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Cyclohexyl Magnesium Chloride CAS 931-51-1

Molecular Formula: C6H11ClMg

Formula Weight: 142.91

ZSpharmac: Cyclohexyl Magnesium Chloride Supplement

Product Name: Cyclohexyl Magnesium Chloride
CAS No: 931-51-1
Purity: 99%

Basic Info

Product Name:Cyclohexyl Magnesium Chloride
Other Names:Cyclohexylmagnesium Chloride Solution
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Clear Very Dark Brown Solution
EINECS No.:213-237-1
Provide:Cyclohexyl Magnesium Chloride
Cyclohexyl Magnesium Chloride COA

What is Cyclohexyl Magnesium Chloride?

Cyclohexanemagnesium chloride is a Grignard reagent, which can be prepared from chlorocyclohexane and metal magnesium. Magnesium cyclohexane is very active in nature and can be combined with compounds with active hydrogen (such as H2O, ROH, RC≡CH…) aldehydes, ketones, esters, acid halides, nitriles, ethylene oxide, halogenated alkyl, carbon dioxide, phosphorus trichloride , boron trichloride, silicon tetrachloride and other reactions.

Cyclohexyl Magnesium Chloride Properties:

density 0.871 g/mL at 25 °C
Fp −40 °F
storage temp. 2-8°C
form Solution
color Clear very dark brown
Water Solubility It reacts violently with water.


Cyclohexyl Magnesium Chloride Uses

  1. Cyclohexanemagnesium chloride is a Grignard reagent, which can be prepared from chlorocyclohexane and metal magnesium.
  2. Cyclohexanemagnesium chloride can be used as a pharmaceutical intermediate and a central anticholinergic and antiparkinsonian drug.

Magnesium Cyclohexyl Chloride Application

Cyclohexyl magnesium chloride can be used to prepare 1-cyclohexyl-1-phenyl-3-piperidine propanol hydrochloride, commonly known as trihexyphenidyl hydrochloride, with a molecular weight of 337.93 and a molecular formula of C20H32ClNO. It can be used as a pharmaceutical intermediate, and it is also a central anticholinergic anti-Parkinson’s disease drug. Its function is to selectively block the cholinergic nerve pathway of the striatum, while the peripheral effect is small, which is beneficial to the recovery of Parkinson’s disease patients.The equilibrium of dopamine as well as acetylcholine in the mind enhances the symptoms of Parkinson’s disease in people.

A production method of 1-cyclohexyl-1-phenyl-3-piperidine propanol hydrochloride, comprising the steps of:

  1. Dropwise add the mixed solution of chlorocyclohexane and diethyl ether to the mixture of magnesium and diethyl ether, and keep refluxing for 2-5 hours to obtain Grignard reaction solution;
  2. Adding acetophenone dropwise to the mixture of piperidine hydrochloride, anhydrous methanol and formaldehyde at room temperature and reacting for 10-60 minutes, cooling and suction filtration to obtain a solid mixture;
  3. Mix the solid mixture with ether, add dropwise the Grignard reaction solution, cool and then add hydrochloric acid dropwise, separate out and dry to obtain 1-cyclohexyl-1-phenyl-3-piperidinepropanol hydrochloric acid Salt.

Preparation of Cyclohexane Magnesium Chloride

  1. 13g of magnesium flakes and 20g of ether were added to a 500mL four-necked reaction flask, and one of the four-necked reaction flasks was provided with a condenser;
  2. Mix 65g of chlorocyclohexane and 80g of diethyl ether, and dropwise add 7g of the mixture of chlorocyclohexane and diethyl ether into the four-necked reaction flask while stirring to induce Grignard reaction;
  3. Refluxing the reactants, adding the remaining mixture of chlorocyclohexane and diethyl ether dropwise to continue the reaction, and controlling the rate of addition to prevent the reaction from being violent and difficult to control;
  4. After the dropwise addition, the mixture was kept at reflux for 3 hours to obtain a Grignard reaction solution.
About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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