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Curcumax CAS 458-37-7

Molecular Formula: C21H20O6

Formula Weight: 368.38

ZSpharmac: Curcumax Supplier

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Product Name: Curcumax
CAS No: 458-37-7
Purity: 99%

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Basic Info

Product Name:Curcumax
Other Names:Curcumin
CAS:458-37-7
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Orange Powder
EINECS No.:207-280-5
Storage:2-8°C
Provide:Curcumax MSDS;
Curcumax COA

What is Curcumax?

Curcumax, additionally called curcumin as well as acid yellow, is a natural phenolic antioxidant drawn out from the origins of ginger plants such as turmeric extract, curcuma, mustard, curry, and likewise turmeric extract. The key chain is unsaturated aliphatic in addition to aromatic groups., is an actually uncommon pigment with diketones in the plant kingdom. It comes from diketone substances. It is a regularly made use of seasoning as well as food coloring. Infection, antibacterial, anti-oxidation (stronger than α-tocopherol), anti-coagulation, reducing blood fat and also anti-atherosclerosis and various other medicinal results. In 1985, Indian scholar Kuttan at first recommended the anticancer impact of curcumin. Over the last few years, the system of curcumin’s repressive effect on the production, spreading as well as likewise change of various tumor cells has actually been located. The National Cancer Cells Institute of the United States notes it as a third-generation cancer cells therapy drug. After being compatible with mitomycin C, the dose of mitomycin C is lessened, and also at the same time, the nephrotoxicity and additionally bone marrow reductions activated by mitomycin C alone can be decreased, and likewise the outcome of mitomycin C on bust cancer cells can be boosted.
Curcumax has a safety result on liver damages induced by different hazardous products such as carbon tetrachloride, aflatoxin B1, acetaminophen, and also cyclophosphamide in vivo as well as additionally artificial insemination, and considerably minimizes the alkalinity in animals with alcoholic liver injury (ALI) Sex-related phosphatase, r-glutamyl transpeptidase (r-GT) task, to avoid the event of speculative fatty liver.

Curcumax Property

Melting point 183 °C
Boiling point 418.73°C (rough estimate)
density 0.93
vapor density 13 (vs air)
refractive index 1.4155-1.4175
Fp 208.9±23.6 °C
storage temp. 2-8°C
solubility ethanol: 10 mg/mL
form powder
Colour Index 75300
pka8.09(at 25℃)
color orange
PH RangeYellow (7.8) to red-brown (9.2)
OdorOdorless
Water Solubility Slightly soluble (hot)

 

Curcumax Uses

  1. Curcumax is widely used in the coloring of food, recipes, cakes, candies, beverage cans, cosmetics and medications.
  2. Curcumax can be made use of as a feed tinting agent. It can be utilized in sweet, jelly, ice cream as well as soft drinks according to the guidelines of our nation, and also the maximum use quantity is 0.01 g/kg.
  3. Curcumax can make turmeric test paper, pH 8-9; determination of boron.
  4. Curcumax is an acid-base sign, pH7.8 (yellow) ~ 9.2 (red-brown). Chromogenic reaction to determine beryllium, zirconium and also magnesium, borate and reagents. A natural phenolic substance, antitumor and also anti-inflammatory compound, as well as has antioxidant homes, can induce apoptosis of cancer cells.

Curcumax Pharmacology

1. Hypolipidemic result
Curcuminol or ether extracts, Curcumax and also unstable oils were given to the rats as well as additionally rabbits with speculative hyperlipidemia to substantially decrease plasma full cholesterol and also B-lipoprotein, in addition to can lessen liver cholesterol, fix a- It is out of stability with B-lipoprotein, nonetheless has no outcome on endogenous cholesterol; it has a much more considerable outcome on reducing plasma triglycerides, and also can reduce plasma triglycerides below common degrees. High sucrose diet regimen plan can cause hyperlipidemia in rats, as well as curcumin can neutralize this hyperlipidemia. Intragastric management of curcumin can minimize liver weight, minimize liver triglyceride, totally free fat, phospholipid content along with serum full triglyceride, VLDL+LDL triglyceride, HDL triglyceride, VLDL+LDL cholesterol as well as likewise absolutely cost-free fat material in blood. Boost cream total cholesterol as well as HDL cholesterol levels. The liver homogenate was incubated artificial insemination, and also 14C-acetic acid was used as the substrate evaluation. The first results exposed that curcumin can prevent the synthesis of fatty acids.

2. Anti-tumor effect
Taking advantage of computer mouse Dalton’s lymphoascites development cells for cells culture as well as additionally in vivo experiments, curcuma essence can prevent the growth of cancer cells. At 0.4 mg/ml, it can prevent the growth of Chinese hamster ovary cells, has cytotoxic outcome on lymphocytes in addition to Dalton’s lymphocytes, and can reduce the growth of pet growths. Its active ingredient is generally Curcumax. Advertised by croton oil, 7,12-dimethylbenzanthracene can create papillary cancer cells in computer system mice, and also curcumin can considerably lessen the possibility of papillary cancer cells in this scenario, as well as can likewise prevent the development of papillary cancer generated by 2O-methylchloranthracene. tumor development. Curcumin likewise lessens the probability of mutagen triggering cancer. Curcumin can in addition protect against the cancer-inducing impact of TPA (12-O-Tetradecanoylphorbol-13-acetate). When 10μmol/ L curcumin was applied topically, the restraint rate of guanylate decarboxylase activity induced by 5nmol/L TPA got to 91%; The inhibition rate of excited 3H-thymidine chimerism into skin DNA was 49%, as well as the restriction rate was associated with concentration. As a result, curcumin could work as an anticancer representative.

3. Anti-inflammatory impact
Curcumax can hold up against carrageenan-induced rat toe swelling in a dose-dependent fashion within the series of 30mg/kg, while at a dosage of 60mg/kg, it inhibits this anti-inflammatory result Salt curcumin reversibly prevents nicotine, acetylcholine, serotonin, barium chloride, and histamine-induced tightening of isolated guinea pig ileum similar to NSAIDs.

4. Anti-pathogenic bacterium result.
Artificial insemination test, Curcumax has repressive impact on microorganisms (Micrococuspyogenes var. Aureus) at the percent concentration. The necessary oil has a solid antifungal result. Turmeric extract lengthens the survival time of virus-inoculated mice.

5. Influence on the cardio system
Curcumax intravenous shot had no substantial outcome on high blood pressure, nor did it have significant impacts over high blood pressure caused by epinephrine, histamine and also acetylcholine. Oral administration of curcumin can combat S-T in addition to T wave modifications in rat electrocardiograms set off by intravenous shot of pituitrin, as well as intragastric administration can also increase myocardial dietary blood flow in computer mice. Curcumin has a significant result on platelet celebration as well as also blood viscosity. The concentration of curcumin in regular body experiments is 1 × 10( -4) mol/L, which substantially hinders platelet aggregation, along with the restriction rate is 35.4% (P< 0.01). After 5 days of intragastric administration in rats (the dosages were 20, 40, 60, 80 mg/( kg. day) especially), compared to the control group, the platelet gathering was harmed, as well as also the plasma density as well as whole blood thickness were reduced. Among them, 40 mg/( kg. day) group had the greatest inhibitory effect on platelet aggregation, with a restriction price of 34.6% (P<0.05). Continued to increase the dosage, the inhibitory effect did not increase progressively. Under the condition of low shear rate (37.5 seconds The effect of blood and plasma viscosity was significant, while at high shear rate (150 sec-1), there was no significant difference.

6. Choleretic effect.
Turmeric extract, Curcumax, volatile oil, curcumone, zingiberene, borneol and sesquiterpene alcohols all have choleretic effects, can increase the production and secretion of bile, and can promote gallbladder contraction, and the effect of curcumin is the most powerful.

7. Effect on Termination of Pregnancy.
Turmeric is made into 100% (crude medicine 1g/ml) and 200% water decoction. Mice were injected intraperitoneally or subcutaneously with turmeric decoction 10 g/kg in the early (6-7 days), middle (10-14 days) and late (16-18 days) gestation periods, once a day for 2 consecutive days. After administration once in the early and middle-term pregnancy mice, vaginal bleeding can be seen in the morning of the next day, necrosis and denatured embryos in the uterus can be seen in the dissection, and most of the late-pregnancy mice give birth within 24 hours after administration once. It shows that intraperitoneal injection or subcutaneous injection has obvious effects on the pregnancy of mice at all stages (oral administration of 50g/kg is invalid), and the pregnancy termination rate is 90-100%, while the embryonic development of the control group is normal. Rabbits were injected intraperitoneally or subcutaneously with turmeric water decoction 8g/kg in the early (8-10 days), middle (13-15 days) and late (23-25 days) pregnancy, once a day for 2-3 consecutive days, 8 early-pregnancy rabbits and 4 mid-pregnancy rabbits all terminated pregnancy, and all 4 late-pregnancy rabbits also aborted. All 6 rabbits in the control group were pregnant normally. The estrogen and anti-estrogen activity of turmeric was determined by the uterine weight gain method of immature mice, and it was shown that turmeric water decoction 10g/kg intraperitoneal injection or subcutaneous injection had no estrogenic activity and anti-estrogenic activity. The effect of turmeric 10g/kg on terminating early pregnancy in animals can be antagonized by progesterone (1mg/mouse), and turmeric 10g/kg can also significantly inhibit the growth of traumatic decidualoma in pseudopregnant mice. The mechanism of abortive effect may be due to its antiprogestogenic activity and uterotonic effect.

The turmeric powder is successively used petroleum ether, 95% ethanol and water extract, in the 1st day of gestation 1-7 day gavage continuously, when the dosage of three kinds of extracts is 100mg/kg, the rate of termination of pregnancy to female rat is respectively 100, 70 and 100%. The pups were born without deformities. The above three extracts had no effect on the ovulation induced by copper sulfate in rabbits.

8. Antioxidant impact
Usage NIH computer mouse brain, heart, liver, kidney, spleen as well as various other organs to make a specific concentration of homogenate. When the unsaturated fat is oxidized into lipid peroxide, the lipid peroxide quickly develops into malondialdehyde. The principle of malondialdehyde responding with thiobarbituric acid to create red compounds was evaluated under the very same conditions, and also the outcomes revealed that curcumin had an apparent incongruity impact on the lipid peroxidation of the 5 major organs. The homogenate concentration of each body organ is 3.39% for brain, 1.16% for heart, 3.97% for liver (1 ), 3.94% for liver (2 ), 2.08% for kidney, as well as 1.67% for spleen; the dosages of curcumin (mg/100ml) are specifically, Brain 0.31-0.123, Heart 20.4-0.8, Liver (1) 20.4-0.8, Liver (2) 0.8-0.128, Kidney 20.4-0.8, Spleen 0.8-0.123, compared to the blank control, except the middle dose of spleen 0.32, low dosage 0.123 P > 0.005, the mind high dosage 0.32 P< 0.01, the rest are all P< 0.001. It has also been reported that curcumin as well as 4-Hydroxycinnamoyl (geruloyl) methane as well as bis (4-Hydroxycinnamoyl) methane all have antioxidant results, and curcumin is the most effective, as well as the 50% repressive focus to air oxidation of linoleic acid is 1.83 × 10 (-2 )% (thiobarbital worth) and 1.15 × 10 (-2 )% (peroxide value), both more than vitamin E.

9. Light effect
Curcumax has weak antiseptic ability under normal conditions, however when exposed to light, micrograms of curcumin revealed solid phototoxicity. Gram-negative germs were much more resistant to curcumin phototoxicity than Gram-positive germs. This phototoxicity of curcumin can just be produced under cardio problems. Therefore, curcumin might be utilized as a photosensitizing medicine in the photo-therapy of psoriasis, cancer cells, microbial as well as viral illness. Curcumin can also stabilize medicines that are prone to photolysis. For example, the photostabilization effect of p-nifedipine is specifically solid, prolonging its half-life by 6 times, which can improve its medicinal effect.

10. Other effects
Curcumin can hinder the biosynthesis of PGS. Turmeric likewise kills flies. Chloroform and ether removes of turmeric extract have inhibitory effects on Trichophyton and Microsporum plaster artificial insemination. Turmeronol An and B can inhibit soybean lipoxygenase with IC50 of 16 and 19 μmol/ L, respectively. These 2 compounds stop the auto-oxidation of linoleic acid at -200 ppm concentration. the

11. The duty of high blood pressure decrease
Turmeric alcohol remove has antihypertensive result on anesthetized pet dogs, which is not affected by injection of atropine and also elimination of vagus nerve. If pre-injected ergot liquid remove, the antihypertensive result can be turned around into a hypertensive result (similar to the reversal effect of coptisine), and the antihypertensive impact of the ether extract is incredibly weak.

12. Anti-bacterial result
Curcumax and its unpredictable oil have excellent anti-bacterial result on Staphylococcus aureus. Turmeric water mixture has different degrees of inhibitory effect on a range of skin fungis in examination tubes. The preparation can prolong the survival time of the immunized mice, yet it is ineffective against the liver injury brought on by chemical (carbon tetrachloride) on the basis of chronic hepatitis. In addition, turmeric prep work can kill flies.

13. The effect of hangover as well as liver protection
Curcumin consisted of in turmeric extract has the functions of inhibiting hepatitis, fixing harmed liver cells, and enhancing liver parenchyma damage. Turmeric essence, Curcumax, unstable oil, turmeric extract, zingiberene, borneol and sesquiterpene alcohol, and so on, all have choleretic results, can enhance the production as well as secretion of bile, and also can advertise gallbladder contraction, amongst which curcumin is the most efficient. powerful.

Production Method of Curcumax

(1) Water is made use of as solvent removal. At 70-80 ° C, initial usage 8 times the quantity of 1% salt hydroxide remedy to remove 0.175 -.036 mm turmeric powder for 60-75min, filter the filter residue and after that essence two times, the amount of solvent as well as time can be lowered appropriately; mixed Include 0.8% salt bisulfite option to the filtrate 3 times, adjust the pH to 3-4 with hydrochloric acid after focus; throw out the supernatant after standing for stratification, as well as filter the reduced layer to obtain semi-solid curcumin, a combination of turmeric oil and turmeric material; liquify the mixture with 70% ethanol at 70 ° C, filter while hot to get rid of the turmeric material insoluble in ethanol, and afterwards remove the filtrate with petroleum ether to different turmeric oil, as well as the oil ether stage is recovered by distillation under minimized pressure Turmeric extract oil is acquired after petroleum ether, as well as the raffinate ethanol stage is distilled under minimized stress to obtain curcumin, and the return can reach 0.5%-1.5%.
( 2) Organic solvent extraction. Curcumin can be liquified in different solvents such as ethanol, ether, acetone or dichloromethane, as well as one of them can be selected to draw out curcumin as well as turmeric oil from 0.16-0.32 mm turmeric powder, and also after separation and concentration, use petroleum ether to extract and different Turmeric oil and raffinate are distilled under lowered pressure to acquire curcumin, as well as the yield is normally 0.55%-1.5%.
( 3) Detailed extraction. Heavy steam distill turmeric powder for 4-6 hrs at 100-105 ° C to obtain turmeric oil, soak the filter residue with 1% sodium hydroxide remedy at 80 ° C for 25 minutes; filter, counteract and acidify the filtrate with hydrochloric acid, and afterwards filter to get curcumin Unrefined product, the completed product is gotten after refining.

About Products:
If you need Curcumax this cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Curcumax, ZSpharmac will provide Curcumax raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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