Zhishang Chemical

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Zhishang Chemical

D-(-)-Salicin CAS 111-42-2

Molecular Formula: C13H18O7

Formula Weight: 286.28

ZSpharmac: D-(-)-Salicin Supplier

Product Name: D-(-)-Salicin
CAS No: 111-42-2
Purity: 99%

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Basic Info

Product Name:D-(-)-Salicin
Other Names:Salicin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Fine Crystalline Powder
EINECS No.:205-331-6
Provide:D-(-)-Salicin MSDS;
D-(-)-Salicin COA

What is D-(-)-Salicin?

D-(-)-Salicin is also known as “salicin” and “salicin”. Molecular formula C13H18O7. Molecular weight 286.27. Colorless crystal or white powder. Melting point 199~202℃, relative density 1.43, [α] 25-62°~-67° (in 3% solution), -45.6° (in 0.6%, in absolute ethanol). Soluble in water, alcohol, alkali and glacial acetic acid, insoluble in ether and chloroform. The aqueous solution is neutral and bitter. Exist in willow leaves, flowers and poplar bark.It can be used for qualitative as well as quantitative analysis of celebrity anise maple and its associated preparations.

D-(-)-Salicin Property

Melting point 196-202 °C
alpha -61.5 º (c=5, water)
Boiling point 388.65°C (rough estimate)
density 1.4340
refractive index -62 ° (C=3, H2O)
storage temp. 2-8°C
solubility 36g/l
form Fine Crystalline Powder
color White
Water Solubility 36 g/L (15 ºC), 250 g/L (60 ºC)


D-(-)-Salicin Uses

  1. D-(-)-Salicin has the effects of treating colds, fever and infection, and relieving arthritis pain and low back pain.
  2. D-(-)-Salicin, a non-phenolic glucoside compound extracted from meadows, is mainly used as a substitute for quinine.
  3. D-(-)-Salicin is used for antipyretic, analgesic and anti-rheumatic.
  4. D-(-)-Salicin is a substrate for the determination of β-glucosidase. nitric acid reagent.

Effect of D-(-)-Salicin on Xylan

Amongst different carbon resources, xylan was discovered to be the only inducer of endoxylanase production by Penicillium janthinellum MTCC 10889 in immersed societies. Endoxylanase synthesis in xylan-induced cultures was initially hindered following synchronised xylose enhancement, potentially through an inducer exclusion mechanism, but it recovered and also reached optimum levels at a later growth stage (120 h). Added xylose after 30 hours of development might not apply its full repressive effect. Although sugar was shown to be an extra potent repressor than xylose, supplements with D-(-)-Salicin (an alcoholic β-glucoside consisting of d-glucose) as well as pure xylan caused a rise in enzyme synthesis by ca. 3.22-fold, followed by a continual high-yield enzyme at least up until the 144th hour of growth. Salicin was considerably less inducible in xylan-inducing cultures when included after 30 hours of development. Adding D-(-)-Salicin as well as xylan helped to partially get over the repressive effect of xylose and glucose. The failing of D-(-)-Salicin to restore endoxylanase synthesis in actinomycin D and also cycloheximide prevented xylan-induced societies, recommending that salicin was incapable to start afresh synthesis of the enzyme.

The Difference Between Extracting and Synthesizing D-(-)-Salicin

Deuterium NMR characterization of the all-natural abundance of 4 commercially readily available samples (Kahlbaum, Aldrich, Fluka, along with Extrasynthese) of D-(-)- Salicin in comparison with 2 drawn out examples from Salix Humboldt and also Salix sativa and one synthetic product, contrasted pentaacetic acid derivatives 2 as well as reported diacetyl salicyl alcohol4. Product 2 from S. humboldiana and also samples from salicin Kahlbaum revealed average (D/H) aromatic values of 117 and also 121 ppm, while for the remainder values of 146, 154, 153 and also 150 ppm were observed, Thus it was revealed that the salicin Kahlbaum was derived from the remove. The (D/H) worths at the 5′ as well as 6′ placements of the sugar moiety suggest theories regarding the origin of the glucose residues, distinguishing those from C3 or C4 plants. Analysis of 4, derived from 3, formed in the β-glucosidase hydrolysis of salicin 1, exposed a trend (D/H)4(para) > (DH) in indigenous samples from S. purpurea and Kahlbaum 3(meta) concerning (D/H)5( meta) > (D/H)6(ortho), the initial example of a deuterium pattern for an ortho-oxo-substituted phenylpropane. Three samples from commercial 1 (Aldrich, Fluka, as well as Extrasynthese) and also the synthetic sample showed practically the very same deuterium content (about 153 ppm) at positions 4 and also 6, while for both meta placements (D/H)3 > (D/ H)5 (about 162 as well as 140 ppm, specifically). Item 4 was the acid-catalyzed deuteration obtained from 3, revealing differential deuterium incorporation at the two meta-positions (ortho/para to the activated phenolic hydroxyl group).

Production Method of D-(-)-Salicin

It is prepared by extracting the bark and leaves of willow plants with hot water. Poplar and willow trees are rich in herbivore-fighting compounds called salicin, the original source of the widely used painkiller aspirin.

About Products:
If you need D-(-)-Salicin as a cosmetic raw material, please contact our service personnel directly, and we will provide you with high-quality products at the best price.
As an experienced D-(-)-Salicin manufacturer and supplier, ZSpharmac will provide D-(-)-Salicin raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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