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Zhishang Chemical

Cristaux De Menthol CAS 2216-51-5

Molecular Formula: C10H20O

Formula Weight: 156.27

ZSpharmac: Cristaux De Menthol Supplement

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Product Name: Cristaux De Menthol
CAS No: 2216-51-5
Purity: 99%

Basic Info

Product Name:Cristaux De Menthol
Other Names:L-Menthol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Flavors and Fragrances
Appearance:Colorless to White Crystals or Crystalline Needles
EINECS No.:218-690-9
Storage:Store Below +30°C.
Provide:Cristaux De Menthol MSDS;
Cristaux De Menthol COA

What is Cristaux De Menthol?

Cristaux De Menthol, also known as hexahydrothymol, common name menthol, scientific name 5-methyl-2-isopropyl-cyclohexanol. It is a very important cycloterpene alcohol. Levo-menthol has a characteristic mint aroma and has a cooling effect. Racemic-menthol also has cooling effect, other isomers have no cooling effect. L-menthol is widely used in medicine and hygiene, and can be used as poultice, ointment, analgesic, local anesthetic, cooling agent, antipruritic, mouthwash, bactericide, as well as for the treatment of toothache, Stomach pain, neuralgia lozenges, etc.; the second major use is spice, levomenthol is the spice with the greatest demand among the cyclic monoterpene alcohols, and can be used as tobacco spice, used together with peppermint oil to prepare toothpaste flavor, and other spice. Preparation of toilet water; Menthol can also be used as a flavoring agent for various foods, such as for the preparation of candy, chewing gum, cakes, fruit wine, refreshing drinks, etc.

Cristaux De Menthol used to be mainly isolated from natural peppermint oil. Natural menthol is affected by weather and sunshine, and its output and quality will fluctuate, and the price will also fluctuate, and the production cost of users is not easy to determine. The quality of synthetic Cristaux De Menthol products is stable, and its price is relatively stable, which is easier for manufacturers to accept. There is not much difference in quality between synthetic menthol and natural products; the former is lower than the latter in price. Due to the increasing industrial use of menthol: in daily chemical, cosmetic, pharmaceutical, food, beverage and tobacco industries, its demand is increasing substantially. Historically, Cristaux De Menthol was extracted from plants, and the yield was greatly affected by seasons, planting areas, etc., resulting in very large price fluctuations.

Since Germany’s Dezhixin Company and Japan’s Takasago Company launched chemically synthesized Cristaux De Menthol, the price has stabilized. Synthetic menthol has a stable taste, relatively cheap price, and is easily accepted by manufacturers. Due to the destruction of the natural environment and the increase in labor costs and other factors As a result, the production of natural menthol is becoming less and less, resulting in a slow rise in the price of Cristaux De Menthol. Therefore, vigorously developing the synthetic menthol industry has good economic prospects.

Cristaux De Menthol Properties:

Melting point 41-45 °C (lit.)
alpha -51 º (589nm, c=10, EtOH)
Boiling point 212 °C (lit.)
density 0.89 g/mL at 25 °C (lit.)
vapor pressure 0.8 mm Hg ( 20 °C)
refractive index 1.46
Fp 200 °F
storage temp. Store below +30°C.
solubility 490mg/l
form Crystals or Crystalline Needles
color Colorless to white
Specific Gravity0.89
optical activity[α]22/D 49°, c = 10 in 95% ethanol
Water Solubility insoluble


Cristaux De Menthol Uses

  1. Cristaux De Menthol is an edible seasoning that is permitted to be utilized in my nation, primarily used for flavoring tooth paste, sweet and drinks. The dose is based on normal manufacturing requirements, typically 1100mg/kg in eating gum; 400mg/kg in sweet; 130mg/kg in baked food; 68mg/kg in gelato; 35mg/kg in sodas.
  2. Cristaux De Menthol is the edible spice that GB2760-1996 specifies that natural thin jiannao is permitted to be utilized. GB2760-2001 specifies that dl-type thin film brain is also enabled to be utilized as a food spice. For the preparation of mint-type seasonings (can account for 10% to 18%), it can additionally be made use of in candy (mint, gum), beverages, gelato, and so on (the dosage is 0.054% to 0.1%).
  3. Both Cristaux De Menthol and racemic menthol can be utilized as flavoring agents in toothpastes, fragrances, beverages as well as sweets. In the world, my country as well as Brazil are the major producers of all-natural mint, as well as the annual outcome of mint oil both gets to 2000-3000t.
  4. The cornerstone of Cristaux De Menthol. It is commonly utilized in confectionery, cosmetics and also toothpaste as a result of its characteristic mint flavor and also cooling impact.

Cristaux De Menthol Production Method

Cristaux De Menthol can be purified from natural mint crude oil and can also be prepared by synthetic method. The essential oil obtained by steam distillation of the aerial parts (stems, branches, leaves and inflorescences) of the Lamiaceae plant mint is called mint crude oil, and the oil yield is 0.5-0.6. There are various methods of synthesizing the thin hemispheres.
1. Manufacture from citronellal Utilize the property of citronellal to be easily cyclized into Cristaux De Menthol, cyclize D-citronellal into L-isopulegol with an acid catalyst (such as silica gel), and separate L-isopulegol Alcohol, hydrogenated to produce levo-mint. Its stereotutor structure can be partially converted into D-citronellal by thermal cracking, which can be recycled.
2. Manufactured from thymol In the presence of aluminum m-cresol, the alkylation reaction of m-cresol is carried out to generate thymol. Catalytic hydrogenation yields all four pairs of menthol stereoisomers (ie, racemic Cristaux De Menthol, racemic neomenthol, racemic isoCristaux De Menthol, and racemic neoisomenthol). It is distilled, the Cristaux De Menthol fraction is de-rotated, and the ester is produced and recrystallized repeatedly to separate and optically separate the isomers. The separated L-menthol ester can be saponified to obtain menthol.

Cristaux De Menthol Synthesis

See Scheme 4 for the route of German Dezhixin Company, which is now the synthetic method of Cristaux De Menthol with the largest output in the world. The advantage of this route is that the synthesis steps are relatively simple, and the disadvantage is that the separation and recovery process is cumbersome. First, m-cresol and propylene are used in Thymol 9 was obtained in 63% yield under Lewis acid catalysis [16], and then the benzene ring was hydrogenated under the catalysis of a nickel/iron/chromium/aluminum alloy to obtain various stereoisomer mixtures of Cristaux De Menthol 6, The yield of this step is 99.5%, which contains 60.3% of the mixture of L-menthol (1R,3R,4S)-6 and D-menthol (1S,3S,4R)-6, and 39.2% of other stereoisomers. ( Mixtures of 1R,3R,4S)-6 and (1S,3S,4R)-6 and other stereoisomers can be separated by rectification. (1R,3R,4S)-6 and (1S,3S,4R) -6 is esterified with benzoate to obtain (1R, 3R, 4S)-10 and (1S, 3S, 4R)-10, respectively, and then inoculated with optically pure menthyl benzoate to obtain high-purity ( 1R, 3R, 4S)-10 and (1S, 3S, 4R)-10, and finally simple hydrolysis of the separated esters can obtain high-purity L-Cristaux De Menthol and D-Menthol. In addition to the product L-Menthol In addition, all other configurations of menthol can be recovered by catalytic dehydrogenation again to obtain thymol 9, and then hydrogenated for separation. The total yield of this route can exceed 90%. For the separation step, Dezhixin The company invented the lipase separation technology in 2002. For example, using lipase extracted from Candida for separation, the ee value of L-menthol obtained can be nearly 100%, but the cost is too high and it is not industrialized.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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