Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical

Dextran Obat CAS 111-42-2

Molecular Formula: C17H32O10

Formula Weight: 396.42998

ZSpharmac: Dextran Obat Supplier

Product Name: Dextran Obat
CAS No: 111-42-2
Purity: 99%

Navigation Bar

Basic Info

Product Name:Dextran Obat
Other Names:Dextran
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Slightly Off-White Solid
EINECS No.:232-677-5
Provide:Dextran Obat MSDS;
Dextran Obat COA

What is Dextran Obat?

Dextran Obat is a polysaccharide that exists in the mucous produced by some microbes throughout the growth procedure. It is divided into α-glucan as well as β-glucan. Later On, Dr. Diluzio of Tulum University isolated it in baker’s yeast. This resistance-enhancing substance is determined as beta-glucan.

Beta-glucan is commonly discovered in foods such as yeast, mushrooms, oats and also barley, among which beta-1,3/ 1,6 is present in yeast and also mushroom glucan, while beta-1,3/ 1,4 is present in Oat and also barley glucans.

β-glucan is various from usual sugars (such as starch, hepatose, dextrin, and so on), and also the major distinction is that the bonding method is various. The molecular structure of typical sugars is α-1,4-glucoside β-glucan is mostly made up of β-1,3-glycosidic bonds as well as has some branched chains of β-1,6-glycosidic bonds. β-glucan has a helical molecular structure because of its unique bonding technique as well as the existence of intramolecular hydrogen bonds. This unique setup is easily approved by the immune system.

Dextran Obat Property

Melting point 483 °C (decomp)
alpha 198 º
refractive index 185 ° (C=6, H2O)
storage temp. 2-8°C
solubility H2O: soluble50mg/mL, clear to very slightly hazy, colorless to faintly yellow
form Solid
color White to slightly off-white
PH2 – 10
Water Solubility Soluble in water, dimethyl sulfoxide, ethylene glycol and glycerol.


Dextran Obat Uses

  1. Dextran Obat is an anti-anemia medication. For iron deficiency anemia. Unfavorable reactions as well as contraindications If there is no steady increase in hemoglobin after injection of this product, the medicine must be discontinued promptly. Contraindicated in patients with liver and renal insufficiency.
  2. Dextran Obat is a blood quantity supplement. Adverse reactions as well as contraindications Sometimes allergies. Heart disease as well as clients with bleeding problems are contraindicated, as well as individuals with heart, liver as well as kidney deficiency should be made use of with care.
  3. Dextran Obat is a medium-molecular-weight dextran mainly utilized to enhance plasma volume, preserve blood pressure, as well as primarily anti-shock. It is suitable for replenishing blood quantity and also maintaining high blood pressure during enormous blood loss. Such as burns, trauma, trauma and various other hemorrhagic as well as physical emergency treatment triggered by excessive blood loss. Low-molecular-weight dextran, mainly to enhance microcirculation, is utilized to stop or eliminate red cell aggregation and also apoplexy in capillary. The function as well as use of small molecular dextran is similar to that of reduced molecular dextran machine.
  4. Dextran Obat In cosmetic solutions, dextran acts as a binder, improving the diffusion of components in cosmetic solutions. An additional essential function is thickening by managing the viscosity of aesthetic solutions, which aids preserve proper uniformity.

Dextran Obat Production Method

Microbial fermentation
Breeding strain Leyconostoc meseteroides. Preparation of medium: According to the ratio of mass/volume, 10% sucrose, 0.25% peptone, 0.08% disodium hydrogen phosphate, add water to 100%, boil to dissolve, filter with filter paper, take 3ml of filtrate and dispense it into test tubes, use Tighten gauze cotton, place it in a grid, pressurize 117.72kPa (1.2kgf/cm2) at 120°C for 30min, let it cool, and put it in an incubator to obtain a clear and transparent liquid medium for inoculation. According to the above liquid medium ratio, add 1.5%-2% agar, boil to dissolve, take 5ml and divide it into test tubes, plug tightly with gauze cotton, 117.72kPa (1.2kgf/cm2), sterilize under pressure for 30min, cool, That is solid medium.
Purification and cultivation of strains Take 5 solid mediums, heat and melt them, place them on a water bath at 50-60°C for incubation, and number them respectively. Select a test tube of bacterial species in a sterile cabinet, dip one ear of white gold fungus and inoculate it into the No. 1 test tube containing solid medium, shake well, and then dip the No. 1 test tube and inoculate it into the No. 2 test tube, shake well, and in turn Inoculated into the No. 5 test tube. Then, while it is still hot (about 50°C), pour it into the correspondingly numbered petri dish one by one, lay it flat, cool it, and place it upside down in an incubator. Convex, transparent, sticky colonies. Select bacterial species in the petri dish No. 3-5, and the normal number of colonies should be 5-20. Use a crayon to draw a circle on the outer wall of the petri dish to select typical colonies (obvious features and suitable size). In a sterile cabinet, dip the delineated colonies with white gold ear and inoculate them in a test tube containing a liquid medium, and incubate at 25°C for 24h. After passage for 2-3 generations, carry out experiments such as fermentation, hydrolysis, and division of small samples, select strains with high yield, good composition, and high yield, and store them in a refrigerator at 2-4 °C for expanded production use.
Leuconostoc membranae [medium]→[25℃, 24h] colony
For seed culture, take 400ml (medium bottle) and 4000ml (large bottle) of liquid culture medium, inoculate a bacterial test tube (3ml) in the middle bottle, and then inoculate about 100ml of the seed liquid cultured in the middle bottle into the large bottle. Cultivated at 25°C for 20-24h, the end point pH is 3.8-4.3, and those with good fermentation can be used for production.
Colony [liquid medium] → [25℃, 20-24h] seed culture medium
Fermentation and precipitation are 15% sucrose, 0.25% peptone, 0.15% disodium hydrogen phosphate, add normal water to 100%, make a fermentation medium and put it in the fermenter, the inoculum amount is 2.5%, stir for 10-15min, control pH7- 7.4, about 25℃, fermented for 20-24h, and the final pH of the fermentation broth was 4.2-5, reaching the end point. Add 85%±5% ethanol to precipitate, and then wash the precipitate with 60%-70% ethanol to obtain the crude Dextran Obat polymer for hydrolysis with a yield of 85%.
Seed culture medium [fermentation medium]→[25℃, 20-24h, pH7-7.4] fermentation broth [85% ethanol, 60%-70% ethanol]→[pH4.2-5] crude polymer dextran
Hydrolysis, Neutralization and Purification The crude polymer Dextran Obat is heated and dissolved in distilled water. Calculated by the mass of the hydrolyzate, add 0.1% hydrochloric acid, keep the temperature at 95-100°C, hydrolyze, add distilled water to dilute the concentration to 11%, and control the endpoint viscosity to 2.7- 2.9, slowly neutralize to pH 6-6.5 with 6mol/L NaOH, add anhydrous calcium chloride 2.4g/L (0.24%), and finally add 766 type coarse-grained activated carbon 8g/L (0.8%), decolorize under stirring, Filtration to obtain the hydrolyzate for division.
Crude product [HCl, NaOH, CaCl2, 766 activated carbon] → [95-100℃, pH6-6.5] Division with the hydrolyzate in one step Take the hydrolyzate and add ethanol to make the concentration 40%-40.5%, keep at 40℃ for 22h Then, the supernatant was collected and divided into two stages, and the precipitates were impurities and macromolecular dextran.
Second-level division The supernatant after the first-level division was added with ethanol to make the concentration reach 45%-45.5%, stirred for 15 minutes, kept at 40°C for 22 hours, and the precipitate was medium molecular Dextran Obat.
The supernatant after the three-level division and the second-level division was added with ethanol to make its concentration reach 48%-48.5%, stirred for 15 minutes, kept at 40°C for 22 hours, and precipitated as low-molecular-weight Dextran Obat.
Add ethanol to the supernatant after the four-level division and the three-level division to make the concentration reach 55.5%-56.5%, stir for 15 minutes, stand at room temperature for 6 hours, and precipitate as small molecule Dextran Obat.

The obtained Dextran Obat is dried and divided, dehydrated with more than 90% ethanol, and the impurities are removed to prepare a loose alcohol-containing powder, which is centrifuged and dried to obtain the finished dextran with a total yield of 60%.
Dextran finished product [more than 90% ethanol] → alcohol-containing powder [centrifugation, drying] → preparation of finished dextran injection Dextran Obat finished product
Make sterile aqueous solution with glucose or sodium chloride respectively according to injection requirements.
Dextran Obat finished product [glucose, water] → glucose injection
Dextran Obat finished product [sodium chloride, water] → [sterilized] sodium chloride injection.

Classification and Use of Dextran Obat

α-, β-, and numbers illustrate the configuration of Dextran Obat and the type of O-glycosidic bonds (the numbers represent the numbering of the carbon atoms of the two monosaccharide molecules; in D-saccharides, α represents the hemiacetal hydroxyl group under the carbocyclic ring , β represents the hemiacetal hydroxyl on the carbocyclic ring).

The well-known general properties of glucans include resistance to acids and enzymes in the oral cavity and water insolubility.

Dextran Obat, also known as dextran, is one of the bacterial polysaccharides. It is produced by the glucan sucrase of bacteria [Leuconostoc mesenteroides (Leuconostoc mesenteroides), dextranicum (L. dextranicum)] cultured in sucrose solution catalyzing the following reaction: n sucrose → glucan sugar + n fructose. In Gluconobacter ox-ydans subsp. industrius [the bacteria containing this substance were previously called Acetobacterviscosum and A. capsulatum], the Refined into glucan.

There are many kinds of Dextran Obat, consisting only of D-glucose, the main chain is α(1,6) bond, and there are also branched chains of α(1,4) or α(1,3) bond. Glucose is a white powder that can be strongly dextrorotated by adding a little bit to water. It is used as a substitute for plasma in medicine.

Glucan (Glucosan) is a polysaccharide formed by the bonding of D-glucose monomers through glycosidic bonds. D-glucose residues are divided into various types due to the different binding patterns between them, and are widely distributed in microorganisms, plants, and animals. Among them, the representative ones are bacterial polyglucoside (from the main chain of α-1, 6 bonds to the side chains of α-1, 4 and α-1, 6 bonds), the kelp polysaccharide (lami-narin of brown algae) , mainly with β-1,3 bonds), xylan of lichens (β-1,4 and β-1,3 bonds), cellulose of higher plants, (β-1,4 combined), amylose (α-1,4 bond), amylopectin (a side chain of α-1,6 bond is branched from the main chain of α-1,4 bond), animal glycogen, etc. It has a high specific rotation [α] and +199° (water); partial hydrolysis mainly yields isomaltose.

Dextran can replace a portion of whole blood during blood transfusion as a plasma volume expander (called plasma replacement). A commercial plasma substitute is partially depolymerized Dextran Obat, dissolved in normal saline. Dextran is a homopolysaccharide composed of several glucose molecules. Dextran is not a monosaccharide but an oligosaccharide. Dextran Obat is divided into a series of polymers such as dextran 100,000, dextran 140,000, and dextran 20,000 according to the number of monosaccharide-glucose units that make up it. .

About Products:
If you need Dextran Obat, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Dextran Obat manufacturer and supplier, ZSpharmac will provide Dextran Obat raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Dextran Obat Quotation