Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     sales20@sdzschem.com

Zhishang Chemical

D-Camphorsulfonic Acid CAS 3144-16-9

Molecular Formula: C10H16O4S

Formula Weight: 232.3

ZSpharmac: D-Camphorsulfonic Acid Supplement

Share on facebook
Facebook
Share on twitter
Twitter
Share on linkedin
LinkedIn
Share on pinterest
Pinterest
Share on whatsapp
WhatsApp
Share on email
Email
Product Name: D-Camphorsulfonic Acid
CAS No: 3144-16-9
Purity: 99%

Basic Info

Product Name:D-Camphorsulfonic Acid
Other Names:D-Camphor-10-Sulfonic Acid
CAS:3144-16-9
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:White to off-White Crystalline Powder
EINECS No.:221-554-1
Storage:Store Below +30°C.
Provide:D-Camphorsulfonic Acid MSDS;
D-Camphorsulfonic Acid COA

What is D-Camphorsulfonic Acid?

Optically active L- and D-camphorsulfonic acids are important chiral isomer drug resolving agents. D-form can be obtained from natural camphor by bromination and sulfonation, and can also be obtained from racemic camphorsulfonic acid by induced crystallization and resolution.

D-Camphorsulfonic Acid Properties:

Melting point 196-200 °C (dec.)(lit.)
alpha 22 º (589nm, c=20, H2O 25 ºC)
Boiling point 344.46°C (rough estimate)
density 1.2981 (rough estimate)
refractive index 21.5 ° (C=5, H2O)
storage temp. Store below +30°C.
solubility Exhibit moderate solubility in HCCl.
pka1.17±0.50(Predicted)
form Crystalline Powder
color White to off-white
PH0.3 (200g/l, H2O)
optical activity[α]20/D +21.5±1°, c = 10% in H2O
Water Solubility SOLUBLE

 

D-Camphorsulfonic Acid Uses

  1. D-camphorsulfonic acid is an intermediate in organic synthesis and a resolving agent.
  2. D-camphorsulfonic acid can be utilized as a solving agent as well as a driver for dipeptide coupling.
  3. D-camphorsulfonic acid is utilized for the splitting up of pharmaceutical intermediates or isomer items.
  4. D-camphorsulfonic acid is made use of in the pharmaceutical sector.

Separation and Preparation of D-Camphorsulfonic Acid

report one,
The method for preparing L- and D-camphorsulfonic acid by inducing crystallization and resolving racemic camphorsulfonic acid comprises the following steps:
(1) the preparation of racemic camphorsulfonate:
Raw material proportioning (weight ratio) racemic camphorsulfonic acid: water: =1: 1.2 above-mentioned raw materials are mixed in proportion, heated to be warming up to 50 DEG C and be incubated 3 hours, adjust pH with ammoniacal liquor to be 5, be cooled to 5 DEG C, centrifuge The dry yield of white solid salt was 80%. Mother liquor is recycled.
(2) preparation of D-camphorsulfonate:
The raw material weight ratio is, racemic camphor sulfonate: water: dextrorotatory optical activity inducer=1: 1.2: 0.1, water and racemic camphor sulfonate are mixed and heated to 80 ° C in proportion, and incubated for 2 hours When cooled to 50°C, add an inducer and keep warm for 1 hour, then cool to 20°C and centrifuge to obtain white solid D-camphorsulfonate, the optical rotation of D-camphorsulfonate is [a]D/20=+18‑‑20 . The mother liquor is used for the preparation of L-camphorsulfonate.
(3) Preparation of D-camphorsulfonic acid
The D-camphorsulfonate obtained above is dissolved in water and configured into a 20% aqueous solution, passed through an exchange column equipped with a cation exchange resin, the aqueous solution is collected and then concentrated to anhydrous through vacuum decompression, acetic anhydride solvent is added to crystallize, and the solution is cooled. to 5°C, filtered, and dried to obtain white crystals, the optical rotation of D-camphorsulfonic acid is [a]D/20=+21‑‑23, mp196‑200°C.
report two,
A preparation method of optically active left-handed and right-handed camphorsulfonic acid, comprising the following steps:
1. Preparation of racemic sulfonic acid: add 100 kilograms of 98% acetic anhydride and 20 kilograms of acetic acid in 200 liters of enamel reaction kettles with stirring, add 75 kilograms of racemic camphor under stirring and cooling, cool down to 0~5 ℃ and add 98% 55 kilograms of sulfuric acid, then kept temperature 5~30 ℃, reacted 60 hours, cooled to -2~5 ℃ after the reaction, kept 15 hours, centrifugal filtration, washed with acetic acid, vacuum-dried, got 70 kilograms of white crystalline racemic camphor Sulfonic acid, weight yield 93%;
2. 2. Prep work of left-handed and right-handed camphorsulfonic acid, splitting: include 23.2 kgs of racemic camphorsulfonic acid while stirring in a 100-liter enamel kettle, 18 kilograms of splitting agent compositions, 20 kilograms of water, mix and warm to 60 ~100℃ for 1 hour, cool to 5~10℃, keep for 1 hour, filter to obtain D-camphorsulfonic acid double salt, add 3 times the amount of water, heat to 60~100℃, adjust the pH value to 4~7 with ammonia water , and then cooled to 5-10° C. to filter and recover the resolving agent composition. The filtrate is ammonium d-camphorsulfonate solution, and the resolution ratio is 99%. The mother liquor from which the double salt has been filtered is added with ammonia water to neutralize to pH 4-7, cooled to 5-10 DEG C, and the resolving agent composition is filtered out. Filtration: Lots the L-camphorsulfonic acid ammonium salt service and also D-camphorsulfonic acid ammonium salt service into An as well as B chromatographic columns respectively, and slowly accumulate the A-column L-camphorsulfonic acid ammonium salt solution and the B-column D-camphor Sulfonic acid ammonium salt solution, A and B solutions were evaporated and concentrated to anhydrous in a thin film evaporator, then acetic acid and acetic anhydride were added for crystallization, cooled to 5 ~ 25 ° C, filtered, and dried to obtain white crystals, L-camphorsulfonic acid. The optical purity is 99.5%, and the optical purity of D-camphorsulfonic acid is 99.7%.

Other Applications of D-Camphorsulfonic Acid

Application 1.
A preparation method of D-(-)-1-phenylglycine (L-phenylglycine), in particular to a method for preparing L-phenylglycine by racemization of D-phenylglycine . The step-by-step polymerization includes: (1) adding 5-10% by weight of an aromatic aldehyde compound to the acidic mother liquor containing dextro-phenylglycine from which the levo-phenylglycine has been filtered. (2) The mother liquor is heated and refluxed at 105-110° C. for 3-5 hours to perform racemization, so that dextro-phenylglycine is converted into scrambled phenylglycine. (3) this reaction solution is combined with the mother liquor after filtering off L-phenylglycine, distilled, concentrated to 110-120 ℃, and then add gyral-phenylglycine and D-camphorsulfonic acid to the original addition of 105-115% by weight. (4) The reaction solution is circulated for optical resolution operation to prepare D-(-)-1-phenylglycine. It has the advantages of shorter technological process, less consumption of raw materials, low product cost, and less pollution of three wastes.
Application 2.
CN201611255258.1 discloses a ferrocene derivative functionalized organic magnetic core material with high mechanical strength for switching power supply transformer, which is composed of the following raw materials in parts by weight: ferrocene monoformyl chloride 15-20, carbon black 6-12 , 65% concentrated nitric acid appropriate amount, thionyl chloride 80-100, ethylene glycol 75-85, deionized water appropriate amount, dichloromethane appropriate amount, ferrous sulfate 3-8, ammonia water appropriate amount, aniline 20-28, dextro-camphor Sulfonic acid 10-20, N,N-dimethylformamide appropriate amount, ammonium persulfate 2-4, anhydrous ethanol appropriate amount, titanate coupling agent 1-3, polyethylene 2-7, clay 1-3, Manganese carbonate 2-5, silicone rubber powder 1-2. In the present invention, ferrocene grafted carbon black is obtained by introducing a hydroxyl group on the surface of carbon black, reacting with ferrocene monoformyl chloride, then ferric tetroxide is precipitated on the surface of carbon black, and then an in-situ polymerization method is used to form a core-shell structure. Nano-organic magnet materials improve the wave-shrinking properties of materials, make electronic components smaller and lighter, and realize miniaturization.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vission
Become the most trusted chemical supplier in the world
Our Business Philosophy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get D-Camphorsulfonic Acid Quotation