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Costus Oil CAS 8023-88-9

Molecular Formula: N/A

Formula Weight: 0

ZSpharmac: Costus Oil Supplier

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Product Name: Costus Oil
CAS No: 8023-88-9
Purity: 99%

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Basic Info

Product Name:Costus Oil
Other Names:Aroma Oil
CAS:8023-88-9
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Tan Viscous Essential Oil
EINECS No.:639-571-1
Storage:2-8°C
Provide:Costus Oil MSDS;
Costus Oil COA

Muxiang is the completely dry root of the seasonal herb of Asteraceae Aucklandialappa Decne. It is primarily created in Yunnan, likewise referred to as Yunmuxiang. The components in woody fragrance primarily consist of Costus Oil, sterols, alkaloids, and also natural acids. Medicinal as well as pharmacodynamic researches in recent years have discovered that the main energetic ingredient of Costus Oil is a blend of various sesquiterpenoids mainly composed of Costunolide as well as Dehydrocostuslactone. It has noticeable pharmacological impacts in anti-inflammation, anti-tumor, anti-virus, restraint of vasoconstriction and also immune law.
The scent contains volatile oil, and its active ingredient is mainly sesquiterpene lactone, which has the features of loosening up smooth muscle, soothing spasm and reasonably lowering high blood pressure. Costus Oil is a tan thick unpredictable crucial oil with an unique woody and also scorched aroma. The powder of this product is brownish purple or yellow-colored brown. It is soluble in ethanol, many non-volatile oils and also mineral oils, as well as insoluble in glycerin as well as propylene glycol. It is obtained from the dried out (shade-dried) root of Coriandrum sativum, a seasonal herb of the category Coriandrum, smashed, steam distilled or extracted with a solvent, and after that distilled from the resinous extract.

Chemical Composition of Costus Oil

The main component of Costus Oil is tertiary nerolidol (nerolidol), also known as nerolidol, which has the highest relative percentage content. Studies have shown that the main components of balsamic oil are alcohol compounds, of which nerolidol, nerolidol and nerolidol Isomers accounted for 93.64% of the total oil. In addition, 13 kinds of chemical components were identified from the volatile oil extracted by the method of steam distillation (SD method), the main component was tertiary nerolidol, and the relative percentage was 57.36%. The extract was analyzed by CO2 supercritical extraction method (SFE-CO2 method) and GC-MS combined analysis technology, and 52 kinds of chemical components were separated, of which nerolidol (38.24% ), 2,4-dimethyl-2,4-heptadienal (25.826%), 2,4-dimethyl-2,6-heptadienal (18.477%).

Studies have also shown that the main component of balsamic is 2,4-dimethyl-2,4-heptadienal (about 31.6%), followed by nerolidol (about 23.9%); research has shown that caryophyllene oxide (54.22 %) content is the highest, while nerolidol content is 10.22%. Due to different varieties, origins and extraction processes, the total amount of Costus Oil and the percentage of nerolidol vary greatly. The pharmacopoeia records that the source of the fragrance is the leguminous plant Dalbergia, but the folks also have the Rutaceae plant Shanyou, Hainan Dalbergia, Indian Dalbergia, and Indian Red Sandalwood for use as fragrances.

The content of different varieties of Costus Oil and the content of main components in the oil were compared by GC-MS. As a result, the volatile oil contained in the medicinal material of Dalbergia balata was 3.61%-3.79%, the volatile oil in the imported balsamic product was 0.81%-3.61%, the volatile oil in Indian red sandalwood was about 0.43%, the volatile oil in Gongjia was about 0.10%, and the volatile oil in mountain orange was about 0.07%. The volatile oil content of Indian Dalbergia is about 0.06%, and the volatile oil of Hainan Dalbergia is very small. Nerolidol accounted for 45.23% to 69.13% of the volatile oil content, and no nerolidol was detected in the volatile oils of capers and gongjia. It can be seen that the quality of Dalbergia is the best; Indian Dalbergia, Hainan Dalbergia (low oil content), Gongjia and Shanyou are not suitable for Dalbergia. In addition, it was denied that the mountain oil mandarin orange was the source of balsamic fragrance from two aspects of the source research and the crude drug identification.

Agarwood often grows in middle-altitude areas, likes light, and has strong stress resistance. It is mostly distributed in semi-deciduous monsoon forests and sparse shrub forests. It is a unique plant in Hainan, and it was later introduced to Guangzhou, Guangxi, Fujian and other places for cultivation. Due to the different climate and environment in the regions where the medicinal materials are grown, the content of Costus Oil varies greatly.

Costus Oil Uses

  1. Costus Oil is used as a raw material for soaps and fragrances.
  2. Costus Oil is used in cosmetics, detergents, aromatherapy, insecticides and medical health care products.

Application of Costus Oil

Chen et al. found that Costus Oil showed strong inhibitory activity on the gene expression of hepatitis B surface antigen HBsAg and hepatitis B e antigen HBeAg in human liver cancer cells Hep3B and HepA2, but had little effect on cell survival. This inhibitory effect mainly occurs at the mRNA level in a dose-response manner, with IC50 of 1.0 μM and 2.0 μM, respectively. This result shows that corynelide and dehydrocorylidene may be developed into specific drugs against hepatitis B virus.

Lee et al found that Costus Oil can inhibit the production of NO and reduce the level of TNF-α in the LPS-activated system for LPS-activated mouse macrophage RAW 264.7 and human monocytes. This activity is very good in vitro and in vivo. significantly. The research team further studied its mechanism of action and believed that this compound can inactivate NF-κB, thereby inhibiting the gene expression of i-NOS (inducible NO synthase), and finally leading to the inhibition of NO production. Therefore, woody oil may be a good candidate for the treatment of endotoxin diseases accompanied by excessive production of NO and TNF-α. Wood balm oil against LPS-activated mouse macrophage RAW 264.7, Kang et al. showed the anti-inflammatory activity of wood balm oil. The results showed that the compound could block the activation of MAPK family enzymes (mitogen-activated protein kinase) and the binding of DNA to AP-1, thereby inhibiting the expression of IL-1β protein and mRNA.

Lee et al. first explored the anti-tumor mechanism of Costus Oil. The experimental results showed that woody oil strongly induces apoptosis of cancer cells by inducing ROS (active O) as a transmitter of mitochondrial permeabilization and release of cytochrome C. .

At present, the compound preparations containing Costus Oil are mainly sold in the market, all of which are administered orally, such as Muxiang Shunqi pills, Muxiang betel nut pills, Muxiang Liqi pills, and Liuwei Muxiang capsules.

Because Costus Oil is hydrophobicity, so preparation injection needs a large amount of organic solvents or uses the solubilizing agent of a large amount of toxic side effects, as using surfactants such as polyoxyethylene castor oil (Cremophor-EL), this type of surfactant has Sensitization, a higher incidence of allergic reactions after heavy use.

Preparation of Costus Oil

method one:
Take 1000g of dry woody powder, soak it with 60% ethanol at room temperature, reflux extract three times (3 × 5000ml), each extraction time is 2 hours, combine the filtrate, concentrate the filtrate under reduced pressure to a density of 1.20, add 5 times the volume of Diluted with water and extracted 3 times with ethyl acetate, combined the ester layer, concentrated under reduced pressure to recover the solvent, then put it on a silica gel column (200-300 mesh, 2000g), first washed 3 column volumes with petroleum ether, and continued to use petroleum ether-ethyl acetate Esters (20:1) were eluted for 4 column volumes, the eluate was collected and the solvent was recovered under reduced pressure at 40°C to obtain 35g of Costus Oil, containing 32% of corynelide and 49% of dehydrocorylidene (w/w ).

Method Two:
The dry blocky root product produced in the same year, clean, cut into 2 mm thick slices, take 300 g, put it in a pot, fry until the surface is slightly yellow at 150°C, take it out and let it cool, crush it, pass it through a 20-mesh sieve, Add 3 times the volume of methanol, soak overnight at room temperature, put it into the percolation cylinder, use 10 times the volume of methanol to extract by percolation at 10°C, filter the percolation liquid, recover methanol under reduced pressure to a final volume of about 200 ml, add 700 ml of concentrated solution ml of distilled water to adjust the volume ratio of methanol content to about 20%, extract with ether, 2500 ml×1, dry and filter the extract with anhydrous Na2SO4, distill and concentrate in a hot water bath, condense with ice water, recover ether, until there is still some remaining in the distillation vessel About 100 mL of solution, stop the distillation, take out the residual solution, put it in a fume hood to evaporate the ether, the residue is refined by molecular distillation, the distillation pressure is 0.13 mbar, the scraping speed is 200 r/min, and the feed rate is 1.2 g /min, collect the distillate below 160°C to get Costus Oil.

About Products:
If you need Costus Oil, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Costus Oil producer and supplier, ZSpharmac will provide Costus Oil raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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