Zhishang Chemical

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Zhishang Chemical

Cystine 500 CAS 56-89-3

Molecular Formula: C6H12N2O4S2

Formula Weight: 240.3

ZSpharmac: Cystine 500 Supplement

Product Name: Cystine 500
CAS No: 56-89-3
Purity: 99%

Basic Info

Product Name:Cystine 500
Other Names:L-Cystine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:White Powder/Solid
EINECS No.:200-296-3
Provide:Cystine 500 MSDS;
Cystine 500 COA

What is Cystine 500?

Cystine 500 is the L-enantiomer of the sulfur-containing amino acid cystine. It acts as a flour treating agent, human metabolite, Saccharomyces cerevisiae metabolite, mouse metabolite and EC (aspartate-semialdehyde dehydrogenase) inhibitor. It is a cystine, an Cystine 500 derivative and a non-protein L-alpha-amino acid. It is the conjugate acid of the Cystine 500 anion. It is the enantiomer of D-cystine. It is a tautomer of the Cystine 500 zwitterion.
Not considered one of the 20 amino acids, Cystine 500 is a sulfur-containing derivative obtained from the oxidation of the thiol side chain of the Cystine 500 amino acid. It acts as an antioxidant, protects tissues from radiation and pollution, and slows the aging process. It also aids in protein synthesis. Cystine 500 is abundant in many proteins in bone tissue and skin, and is present in insulin and the digestive enzymes chromogen A, papain, and trypsinogen. (NCI04)

Cystine 500 Properties:

Melting point >240 °C (dec.) (lit.)
alpha -224 º(c=2 in 1M HCl)
Boiling point 468.2±45.0 °C(Predicted)
density 1.68
refractive index -222.5 ° (C=1, 1mol/L HCl)
storage temp. 2-8°C
solubility 1 M HCl: 100 mg/mL
form Powder/Solid
pka1.0, 2.1, 8.02, 8.71(at 25℃)
color White
optical activity[α]20/D 219±5°, c = 1% in 1 M HCl
Water Solubility 0.112 g/L (25 ºC)


Cystine 500 Uses

  1. Cystine 500 is widely utilized: 1. For biochemical research study. Prepare biological tool. For biochemical and dietary research study, it has the functions of advertising the oxidation as well as decrease features of the body’s cells, raising white blood cells as well as stopping the growth of pathogenic bacteria. Mostly made use of for numerous hair loss problems. It is additionally made use of for acute transmittable diseases such as dysentery, typhoid high temperature, influenza, asthma, neuralgia, dermatitis and also various poisoning illness, and so on, and also has the function of keeping healthy protein arrangement. Additionally utilized as food flavoring agent. 2. Biochemical reagents for the prep work of biological society medium. It is additionally a crucial element of amino acid mixture as well as compound amino acid preparations. 3. It is made use of as a feed nutrition fortifier, which is beneficial to animal development, boosting body weight, liver and kidney functions, and improving hair top quality. 4. It can be made use of as an aesthetic additive, which can advertise wound healing, stop skin allergies and treat dermatitis.
  2. Cystine 500 is made use of for biochemical study, prep work of organic culture tool, medicine for liver disease, avoidance as well as therapy of radiation damages, various alopecia, as well as drug poisoning, and also can likewise be made use of for severe contagious illness, bronchial asthma, neuralgia, dermatitis and burns adjuvant therapy.
  3. Cystine 500 is used in medication, cosmetics, artificial additive, and so on.
  4. Cystine 500 is used in nutritional supplements, tastes. For breastmilk milk powder. Dough gluten booster for baked products (yeast starter), baking powder. It is used in medication to advertise injury healing. Therapy of skin allergic reactions, antidote, hematopoietic agent, etc.
  5. Cystine 500 is an essential component of amino acid mixture and also substance amino acid preparations for the prevention and also treatment of congenital homocystinuria, different alopecias, liver disease, radiation damage, as well as cytopenia and also medication poisoning caused by various factors. It is likewise used for adjuvant treatment of severe infectious diseases, bronchial asthma, neuralgia, dermatitis and also burns.
  6. Cystine 500 is a crucial pharmaceutical intermediate for the prep work of substance amino acid dental preparations or infusions, dyes, cosmetics, dairy products ingredients, oil anti-oxidants, etc. Likewise used in heavy metal remedy, hepatitis and also various other drugs. It can advertise the redox capability of body cells, rise white blood cells to prevent the advancement of pathogenic germs, can decrease leukemia, coronary cardiovascular disease, stop as well as treat fatty liver cirrhosis, advertise hair development and protect against skin aging, yet additionally typhoid dysentery, influenza, bronchial asthma, neuralgia, eczema and also various other conditions. a poisoning illness.
  7. Cystine 500 is needed for certain growth cell lines or cysteine in the society tool; vital for the growth of various microorganisms.
  8. Cystine 500 is made use of as a feed dietary supplement, which is beneficial to animal advancement, increase body weight and liver and also kidney function, and enhance hair top quality.

Cystine 500 Production Method

Today, although the fermentation method as well as enzymatic method of amino acid production have developed swiftly, and the manufacturing expense has gone down, the protein hydrolysis method of producing amino acid has actually been substantially influenced, but some amino acids are still generated by acid hydrolysis of healthy protein. Amino acids, arginine, leucine, tyrosine, serine and also various other amino acids are still mostly hydrolyzed. Due to the fact that my country is rich in all-natural healthy protein sources, such as human hair, pig hair, waste silk, etc are all excellent basic materials. Cystine 500 is typically prepared from pig hair or human hair basic materials with acid hydrolysis, splitting up and filtration (by isoelectric rainfall).
Hydrolyzed in the hydrolysis tank (tank), put 1000kg of 10mol/L HCl, heated at 70-80℃, then put in washed and dried pig hair or human hair about half the amount of hydrochloric acid (500kg) and continue to heat to 100℃ At the same time, the temperature was adjusted, and the temperature was raised to 110-117°C within 1-1.5h, hydrolyzed for 7h (from 100°C), and the filtrate (hydrolyzate) was collected. The neutralized hydrolyzate was introduced into the neutralization tank, 30%-40% NaOH solution was gradually added and kept stirring, and the pH of the hydrolyzate was adjusted to 4.8 to stop adding alkali. Continue to stir for 15min again, re-measure the pH to be 4.8 to obtain the neutralization solution, leave standstill for 36h, filter to get the precipitate, and centrifugally dry to obtain Cystine 500 crude product I.
Crude, neutralization get Cystine 500 crude product I about 200kg, add the HCl liquid 120kg of 10mol/L, water 480kg (total 800kg), heat dissolving, and keep stirring, when being warming up to 80 ℃, add crude product solution weight 2% activated carbon (about 16kg) was decolorized at 80-90°C for 0.5h, filtered to remove the activated carbon, and the obtained filtrate was adjusted to its pH value with 30% NaOH solution, and kept stirring to make it pH 4.8, and allowed to stand for crystallization. , and then the supernatant liquid was precipitated, and the bottom precipitated crystals were dried to obtain Cystine 500 crude product II.
Refine, neutralize and get above-mentioned Cystine 500 crude product II 50kg, add the HCl solution 250L of 1mol/L, stir and heat to make it dissolve, when being warming up to 70 ℃, add the gac (3kg) of crude product II hydrochloric acid solution weight 1% and heat up Decolorize at 85°C for 0.5h, filter to remove activated carbon, and obtain colorless and transparent filtrate. Then add 1.5 times the weight of distilled water, heat at 75-80 ° C, stir to neutralize with 12% ammonia water to pH 3.5-4.0, suck out the mother liquor above the crystallization while hot, filter the crystallization at the bottom, and use distilled water to wash to remove chlorine-free ions, pump Dry and vacuum dry to obtain Cystine 500.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vission
Become the most trusted chemical supplier in the world
Our Business Philososphy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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