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D Malic Acid CAS 636-61-3

Molecular Formula: C4H6O5

Formula Weight: 134.09

ZSpharmac: D Malic Acid Supplier Manufacturers

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Product Name: D Malic Acid
CAS No: 636-61-3
Purity: 99%

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Basic Info

Product Name:D Malic Acid
Other Names:D(+)-Malic acid
CAS:636-61-3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:211-262-2
Storage:Store Below +30°C.
Provide:D Malic Acid MSDS;
D Malic Acid COA

What is D Malic Acid?

D-(+)-malic acid is generally made use of in the fields of chiral medication synthesis, chiral resolution reagents and also chiral accessories, and the research on its reliable preparation innovation is bring in more and more focus. D-malic acid is a vital chiral substance, which is extensively used in the fields of chiral medications, chiral ingredients, chiral supporting representatives, and so on, as well as has crucial development and also application leads. Market demand for D-malic acid: D-malic acid is currently mostly used in the synthesis of drugs abroad. The need in the international market has to do with 50 loads each year, and also the present cost is more than 300,000 yuan per bunch. The functioning basis of the project research study: Nanjing College of Innovation has completed the lab study work with D-malic acid, consisting of the screening of highly energetic enzymes, the prep work and also transformation of enzyme stimulants, the item buildup concentration is greater than 200g/L, as well as the yield has actually reached 80 %.

D Malic Acid Property

Melting point 98-102 °C (lit.)
alpha 2.2 º (c=3, H2O)
Boiling point 167.16°C (rough estimate)
density 1.60
refractive index 6.5 ° (C=10, Acetone)
storage temp. Store below +30°C.
solubility Soluble in methanol, ethanol, acetone, ether.
pka3.61±0.23(Predicted)
form Crystalline Powder
color White
PH2.2 (10g/l, H2O, 20℃)
optical activity[α]20/D +28.0±2°, c = 5.5% in pyridine
Water Solubility soluble

 

D Malic Acid Uses

The uses of D Malic Acid in food, medicine, daily chemical industry and also other divisions are as adheres to:
( 1) Food market: D Malic Acid is used for handling and also preparing drinks, liqueurs, fruit juices, as well as also for the manufacture of candies, jams, and so on. It has antibacterial and also disinfectant impacts on food. It can also be used for PH change of yoghurt fermentation, removal of tartrate in white wine developing, and so on( 2) Cigarette market: malic acid by-products (such as esters) can enhance the taste of tobacco.
( 3) Pharmaceutical industry: Numerous tablet computers and also syrups mixed with malic acid can have a fruity taste as well as are conducive to absorption as well as diffusion in the body.
( 4) Daily chemical sector: D Malic Acid is a great complexing representative as well as ester representative, used in toothpaste solutions, tooth cleaning tablets, synthetic fragrance formulas, and so on, and can additionally be made use of as an element of deodorants and also detergents. Limited usage: for jams and jellies, orange peel jelly. Can be used in milk drinks.

Synthesis of D Malic Acid

图1 D-(+)-苹果酸的合成路线

Bacteria expanded in medium A are inoculated into tool B (bacteria) or tool C (yeast). The microorganisms were incubated at 26 ° C, 220 rpm for 24-hour. Harvested cells were washed from 30 ml of culture in 300 ml flasks with 50 mM phosphate buffer (pH 7.0). The gathered cells were put on hold in 10 ml of pH 7.0-50 mM phosphate buffer containing 0.1% NaCl and 1% DL maleic acid. Breed the big tube including 5 ml of the response mix at 26 ° C, 295 rpm for 48 hr. Finally, the title compound D Malic Acid was gotten by silica gel column chromatography. The artificial route is received Figure 1

图2 D-(+)-苹果酸的合成路线

Execute the reaction of Medium A containing 10 g DL malic acid, 7 g K2HPO4, 2 g (NH4)2SO4 and 0.1 g MgSO4 7H2O in 1 L of pure water. Before autoclaving, change the pH of the medium to pH 7.2 with NaOH. The response was executed in medium B consisting of 100 g DL disodium maleate, 2 g (NH4)2SO4, 1.4 g KH2PO4, 3.1 g Na2HPO4 12H2O and also 0.25 g MgSO4 7H2O in 1 L of pure water. Prior to autoclaving, the pH of the medium was adjusted to pH 7.2. Grow bacteria in 300 ml Erlenmeyer flasks consisting of 30 ml medium at 26 ° C with rotary trembling (220 r.p.m). A. lwofii ATCC 9036 was cultured in medium A for 7 days. Finally, the title compound D Malic Acid was obtained by silica gel column chromatography. The synthetic path is received Number 1.

About Products:
If you need D Malic Acid, the cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of D Malic Acid, our company,
ZSpharmac will provide D Malic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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