Zhishang Chemical

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Zhishang Chemical

Deoxyarbutin CAS 53936-56-4

Molecular Formula: C11H14O3

Formula Weight: 194.23

ZSpharmac: Deoxyarbutin Supplier

Product Name: Deoxyarbutin
CAS No: 53936-56-4
Purity: 99%

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Basic Info

Product Name:Deoxyarbutin
Other Names:4-(Tetrahydro-2H-Pyran-2-yloxy)Phenol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:1308068-626-2
Storage:Under Inert Gas (Nitrogen or Argon) at 2-8°C
Provide:Deoxyarbutin MSDS;
Deoxyarbutin COA

What is Deoxyarbutin?

Deoxyarbutin is a brand-new generation of aesthetic skin brightening and whitening active representative, generally used in sophisticated whitening cosmetics, it can successfully inhibit tyrosinase task, regulate the manufacturing of melanin, get over pigmentation, lighten skin black spots, with rapid as well as enduring skin whitening impact. Deoxyarbutin likewise has a strong antioxidant impact.
The repressive effect of deoxyarbutin on tyrosinase is dramatically better than that of various other whitening energetic agents. The whitening result is 350 times that of arbutin, 150 times that of kojic acid, and also 10 times that of hydroquinone. Compared to the previous, it is more secure. High, much more secure, not just safe and also non-irritating to the skin, yet likewise easily absorbed by the skin, bleaching and also brightening results can be displayed with a percentage of use, and also it is considered to be a very secure cosmetic whitening active agent.

Deoxyarbutin Property

Melting point 88-89 °C(Solv: ligroine (8032-32-4))
Boiling point 349.8±32.0 °C(Predicted)
density 1.174
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
form Solid
color White to Off-White


Deoxyarbutin Efficacy and Action

Deoxyarbutin is a truly reputable tyrosinase evasion, which has a considerable blocking effect on the growth of melanin in the skin. In pet dog skin tests, deoxyarbutin can successfully prevent the task of tyrosinase in addition to the growth of melanin in the skin cells, quickly as well as effectively make the skin white, in addition to furthermore has different levels of bleaching influence on people with different skin tone. When you quit using this energetic element, the effect can still be protected for virtually 8 weeks. After 8 weeks of use, the depigmentation result can be completely turned around, in addition to additionally it will not produce permanent problems to melanocytes. Its effectiveness is 10 times that of hydroquinone, which is typically 350 times of arbutin. As a result, as a new generation of aesthetic skin-lightening in addition to lightening energised representative, it is typically utilized in ingenious whitening cosmetics. Cosmetics with this product as an additive have really been given up the USA, Taiwan and additionally various other areas, in addition to have an actually large application in the future lightening along with skin treatment item market. Besides, it has numerous various other outcomes besides bleaching end result. It can be considered as an intermediate to produce substances, along with to make fluid crystals.
Cyclopeptide alkaloids (see Number 1 for the building formula) are normally taking place compounds that have impressive impacts in relaxing as well as furthermore anti-bacterial homes. The Chinese Academy of Sciences Shanghai Organic So deoxyarbutin was the important intermediate to completely manufacture the material. In addition to that, this item can establish a new liquid crystal thing with water, lecithin, higher fatty alcohol, non-ionic surfactant, etc. Because of its solid skin leaks in the structure, the liquid crystal item generally made up of this compound has an exceptional effect on skin lightening. remarkable end result.

Cyclopeptide alkaloids 结构式

Deoxyarbutin Synthesis Method

1. Direct etherification of hydroquinone: Hydroquinone and 3,4-dihydropyran are first dissolved in a solvent, and the solvent is slowly added at room temperature. Using Fe2(SO4)3﹒ xH2O is used as a catalyst, and deoxyarbutin can be directly obtained by the reaction in acetone. The defect of this method is that the product needs to be separated and purified by column chromatography, which is not conducive to industrialized production.
2. Zhang Wenzheng used hydroquinone as raw material, through the monobenzyl etherification of hydroquinone and the catalysis of another phenolic hydroxyl group under the catalysis of self-made pyridine p-toluenesulfonate, the tetrahydropyran etherification was successfully completed, and the yield was high The hydroquinone protected by benzyl and tetrahydropyran was prepared, and finally deoxyarbutin was synthesized by catalytic hydrogenation to remove the benzyl group. At the same time, different adsorbents including silica gel, calcium chloride, diatomaceous earth, activated carbon and sodium carbonate are added in the dehydrogenation process, and finally alkaline anhydrous sodium carbonate is selected, which can not only avoid the decomposition of the product under acidic conditions, but also The content of hydroquinone can be reduced to below 20ppm, and the specific reaction scheme is as follows:以对苯二酚为原料合成脱氧熊果苷反应路线图

Study on the Stability of Deoxyarbutin in Anhydrous Emulsion System

The whitening representative deoxyarbutin is a powerful tyrosinase prevention that is much safer than hydroquinone and also arbutin. Nonetheless, it is not heat-resistant in liquid remedy and also will decompose to hydroquinone. Pharmaceutical and also cosmetic emulsions are typically oil-in-water (o/w) or water-in-oil (w/o) systems; nonetheless, emulsions can be formulated without an aqueous stage to generate anhydrous solution systems. Anhydrous solution systems can give secure carriers for substances that are sensitive to hydrolysis or oxidation. As a result, in order to enhance the stability of deoxyarbutin in the solution, we selected the polyol-in-silicone oil anhydrous emulsion system as the basic solution of the study. The quantity of deoxyarbutin and the accumulation of hydroquinone in hydrated and anhydrous solutions at various temperature levels were assessed by an established high performance liquid chromatography (HPLC) method. The outcomes showed that water enhanced the decay of deoxyarbutin in the solution, and also the polyol-in-silicon oil, oil-based, anhydrous emulsion system provided a relatively stable setting for deoxyarbutin, postponing its deterioration at 25 ° C and also 45 ° C Degradation under C. Additionally, the structure of the internal hydrophilic phase, consisting of different quantities of glycerol and also propylene glycol, influenced the stability of deoxyarbutin. Therefore, these outcomes will be advantageous in the future use of deoxyarbutin in cosmetics as well as medications. The outcomes showed that water increased the decomposition of deoxyarbutin in the formulation, and the polyol-in-silicon oil, oil-based, anhydrous solution system offered a fairly stable atmosphere for deoxyarbutin, postponing its deterioration at 25 ° C and 45 ° C Deterioration under C. Moreover, the make-up of the internal hydrophilic phase, consisting of various quantities of glycerol and also propylene glycol, impacted the security of deoxyarbutin. As a result, these outcomes will certainly be useful in the future use deoxyarbutin in cosmetics and medicines. The outcomes revealed that water raised the decomposition of deoxyarbutin in the formula, and also the polyol-in-silicon oil, oil-based, anhydrous emulsion system provided a reasonably steady setting for deoxyarbutin, delaying its deterioration at 25 ° C and also 45 ° C Destruction under C. Additionally, the composition of the internal hydrophilic phase, consisting of various quantities of glycerol as well as propylene glycol, impacted the security of deoxyarbutin. As a result, these results will be valuable in the future use deoxyarbutin in cosmetics and medicines. Has varying quantities of glycerol and propylene glycol, which influence the stability of deoxyarbutin. For that reason, these results will be valuable in the future use deoxyarbutin in cosmetics and also medicines. Has differing quantities of glycerol as well as propylene glycol, which impact the security of deoxyarbutin. Consequently, these results will be valuable in the future use deoxyarbutin in cosmetics as well as medicines.

About Products:
If you need Deoxyarbutin, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Deoxyarbutin manufacturer and supplier, ZSpharmac will provide Deoxyarbutin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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