Zhishang Chemical

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Zhishang Chemical

Cupric Gluconate CAS 527-09-3

Molecular Formula: C12H22CuO14

Formula Weight: 453.84

ZSpharmac: Cupric Gluconate Supplier

Product Name: Cupric Gluconate
CAS No: 527-09-3
Purity: 99%

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Basic Info

Product Name:Cupric Gluconate
Other Names:Copper Gluconate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Blue to Blue Powder
EINECS No.:208-408-2
Storage:Inert atmosphere,Room Temperature
Provide:Cupric Gluconate MSDS;
Cupric Gluconate COA

What is Cupric Gluconate?

Cupric Gluconate is a copper light blue great powder. The FAO/WHO Specialist Committee on Food Additives (JECFA) examined copper gluconate as a “valuable, secure and essential” copper supplement. Presently, the USA, Japan and other nations have designated Cupric Gluconate as a permitted food fortifier and also as a treatment drug for copper shortage.Relevant experts believe that trace amounts of copper exist in various enzymes in the body and constitute the active factor of enzymes. Copper enzymes have very important physiological functions. For example, it can improve the biological oxidation function and metabolic function of tissues and cells in the whole body, and increase the oxygen carrying capacity of the blood. , improve blood circulation, improve local blood supply and oxygen supply, and provide a new and promising option for human beings to defeat cancer.

Cupric Gluconate Property

Melting point 155-157 °C(lit.)
refractive index 16.5 ° (C=1, H2O)
storage temp. Inert atmosphere,Room Temperature
solubility Aqueous Acid (Slightly), Water (Sparingly, Sonicated)
form powder
color Light Blue to Blue
optical activity[α]26/D +15°, c = 1 in H2O
Water Solubility slightly soluble

Cupric Gluconate Uses

  1. Cupric Gluconate can be used to deal with parasitic skin infections such as leishmaniasis.
  2. Cupric Gluconate can deal with copper shortage with copper gluconate supplements. An absence of this nutrient can cause anemia, a problem in which the variety of healthy and balanced blood cells is less than typical. As a result, this supplement is likewise valuable in treating anemia caused by nutritional copper shortage. Since nutritional copper is taken into consideration a trace element, copper shortage is unusual.
  3. Cupric Gluconate can likewise deal with weakening of bones, a disease that is prone to fractures. Research study confirms that dietary copper is important for bone advancement. The body relies on this trace element to keep normal bone growth. Therefore, along with calcium, manganese and zinc supplements, copper gluconate can also deal with weakening of bones.
  4. Cupric Gluconate plays an essential duty in managing high blood pressure. For that reason, it is additionally challenging to maintain regular blood pressure in the existence of changing copper degrees. Actually, pet examinations have actually shown that reduced copper degrees can cause raised blood pressure. Consequently, hypertensive people can control their blood pressure by taking copper gluconate supplements.
  5. Cupric Gluconate as an active component in skin treatment items.
    Copper gluconate has antioxidant and also anti-inflammatory homes, and consequently can deal with skin diseases. Its antioxidant properties promote skin regrowth, reduce wrinkles as well as are good for skin anti-aging. On top of that, it is included in oral hygiene products such as mouth wash and tooth paste.

Preparation Method of Cupric Gluconate

The preparation method of Cupric Gluconate includes the following steps:

(1) Dissolve 1 part of copper nitrate in 500 mL of water, heat it to 60° C. while stirring the mixed solution for 1 hour, filter impurities to obtain a blue and transparent copper nitrate solution.

(2) Dissolve 1 part of potassium carbonate in 250 mL of water, and stir until the dissolution is complete to obtain a potassium carbonate solution.

(3) Slowly adding the potassium carbonate solution to the copper nitrate solution, heating to 60° C., and stirring for 1 hour, a pale green precipitate was produced.

(4) filter the light green precipitate, then disperse the light green precipitate in 600 mL of water, heat to 60° C., stir for 20 minutes, then filter and wash with water to obtain a purified light green precipitate, repeat the above steps, A total of 10 washes were performed.

(5) The purified light green precipitate is placed in an oven for drying and pulverized to obtain a green product, namely basic copper carbonate, and the temperature in the oven is 50°C.

(6) test the nitrate content of the basic copper carbonate, if the nitrate content is less than 0.05%, then enter step (7);

(7) Dissolving 1 part of gluconolactone in 80 mL of water, heating at 60° C. until the dissolution is complete and then stopping the heating to obtain a gluconolactone solution;

(8) add 1.1 parts of basic copper carbonate to the gluconolactone solution, stir for 1 hour and then stand for crystallization, and the crystallization mode adopts the direct crystallization of semi-solid phase reaction;

(9) Drying and pulverizing the crystals obtained in step (8) at 50° C. to obtain Cupric Gluconate.

Application of Cupric Gluconate

CN200710028660.0 discloses a kind of bactericide containing Cupric Gluconate, which is characterized in that according to the total mass fraction of 100%, it is composed of copper gluconate 0.01~0.07%, bactericide 0~0.015%, auxiliary agent 0~0.057%, the balance of water composition. The fungicide of the present invention can be well dispersed in an aqueous medium, and can effectively prevent and treat plant diseases, especially bacterial diseases, such as citrus canker, Phytophthora downy mildew, anthracnose, black rot of cabbage, and angular spot of cucumber It has a promoting effect on crop organisms and has no stimulating effect on pests. The liquid is mixed with water and sprayed on the crown of the tree, which has good diffusion on the leaf surface and low toxicity, so it has a great promotion value.

CN201110047274.2 discloses an effervescent tablet for improving immunity and a preparation method thereof. Including Beta Carotene, Vitamin B1, Vitamin B2, Vitamin B6, Vitamin B12, Vitamin C, Vitamin E, Pantothenic Acid, Folic Acid, Biotin, Zinc Gluconate, Cupric Gluconate, Yeast Selenium, Copper Gluconate, Acanthopanax senticosus extract, Astragalus extract, Grifola frondosa extract, citrus extract, inulin, citric acid, malic acid, sodium bicarbonate, aspartame, flavor, sodium chloride, PEG6000, lactose, prepared by direct powder compression It is made into effervescent tablets, which are quickly absorbed and easy to use. It is used for children, the elderly and white-collar workers to supplement vitamins and minerals, improve immunity, and play a role in health care.

Crystallization Application of Food Grade Cupric Gluconate

A preparation method of low-purine soybean sprouts, comprising the following steps,

(1) Soaking and deodorizing: After washing the soybeans under running water, completely soak them in a food-grade Cupric Gluconate solution with a mass concentration of 1-2%, and at the same time irradiate the yellow beans with the C-band ultraviolet light generated by the ultraviolet light irradiation device. Bean sprouts until soybean sprouts sprout;

(2) Inhibition of growth for the first time: take out the sprouted soybeans, rinse them with clean water 2-3 times, and re-soak them in a catalase solution with a temperature of 5-6°C and a concentration of 10000-12000U/ml for a soaking time of 6-8 hours;

(3) Initial growth promotion: after the soybean sprouts obtained in step (2) are taken out, pass through clean water for 2-3 times, and re-immerse in the temperature of 25-27°C and the concentration of 0.1-0.12% polyhexamethylene In the guanidine aqueous solution, the soaking time is 10-12 hours;

(4) Inhibit growth again: after the soybean sprouts obtained in step (3) are taken out, pass through clean water repeatedly for 2-3 times, and re-soak in the temperature of 5-6 ℃ and the concentration of 3000-5000U/ml catalase In the solution, the soaking time is 2-3 hours;

(5) Promoting growth again: after taking out the soybean sprouts obtained in step (4), repeatedly passing through clean water for 2-3 times, and then soaking again in the temperature of 20-22°C and the concentration of 0.1-0.12% polyhexamethylene In the guanidine aqueous solution, the soaking time is 8-10 hours.

About Products:
If you need Cupric Gluconate, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Cupric Gluconate manufacturer and supplier, ZSpharmac will provide Cupric Gluconate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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