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Coumarins in Plants CAS 91-64-5

Molecular Formula: C9H6O2

Formula Weight: 146.14

ZSpharmac: Coumarins in Plants Supplier

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Product Name: Coumarins in Plants
CAS No: 91-64-5
Purity: 99%

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Basic Info

Product Name:Coumarins in Plants
Other Names:Coumarin
CAS:91-64-5
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystals or Crystalline Powder
EINECS No.:202-086-7
Storage:Store Below +30°C.
Provide:Coumarins in Plants MSDS;
Coumarins in Plants COA

What is Coumarins in Plants?

Coumarin (coumarin) is also known as coumarin, 1,2-benzopyrone, 1-benzopyran-2-one, 2H-benzopyran-2-one, oxanaphthone, It is an oxygen heterocyclic compound. It can be extracted from tonka beans (native to Guyana), or prepared by chemical synthesis. Coumarins are the mother nucleus of a large class of coumarin-like compounds that exist in plants and, in addition to tonka bean, occur naturally in many edible plants such as strawberries, black currants, apricots and cherries as well as the herb cinnamon or Among the cassia seeds.

Coumarins in Plants Property

Melting point 68-73 °C (lit.)
Boiling point 298 °C (lit.)
density 0.935
vapor pressure 0.01 mm Hg ( 47 °C)
refractive index 1.5100 (estimate)
Fp 162 °C
storage temp. Store below +30°C.
solubility 1.7g/l
form Crystals or Crystalline Powder
color White
PH RangeNon’ uorescence (9.5) to light green ‘ uorescence (10.5)
Odorat 10.00 % in dipropylene glycol. sweet hay tonka new mown hay
Odor Typetonka
Water Solubility 1.7 g/L (20 ºC)

 

Coumarins in Plants Uses

  1. Coumarin is mainly utilized in the blending spices of soap and different cleaning agents. It is the main component of mixing flavors and also can likewise be utilized as a brightener for electroplating.
  2. Coumarin is used in the manufacture of fragrances, as a fixative, and also in the electroplating sector.
  3. Coumarin is utilized in the manufacture of seasonings. It is often utilized in the prep work of new mowing as well as fougere flavors. And also violet, sunflower, Su Xinlan, hawthorn flower, orchid, lavender and also other tastes. Together with vanillin, it can be made use of for flavoring such as candy and also cakes, and also it can be contributed to tobacco to enhance the natural taste. Including coumarin to the galvanizing (or cadmium, nickel) electroplating service can lower the porosity of the plating layer as well as boost the illumination. Coumarin is a resources for the manufacture of other fragrances as well as a range of various other chemicals. Coumadin is the moms and dad of a big course of derivatives. Several of these by-products exist in nature, while others are created artificially.

Production Method of Coumarin

(1) Prepared from salicylaldehyde by Perkin response. This is the synthesis approach originally embraced by Perkin in 1868. Calcined potassium carbonate can be used as a driver for the reaction of salicylaldehyde as well as acetic anhydride. Include carbonic acid and acetic anhydride to salicylaldehyde, warmth to 187 ° C, boil down acetic acid when the gas stage temperature has to do with 120 ° C, then include acetic anhydride, and also react at 210-212 ° C. The obtained unrefined coumarin was cleaned with water as well as vacuum distilled. Then use ethanol or isopropanol to recrystallize as well as completely dry at 50 ° C to get the finished product.
( 2) The intermediate o-cresol phosphate was gotten by the action of o-cresol and also phosphorus oxychloride, and also was chlorinated at 180 ° C to alter the methyl team right into -CHCI2, and afterwards reacted with sodium acetate at 160-180 ° C for 5h for cyclization Get it. If o-cresol connects with phosgene, the process is completed via the intermediate o-cresol carbonate: o-cresol sodium salt responds with phosgene at 60 ° C and also 0.15 MPa to form o-cresol carbonate. The esterification is chlorinated with chlorine gas at 180-185 ° C to a chlorine web content of regarding 37%, which is equivalent to two chlorine atoms in each cresol side chain. Lastly, in the presence of pyridine or zinc oxide as well as cobalt oxide, it is compressed with acetic acid and also acetic anhydride to get Coumarins in Plants, and the return of this approach is fairly high.

Application of Coumarins in Plants in Medicine

Vitamin K epoxide reductase complex (VKORC1)
Among the various pharmacological effects of Coumarins in Plants and their derivatives, the research on anticoagulant effect is the most mature. As early as the 1970s, Bell et al. proposed that anticoagulant drugs such as coumarin play an anticoagulant effect by inhibiting the reduction of vitamin K 2,3-epoxide (KO) to vitamin K hydrogen type reaction of. Later, it was discovered that warfarin and other coumarin drugs inhibited the activity of the key enzyme for KO reduction, which is vitamin K epoxide reductase (VKOR).

There are currently 3 anticoagulant drugs of the Coumarins in Plants category on the market, namely warfarin potassium, warfarin sodium and Phenprocoumon, all of which were launched earlier. Among them, the clinical trials of warfarin sodium are more detailed. The results of 6 clinical studies showed that warfarin sodium was significantly (p<0.05) superior to placebo, dipyridamole/aspirin and pentoxifylline/aspirin in resisting systemic thrombosis.

DNA gyrase B subunit (gyrB)
In the process of DNA replication, the negative supercoil created by DNA helicase (gyrase) can stabilize the separation of DNA, prevent excessive and non-template double-stranded coiling, and ensure the smooth progress of DNA replication. As a result, people have developed antibacterial drugs targeting gyrase: quinolones and coumarins. Quinolones act on the A subunit of gyrase, while coumarins act on the B subunit of gyrase.

The only currently marketed gyrB inhibitor is the coumarin drug novobiocin sodium. The drug is active against gram-positive bacteria such as Staphylococcus aureus (including methicillin-resistant strains) and other staphylococci; it is often resistant to Enterococcus faecalis and may be susceptible to Enterococcus faecium. Susceptible to Gram-negative bacteria including Haemophilus influenzae, Neisseria, and some Proteus species, but most Enterobacteriaceae are resistant to it. Novobiocin is mainly a bacteriostatic agent, but it also has a bactericidal effect on sensitive bacteria at high concentrations. Novobiocin has the effect of inhibiting DNA helicase and can also remove plasmids, but it is prone to drug resistance in vitro or during treatment. Although novobiocin can be used alone or in combination with other drugs such as rifampicin and sodium fusidate to treat infections caused by staphylococcus and other sensitive bacteria, but now due to the problems of drug resistance and toxicity, novobiocin has been basically replaced by other drugs. Novobiocin is a highly effective sensitizer, and related hypersensitivity reactions include rash, fever, and itching, and Stevens-Johnson syndrome and pneumonia can occur in more severe cases. Jaundice and liver damage can also occur, but jaundice is mainly caused by the yellow metabolite of the drug and partly by hyperbilirubinemia. Other adverse reactions included eosinophilia, leukopenia, thrombocytopenia, agranulocytosis, and hemolytic anemia; gastrointestinal reactions were common.

Photosensitizers
Another major use of Coumarins in Plants listed drugs is as a drug for the treatment of psoriasis and vitiligo. Methoxsalen and trimethalin, which were approved by the US Food and Drug Administration (FDA) in 1954, were developed by Valeant as psoralens, which can be used as photosensitizers in photochemotherapy or PUVA therapy. In addition, methoxsalen can also be selectively used for atopic dermatitis, multimorphic light eruption, T-cell lymphoma (such as mycosis fungoides), etc. In a study of PUVA therapy in 41 patients with psoriasis, administering methoxsalen 25 mg/m2 to the patients according to the body surface can make their blood drug concentrations more consistent, and relatively reduce the risk of obesity caused by the patients. Potential for overdose or underdose due to discrepancies.

Transforming growth factor beta 1 (TGF-beta1)
Transforming growth factor-beta (TGF-beta) was identified by DeLarco and Todaro in 1978 from the culture medium of mouse sarcoma virus cell strains, and was named transforming growth factor because of its characteristic of cell transformation. TGF-β is an important cytokine in organisms, which has a variety of biological effects, including embryonic development, wound healing, chemotaxis and cell cycle regulation. Studies have found that TGF-β can stimulate tissue fibrosis and extracellular matrix deposition, disrupt immune function, stimulate angiogenesis and promote epithelial-mesenchymal transition.

Coumarins in Plants amide derivative nicousamide (nicousamide) is a clinical phase II drug intended for renal dysfunction, including the treatment of diabetic nephropathy and hypertensive nephropathy. Studies have shown that nicousamide inhibits or slows down the process of renal fibrosis by inhibiting the phosphorylation of TGF-β receptor and its downstream proteins.

About Products:
If you need Coumarins in Plants cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Coumarins in Plants, ZSpharmac will provide Coumarins in Plants raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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