Zhishang Chemical

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Zhishang Chemical

Di-Tert-Butyl Dicarbonate CAS 24424-99-5

Molecular Formula: C10H18O5

Formula Weight: 218.25

ZSpharmac: Di-Tert-Butyl Dicarbonate Supplement

Product Name: Di-Tert-Butyl Dicarbonate
CAS No: 24424-99-5
Purity: 99%

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Basic Info

Product Name:Di-Tert-Butyl Dicarbonate
Other Names:(BOC)2O FLUKA
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Low Melting Crystalline Solid
EINECS No.:246-240-1
Provide:Di-Tert-Butyl Dicarbonate MSDS;
Di-Tert-Butyl Dicarbonate COA

What is Di-Tert-Butyl Dicarbonate?

Di-Tert-Butyl Dicarbonate is a natural substance with a molecular formula of C10H18O5, which is made use of to present a tert-butoxycarbonyl safeguarding team in natural synthesis. It is especially utilized in the security of the very first amino group of amino acids, as well as is widely made use of in the synthesis of medicine, protein as well as peptide synthesis, biochemical food, cosmetics and various other products.

Di-Tert-Butyl Dicarbonate Property

Melting point 23 °C (lit.)
Boiling point 56-57 °C/0.5 mmHg (lit.)
density 0.95 g/mL at 25 °C (lit.)
refractive index n20/D 1.409(lit.)
Fp 99 °F
storage temp. 2-8°C
form Low Melting Crystalline Solid
color White
Specific Gravity0.950
Water Solubility Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water.


Di-Tert-Butyl Dicarbonate Uses

  1. Di-Tert-Butyl Dicarbonate is utilized to present tert-butoxycarbonyl protecting team in organic synthesis.
  2. Di-Tert-Butyl Dicarbonate is specifically used for amino defense of amino acids. It is extensively used in the synthesis of medication, protein and also peptide synthesis, biochemical food, cosmetics and also other items.
  3. Di-Tert-Butyl Dicarbonate is a reagent for the preparation of tert-butoxycarbonyl protected amines. Reagents for presenting tert-butoxycarbonyl safeguarding groups. Alcohols such as tert-butoxycarbonyl by-products can be shielded by Lewis acid catalysis.
  4. Di-Tert-Butyl Dicarbonate is used as an intermediate in medicine as well as natural synthesis, as well as is a crucial amino shielding agent used in the synthesis of medicine as well as agrochemical products.

Preparation of Di-Tert-Butyl Dicarbonate

Sodium Tert-Butoxide Hits Di-Tert-Butyl Dicarbonate: Will it Fall

Di-Tert-Butyl Dicarbonate protecting groups, which do not require high reagents and equipment, are frequent visitors in organic synthesis. Based on the sensitivity of Boc to acids and the stability to bases, deprotection is generally carried out under acidic conditions, with few cases of basic and neutral de-Boc.

If the substrate is sensitive to acid and cannot be deprotected under acidic conditions, other protecting groups should be selected in the route design process to avoid troubles later in the study. If you have to face this situation, sodium (potassium tert-butoxide) may help you out.

In 2003, Pfizer researchers published an article that sodium tert-butoxide can remove the Di-Tert-Butyl Dicarbonate protecting group of N with active hydrogen in the tetrahydrofuran system. The mechanism is shown in Figure 1 below.

After deprotonation of sodium tert-butoxide, the anion of tert-butanol is removed to form an intermediate state of isocyanate, and metastable carbamic acid is generated in the presence of water. After carbon dioxide is released, the deprotection reaction of the compound in Figure 2 below is completed in high yield:

The reaction of potassium (sodium) tert-butoxide to remove Di-Tert-Butyl Dicarbonate is rarely used in the process, but it is helpful for the analysis of impurity spectrum in the process of process optimization. For related impurity spectrum studies, see the link:

Potassium tert-butoxide hits Di-Tert-Butyl Dicarbonate: Methylation impurity profile of BocNHR

Other conditions for alkaline removal of Boc, such as sodium hydroxide aqueous solution and potassium carbonate aqueous solution, are basically the mechanism of hydrolysis of amides in an alkaline environment.

I remember that in the first few years of work, the QQ group discussed a reaction to remove Cbz. I tried many hydrogenation removal and HBr removal conditions, but I couldn’t get it. As a result, the hydroxide aqueous solution was easily solved, and the route of hydrolysis of amides in an alkaline environment was taken. .

In organic synthesis, the most intuitive is the reaction in acidic, basic and neutral environments, and when the characteristic reaction does not work, it cannot be limited to functional groups.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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