Dehista Chlorpheniramine Maleate CAS 113-92-8

Molecular Formula: C20H23ClN2O4

Formula Weight: 390.86

ZSpharmac: Dehista Chlorpheniramine Maleate Supplement

Product Name: Dehista Chlorpheniramine Maleate

CAS No: 113-92-8

Purity: 99%

Basic Info

Product Name:	Dehista Chlorpheniramine Maleate
Other Names:	Chlorpheniramine Maleate
CAS:	113-92-8
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Pharmaceutical Raw Materials
Appearance:	White Crystalline Powder
EINECS No.:	204-037-5
Storage:	2-8°C
Provide:	Dehista Chlorpheniramine Maleate MSDS； Dehista Chlorpheniramine Maleate COA

What is Dehista Chlorpheniramine Maleate?

Dehista Chlorpheniramine Maleate, used for allergic rhinitis, colds and sinusitis and allergic skin conditions such as urticaria, allergic drug eruption or eczema, angioedema, itching due to insect bites.
Dehista Chlorpheniramine Maleate is one of the most commonly used antihistamines in veterinary, small animals. Although not generally used as an antidepressant or anxiolytic, Dehista Chlorpheniramine Maleate appears to have these properties, is a drug used for allergic symptoms, and belongs to the first generation of histamine H1 receptor antagonists (also known as antihistamines) .

Dehista Chlorpheniramine Maleate Properties:

Melting point	130-135 °C (lit.)
alpha	-1～+1°(D/20℃)(c=5,DMF)
density	1.1984 (rough estimate)
refractive index	1.6800 (estimate)
Fp	9℃
storage temp.	2-8°C
solubility	Freely soluble in water, soluble in ethanol (96 per cent)
form	neat
PH	4.0～5.5 (10g/l, 25℃)
Water Solubility	1-5 g/100 mL at 21 ºC

Dehista Chlorpheniramine Maleate Uses

Dehista Chlorpheniramine Maleate The antihistamine result of this item exceeds that of diphenhydramine and also promethazine, with small dose as well as mild negative effects. For urticaria, vasodilatory rhinitis, colds, bronchial asthma, rhinitis, get in touch with dermatitis, and also for allergies, insect attacks as well as motion sickness caused by drugs and food.
Dehista Chlorpheniramine Maleate is utilized in antihistamines. Comparable to clotrimide, brompheniramide is also an antihistamine. The manufacturing technique of brompheniramine is likewise similar to that of clotrimide, other than that the starting material is replaced by a bromobenzene compound.

Dehista Chlorpheniramine Maleate Pharmacological Actions and Interactions

Pharmacological Action：

Dehista Chlorpheniramine Maleate is an H1 receptor antagonist, as well as its chemical framework is an alkylamine. It can mainly competitively block histamine H1 receptors on allergic reaction target cells, to ensure that histamine can not bind to H1 receptors, consequently inhibiting the allergic reactions triggered by it. However chlorpheniramine does not impact the metabolic rate of histamine, neither does it stop the launch of histamine in the body. Dehista Chlorpheniramine Maleate likewise has central repressive as well as anticholinergic effects, so after taking the drug, there will be sleepiness, dry mouth, constipation, thickened sputum and dry nasal mucosa. After a long period of technique in clinical, it is thought that chlorpheniramine has solid antihistamine impact, small dosage and small side effects. The antihistamine result of chlorpheniramine is stronger than that of diphenhydramine and promethazine, but the central inhibitory impact is weaker, and the anticholinergic result is likewise weak. Because of light negative responses such as sleepiness, it is suitable for kids and also people who require to function throughout the day. Dehista Chlorpheniramine Maleate still has the result of reducing tracheal secretion and also gastric acid secretion. Prior to the introduction of a new generation of antihistamines, it was one of the most generally made use of antihistamine in clinical technique.

Medicine Interactions：

① Combination with alcohol and also other main nerve system depressants, such as barbiturates, hypnotics, opioid anesthetics, anti-anxiety sedatives, as well as antiepileptic medications, can enhance the main nerve system depressant effect of antihistamines, yet the brand-new Antihistamines have weak communications. ② Mix with other anticholinergic drugs, such as atropine, tricyclic antidepressants as well as monoamine oxidase preventions, can enhance the anticholinergic impact of these medications. ③ When some antihistamines metabolized by the liver are integrated with liver medicine enzyme inhibitors, damaging responses might boost. ④ Some antihistamines might mask the toxicity signs and symptoms of particular ototoxic medications, such as aminoglycoside anti-biotics. ⑤ Antihistamines can prevent the skin test reaction of allergenic materials, so all antihistamines need to be quit a number of days prior to the skin test to prevent influencing the skin test outcomes. ⑥ Mix of this product with phenytoin may inhibit its liver metabolic rate as well as boost its poisoning, so the focus of phenytoin need to be checked. ⑦ Can improve the effects of amantadine, anticholinergic medicines, haloperidol, phenothiazines as well as sympathomimetic drugs. ⑧ Drinking alcohol or taking central nervous system depressants at the same time can improve the effectiveness of this product. 374 words (Less than 1 web page).

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Dehista Chlorpheniramine Maleate Tablets

1 What is the primary function?
Dehista Chlorpheniramine Maleate Tablets is an anti-allergic substance abuse to deal with skin allergic reactions: urticaria, dermatitis, dermatitis, pruritus, etc. It can additionally be used for allergic rhinitis, medication as well as food allergies.
2 That should not take it?
Have experienced allergic signs and symptoms such as breakout, itching, or swelling of face, lips, tongue, and problem breathing while taking this product.
Neonatal and also early babies must not use this medication.
3 Just how should it be taken?
This product is short-lived as well as you may require to take it a number of times a day. It is suggested to use it at the same time each time daily for far better healing result.
4 Usual side effects that might happen?
Typical adverse effects include: sleepiness, thirst, polyuria, sore throat, drowsiness, etc 5 Do’s and Do n’ts of Taking Your Medication
First: individuals with bladder neck obstruction, pyloric and also duodenal blockage, severe constipation, hyperthyroidism, glaucoma, peptic ulcer, high blood pressure as well as prostatic hypertrophy, please utilize it with caution under the advice of a medical professional.
Second: Anti-allergic drugs might mask the allergy of the skin test. If you need to do a skin test, it should be done 48 hours after you stop taking this drug.
1. Don’t: Do not utilize the medicine for more than 7 days in a row. If your symptoms do not boost after 7 days of medicine, or if you have signs such as headache, rash, or fever, consult your medical professional instantly.Children and elderly patients should take it under the guidance of a specialist.
2. Don’t: If you feel dizzy or tired after taking the medicine, please stop engaging in activities that require concentration, such as driving and mechanical operation.
3. Don’t: Avoid overheating in hot weather or during exercise, because this medicine can reduce sweating and make people more prone to heat stroke.
Four do not: avoid drinking alcohol, so as not to aggravate certain side effects.

Production method of Dehista Chlorpheniramine Maleate

By 2-chlorobenzyl pyridine obtained by two-step condensation. In a dry reaction pot, add sodium ammonia and anhydrous toluene, heat to reflux, and drop 2-p-chlorobenzylpyridine and bromoacetaldehyde diethyl acetal simultaneously. After the addition was completed, the reaction was refluxed for 8h. After cooling and standing, the toluene solution was taken, and the solid was dissolved in a small amount of water and extracted with toluene. The extract was combined with the toluene solution, washed with water until neutral, and the toluene was recovered to obtain 3-p-chlorobenzene-3-(2-pyridyl)-propionaldehyde diethyl acetal. It was mixed with DMF and added to the reaction pot, and the mixed solution of formic acid and water was added under stirring. Heated to 110-120°C for 2h, and 150-160°C for 3h. Cool, recover DMF under reduced pressure, dilute with heating water, and adjust pH to 14 with lye. Then extract with toluene, wash the extract with water until neutral, recover toluene, then distill under reduced pressure, collect fractions at 150-190° C. to obtain cDehista Chlorpheniramine Maleate.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vission
Become the most trusted chemical supplier in the world
Our Business Philososphy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.