Zhishang Chemical

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Zhishang Chemical

D-Phenylalanine CAS 673-06-3

Molecular Formula: C9H11NO2

Formula Weight: 165.19

ZSpharmac: D-Phenylalanine Supplier

Product Name: D-Phenylalanine
CAS No: 673-06-3
Purity: 99%

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Basic Info

Product Name:D-Phenylalanine
Other Names:(R)-Phenylalanine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to off-White Powder
EINECS No.:211-603-5
Storage:Store at RT.
Provide:D-Phenylalanine MSDS;
D-Phenylalanine COA

What is D-Phenylalanine?

The scientific name of phenylalanine is α-amino-β-phenylpropionic acid, which is a kind of α-amino acid. There are L-type, D-type as well as racemic DL-type, among which L-type is among the crucial amino acids for human body. Phenylalanine is a brand-new amino acid that was first discovered by Schulze in addition to Barbieri in the late 1880s as well as separated from lupine seedlings, as well as an empirical chemical formula was suggested as C9H11NO2. Erlemeyer and additionally Lipp first efficiently synthesized phenylalanine by chemical synthesis in 1882, yet did not explore its spatial arrangement. After that Fischer inadvertently isolated phenylalanine when he hydrolyzed casein with hydrochloric acid in 1901. Ever since, the study on phenylalanine has actually been much more strengthened. D-phenylalanine is a sort of α-amino acid, its physical state is white powder or white crystalline solid at area temperature level, its melting point is 283 ° C, its isoelectric point (25 ° C )is 5.48, its solubility in water is 27g/L at 25 ° C, Rather soluble in methanol as well as also ethanol, insoluble in ether, and so on. Particular rotation [α] 25D=+34.5 (c=1.0, WATER). Like various other D-amino acids, D-phenylalanine is an extremely important chiral intermediate in all-natural synthesis, brand-new medicine development, synthesis of polypeptide substances, and so on, and also as a result of the special framework as well as additionally task of D-phenylalanine Sexuality is gaining a raising number of focus.

D-Phenylalanine Property

Melting point 273-276 °C(lit.)
Boiling point 293.03°C (rough estimate)
alpha 33.5 º (c=2, H2O)
density 1.1603 (rough estimate)
refractive index 34 ° (C=2, H2O)
storage temp. Store at RT.
solubility Methanol (Slightly), Water (Slightly)
form Powder
pka2.2(at 25℃)
color White to off-white
Water Solubility 27 g/L (20 ºC)


D-Phenylalanine Uses

  1. D-Phenylalanine is used in biochemical research study.
  2. D-Phenylalanine is a drug intermediate, primarily made use of to deal with as well as avoid weakening of bones, cardio, diabetes, arteriosclerosis and other conditions.
  3. D-phenylalanine is utilized as a pharmaceutical intermediate or basic material for the synthesis of nateglinide as well as various other drugs.

Application of D-Phenylalanine

Studies have found that L-phenylalanine exists widely in nature and is one of the essential amino acids for the human body. It mainly exists in various proteins, such as fibrin and hemoglobin. L-phenylalanine also plays an important role in the secretion of thyroid hormones, hair and skin melanin. As an unnatural amino acid, D-phenylalanine has similar physical and chemical properties to L-phenylalanine except that it cannot directly participate in the synthesis of human protein, and D-phenylalanine is due to its special chiral structure and biological activity. It has incomparable application value of L-phenylalanine in the fields of industry, agriculture, food, medicine and pesticides. In light industrial production, it has become more and more common to apply unnatural amino acids to the production of cosmetics to improve and enhance product quality and performance. For example, some manufacturers add amino acids to facial cleanser. The pH of such products is closer to that of human skin than in the past, so it is gentle and skin-friendly, non-irritating and can protect the skin. In the biochemical reagent industry, since D-amino acid basically does not participate in human metabolism, the half-life of antibiotic drugs with D-amino acid structure in human metabolism is significantly longer than that of drugs with L-amino acid structure, so about D-amino acid derivatives in hand Demand for sex drug research is also on the rise. Among them, biochemical reagents such as N-tert-butoxycarbonyl-D-phenylalanine (BOC-D-phenylalanine) and fluorenylmethoxycarbonyl-D-phenylalanine (FMOC-D-phenylalanine) are all made of D-phenylalanine amino acids as substrates for derivatization synthesis.

At present, D-phenylalanine is often seen active in the fields of medicine and pesticides. D-phenylalanine can prevent the activity of enkephalin kinase and inhibit the decomposition of enkephalin, so it is applied to enkephalin and kephalin inhibitors as diuretics and anti-addiction drugs. Drugs synthesized by D-phenylalanine can also be used to prevent and treat Marek’s disease. D-phenylalanine is also partly used in the treatment of hypertension and diabetes drugs. D-phenylalanine is also widely used as a raw material for the treatment of arthritis, depression and other drugs. In addition, there are many other important compounds that require D-phenylalanine to be prepared, such as: pyrrolidone polypeptide compound, carrier α-amidate for biofilm transmission, AIDS (HIV-1) protease inhibitor, Bombesin receptor antagonists for the treatment of sexual dysfunction, new NEP and ACE inhibitors hydroxamic acid derivatives, N-(amido-alkyl)-4-3-hydroxybenzene for detoxification Base-piperidine and its derivatives, growth inhibitor analogues for the treatment of gastrinoma, drugs for the prevention and treatment of arteriosclerosis, analgesics, peptide-based antithrombotics, neurological disorders, metalloproteinase inhibitors, anti D-phenylalanine is used in fungal drugs and organotin pesticides. At present, D-phenylalanine is mainly used as the raw material of the famous antidiabetic drug nategliner and the antitumor drug Baishixin.

Diethanolamine Sigma Induces Differential DNA Synthesis in Hepatocytes

In the past more than a century, the production and preparation methods of amino acids have always been one of the research hotspots. At present, the research on the production method of L-phenylalanine has been relatively mature, mainly including direct fermentation method, enzymatic method and chemical synthesis method. However, D-phenylalanine is an unnatural amino acid that is difficult to obtain from natural products, and it cannot be prepared by direct fermentation. The chemical synthesis production process is complex, requiring high equipment and making it difficult to produce on a large scale. With the continuous expansion of the application of D-phenylalanine in light industry, medicine, pesticide, food and other fields, the market demand will also continue to increase, so look for D-phenylalanine with simple process and cheap raw materials The preparation method of acid has become one of the research directions of chemists. At present, the methods for preparing D-phenylalanine mainly include resolution method, biological method and asymmetric chemical synthesis method, among which the asymmetric synthesis method, especially the asymmetric catalytic hydrogenation method, has shown broad prospects.

About Products:
If you need D-Phenylalanine as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced D-Phenylalanine manufacturer and supplier, ZSpharmac will provide D-Phenylalanine raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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