Zhishang Chemical

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Zhishang Chemical

Curamed Curcumin CAS 458-37-7

Molecular Formula: C21H20O6

Formula Weight: 368.38

ZSpharmac: Curamed Curcumin Supplement

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Product Name: Curamed Curcumin
CAS No: 458-37-7
Purity: 99%

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Basic Info

Product Name:Curamed Curcumin
Other Names:Curcumin
CAS:458-37-7
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Orange Powder
EINECS No.:207-280-5
Storage:2-8°C
Provide:Curamed Curcumin MSDS;
Curamed Curcumin COA

What is Curamed Curcumin?

Curamed Curcumin, additionally known as curcumin, acid yellow, is a natural phenolic antioxidant drawn out from the rhizomes of ginger plants such as turmeric extract, curcuma, mustard, curry, along with turmeric remove. The major chain is unsaturated aliphatic as well as aromatic teams.Over the last few years, curcumin has really been located to avoid the manufacturing, spreading and also change of different growth cells. It is kept in mind as a third-generation oncology medicine by the National Cancer Cells Institute. After being combined with mitomycin C, the dose of mitomycin C can be reduced, and the nephrotoxicity as well as bone marrow reductions brought on by mitomycin C alone can be decreased, as well as likewise the influence of mitomycin C in the therapy of bust cancer cells can be enhanced.

Curamed Curcumin Properties:

Melting point 183 °C
Boiling point 418.73°C (rough estimate)
density 0.93
vapor density 13 (vs air)
refractive index 1.4155-1.4175
Fp 208.9±23.6 °C
storage temp. 2-8°C
solubility ethanol: 10 mg/mL
form powder
Colour Index 75300
pka8.09(at 25℃)
color orange
PH RangeYellow (7.8) to red-brown (9.2)
OdorOdorless
Water Solubility Slightly soluble (hot)

 

Curamed Curcumin Efficacy and Role

1. Antioxidants
Curamed Curcumin is a strong antioxidant that protects the body from free radical damage. Its antioxidant capacity is proven to be comparable to vitamin E and vitamin C.

An in vitro study using bovine aortic endothelial cells to measure the effects of curcumin on stress oxidation showed that curcumin enhanced cellular resistance to oxidative damage over time.

2. Anti-inflammatory
Laboratory studies have shown that Curamed Curcumin can exhibit anti-inflammatory effects by inhibiting pro-inflammatory factors, and exert anti-inflammatory effects by reducing histamine levels and increasing epinephrine secretion of anti-inflammatory substances. The laboratory has identified several Substances that can cause inflammation that can be inhibited by curcumin include phospholipase, lipoxygenase, cyclooxygenase 2, leukotrienes, thromboxane, prostaglandins, nitric oxide, etc.

3. Protect the liver and gallbladder
Curamed Curcumin’s antioxidant properties and mechanistic pro-inflammatory factors protect the liver from many compounds, such as carbon tetrachloride, acetaminophen, and aflatoxins, among others.

Sodium curcumin, a salt of curcumin, exerts choleretic effects by increasing biliary excretion of bile salts, cholesterol and bilirubin, and increasing bile solubility.

4. Cardiovascular protection
Abnormal aggregation of platelets can easily lead to the formation of blood clots. Curcumin has been shown to prevent abnormal aggregation of platelets by enhancing prostacyclin synthesis and inhibiting thromboxane synthesis, thereby improving blood circulation.

At the same time, Curamed Curcumin may reduce cholesterol and triglyceride levels in the body by reducing the absorption of cholesterol in the intestine and increasing the conversion of cholesterol into bile acids in the liver. These effects can accelerate the blood patency in the cardiovascular system to protect Cardiovascular health.

5. Antibacterial properties
Curamed Curcumin inhibits the reproduction of a variety of bacteria and fungal growth, and has moderate activity against some parasites and other protozoa. In an experiment in guinea pigs infected with dermatophytes and fungi, the disappearance of lesions was observed after 7 days of treatment with curcumin.

6. Relieves and treats stomach ulcers
Curamed Curcumin has been proven to relieve or treat gastric ulcers, and a clinical trial of 25 patients with endoscopically diagnosed gastric ulcers showed that after taking 600 mg of turmeric powder five times a day for 4 weeks, 48% of the The ulcers healed completely, and 76% of the patients had no ulcers in their stomachs by endoscopy after 12 weeks.

At the same time, no obvious adverse reactions or abnormal blood index were reported in all subjects.

7. Maintain oral health
In folk remedies, a sore tooth is massaged with toasted turmeric powder to remove pain and swelling, or a paste of 1 teaspoon turmeric, ½ teaspoon salt, and ½ teaspoon mustard oil is rubbed against teeth and gums twice daily , relieves gingivitis and periodontitis.

A randomized trial found that gingival index and plaque index were recorded on days 0, 14, and 21 after continuous mouthwash with curcumin, and the results showed that curcumin played a role in the prevention of plaque and gingivitis. With a good effect.

8. Anti-cancer
In a number of studies involving cancer and cancer cells, it has been found that Curamed Curcumin may play an inhibitory role in different aspects of various cancers. It effectively inhibits the uncontrolled metastases of melanoma cancer cells that cause skin cancer, also inhibits the proliferation of breast tumor cells, inhibits the activity of cancer-inducing chemicals in the skin, stomach, and colon, as well as by modulating protease activity to inhibit angiogenesis, thereby preventing the growth and metastasis of cancer cells.

At the same time, because of its own antioxidant properties, curcumin can scavenge free radicals and reduce the level of high glutathione caused by free radicals, thereby increasing liver detoxification and reducing the possibility of cell canceration.

Production method of Curamed Curcumin

(1) Water for solvent extraction. At 70-80°C, firstly extract 0.175-.036mm turmeric powder with 8 times the amount of 1% sodium hydroxide solution for 60-75min. After filtering, the filter residue is extracted twice, and the amount of solvent and time can be reduced in turn; The filtrate was added three times with 0.8% sodium bisulfite solution, and after concentration, the pH was adjusted to 3-4 with hydrochloric acid; after standing for stratification, the supernatant was discarded, and the lower layer was filtered to obtain semi-solid Curamed Curcumin. , turmeric oil and turmeric resin mixture; dissolve the mixture with 70% ethanol at 70°C, filter while hot to remove ethanol-insoluble turmeric resin, the filtrate is then extracted with petroleum ether to separate the turmeric oil, and the petroleum ether phase is recovered by distillation under reduced pressure After petroleum ether, turmeric oil is obtained, and the raffinate ethanol phase is distilled under reduced pressure to obtain Curamed Curcumin, and the yield can reach 0.5%-1.5%.
(2) Organic solvent extraction. Curamed Curcumin can be dissolved in various solvents such as ethanol, ether, acetone or dichloromethane. One of them can be used to extract curcumin and turmeric oil from 0.16-0.32mm turmeric powder, and after separation and concentration, use petroleum ether to extract and separate. Turmeric oil, the raffinate phase is distilled under reduced pressure to obtain curcumin, and the yield is generally 0.55%-1.5%. (
3) Step-by-step extraction. Steam distillation of turmeric powder at 100-105°C for 4-6h to obtain turmeric oil, soak the filter residue with 1% sodium hydroxide solution at 80°C for 25min; filter, neutralize and acidify the filtrate with hydrochloric acid, and then filter to obtain Curamed Curcumin The crude product is refined and the finished product is obtained.

Identification Test For Curamed Curcumin

Solubility Insoluble in water and also ether; soluble in ethanol and also glacial acetic acid. Identified by OT-42 method. Melting range 179 ~ 182 ℃. Determined by traditional methods.
The ethanol solution of color reaction An example should be pure yellow as well as have light environment-friendly fluorescence; if this ethanol extract is included with focused sulfuric acid, it will certainly create deep purple red.
Color Response B Treat an aqueous or weaken ethanol remedy of the example with hydrochloric acid until it starts to turn a little orange. Divide this mixture into 2 parts, as well as include a small amount of boric acid powder or crystals to one part, which turns reddish substantially compared to the part without boric acid. A number of pieces of filter paper can likewise be dipped in the ethanol solution of the pigment, dried at 100 ° C, and then wetted with a thin down service of boric acid (with a couple of declines of hydrochloric acid included). It should be cherry red when completely dry.
Chromatography: Take 5ml of the test remedy (0.01 g of sample dissolved in 1mL of 95% ethanol) and also drop it on thin layer chromatography (microcrystalline cellulose, 0.1 mm), put it in a container containing 3-methyl-1-butanol/ ethanol/water In the advancement container of the mixed service of ammonia (4:4:2:1), the front of the solvent is increased by 10-15 cm. Observed under UV light after eventually as well as evening:
There are three yellow areas with Rf in between 0.2 and also 0.4;
The Rf of various other areas is 0.6 to 0.8;
All areas fluoresced yellow under UV light.
6.95% ethanol solution has the optimum absorption optimal at 425nm.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Curamed Curcumin Quotation