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(D-ALA2)-Leucine Enkephalin CAS 64963-01-5

Molecular Formula: C29H39N5O7

Formula Weight: 569.65

ZSpharmac: (D-ALA2)-Leucine Enkephalin Supplement

Product Name: (D-ALA2)-Leucine Enkephalin
CAS No: 64963-01-5
Purity: 99%

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Basic Info

Product Name:(D-ALA2)-Leucine Enkephalin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:265-291-0
Storage:Keep in Dark Place,Sealed in Dry,Store in Freezer, Under -20°C
Provide:(D-ALA2)-Leucine Enkephalin MSDS;
(D-ALA2)-Leucine Enkephalin COA

What is (D-ALA2)-Leucine Enkephalin?

(D-ALA2)-Leucine Enkephalin is commonly dispersed in the human body as well as has extremely crucial physiological attributes. It not simply has an unique effect on mind cells, it can activate brain cells in a resting state, as well as additionally has an exceptional recovery effect on sequelae brought on by mind injury; it plays an important role in immune feature, including enhancing the body immune system, T The task of lymphocytes, NK cells, macrophages, and more, anti-virus, improve the launch of γ-interferon, and so on; the switched on immune cells can promote the secretion of endocrine cells to sign up with immune standard, consequently influencing the genetics regulation and expression function of DNA.

(D-ALA2)-Leucine Enkephalin Property

Melting point 160-163.5 °C
Boiling point 991.9±65.0 °C(Predicted)
density 1.257±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility DMF (Slightly), DMSO (Slightly)
form Solid
color White to Off-White


(D-ALA2)-Leucine Enkephalin Uses

(D-ALA2)-leucine enkephalin is a natural synthesis intermediate as well as a pharmaceutical intermediate, which can be made use of in the process of lab organic research and development and chemical and pharmaceutical research and development, especially in the process of biochemical research and development.

(D-ALA2)-Leucine Enkephalin Assay Method

Xia Yuqin et al. established a novel redox precolumn derivatization fluorescence detection high performance liquid chromatography method for the determination of (D-ALA2)-leucine enkephalin drugs. Methods The (D-ALA2)-leucine enkephalin was mixed with 0.012mol/L sodium periodate, 0.01mol/L catechol and 0.3mol/L boric acid in a volume ratio of 2:2:1:1, After reacting at 120℃ for 10min, the samples were separated by reversed-phase column, with 0.25mol/L borate buffer (pH 7.6) and methanol as mobile phases, gradient elution was adopted, and fluorescence detector was used for detection. At the same time, the content of L-EK in vitro and in blood samples was determined by comparing with high performance liquid chromatography UV method and O-phthalaldehyde (OPA) pre-column derivatized fluorescence detection high performance liquid chromatography.

Results The redox-column derivatization fluorescence detection high performance liquid chromatography was used to detect (D-ALA2)-leucine enkephalin in blood samples, the linear range was 0.5-50.0 mg/L, and the linearity was good (r=0.999 8). The detection limit was 0.1 mg/L, and compared with the other two methods, it was not disturbed by endogenous substances. Conclusion The novel redox precolumn derivatization fluorescence detection high performance liquid chromatography has good specificity and high sensitivity, especially suitable for the determination of (D-ALA2)-leucine enkephalin in biological samples.

Effects of (D-ALA2)-Leucine Enkephalin and its Analogues on Gastric Secretion

The result of enkephalin analogs on gastric secretion was explored. Histamine-stimulated gastric secretion was found to be significantly boosted intoxicated of the enkephalin analog Tyr-D-Ala-Gly-Phe-(NO2)NH2. The enkephalin analog Tyr-Gly-Gly-Phe-Leu-D-Arg increased the amount of stomach juice as well as pepsin secretion, yet the debit of hydrochloric acid was lower than in try outs histamine mixture alone. One more enkephalin analog, Tyr-D-Ala-Gly-Phe-D-Leu-Arg, presented at the same time as histamine, considerably minimized gastric secretion just 90-105 minutes after the begin of perfusion.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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