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D-Panthenol CAS 81-13-0

Molecular Formula: C9H19NO4

Formula Weight: 205.25

ZSpharmac: D-Panthenol Supplier

Product Name: D-Panthenol
CAS No: 81-13-0
Purity: 99%

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Basic Info

Product Name:D-Panthenol
Other Names:Dexpanthenol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Slightly Yellow Liquid
EINECS No.:201-327-3
Provide:D-Panthenol MSDS;
D-Panthenol COA

What is D-Panthenol?

Dexpanthenol (D-panthenol) is the equivalent of D-pantothenic acid, the precursor of coenzyme A, and also a vital vitamin medication. It can be converted into pantothenic acid in the body and afterwards manufactured right into coenzyme A, which promotes human protein, fat, and also sugar. Metabolism of course, protect the mucous membrane as well as radiance of the skin surface, and also avoid the event of conditions. Hair lotion, mousse, moisturizer, and so on.

D-Panthenol Property

Melting point 64~69℃
alpha 30.5 º (c=5, H2O on anh. sub)
Boiling point 118-120 °C (2.7 mmHg)
density 1.20 g/mL at 20 °C (lit.)
vapor pressure 0Pa at 25℃
refractive index 1.495-1.502
Fp 118-120°C/0.02m
storage temp. 2-8°C
solubility DMSO (Sparingly), Methanol (Slightly), Water (Sparingly)
form Viscous Liquid or Semi Solid
color Clear colorless to slightly yellow
PHpH (100g/l,25℃) : 8.5~10.5
optical activity[α]20/D +30±1°, c = 5% in H2O
Water Solubility soluble


D-Pantothenic Acid Skin Care Effect and Efficacy

Anti-inflammatory and sedative
D-panthenol can stimulate the growth of epithelial cells in the skin, so it can calm down inflammation, promote metabolism, and accelerate wound healing. Therefore, panthenol is generally added to cosmetics and skin care products for acne-prone skin. When its anti-inflammatory and sedative effect is applied to acne-prone skin, it will make the acne disappear faster, and the wound left after squeezing the acne will heal faster, so panthenol is a very strong ingredient for acne-prone skin.

Moisturizing effect
The molecular diameter and molecular weight of D-panthenol are very small, and it can penetrate deep into the skin barrier, penetrate deep into the stratum corneum of the skin, and bring the water in it into the skin, thus playing the role of moisturizing. More studies have shown that after using products containing 2.5% D-panthenol for 7 days, compared with the control group products, it was found that the water content of the stratum corneum of people who used products containing 2.5% D-panthenol had a significant increase. So its moisturizing effect is also very powerful.

Regulatory improvement
Studies have shown that when D-panthenol combined with vitamin B6 is fully absorbed by the skin, it can increase the content of hyaluronic acid in the skin and strengthen the body’s metabolism of proteins, sugars and fats. Thereby play a role in regulating the skin. At the same time, panthenol also has the effect of enhancing skin elasticity, improving rough skin, and relieving skin itching, which is very friendly to sensitive skin.

Properties of D-Panthenol

1. Excellent deep hydrating performance: Panthenol has a little molecular weight, which can effectively permeate the stratum corneum as well as penetrate the stratum corneum on the skin surface. It has a solid moisturizing result, effectively improves skin roughness, and makes skin soft as well as non-sticky.

2. Accelerate wound recovery: Promote the development of epithelial cells, speed up the healing time of epidermal wounds, and fixing tissue trauma; it works for eczema, sunburn, and also child diaper rash.

Numerous researches in computer mice have actually shown that pantothenic acid can enhance the performance of fibroblasts. It aids in wound healing and is as a result made use of in anti-aging products. A complex having panthenol and niacinamide has been revealed to enhance indicators of skin aging in women aged 30-60.

3. The impact on hair treatment: D-Panthenol can permeate right into the hair, moisturizing hair for a long period of time, enhancing hair appeal, minimizing hair split finishes, avoiding dryness and also damage, as well as fixing damaged hair.

After utilizing a hair shampoo or conditioner which contains D-Panthenol, it can leave some sticky and also clear deposit on your hair. These materials can cover the hair as well as play a glossy function.Although not thickening and strengthening hair, this sort of vitamin B5 can enhance hair top quality by working as a lubricating substance.

At the same time, in hair treatment things, panthenol can not just cover the hair surface area for defense, nonetheless also permeate deeply ideal into the hair. In hair damages experiments (routine as well as blonde hair), panthenol was uncovered to reduce damages.

4. Nursing result on nails: D-Panthenol can enhance hydration and additionally improve nail adaptability.

Preparation of D-Panthenol

Think of 3kg of D-(-)-pantolactone as well as also include in a 10L house heating activator; action 6L of ethyl acetate as well as add to the reactor, heat along with blend, include 5g of triggered carbon after reflux, and likewise decolorize for half an hour; suction filter, Positioned the filtrate right into a 25L container, include 12L of oil ether, mix well, along with later on mean development at 5 ° C for 2h; suction filter the solid, afterwards totally dry the strong under vacuum at 40 ° C for 2h, together with recover the filtrate; include 5L of ethyl acetate to the solid, along with heat to reflux under blending, include 5g of turned on carbon, decolorize for half an hour; filter, consist of the filtrate right into a 25L container, include 10L of oil ether, mix along with also mean condensation at 5 ° C for 2h; suction filter, and also afterwards vacuum completely dry the strong at 40 ° C for 10 hrs to obtain 2.7 kg of white strong Return 90%. Take 1.0 kg of polished D-(-)-pantolactone and also in addition 580g of 3-amino-1-propanol right into the activator, warm to 50 ° C, respond for 3 personnels, as well as incredible to location temperature to obtain D-panthenol Things is a clear, anemic in addition to hygroscopic viscous liquid, and in addition 1.58 kg of ended up thing is acquired. The total return of the product is 90%. The important things is analyzed by the previous quality control technique, and all quality assurance indications remain in consistency with the guidelines, in addition to the information transforming is +30.8 °.

Content Analysis of D-Panthenol

Precisely weigh regarding 400mg of D-panthenol example, put it in a 300ml reflux flask with a basic opening, add 50.0 mL of 0.1 mol/L perchloric acid antarctic acetic acid remedy, and also reflux for 5h. After cooling, cover the condenser with metal aluminum foil to stop contamination by water, and wash the condenser with antarctic acetic acid. Include 5 declines of crystal violet examination service (TS174), and afterwards titrate with 0.1 mol/L potassium hydrogen phthalate in antarctic acetic acid to a green end point. At the same time, conduct a blank examination and make necessary adjustments. Each mL of 0.1 mol/L perchloric acid amounts 20.53 mg of panthenol (C9H19NO4).

About Products:
If you need D-Panthenol as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced D-Panthenol manufacturer and supplier, ZSpharmac will provide D-Panthenol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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