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D-Biotin CAS 58-85-5

Molecular Formula: C10H16N2O3S

Formula Weight: 244.31

ZSpharmac: D-Biotin Supplier

Product Name: D-Biotin
CAS No: 58-85-5
Purity: 99%

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Basic Info

Product Name:D-Biotin
Other Names:BIOTIN
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:200-399-3
Provide:D-Biotin MSDS;
D-Biotin COA

What is D-Biotin?

It is a coenzyme – or corresponding enzyme – utilized in numerous metabolic responses in the body. D-Biotin is associated with lipid as well as additionally protein metabolic procedure, assisting to change food right into sugar, which the body can utilize for power. It is likewise vital for keeping the skin, hair in addition to mucous membrane layer layers.

D-Biotin Property

Melting point 231-233 °C(lit.)
alpha 89 º (c=1, 0.1N NaOH)
Boiling point 573.6±35.0 °C(Predicted)
density 1.2693 (rough estimate)
refractive index 90.5 ° (C=2, 0.1mol/L NaOH)
storage temp. -20°C
solubility H2O: 0.2 mg/mL Solubility increases with addition of 1 N NaOH.
form powder
color White crystalline powder or fine long needles
PH4.5 (0.1g/l, H2O)
optical activity[α]20/D +91±2°, c = 1% in 0.1 M NaOH
Water Solubility Soluble in hot water, dimethyl sulfoxide, alcohol and benzene.


Efficacy of D-Biotin

1. Boost loss of hair (baldness).
Hair loss is a health and wellness problem that lots of people are worried about. It relates to look and also self-esteem. It is approximated that almost 50% of males and females are impacted by various patterns of loss of hair.

Nutrient deficiencies are typically associated with persistent telogen effluvium, androgenetic alopecia, female pattern baldness, and also patchy alopecia. While biotin is good for hair development and stamina, one of the main symptoms of a shortage is loss of hair.

A case study (with formula-fed babies lacking in biotin) indicated that biotin supplementation minimized the signs of perioral dermatitis and also irregular hairloss triggered by the shortage.

* Summary: The result of D-Biotin on boosting hair loss is unidentified. Up to now, there is no full medical experiment to prove that in the lack of shortage, additional supplements can stop or deal with loss of hair.

2. Boost fragile nails (BrittleNails).
Nail brittleness is a disease of unusual nail framework. The major symptom is loss of elasticity as well as gentleness of the nails, accompanied by splitting, peeling and crushing. It is estimated that regarding 20% of the populace is influenced by this condition, and the incidence rate of women is higher than that of males. 2 times.

Nail brittleness is usually idiopathic (referring to unknown cause) and might be brought on by skin or systemic diseases, dietary deficiencies, substance abuse, or injury.

In animal medicine, D-Biotin is often used to boost hoof problems or abnormalities in ungulates (such as horses, livestock as well as lamb).

Biotin supplementation has actually also been discovered to aid enhance nail brittleness (63% to 91% of subjects reported enhancement) and nail plate thickness in several human researches.

The underlying system relates to boosting the synthesis of lipid molecules needed to make nail plate keratinocytes.

* Recap: D-Biotin might have the impact of boosting brittle nails, yet because of the little scale of the study, more massive explores exact design are required to confirm.

3. enhance diabetes mellitus.
Diabetes is one of the oldest illness in human background, first found in ancient Egypt 3,000 years back.

The primary pathogenic aspects of diabetes are related to genes and also life elements, such as lack of exercise, inactive, smoking and alcohol consumption. Amongst them, obesity represent concerning 55% and also is the most typical pathogenic variable.

One small research found that blood biotin focus were normally reduced in diabetic person clients compared with healthy and balanced individuals, which supplements helped improve fasting blood glucose worths.

One more double-blind regulated research study mentioned (for a duration of 90 days, the subjects were 447 diabetic people with poor blood sugar level control), compared to drug treatment alone, the extra use of chromium and also biotin can have a better result on blood glucose control (enhancing glycation hemoglobin and fasting blood sugar).

The underlying device is connected to variables such as D-Biotin’s promotion of glucose synthesis into fat, glucokinase secretion (advertising glycogen synthesis) and also causing insulin, so it is believed to assist maintain blood sugar stability.

* Summary: The combined use biotin and chromium can make blood sugar level control extra reliable, however the result of using it alone remains to be verified.

4. Numerous sclerosis.
Several sclerosis is an autoimmune disease brought on by modern damages to the myelin sheath (which surrounds nerve fibers) in the brain or spine, which consequently impacts various other parts of the body.

Depending upon the afflicted component, feasible signs and symptoms include numbness of limbs, damaged vision, tiredness, slurred speech, and also dizziness.

An initial little research study pointed out that high dosages of D-Biotin can aid improve the professional symptoms of several sclerosis (slow down the progression of the illness and the level of special needs).

One more double-blind controlled research also located (for 12 months, 154 people with numerous sclerosis) that high-dose biotin (100? mg/three times a day) can help reduce disability condition compared with placebo Scale ratings (ExpandedDisabilityStatusScale) and improved clinical perceptions.

The underlying mechanism is related to the adhering to 2 buildings of D-Biotin.

A . Activate carboxylase (carboxylase), promote myelin repair service (by boosting fatty acid synthesis).

B . Shields axons from hypoxia-induced deterioration (by increasing neuronal energy production).

* Summary: High doses of biotin may help boost multiple sclerosis, yet more experiments are required to validate.

D-Biotin Deficiency Symptoms

D-Biotin deficiency is mainly seen in those who eat raw eggs for a long time. Biotin deficiency can also occur if the diet is deficient in biotin, and antibiotics such as sulfonamides are given in large quantities at the same time, or long-term use of total parenteral nutrition neglects to supplement biotin. The main manifestations of deficiency are skin symptoms, which can be seen as thinning hair, loss of luster, dry skin, scaly dermatitis, and red rash. In severe cases, the rash can extend to the eyes, nose, and mouth. In addition, it is accompanied by loss of appetite, nausea, vomiting, tongue papilla atrophy, graying of mucous membranes, numbness, depression, fatigue, myalgia, hypercholesterolemia, and EEG abnormalities.

Most of these symptoms occurred after 10 weeks of D-Biotin deficiency. The main site of biotin absorption is the proximal small intestine. At low concentrations, it is actively absorbed by carrier transport; at high concentrations, it is absorbed by simple diffusion. The absorbed biotin is transported to the liver and kidney for storage through the portal circulation, and biotin is also contained in other cells, but the amount is small. Raw egg whites contain avidin, which binds to biotin and inhibits biotin absorption. Achlorhydria patients can reduce the absorption of D-Biotin.

The Synthetic Method of D-Biotin

Using fumaric acid (2) as the starting product, with bromine enhancement, dibromo: substance is changed by benzylamine and phosgene ring closure to generate imidazolidinone maleic acid (3 ), which wants that exchanged acid anhydride (4) and likewise Cyclohexanol ring-opening is racemic monoester (5 ), and also 5 is resolved into called for optical isomer (6) with (+)-ephedrine high return, as well as likewise the enantiomeric blood circulation of 6 returns acid anhydride (4 ). Lithium borohydride reduces the ester bond in 6 to make it an alcoholic hydroxyl team and additionally converts it right into a lactone (7) of the favored arrangement, which is treated with potassium thioacetate to develop a thiolactone (8 ), which seeks that based upon Grignard response as well as dehydration Intermediate (9) was acquired with the intro of the initial 3 carbon atoms in the side chain. Catalytic hydrogenation saturates the side chain ethylenic bond in addition to stereospecifically creates the 3rd chiral center (10 ), which is then treated with hydrobromic acid to produce a cyclic sulfonium salt (11 ). A malonate residue was presented at the carbon atom to obtain a biotin forerunner (12 ). Eventually, after acidic hydrolysis, the benzyl group utilized to secure both amino teams is gotten rid of, as well as the malonate is exchanged a diacid as well as additionally decarboxylated to get optically pure biotin (1 ). The complete return of the entire treatment is higher than 25%, as well as the typical return of each step mores than 90%.

About Products:
If you need D-Biotin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced D-Biotin manufacturer and supplier, ZSpharmac will provide D-Biotin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get D-Biotin Quotation