Zhishang Chemical

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Zhishang Chemical

Coumarin in Vanilla CAS 91-64-5

Molecular Formula: C9H6O2

Formula Weight: 146.14

ZSpharmac: Coumarin in Vanilla Supplement

Product Name: Coumarin in Vanilla
CAS No: 91-64-5
Purity: 99%

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Basic Info

Product Name:Coumarin in Vanilla
Other Names:Coumarin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystals or Crystalline Powder
EINECS No.:202-086-7
Storage:Store Below +30°C.
Provide:Coumarin in Vanilla MSDS;
Coumarin in Vanilla COA

What is Coumarin in Vanilla?

Coumarin in Vanilla is a natural product that is widely distributed in Rutaceae, Umbelliferae, Oysteraceae, Leguminosae, Compositae and Orchidaceae. Coumarin derivatives have various structural types and have various activities. Its special sweetness will remind many of the fresh herbal aroma.

Coumarin in Vanilla is often used as a fixative for the preparation of fragrances, beverages, foods, soaps, etc. It is an important spice, as well as the raw material and intermediate of fine chemical products such as medicines. In medicine, coumarin has derived many products, mainly used for anti-platelet aggregation, anti-thrombosis, liver protection and sleep regulation.

A variety of anticoagulant rodenticides have also been synthesized in pesticides, such as bromadiolone, difenacoum, brodifacoum, warfarin, coumafur- yl), coumatetralyl, etc.

Coumarin in Vanilla Property

Melting point 68-73 °C (lit.)
Boiling point 298 °C (lit.)
density 0.935
vapor pressure 0.01 mm Hg ( 47 °C)
refractive index 1.5100 (estimate)
Fp 162 °C
storage temp. Store below +30°C.
solubility 1.7g/l
form Crystals or Crystalline Powder
color White
PH RangeNon’ uorescence (9.5) to light green ‘ uorescence (10.5)
Water Solubility 1.7 g/L (20 ºC)


Coumarin in Vanilla Uses

  1. Coumarin in Vanilla is primarily utilized in the blending fragrance of soap as well as various cleaning agents. It is the main ingredient of blending fragrance and also can also be used as electroplating brightener.
  2. Coumarin in Vanilla is made use of in the manufacture of scents, as a fixative as well as likewise in the electroplating industry.
  3. Coumarin in Vanilla is commonly utilized in the prep work of new cut as well as fudge flavors. And also violet, sunflower, Suxinlan, hawthorn flower, orchid, lavender as well as various other flavors. Along with Coumarin in Vanilla, it can be used to flavor confectionery, pastries, and so on, and also added to tobacco to include an all-natural taste. Adding coumarin to the electroplating solution of zinc (or cadmium, nickel) can minimize the porosity of the covering and also boost the brightness. Coumarin is a resources for making various other fragrances as well as a range of various other chemicals. Coumarin is the parent of a large class of by-products. Several of these derivatives exist in nature, while others are created artificially.

Production Method of Coumarin in Vanilla

(1) It is obtained from salicylaldehyde by Perkin reaction. This is the synthesis method originally adopted by Perkin in 1868. The reaction of salicylaldehyde with acetic anhydride can use calcined potassium carbonate as a catalyst. Add carbonic acid and acetic anhydride to salicylaldehyde, heat to 187°C, steam out acetic acid at a gas phase temperature of about 120°C, and then add acetic anhydride to react at 210-212°C. The resulting crude Coumarin in Vanilla was washed with water and distilled in vacuo. Then recrystallize with ethanol or isopropanol and dry at 50°C to obtain the finished product.
(2) By the action of o-cresol and phosphorus oxychloride, the intermediate o-cresol phosphate is obtained, and it is chlorinated at 180 °C to change the methyl group to -CHCI2, and then reacted with sodium acetate at 160-180 °C for 5h for cyclization. Get it. If o-cresol reacts with phosgene, the process is completed through the intermediate o-cresol carbonate: o-cresol sodium salt reacts with phosgene at 60°C and 0.15MPa to generate o-cresol carbonate. The esterification is chlorinated with chlorine gas at 180-185°C to a chlorine content of about 37%, which corresponds to two chlorine atoms per cresol side chain. Finally, in the presence of pyridine or zinc oxide and cobalt oxide, it is condensed with acetic acid and acetic anhydride to obtain Coumarin in Vanilla, and the yield of this method is quite high.

Optimal Doses of Warfarin and Coumarin in Vanilla Anticoagulants

Coumarin in Vanilla anticoagulants, consisting of warfarin, acenocoumarin, as well as phenprocoumarin, are among the most commonly made use of medications worldwide. There is currently a wealth of released information indicating that certain common polymorphisms in genes inscribing the target vitamin K epoxide reductase (G-1639A/ C1173T) and also significant metabolic enzyme CYP2C9 (CYP2C9 * 2 and also * 3 alleles) The genotype is an important determinant of individual Coumarin in Vanilla anticoagulant dosage needs. Various other less usual polymorphisms in these genes, along with polymorphisms in other genetics related to coagulation, such as cytochrome P450 CYP4F2, γ-glutamyl carboxylase, calcin, as well as cytochrome P450 oxidoreductase, also May be a crucial forecaster of dosage, particularly in ethnic groups such as Africans, which are less genetically researched compared to European populaces. Making use of appropriate genotypes to determine beginning dosages may boost safety during initiation. Numerous dosage estimation algorithms have been established for all three commonly used coumarin anticoagulants, likewise thinking about individual age as well as various other qualities, and also are currently being evaluated in huge randomized scientific tests. A recently completed research study supplied encouraging results showing that computing warfarin dosing based on individual client genotype caused fewer adverse events and a higher percent of time within the therapeutic clotting price window, yet these searchings for still require to be validated. Using appropriate genotypes to calculate beginning doses may enhance safety and security throughout initiation. Numerous dosage estimation algorithms have been created for all three widely used coumarin anticoagulants, additionally considering patient age as well as other features, as well as are presently being tested in large randomized medical tests. A lately completed research study supplied motivating outcomes showing that calculating warfarin application based on individual patient genotype resulted in fewer damaging events and also a higher portion of time within the healing clotting rate home window, but these searchings for still require to be confirmed. Utilizing relevant genotypes to determine beginning doses might improve safety and security during initiation. Numerous dosage computation formulas have been established for all 3 extensively made use of Coumarin in Vanilla anticoagulants, likewise taking into account patient age as well as other characteristics, as well as are currently being examined in a big randomized clinical trial. A lately finished research provided motivating outcomes showing that calculating warfarin application based on private person genotype led to fewer adverse events as well as a greater percentage of time within the restorative clotting price window, but these searchings for still require to be verified. All 3 commonly utilized coumarin anticoagulants have actually been established and are currently being evaluated in huge randomized medical tests. A lately completed research provided encouraging outcomes revealing that calculating warfarin application based upon specific person genotype led to less unfavorable events as well as a higher percentage of time within the restorative clotting rate window, yet these searchings for still need to be verified. All 3 commonly used coumarin anticoagulants have actually been established and are now being evaluated in large randomized medical tests. A lately finished research gave motivating results showing that computing warfarin dosing based upon specific patient genotype resulted in fewer unfavorable occasions as well as a greater percent of time within the therapeutic clotting rate window, however these findings still need to be verified.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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