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Zhishang Chemical

Dexpanthenol Cena CAS 81-13-0

Molecular Formula: C9H19NO4

Formula Weight: 205.25

ZSpharmac: Dexpanthenol Cena Supplement

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Product Name: Dexpanthenol Cena
CAS No: 81-13-0
Purity: 99%

Basic Info

Product Name:Dexpanthenol Cena
Other Names:D Panthenol
CAS:81-13-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless to Slightly Yellow Viscous Liquid or Semi Solid
EINECS No.:201-327-3
Storage:2-8°C
Provide:Dexpanthenol Cena MSDS;
Dexpanthenol Cena COA

What is Dexpanthenol Cena?

Dexpanthenol Cena is commonly known as provitamin B5. Panthenol can be divided into three forms: spheroid (DL-type), dextrorotatory body (D-type) and levorotatory body (L-type), of which only dextrorotatory body has biological activity, The levorotatory body has no biological activity. D-panthenol, also known as dexpanthenol, is an optically active stereoisomer of panthenol, the English name is dexpanthenol; D-pantothenyl aleohol.

Dexpanthenol Cena (D-panthenol) is a matching of D-pantothenic acid, a forerunner of coenzyme A, as well as an essential vitamin drug. It can be exchanged pantothenic acid and afterwards synthesized right into coenzyme A after entering the human body, promoting human healthy protein, fat as well as sugar. As a nutritional supplement, Dexpanthenol Cena is extensively made use of in the pharmaceutical, food, and cosmetic markets, and also certain preparations such as oral fluid, eye declines, multivitamin shots, washing Hair lotion, mousse, moisturizer, etc.

Dexpanthenol Cena Properties:

Melting point 64~69℃
alpha 30.5 º (c=5, H2O on anh. sub)
Boiling point 118-120 °C (2.7 mmHg)
density 1.20 g/mL at 20 °C (lit.)
refractive index 1.495-1.502
Fp 118-120°C/0.02m
storage temp. 2-8°C
solubility DMSO (Sparingly), Methanol (Slightly), Water (Sparingly)
pka13.03±0.20(Predicted)
form Viscous Liquid or Semi Solid
color Clear colorless to slightly yellow
PHpH (100g/l,25℃) : 8.5~10.5
optical activity[α]20/D +30±1°, c = 5% in H2O
Water Solubility soluble

 

Dexpanthenol Cena Uses

  1. Dexpanthenol Cena is used in hair care, a skin moisturizer, and to aid in skin wound healing, fight inflammation, and aid in post-sun repair.
  2. Dexpanthenol Cena is commonly made use of in medication, food, cosmetics as well as fluid preparations.
  3. Dexpanthenol Cena is a pharmaceutical intermediate and a precursor of vitamin B5.

Preparation of Dexpanthenol Cena

Weigh 3kg of D-(-)-pantolactone, add 10L of heating reactor; weigh 6L of ethyl acetate and add it to the reactor, heat and stir, add activated carbon 5g after reflux, decolorize for 30 minutes; suction filtration, The filtrate was added to a 25L container, and 12L of petroleum ether was added. After mixing evenly, the solid was allowed to stand for crystallization at 5°C for 2h; the solid was suction filtered, then the solid was vacuum dried at 40°C for 2h, and the filtrate was recovered; the solid was added to 5L of ethyl acetate, and heated to reflux with stirring. , add activated carbon 5g, decolorize for 30 minutes; filter, add the filtrate into a 25L container, add 10L petroleum ether, mix and stand for crystallization at 5°C for 2h; suction filtration, and then the solid is vacuum-dried at 40°C for 10 hours to obtain 2.7kg of white solid Yield 90%. 1.0kg of purified D-(-)-pantolactone and 580g of 3-amino-1-propanol were added to the reactor, heated to 50°C, reacted for 3h, and cooled to room temperature to obtain Dexpanthenol Cena The product is a clear, colorless and easily hygroscopic viscous liquid, and the finished product is 1.58kg, and the total product yield is 90%. The product has been tested by the above quality control method, and all quality control indicators are in compliance with the regulations, and the specific rotation is +30.8°.

Dexpanthenol Cena Absorption, Distribution and Excretion

absorb
Dexpanthenol Cena is soluble in water and alcohol, but insoluble in fat and oil-based substances. With an appropriate carrier, dexpanthenol penetrates easily into the skin. Penetration and absorption are reduced when dexpanthenol is administered as an oil/water formulation.
elimination route
Milk from nursing mothers on a normal diet contains about 2 micrograms of pantothenic acid per milliliter. About 70% of oral pantothenic acid is excreted unchanged in the urine and about 30% is excreted in the feces.
Circulation
Dexpanthenol Cena is easily converted to pantothenic acid, which is widely distributed in body tissues, mainly in the form of coenzyme A. The highest concentrations were found in the liver, adrenal glands, heart and kidneys.
Dexpanthenol Cena is easily converted to pantothenic acid, which is widely distributed in body tissues, mainly in the form of coenzyme A. The highest concentrations were found in the liver, adrenal glands, heart and kidneys. Milk from nursing mothers on a normal diet contains about 2 micrograms of pantothenic acid per milliliter. About 70% of oral pantothenic acid is excreted unchanged in the urine and about 30% is excreted in the feces.

Dexpanthenol Cena Performance

1. Superior deep hydrating efficiency: Panthenol has a small molecular weight, can effectively permeate the stratum corneum, infiltrate the stratum corneum on the surface of the skin, has a strong moisturizing impact, effectively improve rough skin, make skin soft and also non-sticky.

2. Accelerates wound healing: boosts the development of epithelial cells, speeds up the healing time of epidermal wounds, as well as repairs cells wounds; it has alleviative impacts on dermatitis, sunburn, as well as child diaper breakout.

A number of studies in computer mice have actually revealed that pantothenic acid can raise the productivity of fibroblasts. It helps in wound healing and also is therefore made use of in anti-aging products. Research studies have actually shown that in females aged 30-60, a facility containing panthenol and also niacinamide can enhance the indicators of skin aging.

3. Take care of hair: Panthenol can penetrate right into the hair, lasting moisturizing hair, improving hair radiance, reducing hair divides, protecting against dry skin and damage, and also repairing damaged hair.

After using shampoos or conditioners that contain panthenol, you can leave some sticky, clear residue on your hair. These substances encapsulate the hair and give it shine. Although not thickening and strengthening hair, this form of vitamin B5 acts as a lubricant to improve hair quality.

At the same time, in hair care products, panthenol can not only cover the surface of the hair for protection, but also penetrate deeply into the hair. In hair damage experiments (regular and bleached hair), panthenol was found to reduce breakage.

4. Nursing effect on nails: Panthenol can enhance hydration and improve nail flexibility.

Protective Effect of Dexpanthenol Cena on Cisplatin-Induced Nephrotoxicity in Rats

Cisplatin (CIS) is an antineoplastic representative utilized to deal with strong organ growths. Harmful side effects of CIS therapy consist of nephrotoxicity, neurotoxicity, ototoxicity, myelosuppression, and also hepatotoxicity. Dexpanthenol Cena (DEX) has antioxidant and anti-inflammatory residential or commercial properties as well as security against totally free radicals. We examined the protective impact of DEX against CIS-induced nephrotoxicity. The pets were separated into four groups of 10 pets each. The control group was given saline. The DEX group was treated with DEX for 10 days. The CIS team received single-dose CIS treatment. The DEX + CIS group received a solitary dosage of CIS followed by DEX for 10 days. The renal tubular injury, swelling as well as histopathological ratings were substantially greater in the CIS group than in the control group. Compared to the CIS team, the DEX + CIS group showed less tubular damage as well as swelling, in addition to lower histopathological evaluation scores. Significant cortical tubule damage and interstitial swelling were observed in the CIS team. The DEX+CIS team had a little less tubular damage, moderate tubular dilation, and also much less cast formation; in addition, the swelling was not as serious as that in the CIS group.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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