Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Close this search box.

Cupric Gluconate CAS 527-09-3

Molecular Formula: C12H22CuO14

Formula Weight: 453.84 

ZSpharmac: Cupric Gluconate Supplier

Product Name: Cupric Gluconate
CAS No: 527-09-3
Purity: 99%

Navigation Bar

Basic Info

Product Name:Cupric Gluconate
Other Names:Copper(II)Gluconate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Blue to Blue Powder
EINECS No.:208-408-2
Storage:Room Temperature
Provide:Cupric Gluconate MSDS;
Cupric Gluconate COA

What is Cupric Gluconate?

Copper gluconate is copper light blue great powder. The FAO/WHO Expert Board on Preservative (JECFA) assessed copper gluconate as a copper supplement with “effectiveness, safety and security, as well as need”. Presently, the United States, Japan and also other nations have assigned copper gluconate as a food fortifier permitted to be made use of, and also as a treatment for copper shortage.

Cupric Gluconate Property

Melting point 155-157 °C(lit.)
Boiling point 673.6℃[at 101 325 Pa]
density 1.777[at 20℃]
vapor pressure 13.3Pa at 20℃
refractive index 16.5 ° (C=1, H2O)
storage temp. Inert atmosphere,Room Temperature
solubility Aqueous Acid (Slightly), Water (Sparingly, Sonicated)
form powder
color Light Blue to Blue
optical activity[α]26/D +15°, c = 1 in H2O
Water Solubility slightly soluble


Cupric Gluconate Uses

  1. Copper gluconate is a kind of copper supplement commonly used in cosmetic cosmetics as well as skin treatment products. It can additionally be made use of to deal with troubles such as copper scarcity, which causes anemia.
  2. Copper gluconate is a dietary supplement. According to Japanese policies, it is enabled to be utilized in milk changes to reinforce copper, and additionally the copper web content of milk replacement beverages with basic customized milk focus shall not exceed 0.6 mg per litre.
  3. Copper gluconate is taken advantage of as a preservative and pharmaceutical raw material.

Copper Gluconate Preparation Method

(1) dissolving the soluble copper salt in an appropriate amount of water, filtering impurities after heating and stirring to obtain a soluble copper salt solution;

(2) dissolving the soluble carbonate in an appropriate amount of water, and stirring until completely dissolved to obtain a soluble carbonate solution;

(3) slowly adding the soluble carbonate solution to the soluble copper salt solution, heating and stirring to produce a light green precipitate;

(4) filter the light green precipitate, then disperse the light green precipitate in an appropriate amount of water, heat and stir, then filter and wash to obtain the purified light green precipitate;

(5) pulverize the light green precipitate after the purification is placed in an oven for drying to obtain a green product, i.e. basic copper carbonate;

(6) Test the acid radical content of the basic copper carbonate, if the acid radical content is greater than or equal to 0.05%, repeat steps (4)-(5); if the acid radical content is less than 0.05%, then enter step (7);

(7) Dissolving gluconolactone in an appropriate amount of water, heating until the dissolution is complete, and stopping heating to obtain a gluconolactone solution;

(8) adding basic copper carbonate to the gluconolactone solution, stirring and standing to crystallize;

(9) drying and pulverizing the crystal obtained in step (8) at 50-60° C. to obtain Cupric Gluconate.

Specifically, the parts by weight of raw materials for preparing the Cupric Gluconate are: 1 part of soluble copper salt; 1-1.15 parts of soluble carbonate; 1.1-1.2 parts of basic copper carbonate; 1 part of gluconolactone.

Specifically, when the soluble copper salt was dissolved in an appropriate amount of water, it was heated to 60° C. and the mixed solution was stirred for 1 hour, and impurities were filtered to obtain a blue transparent solution.

Preferably, in the step (3), the heating temperature is 60° C., and the stirring time is 1 hour.

Preferably, in the step (4), the light green precipitate is dispersed in an appropriate amount of water, heated to 60°C, and the mixture is stirred for 20 minutes, then filtered and washed with water, and the above steps are repeated for a total of 10 washes.

Preferably, the temperature in the oven in the step (5) is 50-60°C.

Preferably, in the step (8), the stirring time for the mixed solution is 1 hour.

Preferably, in the step (9), the temperature for drying the crystal is 50-60°C.

Preferably, the crystallization method adopts semi-solid phase reaction direct crystallization.

In summary, owing to adopting above-mentioned technical scheme, the beneficial effect of the present invention is:

The invention has the advantages of adopting semi-solid phase crystallization, avoiding high-temperature concentration to produce red precipitate, and directly crystallizing without using organic solvents, greatly reducing crystallization cost, effectively improving crystallization yield, good product quality, and simple production equipment ,Low energy consumption.

Specific Implementation of Cupric Gluconate

All the functions revealed in this spec, except equally unique functions and/or steps, can be combined in any way.

In this instance, the parts by weight of basic materials for preparing the Cupric Gluconate are: 1 part of copper nitrate; 1 part of potassium carbonate; 1.1 parts of basic copper carbonate; 1 part of gluconolactone.

Its prep work method consists of the following steps:
( 1) When 1 part of copper nitrate is liquified in 500 mL of water, heat it to 60 ° C. and stir the mixed service for 1 hr, then filter the impurities to acquire a blue clear copper nitrate service.

( 2) Dissolve 1 part of potassium carbonate in 250 mL of water and also mix till totally dissolved to get potassium carbonate option.

( 3) The potassium carbonate service was slowly included in the copper nitrate option, heated to 60 ° C., and also mixed for 1 hour to generate a light environment-friendly precipitate.

( 4) filter the light eco-friendly precipitate, after that disperse the light eco-friendly precipitate in 600mL water, heat to 60 ° C, mix for 20 mins, after that filter and wash to get the detoxified light environment-friendly precipitate, repeat the above actions, A total amount of 10 cleans were executed.

( 5) Put the detoxified light environment-friendly precipitate in an oven for drying out and shatter to get an eco-friendly product, particularly fundamental copper carbonate, as well as the temperature in the stove is 50 ° C.
( 6) test the nitrate material of the basic copper carbonate, if the nitrate web content is less than 0.05%, then get in step (7 );

( 7) Dissolve 1 part of gluconolactone in 80 mL of water, heat at 60 ° C up until the dissolution is full, and afterwards stop warming to obtain a gluconolactone solution;

( 8) Add 1.1 parts of standard copper carbonate to the gluconolactone solution, delegate mean crystallization after mixing for 1 hr, and also the condensation method adopts semi-solid phase response to straight crystallize;

( 9) drying and pulverizing the crystal gotten symphonious (8) at 50 ° C. to obtain Cupric Gluconate.

About Products:
If you need Cupric Gluconate, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Cupric Gluconate manufacturer and supplier, ZSpharmac will provide Cupric Gluconate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Cupric Gluconate Quotation