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D-Glucosamine Hydrochloride CAS 66-84-2

Molecular Formula: C6H14ClNO5

Formula Weight: 215.63

ZSpharmac: D-Glucosamine Hydrochloride Supplier

Product Name: D-Glucosamine Hydrochloride
CAS No: 66-84-2
Purity: 99%

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Basic Info

Product Name:D-Glucosamine Hydrochloride
Other Names:Glucosamine Hydrochloride
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline
EINECS No.:200-638-1
Provide:D-Glucosamine Hydrochloride MSDS;
D-Glucosamine Hydrochloride COA

What is D-Glucosamine Hydrochloride?

D-glucosamine hydrochloride (also known as glucosamine hydrochloride) is a drug for the treatment of bone and joint diseases and an antibiotic synergist. It is also a sweetener and antioxidant for food, and can also be used as a nutritional supplement for diabetics. It can also inhibit the growth of cancer cells and is the main raw material for the synthesis of new anticancer drug chlorurecin. Glucosamine hydrochloride and its derivatives have broad application prospects in medicine, light industrial cosmetics and other fields.

D-Glucosamine Hydrochloride Property

Melting point 190-194 °C (dec.)(lit.)
alpha 72.5 º (c=2, H2O, 5hrs.)
refractive index 72 ° (C=1, H2O)
storage temp. 2-8°C
solubility H2O: 0.1 g/mL, clear, colorless
form crystalline
color White
Water Solubility soluble


D-Glucosamine Hydrochloride Uses

  1. D-glucosamine hydrochloride is extracted from all-natural chitin and also is a marine organic prep work that can advertise the synthesis of mucopolysaccharides in the human body, raise the viscosity of joint synovial liquid, as well as enhance the metabolic rate of articular cartilage; it has the impact of promoting antibiotic injection It is made use of for the synthesis of water-soluble anticancer drug chlorureamycin, which has the anticancer buildings of nitrosourea compounds, as well as at the same time has the qualities of much less toxicity in hindering bone marrow.Certain alleviative result; Supplementing glucosamine tool can improve N-glycosylation of generated healthy proteins as well as additionally impact cell line variation such as ring cells as well as stem cells; Glucosamine, an amino sugar, is a forerunner of the biosynthetic hexosamine course body, which can create the development of UDP-N-acetylglucosamine (UDP-GlcNAc).
  2. D-glucosamine hydrochloride can be made into medication for dealing with rheumatoid joint inflammation, abscess, and also enteritis, and it is a dietary additive for food as well as cosmetics, and a culture representative for biochemical cells.

Pharmacological Effects of D-Glucosamine Hydrochloride

D-Glucosamine Hydrochloride is an amino monosaccharide existing in the body, specifically in articular cartilage. It is a crucial component essential for the synthesis of proteoglycans in the human articular cartilage matrix. It selectively acts on bone joints and blocks bone joints It stimulates chondrocytes to produce glycoproteins with normal multimer structure, and also inhibits the activity of enzymes that damage cartilage, such as collagen and phospholipase A2, and inhibits the generation of superoxide free radicals that damage cells, preventing cortical Hormones and some non-steroidal anti-inflammatory drugs can damage chondrocytes and reduce the release of endotoxin factors that damage cells. Through the above channels, this product has a direct anti-inflammatory effect, which can relieve the pain symptoms of bone and joint, improve joint function, and prevent the development of osteoarthritis.

D-Glucosamine Hydrochloride Production Method

Traditional D-Glucosamine Hydrochloride production method usually adopts chitin acid hydrolysis method, as, the preparation method process steps of the glucosamine hydrochloride that the patent No. is 01127784.X is: acid hydrolysis, filtration, concentration, purification, reconcentration, cooling, Filter, spray ethanol, pump out ethanol, and finally dry it. Although the amount of ethanol required for washing hydrochloric acid is reduced, the process route is long and complicated, and the purpose of low-cost production cannot be achieved, and the problem of pollution cannot be overcome. In addition, due to the use of a large amount of water in the reaction process, the operation is cumbersome, the energy consumption is high, and the amount of sewage discharge is large.

CN101125892A discloses a kind of production method of D-Glucosamine Hydrochloride, comprises the following steps:

1) Acid hydrolysis: put hydrochloric acid and chitin into the reactor at a ratio of 5:1 at a temperature below 50°C. After feeding, control the temperature of the reactor at 85°C to 88°C and keep it warm for 3 hours to obtain the crude material liquid ;

2) Decolorization and pressure filtration: add activated carbon to the crude product liquid for decolorization, cool down to 50°C, and perform pressure filtration to obtain the filtrate;

3) Purification: Purify the filtrate through a secondary reverse osmosis system to obtain a purified filtrate;

4) Concentration and crystallization: the purified filtrate is vacuum concentrated and crystallized at a pressure of -0.09 to -0.1Mpa and a temperature of 50 to 55°C, and the material is cooled and discharged when crystals appear;

5) washing the crystal first, and then drying it until the water content is below 0.5%;

6) Crushing, sieving and packaging.

In the production process of the product of the present invention, the ratio of hydrochloric acid to chitin is adjusted to be 5:1, the temperature is controlled at 85°C to 88°C, and the time is controlled at 3 hours. There is no need to cool and crystallize, and directly add activated carbon to the reaction vessel for decolorization. , saves the separation and water dissolution of crude product crystals, saving time and water. The crude feed liquid is not directly concentrated after being filtered by a filter press, but is filtered through an ultrafiltration system to remove grease and inorganic salts, which solves the problems of clarity and light transmittance of the finished product, and improves product quality. The concentrated crystals are washed, dried, crushed and sieved, packaged and shipped.

About Products:
If you need D-Glucosamine Hydrochloride as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced D-Glucosamine Hydrochloride manufacturer and supplier, ZSpharmac will provide D-Glucosamine Hydrochloride raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get D-Glucosamine Hydrochloride Quotation