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Deoxyarbutin CAS 53936-56-4

Molecular Formula: C11H14O3

Formula Weight: 194.23

ZSpharmac: Deoxyarbutin Supplier

Product Name: Deoxyarbutin
CAS No: 53936-56-4
Purity: 99%

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Basic Info

Product Name:Deoxyarbutin
Other Names:4-[(Tetrahydro-2H-Pyran-2-yl)Oxy]phenol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:1308068-626-2
Provide:Deoxyarbutin MSDS;
Deoxyarbutin COA

What is Deoxyarbutin?

Deoxyarbutin is a new generation of cosmetic skin brightening and also lightening active representative, mostly made use of in high-grade whitening cosmetics, it can efficiently hinder the task of tyrosinase, regulate the manufacturing of melanin, conquer coloring, dilute skin black spots, has fast as well as durable skin whitening impact. Deoxyarbutin additionally has a solid antioxidant effect. The inhibitory impact of deoxyarbutin on tyrosinase is significantly far better than that of other whitening energetic representatives. Compared with the former, it is more secure Greater and much more secure, not only non-toxic and also non-irritating to the skin, yet also conveniently absorbed by the skin, a small amount of use can reveal whitening and also brightening effects, and is thought about to be an extremely safe cosmetic whitening active representative.

Deoxyarbutin Property

Melting point 88-89 °C(Solv: ligroine (8032-32-4))
Boiling point 349.8±32.0 °C(Predicted)
density 1.174
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
form Solid
color White to Off-White


Efficacy of Deoxyarbutin

Deoxyarbutin is an extremely trusted tyrosinase avoidance, which can significantly obstruct the development of melanin in the skin. In pet skin tests, deoxyarbutin can successfully prevent the task of tyrosinase as well as also the development of melanin in skin cells, promptly and likewise properly make the skin white, and likewise have various levels of whitening results on people with various skin shades. When you stop using this ingredient, the result can still be maintained for virtually 8 weeks, in addition to its depigmentation effect can be totally reversed after 8 weeks of quiting, and will not trigger long-term damages to melanocytes. Its performance is 10 times that of hydroquinone, which is the ordinary 350 times that of arbutin. As a result, as a brand-new generation of aesthetic lightening up as well as bleaching active representative, it is normally made use of in state-of-the-art bleaching cosmetics. Cosmetics with this product as an additive have actually been given in the U.S.A., Taiwan as well as also various other areas, and also will have unbelievably wide applications in the future lightening as well as skin treatment products market. In addition, together with the bleaching result, it also has numerous different other results. It can be viewed as an intermediate in the synthesis of compounds as well as likewise in the synthesis of liquid crystals.

Cyclopeptidealkaloids (see Number 1 for the architectural formula) is a typically happening material that has outstanding impacts in relaxing and anti-bacterial impacts. Shanghai Organic Academy of Chinese Academy of Sciences fully manufactured the compound with deoxyarbutin as the important intermediate. Additionally, this product can create a brand-new kind of liquid crystal product with water, lecithin, better fatty alcohols, non-ionic surfactants, and more. Due to the reality that it has strong skin permeability, the fluid crystal product comprised of this material as the text has the result of lightening skin. reliable.

The Synthetic Method of Deoxyarbutin

1. Hydroquinone direct etherification method: first dissolve hydroquinone and 3,4-dihydropyran in the solvent, and slowly add the solvent at room temperature. Use Fe2(SO4)3. xH2O is used as a catalyst, and the reaction in acetone can directly obtain deoxyarbutin. The defect of this method is that the product needs to be separated and purified by column chromatography, which is not conducive to industrial production.
2. Zhang Wenzheng used hydroquinone as a raw material, and through hydroquinone monobenzyl etherification, another phenolic hydroxyl group was catalyzed by self-made pyridine p-toluenesulfonate, successfully completed tetrahydropyran etherification, and a high yield Prepare hydroquinone protected by benzyl and tetrahydropyran respectively, and finally deoxygenated arbutin by catalytic hydrogenation to debenzyl. At the same time, different adsorbents including silica gel, calcium chloride, diatomaceous earth, activated carbon and sodium carbonate are added in the dehydrogenation process, and the final selection of alkaline anhydrous sodium carbonate can not only avoid the decomposition of the product under acidic conditions, but also The hydroquinone content can be reduced to below 20ppm, and the specific reaction scheme is as follows:


Precautions for Deoxyarbutin

Deoxyarbutin is easy to oxidize, as well as it is simple to alter color when placed in the existence of water. Focus on the formula:
1. Nitrogen filling;
2. Add anti-oxidants that can be compounded;
3. The home heating temperature need to not be greater than 80 ° C, and also it is better to include it to the reduced temperature level stage;
4. Fully research the formula to get rid of the result of staining.

About Products:
If you need Deoxyarbutin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company as an experienced Deoxyarbutin manufacturer and supplier, ZSpharmac will provide Deoxyarbutin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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