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Zhishang Chemical

Diazolidinyl Urea CAS 78491-02-8

Molecular Formula: C8H14N4O7

Formula Weight: 278.22

ZSpharmac: Diazolidinyl Urea Supplier

Product Name: Diazolidinyl Urea
CAS No: 78491-02-8
Purity: 99%

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Basic Info

Product Name:Diazolidinyl Urea
Other Names:Diazolidinyl Urea
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:278-928-2
Provide:Diazolidinyl Urea MSDS;
Diazolidinyl Urea COA

What is Diazolidinyl Urea?

Diazolidinyl urea is a new type of cosmetic preservative developed by Sutton Company of the United States in the 1980s. It has broad-spectrum antibacterial activity, not only inhibits and kills Gram-positive bacteria, bacteria, yeasts, molds and fungi, but also has special effects on Gram-negative bacteria such as Pseudomonas aeruginosa and Escherichia coli. No hazardous adverse effects. Neither cationic, anionic or nonionic surfactants nor healthy proteins affected the bactericidal task of diazolidinyl urea. It is compatible with nearly all cosmetic components.

Diazolidinyl Urea Property

Boiling point 421.04°C (rough estimate)
density 1.4734 (rough estimate)
vapor pressure 0Pa at 20℃
refractive index 1.6590 (estimate)
storage temp. 2-8°C
solubility Water (Slightly)
form Solid
color White to Off-White
Water Solubility 1000g/L at 20℃


Application of Diazolidinyl Urea

Diazolidinyl urea is the most extensively made use of brand-new preservative on the planet in the 1980s. It has broad-spectrum anti-bacterial activity and also has unique results on Gram-negative bacteria. It is structurally similar to imidazolidinyl urea, but is more reliable against yeast, mold and microorganisms. The hydroxymethyl group of diazolidinyl urea is a bactericidal energetic team with antiseptic effect. It is just one of one of the most frequently utilized preservatives after parabens in the cosmetic sector. Its application examples are as follows:

1. Prepare a face mask of maker’s lees yeast. The raw products and also weight ratios in the formula are: 33 parts of maker’s yeast, 8 parts of vitamin E-8, 11 parts of pearl powder, 3 parts of beer barley malt starch, pyrrolidone 7 parts of salt carboxylate, 1.6 parts of diazolidinyl urea, 0.05 parts of plant vital oil, 6 parts of polyvinyl alcohol, 2 parts of polyoxyethylene (20) sorbitan monolauryl axillary ester, 2 parts of glycerol, cleansed water Amount to 100 parts. The dosage as well as physical and also chemical homes of each resources in today innovation generate a synergistic impact, so regarding attain the result of getting rid of complimentary radicals as well as reducing areas as well as beautifying. The pH worth of today creation is close to that of human skin, and also has no irritability to the skin; after usage, the skin is certainly comfortable, soft as well as non-greasy, and has obvious results of hydrating, whitening, repairing and also beautifying the skin.

2. Prep work of a brand-new type of eco-friendly printing ink. Made from the adhering to raw materials partially by weight: 26-32 parts of plastic chloride-acrylate copolymer resin, 3-4 parts of methyl methacrylate, 3-9 parts of acrylic resin, 4-7 parts of acetyl tri-n-butyl citrate 10-13 parts of butyl octanol, 0.3-0.6 parts of 2-mercaptobenzimidazole, 0.4-0.7 parts of diazolidinyl urea, 1-4 parts of attapulgite, 0.6-0.9 parts of ammonium persulfate, covering 0.5-0.8 parts of polysaccharides, 2-3 parts of hand oil, 3-5 parts of organic pigments, 4-6 parts of additives, proper quantity of water. It has the advantages of low cost, multiple functions, antibacterial, heat resistance, high solidity, anti-bacterial, wear-resistant, chemical rust resistance, rapid drying rate, as well as excellent printing versatility. The preparation approach is easy, the procedure is convenient as well as the practicability is solid.

3. Prepare a cooking area wipe formula. It includes the complying with substances by weight percentage: 30%-60% of environmentally friendly solvents, 2%-4% of non-ionic surfactants, 3%-8% of anionic surfactants, 0.5%-2% of silicone defoamers, safety Movie 0.5%-2%, iodopropynyl n-butyl carbamate 0.05%-0.1%, diazolidinyl urea 0.05%-1%, 1,3 dimethylol-5,5 dimethylhydantoin 0.05%-1%, the rest is RO water. The prep work approach of the kitchen area wet towel substance liquid is likewise shielded. The kitchen area damp wipes prepared by the present invention are environmentally friendly, very easy to biodegrade, strong cleaning capacity, no strange odor, much less foam, no irritation, no sticky feel, a safety layer formed on the hard surface area, anti-fouling homes, and also convenient for next cleaning. advantage.

4. Prepare an eco-friendly anti-corrosion as well as anti-scaling make-up, computed by weight, consisting of: 10-18 parts of customized polyepoxysuccinic acid, 10-20 parts of acrylic acid copolymer, 5-12 parts of tannin, 20-30 components Components of salt silicate, 5-12 parts of sodium D-gluconate, 10-20 parts of polydiene dimethyl ammonium chloride, 8-10 parts of zinc sulfate, 10-20 parts of diazolidinyl urea, 50-80 parts Detoxified water; where, the customized polyepoxysuccinic acid is based upon epoxysuccinate as well as 2-acrylamide-2-methylpropanesulfonic acid, 3-prop-2-enoyloxypropane-1-sulfonic acid The acrylic acid copolymer is gotten by copolymerizing acrylic acid, 2-acrylamide-2-methylpropanesulfonic acid and also 2-acrylamide phenylboronic acid as monomers.

Preparation of Diazolidinyl Urea

Using 30% glyoxal as raw material, diazolidinyl urea, a high-efficiency broad-spectrum preservative, was prepared through oxidation reaction, cyclization reaction and methylolation reaction. Glyoxal was oxidized with nitric acid at 40°C for 4h, urea was added to the oxidation product and cyclized at 75°C for 3h, and the cyclized product allantoin and formaldehyde were reacted at reflux temperature for 1h. The total synthetic yield is 51%, and the nitrogen content of the product is 20.20% through elemental analysis. The purity of the product is 99% as determined by fluorescence spectroscopy.

Step 1: Preparation of allantoin. In a four-necked flask equipped with an electric stirrer, a condenser, a constant pressure dropping funnel and a thermometer, add 0.25 mol of glyoxal with a mass fraction of 30 %, stir to raise the temperature to 40 °C, add dropwise 0.20 mol of dilute nitric acid, 0.5 After the addition is completed within h, after a total of 4 hours of heat preservation reaction, a certain amount of water is distilled off and left to stand, and the precipitated oxalic acid is recovered as a by-product. Add 0.8mol urea to the filtrate, add mixed acid catalyst under stirring, heat to 75 °C, continue to react for 3 hours, then cool, filter, wash with water, and dry to obtain allantoin with a yield of 52% (calculated as glyoxal) and a melting point of 236 ~237°C.

Step 2: Preparation of diazolidinyl urea. Add 0.2mol allantoin and 0.8mol formaldehyde solution into a three-neck flask equipped with a stirrer and a reflux condenser, heat, stir and reflux (80°C) for 1h, then change the reflux device to a vacuum distillation device, distill out water, and dry Obtain 54.8 g of diazolidinyl urea, yield 98%. Determined by fluorescence spectroscopy, its purity is 99%.

Content Determination of Diazolidinyl Urea

Fluorescence spectrophotometer measurement: Diazolidinyl urea decomposes in ammonium acetate-acetic acid buffer solution due to the breakage of N-methylol bond, releasing formaldehyde. The latter undergoes a Hantzsch reaction with acetylacetone in the presence of ammonia to give dihydropyridine derivatives:

Dihydropyridine derivatives have characteristic absorption at 410nm and fluorescence at 510nm. The content of diazolidinyl urea can be quantitatively determined by detecting the fluorescence intensity of dihydropyridine derivatives. The degree of cleavage of the N-methylol bond of diazoalkylurea is related to the reaction conditions. Under the conditions of this experiment, two N-methylol bonds in each molecule of diazolidinyl urea were broken to release two molecules of formaldehyde.

The determination procedure is as follows: Weigh 12.9mg of diazolidinyl urea into a 100ml volumetric flask, use (1 +9) methanol to make up the volume, and then dilute 100 times with methanol aqueous solution to obtain a test solution with a theoretical content of 1.29μg/ml. Take 4ml of the solution to be tested, add an equal volume of Nash’s reagent and react at 60°C for 1h, then measure its fluorescence intensity under the same conditions. The measured relative fluorescence intensity was 26.5.

About Products:
If you need Diazolidinyl Urea, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Diazolidinyl Urea manufacturer and supplier, ZSpharmac will provide Diazolidinyl Urea raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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