience and technology to ensure product quality and stable supply. No matter where you are, we can provide you with the Diazolidinyl Urea raw materials you need to support your production and research and development.

We always adhere to the principle of honest operation, strictly control product quality, and serve every customer with a customer-first attitude. Over the years, we have established good cooperative relationships with customers at home and abroad and won their trust and praise.

If you have needs or are interested in our products, please contact our service staff directly, we will wholeheartedly provide you with the best quality services and products. Looking forward to cooperating with you and developing together!

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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