1. Hypolipidemic result
Curcuminol or ether extracts, Curcumax and also unstable oils were given to the rats as well as additionally rabbits with speculative hyperlipidemia to substantially decrease plasma full cholesterol and also B-lipoprotein, in addition to can lessen liver cholesterol, fix a- It is out of stability with B-lipoprotein, nonetheless has no outcome on endogenous cholesterol; it has a much more considerable outcome on reducing plasma triglycerides, and also can reduce plasma triglycerides below common degrees. High sucrose diet regimen plan can cause hyperlipidemia in rats, as well as curcumin can neutralize this hyperlipidemia. Intragastric management of curcumin can minimize liver weight, minimize liver triglyceride, totally free fat, phospholipid content along with serum full triglyceride, VLDL+LDL triglyceride, HDL triglyceride, VLDL+LDL cholesterol as well as likewise absolutely cost-free fat material in blood. Boost cream total cholesterol as well as HDL cholesterol levels. The liver homogenate was incubated artificial insemination, and also 14C-acetic acid was used as the substrate evaluation. The first results exposed that curcumin can prevent the synthesis of fatty acids.
2. Anti-tumor effect
Taking advantage of computer mouse Dalton’s lymphoascites development cells for cells culture as well as additionally in vivo experiments, curcuma essence can prevent the growth of cancer cells. At 0.4 mg/ml, it can prevent the growth of Chinese hamster ovary cells, has cytotoxic outcome on lymphocytes in addition to Dalton’s lymphocytes, and can reduce the growth of pet growths. Its active ingredient is generally Curcumax. Advertised by croton oil, 7,12-dimethylbenzanthracene can create papillary cancer cells in computer system mice, and also curcumin can considerably lessen the possibility of papillary cancer cells in this scenario, as well as can likewise prevent the development of papillary cancer generated by 2O-methylchloranthracene. tumor development. Curcumin likewise lessens the probability of mutagen triggering cancer. Curcumin can in addition protect against the cancer-inducing impact of TPA (12-O-Tetradecanoylphorbol-13-acetate). When 10μmol/ L curcumin was applied topically, the restraint rate of guanylate decarboxylase activity induced by 5nmol/L TPA got to 91%; The inhibition rate of excited 3H-thymidine chimerism into skin DNA was 49%, as well as the restriction rate was associated with concentration. As a result, curcumin could work as an anticancer representative.
3. Anti-inflammatory impact
Curcumax can hold up against carrageenan-induced rat toe swelling in a dose-dependent fashion within the series of 30mg/kg, while at a dosage of 60mg/kg, it inhibits this anti-inflammatory result Salt curcumin reversibly prevents nicotine, acetylcholine, serotonin, barium chloride, and histamine-induced tightening of isolated guinea pig ileum similar to NSAIDs.
4. Anti-pathogenic bacterium result.
Artificial insemination test, Curcumax has repressive impact on microorganisms (Micrococuspyogenes var. Aureus) at the percent concentration. The necessary oil has a solid antifungal result. Turmeric extract lengthens the survival time of virus-inoculated mice.
5. Influence on the cardio system
Curcumax intravenous shot had no substantial outcome on high blood pressure, nor did it have significant impacts over high blood pressure caused by epinephrine, histamine and also acetylcholine. Oral administration of curcumin can combat S-T in addition to T wave modifications in rat electrocardiograms set off by intravenous shot of pituitrin, as well as intragastric administration can also increase myocardial dietary blood flow in computer mice. Curcumin has a significant result on platelet celebration as well as also blood viscosity. The concentration of curcumin in regular body experiments is 1 × 10( -4) mol/L, which substantially hinders platelet aggregation, along with the restriction rate is 35.4% (P< 0.01). After 5 days of intragastric administration in rats (the dosages were 20, 40, 60, 80 mg/( kg. day) especially), compared to the control group, the platelet gathering was harmed, as well as also the plasma density as well as whole blood thickness were reduced. Among them, 40 mg/( kg. day) group had the greatest inhibitory effect on platelet aggregation, with a restriction price of 34.6% (P<0.05). Continued to increase the dosage, the inhibitory effect did not increase progressively. Under the condition of low shear rate (37.5 seconds The effect of blood and plasma viscosity was significant, while at high shear rate (150 sec-1), there was no significant difference.
6. Choleretic effect.
Turmeric extract, Curcumax, volatile oil, curcumone, zingiberene, borneol and sesquiterpene alcohols all have choleretic effects, can increase the production and secretion of bile, and can promote gallbladder contraction, and the effect of curcumin is the most powerful.
7. Effect on Termination of Pregnancy.
Turmeric is made into 100% (crude medicine 1g/ml) and 200% water decoction. Mice were injected intraperitoneally or subcutaneously with turmeric decoction 10 g/kg in the early (6-7 days), middle (10-14 days) and late (16-18 days) gestation periods, once a day for 2 consecutive days. After administration once in the early and middle-term pregnancy mice, vaginal bleeding can be seen in the morning of the next day, necrosis and denatured embryos in the uterus can be seen in the dissection, and most of the late-pregnancy mice give birth within 24 hours after administration once. It shows that intraperitoneal injection or subcutaneous injection has obvious effects on the pregnancy of mice at all stages (oral administration of 50g/kg is invalid), and the pregnancy termination rate is 90-100%, while the embryonic development of the control group is normal. Rabbits were injected intraperitoneally or subcutaneously with turmeric water decoction 8g/kg in the early (8-10 days), middle (13-15 days) and late (23-25 days) pregnancy, once a day for 2-3 consecutive days, 8 early-pregnancy rabbits and 4 mid-pregnancy rabbits all terminated pregnancy, and all 4 late-pregnancy rabbits also aborted. All 6 rabbits in the control group were pregnant normally. The estrogen and anti-estrogen activity of turmeric was determined by the uterine weight gain method of immature mice, and it was shown that turmeric water decoction 10g/kg intraperitoneal injection or subcutaneous injection had no estrogenic activity and anti-estrogenic activity. The effect of turmeric 10g/kg on terminating early pregnancy in animals can be antagonized by progesterone (1mg/mouse), and turmeric 10g/kg can also significantly inhibit the growth of traumatic decidualoma in pseudopregnant mice. The mechanism of abortive effect may be due to its antiprogestogenic activity and uterotonic effect.
The turmeric powder is successively used petroleum ether, 95% ethanol and water extract, in the 1st day of gestation 1-7 day gavage continuously, when the dosage of three kinds of extracts is 100mg/kg, the rate of termination of pregnancy to female rat is respectively 100, 70 and 100%. The pups were born without deformities. The above three extracts had no effect on the ovulation induced by copper sulfate in rabbits.
8. Antioxidant impact
Usage NIH computer mouse brain, heart, liver, kidney, spleen as well as various other organs to make a specific concentration of homogenate. When the unsaturated fat is oxidized into lipid peroxide, the lipid peroxide quickly develops into malondialdehyde. The principle of malondialdehyde responding with thiobarbituric acid to create red compounds was evaluated under the very same conditions, and also the outcomes revealed that curcumin had an apparent incongruity impact on the lipid peroxidation of the 5 major organs. The homogenate concentration of each body organ is 3.39% for brain, 1.16% for heart, 3.97% for liver (1 ), 3.94% for liver (2 ), 2.08% for kidney, as well as 1.67% for spleen; the dosages of curcumin (mg/100ml) are specifically, Brain 0.31-0.123, Heart 20.4-0.8, Liver (1) 20.4-0.8, Liver (2) 0.8-0.128, Kidney 20.4-0.8, Spleen 0.8-0.123, compared to the blank control, except the middle dose of spleen 0.32, low dosage 0.123 P > 0.005, the mind high dosage 0.32 P< 0.01, the rest are all P< 0.001. It has also been reported that curcumin as well as 4-Hydroxycinnamoyl (geruloyl) methane as well as bis (4-Hydroxycinnamoyl) methane all have antioxidant results, and curcumin is the most effective, as well as the 50% repressive focus to air oxidation of linoleic acid is 1.83 × 10 (-2 )% (thiobarbital worth) and 1.15 × 10 (-2 )% (peroxide value), both more than vitamin E.
9. Light effect
Curcumax has weak antiseptic ability under normal conditions, however when exposed to light, micrograms of curcumin revealed solid phototoxicity. Gram-negative germs were much more resistant to curcumin phototoxicity than Gram-positive germs. This phototoxicity of curcumin can just be produced under cardio problems. Therefore, curcumin might be utilized as a photosensitizing medicine in the photo-therapy of psoriasis, cancer cells, microbial as well as viral illness. Curcumin can also stabilize medicines that are prone to photolysis. For example, the photostabilization effect of p-nifedipine is specifically solid, prolonging its half-life by 6 times, which can improve its medicinal effect.
10. Other effects
Curcumin can hinder the biosynthesis of PGS. Turmeric likewise kills flies. Chloroform and ether removes of turmeric extract have inhibitory effects on Trichophyton and Microsporum plaster artificial insemination. Turmeronol An and B can inhibit soybean lipoxygenase with IC50 of 16 and 19 μmol/ L, respectively. These 2 compounds stop the auto-oxidation of linoleic acid at -200 ppm concentration. the
11. The duty of high blood pressure decrease
Turmeric alcohol remove has antihypertensive result on anesthetized pet dogs, which is not affected by injection of atropine and also elimination of vagus nerve. If pre-injected ergot liquid remove, the antihypertensive result can be turned around into a hypertensive result (similar to the reversal effect of coptisine), and the antihypertensive impact of the ether extract is incredibly weak.
12. Anti-bacterial result
Curcumax and its unpredictable oil have excellent anti-bacterial result on Staphylococcus aureus. Turmeric water mixture has different degrees of inhibitory effect on a range of skin fungis in examination tubes. The preparation can prolong the survival time of the immunized mice, yet it is ineffective against the liver injury brought on by chemical (carbon tetrachloride) on the basis of chronic hepatitis. In addition, turmeric prep work can kill flies.
13. The effect of hangover as well as liver protection
Curcumin consisted of in turmeric extract has the functions of inhibiting hepatitis, fixing harmed liver cells, and enhancing liver parenchyma damage. Turmeric essence, Curcumax, unstable oil, turmeric extract, zingiberene, borneol and sesquiterpene alcohol, and so on, all have choleretic results, can enhance the production as well as secretion of bile, and also can advertise gallbladder contraction, amongst which curcumin is the most efficient. powerful.
