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D-Phenylalanine CAS 673-06-3

Molecular Formula: C9H11NO2

Formula Weight: 165.19

ZSpharmac: D-Phenylalanine Supplier

Product Name: D-Phenylalanine
CAS No: 673-06-3
Purity: 99%

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Basic Info

Product Name:D-Phenylalanine
Other Names:(R)-Phenylalanine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Powder
EINECS No.:211-603-5
Storage:Store at RT.
Provide:D-Phenylalanine MSDS;
D-Phenylalanine COA

What is D-Phenylalanine?

The taxonomic name of phenylalanine is α-amino-β-phenylpropionic acid, which is a kind of α-amino acid. There are L-type, D-type and also racemic DL-type, among which L-type is among the vital amino acids for body. Phenylalanine is a brand-new amino acid that was first uncovered by Schulze and likewise Barbieri in the late 1880s as well as likewise isolated from lupine seed startings, as well as also an empirical chemical formula was recommended as C9H11NO2. Erlemeyer in addition to Lipp at first effectively synthesized phenylalanine by chemical synthesis in 1882, yet did not discover its spatial plan. Ever since, the research study on phenylalanine has actually been much more strengthened. D-phenylalanine is a kind of α-amino acid, its physical state is white powder or white crystalline solid at area temperature level, its melting point is 283 ° C, its isoelectric factor (25 ° C )is 5.48, its solubility in water is 27g/L at 25 ° C, A little soluble in methanol as well as also ethanol, insoluble in ether, and so on. Specific turning [α] 25D=+34.5 (c=1.0, H2O). Like different other D-amino acids, D-phenylalanine is a really crucial chiral intermediate in organic synthesis, brand-new medication growth, synthesis of polypeptide compounds, and so on, in addition to due to the unique framework and also job of D-phenylalanine Sexuality is obtaining an expanding number of interest.

D-Phenylalanine Property

Melting point 273-276 °C(lit.)
alpha 33.5 º (c=2, H2O)
Boiling point 293.03°C (rough estimate)
density 1.1603 (rough estimate)
refractive index 34 ° (C=2, H2O)
storage temp. Store at RT.
solubility Methanol (Slightly), Water (Slightly)
pka2.2(at 25℃)
form Powder
color White to off-white
Water Solubility 27 g/L (20 ºC)


Application of D-Phenylalanine

Research studies have located that L-phenylalanine exists widely in nature and is just one of the crucial amino acids for the human body. It primarily exists in different proteins, such as fibrin as well as hemoglobin. L-phenylalanine additionally plays a vital role in the secretion of thyroid hormonal agents, hair as well as skin melanin. As an unnatural amino acid, D-phenylalanine has similar physical and chemical buildings to L-phenylalanine other than that it can not directly take part in the synthesis of human protein, as well as D-phenylalanine is because of its special chiral structure and organic task. It has unparalleled application value of L-phenylalanine in the fields of industry, farming, food, medication and chemicals. In light industrial production, it has actually become more and more typical to use abnormal amino acids to the manufacturing of cosmetics to enhance and boost item quality and performance. For example, some producers add amino acids to facial cleanser. The pH of such products is closer to that of human skin than in the past, so it is gentle and skin-friendly, non-irritating and can protect the skin. In the biochemical reagent market, considering that D-amino acid primarily does not participate in human metabolic process, the half-life of antibiotic drugs with D-amino acid structure in human metabolism is considerably longer than that of drugs with L-amino acid structure, so regarding D-amino acid derivatives in hand Need for sex drug research is likewise growing. Among them, biochemical reagents such as N-tert-butoxycarbonyl-D-phenylalanine (BOC-D-phenylalanine) and fluorenylmethoxycarbonyl-D-phenylalanine (FMOC-D-phenylalanine) are all made from D-phenylalanine amino acids as substratums for derivatization synthesis.

Presently, D-phenylalanine is frequently seen active in the fields of medication and pesticides. D-phenylalanine can prevent the task of enkephalin kinase and hinder the disintegration of enkephalin, so it is related to enkephalin as well as kephalin preventions as diuretics and also anti-addiction drugs. Drugs synthesized by D-phenylalanine can likewise be made use of to avoid as well as treat Marek’s illness. D-phenylalanine is also partly used in the treatment of hypertension and also diabetes mellitus drugs. D-phenylalanine is likewise extensively used as a basic material for the therapy of joint inflammation, anxiety and other medicines. Additionally, there are numerous various other important compounds that need D-phenylalanine to be prepared, such as: pyrrolidone polypeptide substance, provider α-amidate for biofilm transmission, AIDS (HIV-1) protease inhibitor, Bombesin receptor villains for the therapy of sexual dysfunction, new NEP and ACE inhibitors hydroxamic acid by-products, N-(amido-alkyl)-4 -3-hydroxybenzene for detoxification Base-piperidine and also its by-products, growth prevention analogues for the therapy of gastrinoma, drugs for the avoidance and also therapy of arteriosclerosis, anesthetics, peptide-based antithrombotics, neurological disorders, metalloproteinase preventions, anti D-phenylalanine is utilized in fungal medications and also organotin pesticides. Presently, D-phenylalanine is mainly made use of as the raw material of the renowned antidiabetic medication nategliner and the antitumor medication Baishixin.

Preparation of D-phenylalanine

In the past more than a century, the production and preparation methods of amino acids have always been one of the research hotspots. At present, the research on the production method of L-phenylalanine has been relatively mature, mainly including direct fermentation method, enzymatic method and chemical synthesis method. However, D-phenylalanine is an unnatural amino acid that is difficult to obtain from natural products, and it cannot be prepared by direct fermentation. The chemical synthesis production process is complex, requiring high equipment and making it difficult to produce on a large scale. With the continuous expansion of the application of D-phenylalanine in light industry, medicine, pesticide, food and other fields, the market demand will also continue to increase, so look for D-phenylalanine with simple process and cheap raw materials The preparation method of acid has become one of the research directions of chemists. At present, the methods for preparing D-phenylalanine mainly include resolution method, biological method and asymmetric chemical synthesis method, among which the asymmetric synthesis method, especially the asymmetric catalytic hydrogenation method, has shown broad prospects.

About Products:
If you need D-phenylalanine as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced D-phenylalanine manufacturer and supplier, ZSpharmac will provide D-phenylalanine raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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