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Diazolidinyl Urea CAS 78491-02-8

Molecular Formula: C8H14N4O7

Formula Weight: 278.22

ZSpharmac: Diazolidinyl Urea Raw Material Supplier

Product Name: Diazolidinyl Urea
CAS No: 78491-02-8
Purity: 99%

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Basic Info

Product Name:Diazolidinyl Urea
Other Names:Diazolidinylurea
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:278-928-2
Provide:Diazolidinyl Urea MSDS;
Diazolidinyl Urea COA

What is Diazolidinyl Urea?

Diazoalkylurea is a new cosmetic chemical created by the American Sutton Firm in the 1980s. It has broad-spectrum anti-bacterial task. It not simply inhibits Gram-positive bacteria, microorganisms, yeasts, mold and molds and fungis, yet furthermore has distinct impacts on Gram-negative germs such as Pseudomonas aeruginosa and Escherichia coli. Within the dosage option There are no unsafe damaging results. Neither cationic, anionic or nonionic surfactants neither proteins affect the antibacterial job of diazoalkylurea. It works with primarily all aesthetic parts.

Diazolidinyl Urea Property

Boiling point 421.04°C (rough estimate)
density 1.4734 (rough estimate)
vapor pressure 0Pa at 20℃
refractive index 1.6590 (estimate)
storage temp. 2-8°C
solubility Water (Slightly)
form Solid
color White to Off-White
Water Solubility 1000g/L at 20℃


Diazolidinyl Urea Applications

1. Prepare a white wine yeast facial mask. The raw products and weight proportions in the formula are: 33 parts of white wine yeast, 8 parts of vitamin E-8, 11 parts of pearl powder, 3 parts of beer barley malt starch, and pyrrolidone. 7 parts of sodium carboxylate, 1.6 parts of Diazolidinyl Urea, 0.05 parts of plant important oil, 6 parts of polyvinyl alcohol, 2 parts of polyoxyethylene (20) sorbitan monolauryl ester, 2 parts of glycerol, and purified water included in 100 share. The dosage and physical and chemical residential properties of each raw material in today innovation generate a collaborating effect, therefore accomplishing the effects of free extreme scavenging and imperfection improvement. The PH value of the here and now invention is close to that of human skin and is non-irritating to the skin; after usage, the skin really feels clearly comfy, soft and non-greasy, and has apparent results of hydrating, lightening and repairing the skin.

2. Prepare a new kind of environmentally friendly printing ink. Made from the following resources by weight: 26-32 parts of vinyl chloride-acrylate copolymer material, 3-4 parts of methyl methacrylate, 3-9 parts of acrylic material, 4-7 parts of acetyl tri-n-butyl citrate parts, 10-13 parts of butyl octanol, 0.3-0.6 parts of 2-thiol benzimidazole, 0.4-0.7 parts of Diazolidinyl Urea, 1-4 parts of attapulgite, 0.6-0.9 parts of ammonium persulfate, 0.5 parts of chitosan -0.8 components, 2-3 parts of palm oil, 3-5 parts of organic pigments, 4-6 parts of additives, and proper quantity of water. It has the advantages of inexpensive, diversified features, antibacterial, heat resistance, high solidity, antibacterial, wear resistance, chemical corrosion resistance, fast drying out rate, and great printing versatility. The preparation method is simple, simple to run and extremely functional.

3. Prepare a kitchen wipes substance. It consists of the complying with products in weight percent: 30%-60% of eco-friendly solvent, 2%-4% of non-ionic surface task, 3%-8% of anionic surface task, 0.5%-2% of silicone defoaming representative, security Membrane layer 0.5%-2%, iodopropynyl n-butyl carbamate 0.05%-0.1%, Diazolidinyl Urea 0.05%-1%, 1,3 dihydroxymethyl-5,5 dimethyl hydantoin 0.05%- 1%, the rest is RO water. The preparation technique of the kitchen cleans compound fluid is likewise secured. The kitchen cleans prepared by the invention are environmentally friendly, very easy to biodegrade, have strong cleaning capability, no peculiar scent, less foam, no irritability, non-sticky feel, develop a protective layer on the hard surface, have anti-fouling homes, and are convenient for cleaning up following time benefit.

4. Prepare an eco-friendly deterioration and range prevention composition, computed by weight, including: 10-18 parts of customized polyepoxy succinic acid, 10-20 parts of acrylic acid copolymer, 5-12 parts of tannin, 20-30 parts Parts of salt silicate, 5-12 parts of salt D-gluconate, 10-20 parts of polydiene dimethyl ammonium chloride, 8-10 parts of zinc sulfate, 10-20 parts of Diazolidinyl Urea, 50-80 parts of detoxified water; Wherein, the changed polyepoxysuccinic acid is constructed from epoxysuccinate, 2-acrylamide-2-methylpropanesulfonic acid, and 3-prop-2-enoyloxypropane-1-potassium sulfonate. The acrylic copolymer is gotten by copolymerizing acrylic acid, 2-acrylamido-2-methylpropanesulfonic acid and 2-acrylamide phenylboronic acid as monomers.

Diazolidinyl Urea Preparation

Utilizing 30% glyoxal as resources, the high-efficiency broad-spectrum preservative diazoalkylurea is prepared via oxidation response, cyclization response and hydroxymethylation reaction. Glyoxal was oxidized with nitric acid at 40 ° C for 4 hours, urea was contributed to the oxidation item and cyclized at 75 ° C for 3 hours, and the cyclized item allantoin and formaldehyde were reacted at reflux temperature for 1 hour. The overall synthesis return is 51%, and the nitrogen content of the product according to important analysis is 20.20%. The pureness of the item was established to be 99% by fluorescence spectroscopy.

Action 1: Preparation of allantoin. In a four-necked flask geared up with an electrical stirrer, condenser, consistent pressure going down funnel and thermostat, add 0.25 mol of glyoxal with a mass fraction of 30%, mix and raise the temperature to 40 ° C, add dropwise 0.20 mol of thin down nitric acid, 0.5 The addition is finished within h, and after an overall of 4 h of incubation response, a certain quantity of water is distilled out and delegated stand, and the precipitated oxalic acid is recouped as a byproduct. Include 0.8 mol urea to the filtrate, add combined acid catalysis under stirring, heat to 75 ° C, continue the reaction for 3 hours, then great, filter, laundry with water, and completely dry to obtain allantoin, return 52% (determined as glyoxal), melting point 236 ~ 237 ℃.

Step 2: Preparation of Diazolidinyl Urea. Add 0.2 mol allantoin and 0.8 mol formaldehyde service to a three-necked flask furnished with a stirrer and reflux condenser, warm, mix and reflux (80 ° C) for 1 hour, then change the reflux gadget to a vacuum purification device, heavy steam out the water, and completely dry Diazolidinyl Urea 54.8 g was gotten with a yield of 98%. Measured by fluorescence spectroscopy, its pureness is 99%.

Content Determination of Diazolidinyl Urea

Fluorescence spectrophotometer dimension: Diazoalkylurea decays due to the damage of the N-hydroxymethyl bond in ammonium acetate-acetate barrier solution and launches formaldehyde. The last goes through Hantzsch reaction with acetylacetone in the presence of ammonia to develop dihydropyridine derivatives:

Dihydropyridine derivatives have characteristic absorption at 410nm and fluorescence at 510nm. The material of diazoalkylurea can be quantitatively figured out by identifying the fluorescence intensity of dihydropyridine derivatives. The degree of bosom of the N-hydroxymethyl bond of diazoalkylurea is associated with the response problems. Under the conditions of this experiment, 2 N-hydroxymethyl bonds in each molecule of diazoalkylurea are damaged to launch two particles of formaldehyde.

The dimension steps are: consider 12.9 mg Diazolidinyl Urea right into a 100 ml volumetric flask, weaken it to quantity with (1 + 9) methanol, and after that dilute it 100 times with methanol liquid option to obtain an examination solution with a theoretical content of 1.29 μg/ ml. Take 4 ml of the test option, include an equivalent quantity of Nash’s reagent, react at 60 ° C for 1 hour, and then gauge the fluorescence intensity under the exact same conditions. The loved one fluorescence strength measured was 26.5.

About Products:
If you need the cosmetic raw material Diazolidinyl Urea, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Diazolidinyl Urea manufacturer and supplier, our company, ZSpharmac will provide Diazolidinyl Urea raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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