Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical

Dehydroacetic Acid CAS 520-45-6

Molecular Formula: C8H8O4

Formula Weight: 168.15

ZSpharmac: Dehydroacetic Acid Supplement

Share on facebook
Facebook
Share on twitter
Twitter
Share on linkedin
LinkedIn
Share on pinterest
Pinterest
Share on whatsapp
WhatsApp
Share on email
Email
Product Name: Dehydroacetic Acid
CAS No: 520-45-6
Purity: 99%

Navigation Bar

Basic Info

Product Name:Dehydroacetic Acid
Other Names:Dehydroacetic Acid, 98%
CAS:520-45-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Yellow or Cream Fine Crystalline Powder
EINECS No.:208-293-9
Storage:Store Below +30°C.
Provide:Dehydroacetic Acid MSDS;
Dehydroacetic Acid COA

What is Dehydroacetic Acid?

Dehydroacetic acid is also known as 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione, methylacetylpyranone, DHA. Those precipitated from water are white needle-like crystals or crystalline powders, and those precipitated from ethanol are prismatic crystals. Odorless. There is a weak sour taste. Melting point 109 ~ 110 ℃. Boiling point 269.9%, 132~133℃(0.667×103Pa). Solubility (25℃, g/100g): acetone 22, benzene 8, methanol 5, ether 5, ethanol 3, carbon tetrachloride 3, propylene glycol 1.7, olive oil 1.6, n-hexane 0.7, water <0.1, glycerin <0.1, Also soluble in caustic solutions. Not hygroscopic. The pH=4 of the saturated aqueous solution. Dehydroacetic acid is an intermediate in organic synthesis, a toughening agent, and a broad-spectrum food preservative, especially with strong antibacterial ability to mold and yeast, which is 2-10 times that of sodium benzoate, and is often used in the form of sodium salt. Preservative in fruit juice, fermented bean curd, pickles and cakes. However, excessive use is harmful to humans and animals. Many countries have strict regulations on the use of this preservative. The maximum residue limit specified in the United States is 65mg/kg, and the maximum residue allowed for food in Japan and Taiwan The limit is 0.5g/kg. my country’s food additive use standard GB2760-2014 stipulates that the limit of dehydroacetic acid in pickled vegetables and starch products is 1.0g/kg, and other butter, cakes, meat products, juice, seasoning and other products. The specified addition amount shall not exceed 0.3 ~ 0.5g/kg. Therefore, the accurate determination of dehydroacetic acid in food is a very important work to ensure food safety.

Dehydroacetic Acid Properties:

Melting point 111-113 °C (lit.)
Boiling point 270 °C (lit.)
density 1.1816 (rough estimate)
vapor pressure 0.001 hPa (20 °C)
refractive index 1.4611 (estimate)
Fp 157°C
storage temp. Store below +30°C.
solubility 2g/l
form Fine Crystalline Powder
pka5.53±0.40(Predicted)
color Light yellow or cream

 

Dehydroacetic Acid Uses

  1. Dehydroacetic acid is used as an intermediate in organic synthesis; as a paste for resin emulsions such as vinyl acetate solution and also plastic acrylic solution, it is likewise utilized as a paste for mixes of polyvinyl alcohol, carboxymethyl cellulose, starch, bone adhesive, and so on; recently it is a lot more extensively utilized It is utilized in adhesives, insect coils, feed, shampoo, toothpaste and also other fields; because this item has inhibitory result on mold and mildew, yeast, and gram bacilli, it is used as a mold inhibitor and preservative in medicine, cosmetics as well as food. GB2760-1996 stipulates that it can be made use of for fermented bean curd, various pickles and also initial orange juice.
  2. Dehydroacetic acid can advertise the growth of brain cells, boost mind function, boost knowledge and also brain, protect against senile dementia, and also advertise retinal development in infants as well as young kids.
  3. Dehydroacetic acid is bacteriostatic impact is basically not influenced by PH, however the antiseptic result is the most effective under neutral problems. It is additionally used as a food chemical. Residential guidelines can be used for the preservative of fermented bean curd, pickles and also initial orange sauce. The maximum use quantity is 0.3 g/kg.
  4. Dehydroacetic acid is an intermediate in organic synthesis, a strengthening representative, and also a broad-spectrum food chemical.Considering that its antibacterial homes were found in 1940, it has been taken notice of by lots of countries, and also has been permitted to be used for food conservation. As an artificial additive, dehydroacetic acid is allowed to be used in cheese, butter, margarine, sodas, fermented milk as well as lactic acid microorganisms beverages, soybean paste, packing, and so on. Salt dehydroacetate is generally utilized as a preservative. The product is also utilized in day-to-day cosmetics, fiber products, medicine (such as the therapy of ringworm), and the preservation of dental materials.

Production Method of Dehydroacetic Acid

Preparation of crude fish oil Take the fresh fish liver that has removed the gallbladder, washed and chopped, put it in a pot, add water, pass steam to 80 ° C, flow out the oil, filter, cool the filtrate to 0 ° C, precipitate solid fat, and filter under pressure , the filtrate is crude fish oil. Fish oil[water]→[80℃]oil quality[filtration]→crude fish oil or minced fish as raw material, minced and mixed with starch at 7-10℃, extracted with hexane for 15min, filtered to obtain filtrate. The filtrate was washed with sodium chloride solution, dehydrated by adding anhydrous sodium sulfate, and hexane was recovered to obtain crude fish oil. Minced fish [starch, hexane]→[7-10℃, 15min] filtrate [NaCl]→[anhydrous sodium sulfate] crude fish oil Preparation of refined fish oil Take crude fish oil, add sodium hydroxide ethanol solution to saponify, filter, The filtrate was acidified with acid, extracted with an organic solvent insoluble in water, the extract was washed with water, and the organic layer was removed. The aqueous layer was a light red or reddish-brown clear liquid, which was placed at 10°C for 30 minutes without solid precipitation to obtain refined fish oil. Crude fish oil [alkaline ethanol solution] → filtrate [organic solvent] → [HCl] extract [water washing] → refined fish oil pre-concentration, alcoholysis and ethyl esterification of refined fish oil, and urea inclusion crystallization method to saturate the fish oil The fatty acid with less degree is removed to obtain fish oil fatty acid ethyl ester. Refined fish oil [ethanol, urea inclusion crystal] → preparation of fish oil fatty acid ethyl ester DHA Put the fish oil fatty acid ethyl ester into the extraction tank, open the steel cylinder, after the CO2 is condensed, pressurize it to the set pressure by the high-pressure metering pump, and then preheat it. After heating to the working temperature, enter the extraction tank. SC-CO2 carries fish oil fatty acid ethyl ester into the rectification column, the components come out from the top of the column according to the solubility, and enter the separator to receive after decompression. Experimental conditions: the extraction pressure is 11-15MPa, and the extraction temperature is 35°C; the rectification pressure is 11-15MPa, and the rectification temperature is 40-85°C. Collect the EPA-rich fraction of 12-13.5MPa and the DHA-rich fraction of 14-15MPa, and measure by gas chromatography, EPA+DHA is purified to 90%. The EPA-rich fraction and the DHA-rich fraction are subjected to secondary extraction at 11.5-13MPa and 13.5-15MPa respectively, EPA is purified to 67%, and DHA is purified to more than 90%. Fish oil fatty acid ethyl ester [supercritical CO2 extraction] → [separation] DHA

Extraction of fish oil Mince herring leftovers, add half the amount of water, adjust pH to 8.5-9.0, keep warm for 45 minutes, add 5% salt, stir to dissolve, continue to keep warm for 15 minutes, filter, press filter residue, combine filtrate and pressing liquid , Centrifuge while hot to obtain herring oil. The total content of EPA and DHA in herring oil was 8.9%. Herring scraps [H2O, 5%NaCl] → [pH8.5-9] [filtration, centrifugation] → preparation of herring oil polyunsaturated fatty acid (PUFA) Herring oil was added with sodium hydroxide ethanol (95%) solution, Nitrogen-filled reflux saponification, the saponification liquid is cooled to 15-20 ° C, a large amount of fatty acid sodium salts are precipitated, squeezed and filtered, the filtrate is cooled to -20 ° C, and then pressure filtered. Add an equal volume of water to the filtrate, adjust pH to 3-4, and centrifuge for 10 min to obtain PUFA-I. Dissolve PUFA-I in ethanolic sodium hydroxide solution, cool at -20°C, filter under pressure, add a small amount of water to the filtrate, cool at -10°C, and filter Chemicalbook to remove cholesterol crystals. A small amount of water was added to the filtrate, cooled at -20°C, centrifuged for 5 minutes, the upper layer was poured out, and the lower layer of gelatin (PUFA sodium salt) was acidified and centrifuged for 10 minutes to obtain PUFA-II. The total content of EPA and DHA in PUFA-II was 64.8%. Herring oil [NaOH ethanol] → [nitrogen] saponification solution [cooling] filtrate [pH3-4] → [centrifugation] PUFA-I [NaOH ethanol] → PUFA-II

Using arachidonic acid as raw material, after desaturation, EPA is obtained. EPA is extended by C2 chain to obtain docosapentaenoic acid. Docosapentaenoic acid is desaturated to give DHA. Arachidonic acid [desaturation]→EPAEPA[C2 chain extension]→docosapentaenoic acid [desaturation]→DHA

At present, the high-vacuum distillation method, molecular distillation method, silver nitrate complex method, simple supercritical CO2 extraction and industrial chromatographic preparation process commonly used at home and abroad all have many drawbacks and deficiencies, and are not suitable for high-purity EPA and DHA. Industrial development. The supercritical multi-fluid precision rectification technology is used to directly separate high-purity EPA and DHA. It is operated under normal temperature conditions. The product is not easy to be oxidized and degraded. production.

The process of extracting fish oil is to use light lye to decompose the protein tissue of fish liver and destroy the binding relationship between protein and liver oil, so as to separate fish oil more fully. This method of liver oil is of good quality and low price, and many fish oil factories in my country use this method to produce fish oil.

The light alkali used in the traditional light alkali hydrolysis method to extract fish oil is a dilute solution of sodium hydroxide, and the salt is a sodium chloride solution, and the process is very mature. However, the waste liquid produced by the extraction process has a high content of sodium salt and cannot be further utilized, thus forming a new waste. According to the extraction principle of the light alkaline hydrolysis process, Yang Guane et al. replaced the sodium hydroxide and sodium chloride in the light alkaline hydrolysis process with potassium hydroxide and potassium nitrate, and the extraction rate and quality of fish oil remained stable; the waste residue and waste liquid after extraction of fish oil It contains a large amount of amino acids and proteins, which can be further utilized as raw materials of high-efficiency green fertilizers, and no new wastes are generated. The extraction method is as follows: after a certain amount of cod liver is homogenized in a homogenizer, add it to a three-necked flask, add half to one and a half volumes of water, stir and heat the water bath to 45-50°C, add 40% potassium hydroxide in two times Aqueous solution, adjust pH to 8-9, continue stirring to heat up to 80-90 ℃, keep warm for 30 minutes, add 4% potassium nitrate by weight of fish liver, continue stirring, salt out for 15 minutes, centrifuge while hot, and separate crude fish oil. Cod liver[water]→[45-50℃][4%KOH]→[pH8-9][80-90℃]→[30min][4%KNO3]→[15min][centrifugation]→crude fish oil

Product determination method: peroxide value-sodium thiosulfate back-dropping method; acid value-base titration method; iodine value-sodium thiosulfate titration method; saponification value-hydrochloric acid back-dropping method; DHA, EPA content determination-gas chromatography . Results (n=3): fish oil extraction rate was 24.4%; acid value was 2.58; iodine value was 309; saponification value was 178.7; peroxide value was 0.070%; DHA content was 19.60%.

The Detection Method of Dehydroacetic Acid

With the help of the concept and also concept of HPLC (High Performance Fluid Chromatography), UPLC covers brand-new technologies such as tiny bit packing, really reduced system volume and rapid discovery techniques, which boosts the analytical throughput, sensitivity and chromatographic peak capability. Compared with traditional HPLC, the speed, sensitivity and also resolution of UPLC are 9.0, 3.0 and 1.7 times that of HPLC, specifically. It shortens the analysis time, reduces the amount of solvent, as well as minimizes the cost of evaluation. At present, UPLC approach is primarily made use of in the fields of medicine, food, setting, and biochemical analysis. Wang Feng developed an approach for the resolution of dehydroacetic acid in various foods by ultra-high efficiency liquid chromatography (UPLC). Methods The CAPCELLPAKMG-C18 column was utilized, methanol-0.02 mol/L ammonium acetate (pH7.0 ~ 8.5)= 10 ∶ 90 as the mobile phase, the flow rate was 0.5 mL/min, the column temperature level was 30 ℃, the discovery wavelength was 293nm, the standard enhancement The recuperations varied from 97.6% to 101.2%, the minimum detection limitation was 1 μg/ mL, as well as the family member standard deviation of the method precision was less than 10%.

HPCE is just one of one of the most rapidly developing logical approaches over the last few years. It is a type of liquid-phase separation innovation that uses high-voltage electric field as the driving force and also vein as the separation channel to attain splitting up according to the distinctions in the movement and circulation behavior of each component in the sample. This method integrates the common advantages of chromatography and electrophoresis innovation, has a variety of various separation systems, can fulfill the food analysis requirements of complicated matrices to a big degree, and is more and more widely utilized in the field of food as well as drug analysis. Zhang Lichun et al. developed a high-performance capillary electrophoresis (HPCE) method for the synchronised resolution of benzoic acid, sorbic acid, dehydroacetic acid, and methylparaben, ethylparaben, propylparaben, and also butylparaben in drinks. ester method. Under the ideal problems of 40 mmol/L borax salt buffer system, splitting up voltage of 25 kV, pH of 9.35, discovery wavelength of 200 nm, and also column temperature level of 20 ° C, the 7 preservatives were entirely divided within 14 minutes.

GC separates the mix into solitary elements and then goes into the MS for discovery and also evaluation, which can quickly and conveniently recognize the splitting up as well as detection of numerous components of complex substances. Lei Ningsheng et al. made use of GC-MS to detect dehydroacetic acid in fresh as well as wet rice noodles. The example was vortexed with dichloromethane, extracted by ultrasonic, and also concentrated at high speed after centrifugation. The concentrate was divided by DB-5MS capillary column, as well as ionized by EI resource The discovery limit was 10 μg/ kg, the recuperation price was 87.6% -113.0%, and also the loved one standard deviation was 3.54% -6.15%. Tang Shuangshuang used gas chromatography-mass spectrometry to establish dehydroacetic acid in meat items. At the same time, 3 anti-oxidants and 7 preservatives were divided as well as figured out. The minimal discovery limitation of 10 substances was 0.2-0.8 mg/kg, and also the recuperation range was 89.6% to 97.8%.

Ultra-high efficiency liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was utilized to at the same time identify 11 sort of preservatives and 6 kinds of anti-oxidants in seasonings. mm, 1.7 μm) separation, 20 mmol/L ammonium acetate aqueous solution-acetonitrile as mobile phase, gradient elution, as well as MS/MS discovery in negative ion numerous reaction surveillance (MRM) mode of electrospray ion source. Source temperature: 120 ℃; Blood vessel voltage: 3.1 kV; Photomultiplier voltage: 650V; Desolvation temperature: 350 ℃; Desolvation gas (nitrogen) circulation: 600L/h; Crash gas (argon) flow: 350L/h; Cone gas circulation: 50L/h; retention time of dehydroacetic acid is 6.65 min, mass spectrometry parameters are parent ion 167m/z, product ion 83m/z (quantitative ion) and 123m/z, discovery limitation is 5mg/kg, The recoveries ranged from 94% to 118%, as well as the RSD values were within 7%. Chen Xiaohong et al. likewise used ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) to simultaneously establish dehydroacetic acid in rice white wine as well as a glass of wine, as well as attained excellent outcomes.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Dehydroacetic Acid Quotation