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Creatine Monohydrate CAS 6020-87-7

Molecular Formula: C4H11N3O3

Formula Weight: 149.15

ZSpharmac: Creatine Monohydrate Supplier

Product Name: Creatine Monohydrate
CAS No: 6020-87-7
Purity: 99%

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Basic Info

Product Name:Creatine Monohydrate
Other Names:Glycine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Yellow Crystalline Powder
EINECS No.:611-954-8
Provide:Creatine Monohydrate MSDS;
Creatine Monohydrate COA

What is Creatine Monohydrate?

Creatine in the body is developed from amino acids during a chemical treatment in the liver, and also later sent out from the blood to muscular tissue cells where it is exchanged creatine. The movement of human muscle mass depends on the decay of adenosine triphosphate (ATP) to offer energy. Creatine Monohydrate can automatically change the water going into the muscle mass, widen the cross-section of the muscle, and likewise increase the explosive power of the muscle.

Creatine Monohydrate Property

Melting point 292 °C (dec.)(lit.)
RTECS MB7706000
storage temp. 2-8°C
solubility slightly soluble in water, insoluble in ethanol and ether.
form Crystalline Powder
color White to yellow
PH6.9 (10g/l, H2O, 20℃)
Water Solubility 13 g/L (20 ºC)


Creatine Monohydrate Uses

  1. Creatine Monohydrate can prevent the generation of muscle mass fatigue elements, reduce tiredness and also tension, recover physical conditioning, accelerate human protein synthesis, make muscular tissues more powerful, enhance muscular tissue elasticity, lower cholesterol, blood fat, and blood sugar level levels, enhance muscular atrophy in middle-aged and also elderly individuals, hold-up senescence.
  2. Creatine Monohydrate can be used to promote skeletal muscular tissue to adapt to arduous workout and also dietary supplements versus fatigue in weak people; it can additionally be made use of to prepare medications for the treatment of heart problem as well as breathing deficiency; to prepare pharmaceutical prep work including human growth hormonal agent; as well as can be made use of for compounding A brand-new health food with anti-aging and also youth-restoring effects. Given that creatine is not a hormonal agent, it will not cause any type of interference or damage to the endocrine system of the human body, as well as will certainly not cause substance abuse or physiological side effects, so creatine supplements have come to be preferred over the last few years. Creatine exists in fish and also meat foods, however the amount is really tiny. It is challenging to acquire all of it from food in order to attain the everyday intake each that is valuable for growing muscular tissues. Numerous researches have reported that supplementation with Creatine Monohydrate boosts creatine material in skeletal muscle.
  3. Creatine can be exchanged phosphocreatine under the activity of creatine kinase, consequently enhancing the energy-supply metabolic swimming pool of phosphocreatine. Auxiliary feeding of Creatine Monohydrate will create modifications in creatine metabolic rate, which might change the initial growth and also meat high quality of the body. Although there are very few reports on the application of creatine in livestock and fowl production, as well as the results are quite various, it offers a new and also reliable technique for enhancing the high quality of livestock and also fowl meat, showing wonderful application possibility.

Is Creatine Monohydrate Really Poorly Absorbed?

In fact, most studies have found that the absorption rate of creatine monohydrate is not low. The reason why muscle creatine saturation can only be achieved during the impact period is not because the absorption rate of creatine monohydrate is particularly low, but because creatine is such a thing that, if you eat more and more, it is impossible for the muscles to absorb a large amount in a short period of time.

The excretion rate of creatine gradually increases with the amount and time of use, in fact, it gradually increases with the increase of muscle reserves. According to Harris’ research report, within three days after taking creatine orally, the amount of creatine excreted by the kidneys accounted for 40%, 60%, and 68% of the dose respectively. It can be seen that it is not that creatine monohydrate is not absorbed.

Can be excreted from the kidneys, indicating that creatine monohydrate has been absorbed into the blood. It’s just that a large amount of creatine cannot be taken in by the muscles and is directly excreted with urine.

Most studies believe that creatine enters the muscle through a specific process, so the rate of creatine transport into the muscle is limited. Even if the new type of creatine is well absorbed, it can enter the blood in large quantities, but it enters the muscle in the same form as creatine monohydrate. There is also the issue of muscle uptake rate.

Therefore, it is wrong to say that creatine monohydrate is largely destroyed by stomach acid and not absorbed. The method of using creatine during the impact period is also formulated based on the research on the excretion of creatine, not because of absorption.

In the maintenance period after the shock period, a minimum intake of 2 grams per day can maintain creatine concentration. The degradation of creatine in the human body is about 2 grams per day. This also shows that the absorption rate of creatine monohydrate is not very low.

Therefore, in principle, the absorption rate of some new types of creatine is indeed higher than that of creatine monohydrate, but the impact of this on the utilization rate of creatine still needs more research to be clear. There is no need to underestimate the absorption rate of creatine monohydrate in order to promote the new creatine. This is not an objective attitude.

Creatine Monohydrate Synthesis Process

A kind of chemical synthesis technique of creatine monohydrate is characterized in that, comprises the following steps:

① Take chloroacetic acid and methylamine to configure aqueous solutions, then take chlorine aqueous solution and methylamine aqueous solution for 8-12 hours, then react for 7-15 hours at a temperature of 5-45 ° C, and then discharge to obtain sarcosine The solution is ready for use.

② Heat the above-mentioned mixed solution to 45-95 °C, and distill all the methylamine in the mixed solution.

③ Add a neutralization and decomposition reagent to the remaining solution of the material in the above step 2, and obtain the solution after the reaction;

4. above-mentioned solution is carried out decompression concentration, control temperature is 100-120 ℃, after decompression concentration time 2-1-2h, obtain sarcosine aqueous solution;

⑤ Filter the sarcosine aqueous solution obtained above, filter out the dregs, and obtain a relatively pure sarcosine aqueous solution, and then add a pH reagent to adjust the pH value to 8-11;

⑥ Cool the solution obtained in the above step 5, control the cooling temperature at 3-18°C, keep stirring for no less than 8 hours, and then obtain creatine crystals, then perform dilute filtration, washing and drying to obtain creatine monohydrate Crude;

⑦ Recrystallize the crude creatine monohydrate obtained in step 6 above to obtain creatine monohydrate with a purity of 99.8%.

About Products:
If you need Creatine Monohydrate as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Creatine Monohydrate manufacturer and supplier, ZSpharmac will provide Creatine Monohydrate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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