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D-Alpha-Tocopheryl Acetate CAS 58-95-7

Molecular Formula: C31H52O3

Formula Weight: 472.74

ZSpharmac: D-Alpha-Tocopheryl Acetate Raw Material Supplier

Product Name: D-Alpha-Tocopheryl Acetate
CAS No: 58-95-7
Purity: 99%

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Basic Info

Product Name:D-Alpha-Tocopheryl Acetate
Other Names:Vitamin E Acetate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Oil or Semi-Solid
EINECS No.:200-405-4
Storage:Room Temp
Provide:D-Alpha-Tocopheryl Acetate MSDS;
D-Alpha-Tocopheryl Acetate COA

What is D-Alpha-Tocopheryl Acetate?

Vitamin E (VE for short) has important physical functions and is an essential nutrient for the human body. It is commonly used in pharmaceuticals, health and wellness products, beauty and skin treatment products, food and feed ingredients and other sectors. There are four homologues of all-natural VE, specifically α-tocopherol, β-tocopherol, γ-tocopherol and δ-tocopherol. They all have the commonness of natural VE, yet additionally show different personalities, so they are differentiated in functions and appropriate fields. The α-type monomer has the best biological activity and is most efficient when used as medications and healthcare items. D-alpha-tocopherol acetate is among the derivatives of D-alpha tocopherol, which proceeds the biological task of D-alpha tocopherol.

D-Alpha-Tocopheryl Acetate Property

Melting point ~25 °C(lit.)
alpha 3 º (c=2, in ethanol 25 ºC)
Boiling point 224 °C0.3 mm Hg(lit.)
density 0.953 g/mL at 25 °C(lit.)
refractive index n20/D 1.496(lit.)
Fp >230 °F
storage temp. room temp
solubility Practically insoluble in water, freely soluble in acetone, in anhydrous ethanol and in fatty oils, soluble in ethanol (96 per cent).
form oil or semi-solid
color yellow
Odorcryst., odorless
Water Solubility <0.1 g/100 mL at 17 ºC


D-Alpha-Tocopheryl Acetate Uses

  1. D-Alpha-Tocopheryl Acetate is commonly made use of in skin treatment products such as skin creams. Tocopherol acetate is not oxidized and can permeate the skin and enter living cells, of which distressing 5% is exchanged free tocopherol, giving valuable antioxidant results. Taken into consideration that the phenolic hydroxyl teams are obstructed, tocopherol acetate is made use of as a substitute for tocopherol itself, providing a less acidic item with a longer life span. It is assumed that when taken in into the skin, acetate is slowly hydrolyzed to grow back tocopherol, offering sunlight defense.
  2. D-Alpha-Tocopheryl Acetate is made use of in biochemical research; the scientific medication is a fat-soluble vitamin and is taken advantage of clinically for the treatment of normal abortion, intimidated abortion, inability to develop and menopausal problems.

D-Alpha-Tocopheryl Acetate Preparation

Method 1: Take 100 grams of D-alpha tocopherol, blend it with 300 grams of n-hexane and 4 grams of zinc chloride, manage the temperature to 35 ° C, slowly add acetic anhydride dropwise into the reaction pot, execute esterification for 2 hours, wash with water, and concentrate., get the crude item of D-alpha-tocopherol acetate, then mix the unrefined product with 400 grams of ethanol, put it on the column, manage the flow rate and temperature level of the column to 20-50 ° C, and adsorb it through D-101 macroporous adsorption material, and the effluent Concentrate and desolubilize, then mix the concentrated service with 400 grams of ethanol, include 5 grams of triggered carbon, usage external blood circulation at a continuous temperature of 60 ° C for 2 hours, filter and concentrate, and after that filter and concentrate the focused option under high vacuum cleaner conditions. Short-range molecular purification and improvement are made use of to obtain the finished item of D-alpha-tocopheryl acetate. The determined web content of D-alpha-tocopheryl acetate is 98.3%; specific optical rotation +24.2 °; heavy metal (determined as Pb) 9.5 ppm; benzopyrene ≤ 2ppb.

Approach 2. A preparation approach of natural vitamin E, including the adhering to steps:
( 1) Preparation of d-α-tocopherol
a. Take the adhering to basic materials by weight, mix 1.5 parts of tocopherol, 4-6 parts of isopropyl ether, 2-4 parts of hydrochloric acid, 0.5-1.5 parts of stannous chloride, 0.5-1.5 parts of acetic acid, and 0.5-1.5 parts of formaldehyde, Add the above resources into the reaction kettle, mix, raise the temperature to 50-70 ° C, regulate the temperature level to 50-70 ° C and react for 5 hours, after that stop the response;

b. After cooling to room temperature level, stall, different the reduced liquid phase, include detoxified water to the natural phase for cleaning, get rid of the aqueous phase, include anhydrous salt sulfate to the natural stage and completely dry for 2 hours, filter, and wash the filter cake with isopropyl ether., obtain the washing fluid, integrate the filteringed system filtrate and the cleaning liquid to get the total filtrate, and evaporate the solvent under minimized pressure listed below 50 ° C to obtain d-α-tocopherol;( 2) Prep work of d-α-tocopheryl acetate a. Add 1.3 parts by weight of d-α-tocopherol, 2-4 components by weight of cyclohexane, and 0.5-1.5 parts by weight of acetic anhydride into the response kettle, raise the temperature to 70-90 ° C, and maintain it cozy for 5 hours prior to stopping. response;

b. After cooling to area temperature level, include detoxified water for washing, remove the water stage, and focus the natural stage under minimized pressure below 50 ° C to obtain d-α-tocopheryl acetate;( 3 )Molecular distillation a. Degassing: Include d-α-tocopheryl acetate into the raw product container to pre-heat, utilize a metering pump to drive into the degassing scrape, and warmth and degas under a vacuum of 500Pa to obtain the degassed unrefined product; b. Eliminate low boiling point raw material: make use of an equipment pump to pump the degassed crude item right into the molecular distillation phase, conduct heating and purification under a vacuum of 300 Pa, and recuperate and refine the low boiling point raw material to get the low boiling point crude item; c. Pre-removal fraction: Utilize an equipment pump to pump the unrefined item of low-boiling matter right into the second stage of molecular distillation, and conduct home heating and distillation at a vacuum cleaner of 200Pa to obtain the unrefined distillation product; d. Purification products: Utilize an equipment pump to pump the unrefined purification item into the 3rd stage of molecular purification, and carry out distillation under a vacuum of 100Pa. The product acquired by distillation is all-natural vitamin E.

Contact Us

About Products:
If you need D-Alpha-Tocopheryl Acetate, a cosmetic raw material, please contact our service staff directly and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of D-Alpha-Tocopheryl Acetate, our company, ZSpharmac will provide D-Alpha-Tocopheryl Acetate raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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