Zhishang Chemical

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Zhishang Chemical

D-Biotin CAS 58-85-5

Molecular Formula: C10H16N2O3S

Formula Weight: 244.31

ZSpharmac: D-Biotin Supplier

Product Name: D-Biotin
CAS No: 58-85-5
Purity: 99%

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Basic Info

Product Name:D-Biotin
Other Names:BIOTIN
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:200-399-3
Provide:D-Biotin MSDS;
D-Biotin COA

What is D-Biotin?

D Biotin is the 8 sort of the water-soluble vitamin, biotin, similarly called vitamin B7. It is a coenzyme – or complementary enzyme – utilized in lots of metabolic responses in the body. D-Biotin is associated with lipid along with healthy and balanced protein metabolic rate, assisting to convert food right into sugar, which the body can make use of for power. It is likewise vital for keeping the skin, hair as well as mucous membrane layer layers.

D-Biotin Property

Melting point 231-233 °C(lit.)
alpha 89 º (c=1, 0.1N NaOH)
Boiling point 573.6±35.0 °C(Predicted)
density 1.2693 (rough estimate)
refractive index 90.5 ° (C=2, 0.1mol/L NaOH)
storage temp. -20°C
solubility H2O: 0.2 mg/mL Solubility increases with addition of 1 N NaOH.
form powder
color White crystalline powder or fine long needles
PH4.5 (0.1g/l, H2O)
optical activity[α]20/D +91±2°, c = 1% in 0.1 M NaOH
Water Solubility Soluble in hot water, dimethyl sulfoxide, alcohol and benzene.


The Efficacy of D-Biotin

The Synthetic Method of D-Biotin

Using fumaric acid (2) as the starting material, through bromine addition, dibromo: compound is replaced by benzylamine and phosgene ring closure to generate imidazolidinone maleic acid (3), which is then converted into acid anhydride (4) and Cyclohexanol ring-opening is racemic monoester (5), and 5 is resolved into required optical isomer (6) with (+)-ephedrine high yield, and the enantiomeric circulation of 6 returns acid anhydride (4 ). Lithium borohydride reduces the ester bond in 6 to make it an alcoholic hydroxyl group and converts it into a lactone (7) of the desired configuration, which is treated with potassium thioacetate to generate a thiolactone (8), which is then subjected to Grignard reaction and dehydration Intermediate (9) was obtained with the introduction of the first 3 carbon atoms in the side chain.

Catalytic hydrogenation saturates the side chain ethylenic bond and stereospecifically establishes the third chiral center (10), which is then treated with hydrobromic acid to form a cyclic sulfonium salt (11). A malonate residue was introduced at the carbon atom to obtain the D-Biotin precursor (12). Finally, after acidic hydrolysis, the benzyl group used to protect the two amino groups is removed, and the malonate is converted into a diacid and decarboxylated to obtain optically pure D-Biotin (1). The total yield of the whole process is greater than 25%, and the average yield of each step is over 90%.


D-Biotin Deficiency Symptoms, Mechanism of Action and Metabolism

Deficiency Symptoms:

Mechanism of Action and Metabolism:

The transport of D-Biotin to the surrounding tissues requires biotin-binding protein as a carrier. The biotin-binding protein in plasma exists as biotinidase, which has two high-affinity biotin-binding sites.

D-Biotin is mainly excreted through urine. Before being discharged, about half of the biotin is converted into biotin sulfoxide, two norbiotin and four norbiotin before being discharged. The ratio of biotin, demethylbiotin and biotin sulfoxide in human urine is about 3:2:1. Biotin is also excreted in breast milk, but in very small amounts. Since gut bacteria can synthesize biotin, it is not easy to accurately determine the required amount of D-Biotin.

The Chinese Nutrition Society put forward the AI ​​value of Chinese residents in 2000, among which the adult is 30μg/d. The nutritional status of biotin can be evaluated by measuring the content of biotin in blood and urine, the concentration of odd-numbered carbon fatty acids in plasma, and the excretion of related metabolites in urine. D-Biotin widely exists in natural food. Cheese, beef liver, and soybean flour are the most abundant, followed by eggs. Refined grains and most fruits contain less.

About Products:
If you need D-Biotin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced D-Biotin manufacturer and supplier, ZSpharmac will provide D-Biotin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get D-Biotin Quotation