Cortex Eucommiae CAS 327-97-9

Molecular Formula: C16H18O9

Formula Weight: 354.31

ZSpharmac: Cortex Eucommiae Raw Material Supplier

Product Name: Cortex Eucommiae

CAS No: 327-97-9

Purity: 99%

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Basic Info

Product Name:	Cortex Eucommiae
Other Names:	Chlorogenic Acid
CAS:	327-97-9
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White to Almost White Powder
EINECS No.:	206-325-6
Storage:	2-8°C
Provide:	Cortex Eucommiae MSDS； Cortex Eucommiae COA

What is Cortex Eucommiae?

Chlorogenic acid, in addition called “chlorogenic acid”, “coffee tannic acid” and “coffee tannic acid”, is a phenylpropanoid compound created by plants with the shikimic acid training program throughout cardio respiration. It is caffeoyl Quinic acid derivatives have solid antioxidant ability. They likewise have features such as anti-HIV, anti-tumor cells, anti-bacterial, improving major nerves excitability, choleretic, antiteratogenic, anti-allergic, and taking care of the task of cytochrome P450 ligase.

Chlorogenic acid generally exists in plants of the Lonicera classification and the Asteraceae member of the family, and in Eucommia leaves (2-5%), honeysuckle (1-5.9%), sunflower seeds (1.5-3%) and coffee beans (2- 8%) and numerous other plants have higher item. Needle-like crystals are gotten from water as hemihydrate, and take place anhydrous at 110 ° C. Melting point: 208 ° C, [α] D25-33.5 ° (water, C=1), K=2.2 × 10-3 (27 ° C). It has a somewhat sour selection and has astringent homes. The solubility in water is 4% at 25 ° C. It is relatively soluble in hot water, soluble in ethanol and acetone, somewhat soluble in ethyl acetate, and insoluble in chloroform, ether and carbon disulfide. It azeotropes with concentrated hydrochloric acid to acquire blue color. It can make bromine water discolor, and azeotrope with concentrated hydrogen iodide to produce benzoic acid. It can be thermally broken down with water at 230 ° C to phenol. It can be thermally broken down with thin down hydrochloric acid right into caffeic acid and cinchona acid. It can react with thin down antacids at location temperature degree to create coffee. acid and cinchona acid.

The molecular structure of chlorogenic acid has an ester bond, an unsaturated dual bond, 3 hydroxyl teams and 2 phenolic hydroxyl groups. Its chemical homes are reasonably unsteady and it is sensitive to light and warm. From a building viewpoint, chlorogenic acid is an ester produced by the condensation of caffeic acid and quinic acid, and is a phenolic compound. Considered that the particle has an o-diphenolic hydroxyl group, it has exceptionally solid reducing properties and is far more easily oxidized by cost-free radicals, as a result disclosing superb absolutely cost-free extreme scavenging and anti-lipid peroxidation results.

Cortex Eucommiae Property

Melting point	210 °C (dec.) (lit.)
alpha	-36 º (c=1, H2O)
Boiling point	407.55°C (rough estimate)
density	1.3594 (rough estimate)
refractive index	-37 ° (C=1, H2O)
storage temp.	2-8°C
solubility	Soluble in ethanol and acetone.
pka	3.91±0.50(Predicted)
form	Powder, Crystals, Needles and/or Chunks
color	White to almost white
Water Solubility	SOLUBLE IN HOT WATER

Cortex Eucommiae Efficacy and Role

Chlorogenic acid can reduce body fat, anti-oxidant, anti-aging, manage blood sugar, anti-bacterial, anti-inflammatory, antiviral, etc.

Reduce body fat
Many individuals speak about alcohol consumption coffee to reduce weight, and even coffee bean remove is utilized as a weight-loss drug. Actually, the primary contributor to the weight management effect is chlorogenic acid!!
According to experiments conducted by Ae Sim Cho et al., chlorogenic acid dramatically minimized body weight, natural fat mass, plasma leptin and insulin levels, triglycerides in the liver and heart, and cholesterol in adipose tissue and heart. Furthermore, chlorogenic acid can additionally dramatically lower the triglyceride material in adipose tissue.
In another trial, 16 overweight grownups obtained high-dose chlorogenic acid (1050 mg), low-dose CGA (700 mg), or sugar pill for 6 weeks every day. After 22 weeks, the overweight adults’ body fat mass, Body fat percent, heart price and BMI all decreased, and the BMI of six obese topics dropped to the normal range.
Anti-oxidation
Chlorogenic acid is a kind of polyphenols and is acknowledged as an all-natural anti-oxidant. The major part of some antioxidant health items is chlorogenic acid.
Researchers have actually located that chlorogenic acid can lower the apoptosis of retinal afferent neuron brought on by hypoxia or extreme carbon monoxide. Since chlorogenic acid can decrease retinal cell death, chlorogenic acid has the capability to avoid sores caused by retinal degeneration.
Niggeweg et al. released literature in Nature Biotechnology revealing that chlorogenic acid functions as an antioxidant in plants and can postpone animal deterioration and illness brought on by aging.
Regulate blood glucose
Numerous research studies have actually revealed that chlorogenic acid can manage blood glucose, boost insulin resistance, and minimize the risk of kind 2 diabetes mellitus.
In an experiment performed by Ahrens et al., it was verified that chlorogenic acid can considerably minimize the focus of glucose and insulin.
Experiments by Khang WeiOng and others have revealed that the principle of chlorogenic acid can regulate blood glucose is that it can inhibit the expression and activity of liver glucose-6-phosphatase, reduce liver steatosis, enhance lipid profile and skeletal muscular tissue glucose uptake, thus enhancing blood sugar level degrees, sugar Resistance, insulin level of sensitivity and dyslipidemia.
Antibacterial anti-inflammatory
The energetic anti-bacterial component of honeysuckle, Cortex Eucommiae and other standard Chinese organic medications is chlorogenic acid!
Cortex Eucommiae has the result of hindering and removing numerous pathogenic germs. Experiments have revealed that the major principle of chlorogenic acid preventing pathogenic germs is to inhibit the metabolic rate of sugar by pathogenic microorganisms, resulting in not enough power supply to pathogenic germs, therefore hindering their development. On top of that, chlorogenic acid can likewise minimize the number of pathogenic microorganisms by hindering the synthesis of flagella of pathogenic germs.
According to study, Cortex Eucommiae additionally has antiviral impacts, and chlorogenic acid is also considered by researchers to be among the possibly reliable substances against HIV, and might play a crucial duty in future anti-HIV medicines.

Extraction of Chlorogenic acid from Plant-Derived Natural Products

Water extraction approach

The water extraction method, also known as the product approach, is an approach in which the example is immersed in water, heated and boiled for a certain amount of time, the leachate is separated, the sample is heated and steamed multiple times, and lastly the leachate is combined. This is a very typical and old method that remains to now. When this technique is utilized for extraction, the leachate acquired has intricate parts, is reasonably viscous, is challenging to filter, and is not conducive to refining. And the removed target materials are needed to be soluble in water and stable and versatile to temperature level and humidity. Although the removal price of this method is certainly low compared with the subsequent brand-new extraction methods that have actually appeared successively, such as microwave-assisted extraction, reflux extraction, ultrasonic removal, and so on, this method can stay clear of the pollution of organic solvents and safeguard the ecology. environment.

Reflux removal technique

The reflux removal technique refers to using a warmed reflux gadget to essence sample components with unpredictable natural solvents (such as ethanol). The solvent is heated and distilled, compressed through the condenser tube, and after that recedes into the container to remove the raw products. This goes back and forth up until the removal is total. approach The reflux method is an extra standard extraction method The drawbacks of this approach are that the removed Cortex Eucommiae has extreme loss, impure quality, and takes a long time. It is not ideal for extracting substances that are conveniently disintegrated by heat. Nonetheless, the procedure is basic and the removal effectiveness is more than the cool soaking approach

Ultrasonic removal approach

The ultrasonic removal method utilizes the cavitation, mechanical and thermal impacts of ultrasonic waves to destroy the cell structure, accelerate the launch and dissolution of intracellular compounds, and effectively boost the removal performance. Generally, the ultrasonic removal method takes much shorter extraction time than the reflux technique, has less solvent loss, and has greater extraction performance.

Microwave-assisted extraction technique

Microwave-assisted removal is a method that uses electromagnetic waves to separate elements from the matrix and efficiently maintain the original state of the extract. This technique has a short extraction time, is easy to operate, fast and effective.

Enzyme extraction method

Enzymatic method refers to a method that utilizes biocatalyst enzymes to decompose the parts of plant cell walls to improve the extraction price of energetic components. This technique is easy to run, has moderate conditions, and is eco-friendly and harmless. Nonetheless, it must be kept in mind that some phenolic substances might be destroyed when adjusting the pH.

Compared to various other methods, since the enzyme’s activity problems are light, the extraction temperature is low, and the enzyme requires to be chosen beforehand according to the kind of remove to boost the purity of chlorogenic acid.

Enzymatic hydrolysis-ultrasound mixed approach

The chemical hydrolysis-ultrasonic combined method is a reasonably new method. It primarily integrates both approaches with complementary benefits. Compared to a solitary technique, the extraction performance is greater and the extraction top quality is much better. The enzyme-assisted ultrasonic extraction (EAUE) technique based on polyethylene glycol (PEG-200) was made use of to extract chlorogenic acid (CGA) from honeysuckle leaves. The removal procedure was maximized and confirmed, and was compared to various other traditional extraction procedures. Contrast. Under the removal process conditions, the results show that when the polyethylene glycol concentration is 42%, the removal temperature level is 49 ° C, and the pH worth is 4.2, the experimental extraction rate is 6.955%. Compared with thermal reflux extraction, PEG-based EAUE has a far better effect on honeysuckle. The extraction effectiveness of CGA is higher.

Supercritical removal technique

Supercritical extraction is a method that removes sample components with different solubilities together to achieve extraction and splitting up by adjusting the temperature and stress of the extraction fluid. The Cortex Eucommiae drawn out by this technique has much less loss, superb high quality and high removal efficiency, however it is hard to execute mass production because of pricey equipment.

Content Determination of Cortex Eucommiae by HPLC

(1) Chromatographic problems: Make use of octadecylsilane adhered silica gel as the filler; acetonitrile-0.4% phosphoric acid option (13:87) as the mobile phase; the detection wavelength is 327nm. The number of academic plates is greater than 1,000 based on the chromatographic heights of chlorogenic acid.
( 2) Preparation of the recommendation substance service: Specifically weigh a proper quantity of the chlorogenic acid reference substance, area it in a brown measuring container, include 50% methanol to make a service containing 40 μg per ml, and get it (store listed below 10 ° C).
( 3) Prep work of sample solution: Take around 0.5 g of dry example powder, evaluate it precisely, position it in a stoppered Erlenmeyer flask, include 50ml of 50% methanol accurately, consider it, ultrasonicate it for thirty minutes, allow it trendy, consider it, and utilize Add 50% methanol to make up for the reduced weight, drink well, filter, discard the initial filtrate, properly determine 5ml of the extra filtrate, place it in a 25ml brownish measuring bottle, include 50% methanol to the mark, shake well, and it is ready. (4) Decision: Exactly attract 10 μl each of the reference compound and sample solution, inject them right into the liquid chromatograph, and action.

About Products:
If you need Chlorogenic acid as a cosmetic raw material, please contact our service staff directly and we will provide you with high-quality products at the best price.
Our company, as an experienced Chlorogenic acid manufacturer and supplier, ZSpharmac will provide Chlorogenic acid raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.